{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:55:44Z","timestamp":1781996144852,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2022\/02605-6"],"award-info":[{"award-number":["2022\/02605-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.brainres.2025.149456","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T06:49:20Z","timestamp":1738392560000},"page":"149456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Revealing shared molecular drivers of brain metastases from distinct primary tumors"],"prefix":"10.1016","volume":"1851","author":[{"given":"Carlos Alberto","family":"de Carvalho Fraga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2809-637X","authenticated-orcid":false,"given":"Leandro","family":"Tiburske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Victor","family":"Lucena da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-8936","authenticated-orcid":false,"given":"Adriana","family":"Simizo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Cesar","family":"Cafund\u00f3 de Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Kelly","family":"da Silva Fernandes Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry David","family":"Mogoll\u00f3n Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Dominguez","family":"Crespo Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder I.","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2025.149456_b0005","doi-asserted-by":"crossref","unstructured":"Achrol, A.S., Rennert, R.C., Anders, C., Soffietti, R., Ahluwalia, M.S., Nayak, L., Peters, S., Arvold, N.D., Harsh, G.R., Steeg, P.S., Chang, S.D., 2019. Brain metastases. Nature Reviews Disease Primers 2018 5:1 5, 1\u201326. 10.1038\/s41572-018-0055-y.","DOI":"10.1038\/s41572-018-0055-y"},{"key":"10.1016\/j.brainres.2025.149456_b0010","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/CIRCRESAHA.122.322332","article-title":"Integrin-Dependent Cell\u2013Matrix Adhesion in Endothelial Health and Disease","volume":"132","author":"Aman","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.brainres.2025.149456_b0015","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1200\/JCO.2004.12.149","article-title":"Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System","volume":"22","author":"Barnholtz-Sloan","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.brainres.2025.149456_b0020","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1016\/j.cell.2022.06.007","article-title":"Dissecting the treatment-naive ecosystem of human melanoma brain metastasis","volume":"185","author":"Biermann","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2025.149456_b0025","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4065\/82.10.1271","article-title":"Central nervous system tumors","volume":"82","author":"Buckner","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.brainres.2025.149456_b0030","doi-asserted-by":"crossref","unstructured":"Cao, J., Spielmann, M., Qiu, X., Huang, X., Ibrahim, D.M., Hill, A.J., Zhang, F., Mundlos, S., Christiansen, L., Steemers, F.J., Trapnell, C., Shendure, J., 2019. The single-cell transcriptional landscape of mammalian organogenesis. Nature 2019 566:7745 566, 496\u2013502. 10.1038\/s41586-019-0969-x.","DOI":"10.1038\/s41586-019-0969-x"},{"key":"10.1016\/j.brainres.2025.149456_b0035","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1093\/neuonc\/now197","article-title":"Systemic therapy of brain metastases: non\u2013small cell lung cancer, breast cancer, and melanoma","volume":"19","author":"Chamberlain","year":"2017","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2025.149456_b0045","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/neuonc\/nos152","article-title":"Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data","volume":"14","author":"Davis","year":"2012","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2025.149456_b0050","doi-asserted-by":"crossref","DOI":"10.1590\/S0365-05962012000500006","article-title":"Immunohistochemical profile of HIF-1\u03b1, VEGF-A, VEGFR2 and MMP9 proteins in tegumentary leishmaniasis","volume":"87","author":"Fraga","year":"2012","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.brainres.2025.149456_b0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11060-004-8093-6","article-title":"Brain metastases: epidemiology and pathophysiology","volume":"75","author":"Gavrilovic","year":"2005","journal-title":"J Neurooncol"},{"key":"10.1016\/j.brainres.2025.149456_b0060","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cell.2021.12.043","article-title":"Cellular architecture of human brain metastases","volume":"185","author":"Gonzalez","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2025.149456_b0065","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2015.1138017","article-title":"Tight junction modulation of the blood brain barrier: CNS delivery of small molecules","volume":"4","author":"Greene","year":"2016","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.brainres.2025.149456_b0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF02782192","article-title":"Long-term survival with metastatic cancer to the brain","volume":"17","author":"Hall","year":"2000","journal-title":"Med Oncol"},{"key":"10.1016\/j.brainres.2025.149456_b0085","first-page":"1","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"2023","author":"Hao","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.brainres.2025.149456_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111329","article-title":"Class-3 semaphorins: Potent multifunctional modulators for angiogenesis-associated diseases","volume":"137","author":"Jiao","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2025.149456_b0095","doi-asserted-by":"crossref","unstructured":"Jin, S., Guerrero-Juarez, C.F., Zhang, L., Chang, I., Ramos, R., Kuan, C.H., Myung, P., Plikus, M. V., Nie, Q., 2021. Inference and analysis of cell-cell communication using CellChat. Nature Communications 2021 12:1 12, 1\u201320. 10.1038\/s41467-021-21246-9.","DOI":"10.1038\/s41467-021-21246-9"},{"key":"10.1016\/j.brainres.2025.149456_b0100","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.brainres.2025.149456_b0105","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.neuron.2022.03.027","article-title":"Brain metastases: Not all tumors are created equal","volume":"110","author":"Kirschenbaum","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2025.149456_b0125","article-title":"hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data","volume":"3","author":"Morabito","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.brainres.2025.149456_b0135","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2021.1926190","article-title":"The blood\u2013brain and gut\u2013vascular barriers: from the perspective of claudins","volume":"9","author":"Scalise","year":"2021","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.brainres.2025.149456_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijom.2005.09.006","article-title":"VEGF is up-regulated by hypoxic stimulation and related to tumour angiogenesis and severity of disease in oral squamous cell carcinoma: in vitro and in vivo studies","author":"Shang","year":"2006","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.brainres.2025.149456_b0145","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1158\/1078-0432.CCR-21-1694","article-title":"Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases","volume":"27","author":"Smalley","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.brainres.2025.149456_b0150","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1200\/JCO.2011.38.0527","article-title":"Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases","volume":"30","author":"Sperduto","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brainres.2025.149456_b0155","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2016.1154641","article-title":"Junctional proteins of the blood-brain barrier: New insights into function and dysfunction","volume":"4","author":"Stamatovic","year":"2016","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.brainres.2025.149456_b0160","article-title":"Distinct phenotypic states and spatial distribution of CD8+ T cell clonotypes in human brain metastases","volume":"3","author":"Sudmeier","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.brainres.2025.149456_b0165","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.nec.2020.06.005","article-title":"Pathological Features of Brain Metastases","volume":"31","author":"Tadros","year":"2020","journal-title":"Neurosurg. Clin. N. Am."},{"key":"10.1016\/j.brainres.2025.149456_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-004-8092-7","article-title":"Metastatic tumors of the nervous system","volume":"75","author":"Taillibert","year":"2005","journal-title":"J Neurooncol"},{"key":"10.1016\/j.brainres.2025.149456_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01941","article-title":"Immune microenvironment of brain metastases\u2014Are microglia and other brain macrophages little helpers?","volume":"10","author":"You","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.brainres.2025.149456_b0185","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a037242","article-title":"Brain Metastasis Organotropism","volume":"10","author":"Yuzhalin","year":"2020","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.brainres.2025.149456_b0190","doi-asserted-by":"crossref","DOI":"10.1186\/s40425-019-0755-1","article-title":"Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors","volume":"7","author":"Zhu","year":"2019","journal-title":"J. Immunother. Cancer"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325000149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325000149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T20:08:10Z","timestamp":1756498090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325000149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":30,"alternative-id":["S0006899325000149"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149456","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revealing shared molecular drivers of brain metastases from distinct primary tumors","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149456"}}