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Nanomed."},{"key":"10.1016\/j.brainres.2024.149438_b0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-023-02510-6","article-title":"Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations","volume":"13","author":"Kilpatrick","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149438_b0370","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41580-020-0259-3","article-title":"Human organoids: model systems for human biology and medicine","volume":"21","author":"Kim","year":"2020","journal-title":"Nat. Rev. Mol. 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Chem."},{"key":"10.1016\/j.brainres.2024.149438_b0380","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0014-5793(98)00413-X","article-title":"Rapid and irreversible inhibition of creatine kinase by peroxynitrite","volume":"427","author":"Konorev","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainres.2024.149438_b0385","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1042\/bj3460767","article-title":"Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide","volume":"346","author":"Kotsonis","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2024.149438_b0390","first-page":"964","article-title":"Nitric oxide and peroxynitrite serum levels in Parkinson\u2019s disease: correlation of oxidative stress and the severity of the disease","volume":"17","author":"Kouti","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. 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Sci."},{"key":"10.1016\/j.brainres.2024.149438_b0405","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/elan.200503436","article-title":"Peroxynitrite\/nitric oxide balance in ischemia\/reperfusion injury-nanomedical approach","volume":"18","author":"Kubant","year":"2006","journal-title":"Electroanalysis"},{"key":"10.1016\/j.brainres.2024.149438_b0410","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/nprot.2014.158","article-title":"Generation of cerebral organoids from human pluripotent stem cells","volume":"9","author":"Lancaster","year":"2014","journal-title":"Nat. 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Dise."},{"key":"10.1016\/j.brainres.2024.149438_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112714","article-title":"Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors","volume":"42","author":"Lu","year":"2023","journal-title":"Cell Reports"},{"key":"10.1016\/j.brainres.2024.149438_b0460","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","article-title":"Nitric oxide signaling in health and disease","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2024.149438_b0465","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1016\/j.celrep.2016.12.001","article-title":"Cerebral organoids recapitulate epigenomic signatures of the human fetal brain","volume":"17","author":"Luo","year":"2016","journal-title":"Cell Reports"},{"key":"10.1016\/j.brainres.2024.149438_b0470","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1523\/JNEUROSCI.17-07-02645.1997","article-title":"Nitric oxide facilitates long-term potentiation, but not long-term depression","volume":"17","author":"Malen","year":"1997","journal-title":"J. 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Res."},{"key":"10.1016\/j.brainres.2024.149438_b0530","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1254\/jphs.CPJ06007X","article-title":"Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus","volume":"100","author":"Miyamoto","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2024.149438_b0535","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0079-6123(08)63205-7","article-title":"Chapter 10 The role of nitric oxide in development of the patch\u2014cluster system and retinocollicular pathways in the rodent superior colliculus","volume":"118","author":"Mize","year":"1998","journal-title":"Prog. 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C Semin. Med. Genet."},{"key":"10.1016\/j.brainres.2024.149438_b0555","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.958556","article-title":"Vitamin D status in children with a psychiatric diagnosis, autism spectrum disorders, or internalizing disorders","volume":"13","author":"Muskens","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149438_b0560","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1038\/s41380-022-01506-w","article-title":"Genetics of glutamate and its receptors in autism spectrum disorder","volume":"27","author":"Nisar","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2024.149438_b0565","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/dneu.22828","article-title":"Brain organoids: a promising model to assess oxidative stress-induced central nervous system damage","volume":"81","author":"Oyefeso","year":"2021","journal-title":"Dev. 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