{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:30:47Z","timestamp":1788546647094,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.brainres.2025.149482","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:16:18Z","timestamp":1738275378000},"page":"149482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Role of dexmedetomidine in postoperative cognitive dysfunction and sleep improvement in aged rats by regulating the PI3K\/Akt signaling pathway and its mechanism"],"prefix":"10.1016","volume":"1852","author":[{"given":"Ying","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4902-9704","authenticated-orcid":false,"given":"Xiaopeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2025.149482_b0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.vph.2015.05.008","article-title":"The critical role of Akt in cardiovascular function","volume":"74","author":"Abeyrathna","year":"2015","journal-title":"Vascul Pharmacol."},{"key":"10.1016\/j.brainres.2025.149482_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054522","article-title":"Drugging the PI3K\/AKT\/mTOR Pathway in ER+ Breast Cancer","volume":"24","author":"Alves","year":"2023","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.brainres.2025.149482_b0015","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fmed.2020.00528","article-title":"Effect of Intraoperative Dexmedetomidine Dose on Postoperative First Night Sleep Quality in Elderly Surgery Patients: A Retrospective Study With Propensity Score-Matched Analysis","volume":"7","author":"Cai","year":"2020","journal-title":"Front Med (lausanne)."},{"key":"10.1016\/j.brainres.2025.149482_b0020","doi-asserted-by":"crossref","first-page":"1390216","DOI":"10.3389\/fnins.2024.1390216","article-title":"Postoperative cognitive dysfunction: spotlight on light, circadian rhythms, and sleep","volume":"18","author":"Campbell","year":"2024","journal-title":"Front Neurosci."},{"key":"10.1016\/j.brainres.2025.149482_b0025","first-page":"176","article-title":"Dexmedetomidine alleviates postoperative cognitive dysfunction through circular RNA in aged rats. 3","volume":"10","author":"Cao","year":"2020","journal-title":"Biotech."},{"key":"10.1016\/j.brainres.2025.149482_b0030","first-page":"2119","article-title":"Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation","volume":"20","author":"Chen","year":"2019","journal-title":"Mol Med Rep."},{"key":"10.1016\/j.brainres.2025.149482_b0035","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jclinane.2016.10.022","article-title":"Effects of dexmedetomidine administered for postoperative analgesia on sleep quality in patients undergoing abdominal hysterectomy","volume":"36","author":"Chen","year":"2017","journal-title":"J Clin Anesth."},{"key":"10.1016\/j.brainres.2025.149482_b0040","doi-asserted-by":"crossref","unstructured":"Deiner, S., Luo, X., Lin, H.M., Sessler, D.I., Saager, L., Sieber, F.E., Lee, H.B., Sano, M., and the Dexlirium Writing, G., Jankowski, C., Bergese, S.D., Candiotti, K., Flaherty, J.H., Arora, H., Shander, A., Rock, P., 2017. Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial. JAMA Surg. 152, e171505.","DOI":"10.1001\/jamasurg.2017.1505"},{"key":"10.1016\/j.brainres.2025.149482_b0045","doi-asserted-by":"crossref","unstructured":"Evered, L., Silbert, B., Knopman, D.S., Scott, D.A., DeKosky, S.T., Rasmussen, L.S., Oh, E.S., Crosby, G., Berger, M., Eckenhoff, R.G., Nomenclature Consensus Working, G., 2018. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Br J Anaesth. 121, 1005-1012.","DOI":"10.1097\/ALN.0000000000002334"},{"key":"10.1016\/j.brainres.2025.149482_b0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-022-02472-4","article-title":"A crosstalk between gut and brain in sepsis-induced cognitive decline","volume":"19","author":"Giridharan","year":"2022","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.brainres.2025.149482_b0055","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.2147\/NSS.S310351","article-title":"Roles of Exosomes and Exosomal MicroRNAs in Postoperative Sleep Disturbance","volume":"13","author":"Gu","year":"2021","journal-title":"Nat Sci Sleep."},{"key":"10.1016\/j.brainres.2025.149482_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109231","article-title":"Activation of TREM2 attenuates neuroinflammation via PI3K\/Akt signaling pathway to improve postoperative cognitive dysfunction in mice","volume":"219","author":"Han","year":"2022","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.brainres.2025.149482_b0065","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2025.149482_b0070","doi-asserted-by":"crossref","first-page":"8830706","DOI":"10.1155\/2022\/8830706","article-title":"Study on the Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Inflammation in Aged Rats","volume":"2022","author":"Hou","year":"2022","journal-title":"Contrast Media Mol Imaging."},{"key":"10.1016\/j.brainres.2025.149482_b0075","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/ALN.0000000000002038","article-title":"Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice","volume":"128","author":"Hu","year":"2018","journal-title":"Anesthesiology."},{"key":"10.1016\/j.brainres.2025.149482_b0080","doi-asserted-by":"crossref","unstructured":"Li, G., LeiQian, Gu, P., Fan, D., 2021. Dexmedetomidine post-conditioning attenuates cerebral ischemia following asphyxia cardiac arrest through down-regulation of apoptosis and neuroinflammation in rats. BMC Anesthesiol. 21, 180.","DOI":"10.1186\/s12871-021-01394-7"},{"key":"10.1016\/j.brainres.2025.149482_b0085","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/1933719116667606","article-title":"Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome","volume":"24","author":"Li","year":"2017","journal-title":"Reprod Sci."},{"key":"10.1016\/j.brainres.2025.149482_b0090","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10735-023-10120-1","article-title":"Dexmedetomidine alleviates cerebral ischemia-reperfusion injury via inhibiting autophagy through PI3K\/Akt\/mTOR pathway","volume":"54","author":"Li","year":"2023","journal-title":"J Mol Histol."},{"key":"10.1016\/j.brainres.2025.149482_b0095","doi-asserted-by":"crossref","first-page":"1160761","DOI":"10.3389\/fncel.2023.1160761","article-title":"Neurometabolic and structural alterations of medial septum and hippocampal CA1 in a model of post-operative sleep fragmentation in aged mice: a study combining 1H-MRS and DTI","volume":"17","author":"Li","year":"2023","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.brainres.2025.149482_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110945","article-title":"Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1","volume":"211","author":"Li","year":"2024","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.brainres.2025.149482_b0105","article-title":"Neuroinflammation as the Underlying Mechanism of Postoperative Cognitive Dysfunction and Therapeutic Strategies","volume":"16","author":"Li","year":"2022","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.brainres.2025.149482_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110791","article-title":"The potential mechanism of postoperative cognitive dysfunction in older people","volume":"130","author":"Lin","year":"2020","journal-title":"Exp Gerontol."},{"key":"10.1016\/j.brainres.2025.149482_b0115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12871-023-02048-6","article-title":"Effects of dexmedetomidine on postoperative sleep quality: a systematic review and meta-analysis of randomized controlled trials","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.brainres.2025.149482_b0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12974-023-02849-z","article-title":"Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery","volume":"20","author":"Liu","year":"2023","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.brainres.2025.149482_b0125","article-title":"MiR-21-5p reduces apoptosis and inflammation in rats with spinal cord injury through PI3K\/AKT pathway","author":"Lv","year":"2020","journal-title":"Panminerva Med"},{"key":"10.1016\/j.brainres.2025.149482_b0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bbi.2020.10.008","article-title":"Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central alpha2A adrenoceptor","volume":"91","author":"Mei","year":"2021","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.brainres.2025.149482_b0135","doi-asserted-by":"crossref","first-page":"i115","DOI":"10.1093\/bja\/aex354","article-title":"Postoperative cognitive dysfunction and dementia: what we need to know and do","volume":"119","author":"Needham","year":"2017","journal-title":"Br J Anaesth."},{"key":"10.1016\/j.brainres.2025.149482_b0140","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1007\/s00134-012-2685-y","article-title":"Sleep quality of mechanically ventilated patients sedated with dexmedetomidine","volume":"38","author":"Oto","year":"2012","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.brainres.2025.149482_b0145","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/aas.14154","article-title":"Sleep quality and quantity determined by polysomnography in mechanically ventilated critically ill patients randomized to dexmedetomidine or placebo","volume":"67","author":"Oxlund","year":"2023","journal-title":"Acta Anaesthesiol Scand."},{"key":"10.1016\/j.brainres.2025.149482_b0150","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s00011-023-01804-1","article-title":"Activation of the CD200\/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K\/Akt\/NF-kappaB signaling pathway in aged mice","volume":"72","author":"Qian","year":"2023","journal-title":"Inflamm Res."},{"key":"10.1016\/j.brainres.2025.149482_b0155","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1142\/S0192415X21500907","article-title":"Ginsenoside Rb1 Inhibits Cardiomyocyte Autophagy via PI3K\/Akt\/mTOR Signaling Pathway and Reduces Myocardial Ischemia\/Reperfusion Injury","volume":"49","author":"Qin","year":"2021","journal-title":"Am J Chin Med."},{"key":"10.1016\/j.brainres.2025.149482_b0160","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2174\/1567202617666200513085403","article-title":"Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K\/AKT Pathway","volume":"17","author":"Qin","year":"2020","journal-title":"Curr Neurovasc Res."},{"key":"10.1016\/j.brainres.2025.149482_b0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/ACO.0000000000000538","article-title":"Improve postoperative sleep: what can we do?","volume":"31","author":"Su","year":"2018","journal-title":"Curr Opin Anaesthesiol."},{"key":"10.1016\/j.brainres.2025.149482_b0170","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12871-023-02035-x","article-title":"Dexmedetomidine attenuates postoperative spatial memory impairment after surgery by reducing cytochrome C","volume":"23","author":"Sun","year":"2023","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.brainres.2025.149482_b0175","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1111\/ejn.15474","article-title":"The potential role of dexmedetomidine on neuroprotection and its possible mechanisms: Evidence from in vitro and in vivo studies","volume":"54","author":"Unchiti","year":"2021","journal-title":"Eur J Neurosci."},{"key":"10.1016\/j.brainres.2025.149482_b0180","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12964-023-01390-z","article-title":"Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination","volume":"21","author":"Wang","year":"2023","journal-title":"Cell Commun Signal."},{"key":"10.1016\/j.brainres.2025.149482_b0185","doi-asserted-by":"crossref","first-page":"e051584","DOI":"10.1136\/bmjopen-2021-051584","article-title":"Effect of dexmedetomidine on postoperative delirium in patients undergoing brain tumour resections: study protocol of a randomised controlled trial","volume":"11","author":"Wang","year":"2021","journal-title":"BMJ Open."},{"key":"10.1016\/j.brainres.2025.149482_b0190","doi-asserted-by":"crossref","first-page":"20862","DOI":"10.18632\/aging.104104","article-title":"TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K\/AKT\/FoxO3a signaling pathway in Alzheimer's disease mice","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (albany NY)."},{"key":"10.1016\/j.brainres.2025.149482_b0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12871-019-0808-5","article-title":"Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K\/Akt\/mTOR pathway","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.brainres.2025.149482_b0200","first-page":"4259","article-title":"BACE1 gene silencing alleviates isoflurane anesthesia\u2011induced postoperative cognitive dysfunction in immature rats by activating the PI3K\/Akt signaling pathway","volume":"18","author":"Wang","year":"2018","journal-title":"Mol Med Rep."},{"key":"10.1016\/j.brainres.2025.149482_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113006","article-title":"Dexmedetomidine attenuates perioperative neurocognitive disorders by suppressing hippocampal neuroinflammation and HMGB1\/RAGE\/NF-kappaB signaling pathway","volume":"150","author":"Wang","year":"2022","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.brainres.2025.149482_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.899484","article-title":"Dexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K\/AKT\/GSK3beta Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats","volume":"16","author":"Wei","year":"2022","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.brainres.2025.149482_b0215","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1007\/s12035-023-03860-4","article-title":"Esketamine Prevents Postoperative Emotional and Cognitive Dysfunction by Suppressing Microglial M1 Polarization and Regulating the BDNF-TrkB Pathway in Ageing Rats with Preoperative Sleep Disturbance","volume":"61","author":"Wen","year":"2024","journal-title":"Mol Neurobiol."},{"key":"10.1016\/j.brainres.2025.149482_b0220","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12871-022-01711-8","article-title":"A randomized placebo-controlled double-blind study of dexmedetomidine on postoperative sleep quality in patients with endoscopic sinus surgery","volume":"22","author":"Wu","year":"2022","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.brainres.2025.149482_b0225","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/WNR.0000000000001999","article-title":"Sophora flavescens alcohol extract ameliorates insomnia and promotes PI3K\/AKT\/BDNF signaling transduction in insomnia model rats","volume":"35","author":"Wu","year":"2024","journal-title":"Neuroreport."},{"key":"10.1016\/j.brainres.2025.149482_b0230","first-page":"4731","article-title":"Dexmedetomidine protects against sepsis\u2011associated encephalopathy through Hsp90\/AKT signaling","volume":"20","author":"Yin","year":"2019","journal-title":"Mol Med Rep."},{"key":"10.1016\/j.brainres.2025.149482_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112089","article-title":"Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice","volume":"393","author":"Zhang","year":"2020","journal-title":"Exp Cell Res."},{"key":"10.1016\/j.brainres.2025.149482_b0240","doi-asserted-by":"crossref","first-page":"1328790","DOI":"10.3389\/fnbeh.2024.1328790","article-title":"Postoperative cognitive dysfunction-current research progress","volume":"18","author":"Zhao","year":"2024","journal-title":"Front Behav Neurosci."},{"key":"10.1016\/j.brainres.2025.149482_b0245","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12871-023-02267-x","article-title":"Association and prediction of subjective sleep quality and postoperative delirium during major non-cardiac surgery: a prospective observational study","volume":"23","author":"Zheng","year":"2023","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.brainres.2025.149482_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2021.151734","article-title":"Dexmedetomidine reduces the apoptosis of rat hippocampal neurons via mediating ERK1\/2 signal pathway by targeting miR-155","volume":"123","author":"Zhu","year":"2021","journal-title":"Acta Histochem."}],"updated-by":[{"DOI":"10.1016\/j.brainres.2025.149722","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000}}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932500040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932500040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T01:51:31Z","timestamp":1740793891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689932500040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"alternative-id":["S000689932500040X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149482","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of dexmedetomidine in postoperative cognitive dysfunction and sleep improvement in aged rats by regulating the PI3K\/Akt signaling pathway and its mechanism","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149482"}}