{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:46:21Z","timestamp":1777502781890,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160254"],"award-info":[{"award-number":["82160254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101372"],"award-info":[{"award-number":["82101372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["R20213001"],"award-info":[{"award-number":["R20213001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.brainres.2024.149416","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T13:58:07Z","timestamp":1734703087000},"page":"149416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Inhibition of autophagy attenuates cognitive decline and mitochondrial dysfunction in an Alzheimer\u2019s disease mouse model with chronic cerebral hypoperfusion"],"prefix":"10.1016","volume":"1850","author":[{"given":"Qin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofa","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengmin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingwu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglong","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongdong","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2024.149416_b0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"Bjorkoy","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.brainres.2024.149416_b0010","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1007\/s11064-017-2391-9","article-title":"Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating \u03b2\/\u03b3-Secretases","volume":"42","author":"Cai","year":"2017","journal-title":"Neurochem Res."},{"key":"10.1016\/j.brainres.2024.149416_b0015","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/brv.12378","article-title":"Structure, function, and regulation of mitofusin-2 in health and disease","volume":"93","author":"Chandhok","year":"2018","journal-title":"Biol Rev Camb Philos Soc."},{"key":"10.1016\/j.brainres.2024.149416_b0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12906-021-03375-2","article-title":"Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease","volume":"21","author":"Cheng","year":"2021","journal-title":"BMC Complement Med Ther."},{"key":"10.1016\/j.brainres.2024.149416_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203833","article-title":"TFDP3 regulates the apoptosis and autophagy in breast cancer cell line MDA-MB-231","volume":"13","author":"Ding","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2024.149416_b0030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.trsl.2022.12.003","article-title":"Vascular contributions to Alzheimer's disease","volume":"254","author":"Eisenmenger","year":"2023","journal-title":"Transl Res."},{"key":"10.1016\/j.brainres.2024.149416_b0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainres.2018.06.003","article-title":"Chronic cerebral hypoperfusion accelerates Alzheimer's disease pathology with the change of mitochondrial fission and fusion proteins expression in a novel mouse model","volume":"1696","author":"Feng","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2024.149416_b0040","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1089\/ars.2018.7649","article-title":"p62\/SQSTM1 and Selective Autophagy in Cardiometabolic Diseases","volume":"31","author":"Jeong","year":"2019","journal-title":"Antioxid Redox Signal."},{"key":"10.1016\/j.brainres.2024.149416_b0045","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.phrs.2014.02.008","article-title":"Temsirolimus promotes autophagic clearance of amyloid-\u03b2 and provides protective effects in cellular and animal models of Alzheimer's disease","volume":"81","author":"Jiang","year":"2014","journal-title":"Pharmacol Res."},{"key":"10.1016\/j.brainres.2024.149416_b0050","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fnagi.2018.00378","article-title":"A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration","volume":"10","author":"Jin","year":"2018","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.brainres.2024.149416_b0055","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2012.12.016","article-title":"Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy","volume":"152","author":"Kim","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2024.149416_b0060","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2024.149416_b0065","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat Neurosci."},{"key":"10.1016\/j.brainres.2024.149416_b0070","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2024.149416_b0075","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.gendis.2021.01.007","article-title":"Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP\/PS1 double transgenic female mice","volume":"9","author":"Luo","year":"2022","journal-title":"Genes Dis."},{"key":"10.1016\/j.brainres.2024.149416_b0080","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0304-3940(01)01754-2","article-title":"Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease","volume":"304","author":"Mehta","year":"2001","journal-title":"Neurosci Lett."},{"key":"10.1016\/j.brainres.2024.149416_b0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mito.2018.11.002","article-title":"Mitochondrial dynamics, a key executioner in neurodegenerative diseases","volume":"47","author":"Panchal","year":"2019","journal-title":"Mitochondrion"},{"key":"10.1016\/j.brainres.2024.149416_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101191","article-title":"Defective mitophagy in Alzheimer's disease","volume":"64","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.brainres.2024.149416_b0095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/jnc.15620","article-title":"Artesunate restores mitochondrial fusion-fission dynamics and alleviates neuronal injury in Alzheimer's disease models","volume":"162","author":"Qin","year":"2022","journal-title":"J Neurochem."},{"key":"10.1016\/j.brainres.2024.149416_b0100","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.biocel.2016.07.020","article-title":"Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles","volume":"79","author":"Roberts","year":"2016","journal-title":"Int J Biochem Cell Biol."},{"key":"10.1016\/j.brainres.2024.149416_b0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/febs.14712","article-title":"p62\/SQSTM1: 'Jack of all trades' in health and cancer","volume":"286","author":"S\u00e1nchez-Mart\u00edn","year":"2019","journal-title":"Febs J."},{"key":"10.1016\/j.brainres.2024.149416_b0110","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2024.149416_b0115","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259924","article-title":"PEX11\u03b2 and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor","volume":"135","author":"Schrader","year":"2022","journal-title":"J Cell Sci."},{"key":"10.1016\/j.brainres.2024.149416_b0120","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-151126","article-title":"Strong Impact of Chronic Cerebral Hypoperfusion on Neurovascular Unit, Cerebrovascular Remodeling, and Neurovascular Trophic Coupling in Alzheimer's Disease Model Mouse","volume":"52","author":"Shang","year":"2016","journal-title":"J Alzheimers Dis."},{"key":"10.1016\/j.brainres.2024.149416_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146379","article-title":"Chronic cerebral hypoperfusion alters amyloid-beta transport related proteins in the cortical blood vessels of Alzheimer's disease model mouse","volume":"1723","author":"Shang","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2024.149416_b0130","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neures.2018.06.002","article-title":"Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer's disease model mouse","volume":"143","author":"Shang","year":"2019","journal-title":"Neurosci Res."},{"key":"10.1016\/j.brainres.2024.149416_b0135","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00210-017-1417-9","article-title":"Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-\u03baB pathways","volume":"390","author":"Su","year":"2017","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"10.1016\/j.brainres.2024.149416_b0140","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.arr.2015.08.006","article-title":"Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies","volume":"24","author":"Tromp","year":"2015","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.brainres.2024.149416_b0145","doi-asserted-by":"crossref","first-page":"18563","DOI":"10.1073\/pnas.0804758106","article-title":"Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity","volume":"106","author":"Usui","year":"2009","journal-title":"Proc Natl Acad Sci U S a."},{"key":"10.1016\/j.brainres.2024.149416_b0150","first-page":"151","article-title":"Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes","volume":"70","author":"Wada","year":"2016","journal-title":"Acta Med Okayama."},{"key":"10.1016\/j.brainres.2024.149416_b0155","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1080\/15548627.2021.1872187","article-title":"Crocetin promotes clearance of amyloid-\u03b2 by inducing autophagy via the STK11\/LKB1-mediated AMPK pathway","volume":"17","author":"Wani","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.brainres.2024.149416_b0160","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s13105-023-00966-0","article-title":"HIF-1 signaling: an emerging mechanism for mitochondrial dynamics","volume":"79","author":"Xin","year":"2023","journal-title":"J Physiol Biochem."},{"key":"10.1016\/j.brainres.2024.149416_b0165","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4103\/1673-5374.202945","article-title":"Neuroprotective effects of autophagy inhibition on hippocampal glutamate receptor subunits after hypoxia-ischemia-induced brain damage in newborn rats","volume":"12","author":"Xu","year":"2017","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.brainres.2024.149416_b0170","doi-asserted-by":"crossref","first-page":"e2738","DOI":"10.1038\/cddis.2017.161","article-title":"Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage","volume":"8","author":"Yang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2024.149416_b0175","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-024-02043-0","article-title":"Autophagy regulation attenuates neuroinflammation and cognitive decline in an Alzheimer's disease mouse model with chronic cerebral hypoperfusion","author":"Yang","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.brainres.2024.149416_b0180","article-title":"Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review","volume":"22","author":"Yu","year":"2021","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.brainres.2024.149416_b0185","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3233\/JAD-160345","article-title":"Chronic Cerebral Hypoperfusion Accelerates Alzheimer's Disease Pathology with Cerebrovascular Remodeling in a Novel Mouse Model","volume":"53","author":"Zhai","year":"2016","journal-title":"J Alzheimers Dis."},{"key":"10.1016\/j.brainres.2024.149416_b0190","article-title":"Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP\/PS1 Mutated Transgenic Mice","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2024.149416_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.114889","article-title":"Mitophagy activation by rapamycin enhances mitochondrial function and cognition in 5xFAD mice","volume":"463","author":"Zheng","year":"2024","journal-title":"Behav Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324006711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899324006711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:07:28Z","timestamp":1777378048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899324006711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":39,"alternative-id":["S0006899324006711"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149416","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of autophagy attenuates cognitive decline and mitochondrial dysfunction in an Alzheimer\u2019s disease mouse model with chronic cerebral hypoperfusion","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2024.149416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149416"}}