{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:50:36Z","timestamp":1791651036696,"version":"4.3.4"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.brainres.2025.149573","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T03:26:25Z","timestamp":1742009185000},"page":"149573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Comparing levetiracetam and zonisamide effects on rivastigmine anti-Alzheimer\u2019s activity in aluminum chloride-induced Alzheimer\u2019s-like disease in rats: Impact on \u03b17 nicotinic acetylcholine receptors and amyloid \u03b2"],"prefix":"10.1016","volume":"1855","author":[{"given":"Raafat A.","family":"Abdel-Aal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Y.","family":"Meligy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa","family":"Maghraby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israa El-Sayed","family":"Mohamed Ashry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2\u20133","key":"10.1016\/j.brainres.2025.149573_b0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2011.03.011","article-title":"Rivastigmine reverses aluminum-induced behavioral changes in rats","volume":"659","author":"Abdel-Aal","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2025.149573_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109492","article-title":"Rivastigmine ameliorates gentamicin experimentally induced acute renal toxicity","volume":"114","author":"Abdelzaher","year":"2023","journal-title":"Internat. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.brainres.2025.149573_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/brainsci10090628","article-title":"The possible neuroprotective effect of silymarin against aluminum chloride-prompted Alzheimer\u2019s-like disease in rats","volume":"10","author":"Aboelwafa","year":"2020","journal-title":"Brain Sci."},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0020","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1007\/s12035-016-9762-0","article-title":"Neuroprotective effect of nanodiamond in Alzheimer\u2019s disease rat model: a pivotal role for modulating NF-\u03baB and STAT3 signaling","volume":"54","author":"Alawdi","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: Neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"issue":"6","key":"10.1016\/j.brainres.2025.149573_b0030","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3390\/antiox10060947","article-title":"A leaf extract of harrisonia abyssinica ameliorates neurobehavioral, histological and biochemical changes in the hippocampus of rats with aluminum chloride-induced alzheimer\u2019s disease","volume":"10","author":"Anwar","year":"2021","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.brainres.2025.149573_b0035","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1007\/s11033-021-06512-9","article-title":"Recent advances on drug development and emerging therapeutic agents for Alzheimer\u2019s disease","volume":"48","author":"Athar","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.mcna.2018.10.009","article-title":"The Alzheimer\u2019s Disease Clinical Spectrum: Diagnosis and Management","volume":"103","author":"Atri","year":"2019","journal-title":"Med. Clin. N. Am."},{"issue":"9","key":"10.1016\/j.brainres.2025.149573_b0045","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22519","article-title":"Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride-induced Alzheimer\u2019s disease via attenuating neuroinflammation and improving brain insulin signaling","volume":"34","author":"Attia","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"APR","key":"10.1016\/j.brainres.2025.149573_b0050","first-page":"1","article-title":"Neuroprotective effect of cardamom oil against aluminum induced neurotoxicity in rats","volume":"10","author":"Auti","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.brainres.2025.149573_b0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuropharm.2013.05.019","article-title":"High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases","volume":"73","author":"Badin","year":"2013","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.brainres.2025.149573_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24101992","article-title":"Chenodeoxycholic acid ameliorates AlCl3-induced Alzheimer\u2019s disease neurotoxicity and cognitive deterioration via enhanced insulin signaling in rats","volume":"24","author":"Bazzari","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1528-1157.1987.tb03624.x","article-title":"Zonisamide (CI-912) and cognition: results from preliminary study","volume":"28","author":"Berent","year":"1987","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0070","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s40272-021-00448-0","article-title":"Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy","volume":"23","author":"Besag","year":"2021","journal-title":"Paediatr. Drugs"},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0075","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol."},{"issue":"7","key":"10.1016\/j.brainres.2025.149573_b0080","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.eurpsy.2007.06.002","article-title":"Impact of levetiracetam on mood and cognition during prednisone therapy","volume":"22","author":"Brown","year":"2007","journal-title":"Eur. Psychiatry"},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1124\/pr.108.000562","article-title":"Nicotinic acetylcholine receptor signalling: Roles in alzheimer\u2019s disease and amyloid neuroprotection","volume":"61","author":"Buckingham","year":"2009","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0090","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0169-328X(00)00031-0","article-title":"Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients","volume":"76","author":"Burghaus","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.brainres.2025.149573_b0095","series-title":"Aluminum Increases Levels of Beta-Amyloid and Ubiquitin in Neuroblastoma but Not in Glioma Cells","first-page":"397","author":"Campbell","year":"2000"},{"issue":"9","key":"10.1016\/j.brainres.2025.149573_b0100","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid beta: Structure, biology and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0105","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.yebeh.2006.07.011","article-title":"Neuropsychological and psychiatric impact of add-on titration of pregabalin versus levetiracetam: A comparative short-term study","volume":"9","author":"Ciesielski","year":"2006","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainres.2025.149573_b0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-3-319-60189-2_9","article-title":"Aluminum and Alzheimer's Disease","volume":"18","author":"Colomina","year":"2017","journal-title":"Adv Neurobiol."},{"key":"10.1016\/j.brainres.2025.149573_b0115","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.celrep.2017.06.040","article-title":"DFosB regulates gene expression and cognitive dysfunction in a mouse model of Alzheimer\u2019s disease","volume":"20","author":"Corbett","year":"2017","journal-title":"Cell Rep."},{"issue":"17","key":"10.1016\/j.brainres.2025.149573_b0120","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1073\/pnas.88.17.7552","article-title":"Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein","volume":"88","author":"Cras","year":"1991","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0125","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/(SICI)1096-9861(19980413)393:3<374::AID-CNE8>3.0.CO;2-Z","article-title":"Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation","volume":"393","author":"Darvesh","year":"1998","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.brainres.2025.149573_b0130","article-title":"Add-on Effect of Levetiracetam on Cognitive Activity of Carbamazepine and Topiramate Treated Healthy Rats","volume":"9","author":"Dhande","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"issue":"5","key":"10.1016\/j.brainres.2025.149573_b0135","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1600-0447.2012.01910.x","article-title":"Pharmacological approaches in bipolar disorders and the impact on cognition: A critical overview","volume":"126","author":"Dias","year":"2012","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.brainres.2025.149573_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2022.100193","article-title":"Gallic acid and hesperidin elevate neurotransmitters level and protect against oxidative stress, inflammation and apoptosis in aluminum chloride-induced Alzheimer\u2019s disease in rats","volume":"5","author":"Ekundayo","year":"2022","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"10.1016\/j.brainres.2025.149573_b0145","doi-asserted-by":"crossref","DOI":"10.1007\/s10787-024-01541-9","article-title":"Preclinical efficacy of oral and nasal rivastigmine-loaded chitosan nano-particles on AlCl3-induced Alzheimer\u2019s-like disease in rats","author":"ElMosbah","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0150","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1212\/WNL.0000000000207423","article-title":"Alzheimer disease and epilepsy: a mendelian randomization study","volume":"101","author":"Fang","year":"2023","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer\u2019s disease: targeting the cholinergic system","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"11","key":"10.1016\/j.brainres.2025.149573_b0160","first-page":"377","article-title":"Epidemiology of Alzheimer\u2019s disease and other dementias","volume":"66","author":"Garre-Olmo","year":"2018","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.brainres.2025.149573_b0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainresbull.2020.04.009","article-title":"Epilepsy and Alzheimer's Disease: Potential mechanisms for an association","volume":"160","author":"Giorgi","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2025.149573_b0170","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fnmol.2012.00066","article-title":"Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis","volume":"5","author":"Gnatek","year":"2012","journal-title":"Front. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2025.149573_b0175","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0092-8674(93)90312-E","article-title":"Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide","volume":"75","author":"Haass","year":"1993","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0180","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1755-5949.2008.00062.x","article-title":"The aspects and mechanisms of cognitive alterations in epilepsy: the role of antiepileptic medications","volume":"15","author":"Hamed","year":"2009","journal-title":"CNS Neurosci. Ther."},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0185","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0006-8993(99)01808-9","article-title":"Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons","volume":"842","author":"Harada","year":"1999","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0190","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3233\/JAD-200893","article-title":"Efficacy and safety of zonisamide in dementia with lewy bodies patients with parkinsonism: a post hoc analysis of two randomized, double-blind, placebo-controlled trials","volume":"79","author":"Hasegawa","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2025.149573_b0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-2999(94)90704-8","article-title":"Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect","volume":"257","author":"Hayakawa","year":"1994","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0200","first-page":"1","article-title":"Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis","volume":"54","author":"He","year":"2021","journal-title":"Braz. J. Med. Biol. Res. = Revista Brasileira De Pesquisas Medicas e Biologicas"},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0205","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.yebeh.2008.05.012","article-title":"Positive and negative psychotropic effects of levetiracetam","volume":"13","author":"Helmstaedter","year":"2008","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainres.2025.149573_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147645","article-title":"Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats","volume":"1771","author":"Hussain","year":"2021","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0215","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/biomedicines11030848","article-title":"Evaluation of the antioxidant activity of levetiracetam in a temporal lobe epilepsy model","volume":"11","author":"Ignacio-Mej\u00eda","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.brainres.2025.149573_b0220","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2147\/IJN.S39232","article-title":"Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer\u2019s disease","volume":"8","author":"Ismail","year":"2013","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-23894-3","article-title":"Riboflavin attenuates tartrazine toxicity in the cerebellar cortex of adult albino rat","volume":"12","author":"Ismail","year":"2022","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0230","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12640-018-9904-4","article-title":"Attenuation of aluminum chloride-induced neuroinflammation and caspase activation through the AKT\/GSK-3\u03b2 pathway by hesperidin in wistar rats","volume":"34","author":"Justin-Thenmozhi","year":"2018","journal-title":"Neurotox. Res."},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0235","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.biocel.2013.01.011","article-title":"Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity","volume":"45","author":"Kamynina","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"8","key":"10.1016\/j.brainres.2025.149573_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0183565","article-title":"Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin","volume":"12","author":"Kenawy","year":"2017","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.brainres.2025.149573_b0245","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2165\/00023210-200822090-00003","article-title":"CNS adverse events associated with antiepileptic drugs","volume":"22","author":"Kennedy","year":"2008","journal-title":"CNS Drugs"},{"issue":"11","key":"10.1016\/j.brainres.2025.149573_b0250","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"1\u20132","key":"10.1016\/j.brainres.2025.149573_b0255","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainres.2005.07.052","article-title":"Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats","volume":"1057","author":"Kitano","year":"2005","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0260","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/JCP.0000000000000246","article-title":"Zonisamide, topiramate, and levetiracetam efficacy and neuropsychological effects in alcohol use disorders","volume":"35","author":"Knapp","year":"2015","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainres.2025.149573_b0265","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.schres.2017.06.027","article-title":"Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia","volume":"193","author":"Koh","year":"2018","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.brainres.2025.149573_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2019.106659","article-title":"The effect of zonisamide on memory processes - A preclinical study","volume":"102","author":"Krupa-Burtnik","year":"2020","journal-title":"Epilepsy & Behavior: e&b"},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0275","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12011-015-0229-3","article-title":"Protective Effect of Selenium Against Aluminum Chloride-Induced Alzheimer\u2019s Disease: Behavioral and Biochemical Alterations in Rats","volume":"165","author":"Lakshmi","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.brainres.2025.149573_b0280","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.REV120.008207","article-title":"The essential elements of Alzheimer\u2019s disease","volume":"296","author":"Lei","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2025.149573_b0285","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/jnnp.21.3.167","article-title":"Clinical and electroencephalographic observations in Alzheimer\u2019s disease","volume":"21","author":"Letemendia","year":"1958","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0290","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (san Diego, Calif.),"},{"issue":"Pt B","key":"10.1016\/j.brainres.2025.149573_b0295","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuropharm.2014.11.018","article-title":"Role of the nicotinic acetylcholine receptor in Alzheimer\u2019s disease pathology and treatment","volume":"96","author":"Lombardo","year":"2015","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0300","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1684\/epd.2008.0227","article-title":"Effect of levetiracetam on cognitive functions and quality of life: A one-year follow-up study","volume":"10","author":"L\u00f3pez-G\u00f3ngora","year":"2008","journal-title":"Epileptic Disord."},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0305","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11065-007-9043-9","article-title":"Neuropsychological and behavioral effects of antiepilepsy drugs","volume":"17","author":"Loring","year":"2007","journal-title":"Neuropsychol. Rev."},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0310","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/74656","article-title":"A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor","volume":"6","author":"Lu","year":"2000","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.brainres.2025.149573_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsps.2023.101728","article-title":"Impact of levetiracetam on cognitive impairment, neuroinflammation, oxidative stress, and neuronal apoptosis caused by lipopolysaccharides in rats","volume":"31","author":"Mani","year":"2023","journal-title":"Saudi Pharm. J.: SPJ"},{"key":"10.1016\/j.brainres.2025.149573_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108352","article-title":"Efficacy of acetylcholinesterase inhibitors in Alzheimer\u2019s disease","volume":"190","author":"Marucci","year":"2021","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0325","doi-asserted-by":"crossref","first-page":"220","DOI":"10.29252\/ibj.24.4.220","article-title":"Assessment of probiotics mixture on memory function, inflammation markers, and oxidative stress in an Alzheimer\u2019s disease model of rats","volume":"24","author":"Mehrabadi","year":"2020","journal-title":"Iran. Biomed. J."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0330","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/nbdi.2001.0462","article-title":"Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain","volume":"9","author":"Mesulam","year":"2002","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0335","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.bbadis.2016.01.013","article-title":"Role of P-glycoprotein in mediating rivastigmine effect on amyloid-\u03b2 brain load and related pathology in Alzheimer\u2019s disease mouse model","volume":"1862","author":"Mohamed","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0340","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/JAD-200838","article-title":"Aluminum and neurofibrillary tangle co-localization in familial Alzheimer\u2019s disease and related neurological disorders","volume":"78","author":"Mold","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0345","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3858\/emm.2008.40.1.11","article-title":"Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia","volume":"40","author":"Moon","year":"2008","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0350","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0306-4522(03)00460-3","article-title":"Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer\u2019s disease","volume":"122","author":"Mousavi","year":"2003","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.brainres.2025.149573_b0355","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1586\/ern.12.51","article-title":"Recent and future antiepileptic drugs and their impact on cognition: what can we expect?","volume":"12","author":"Mula","year":"2012","journal-title":"Expert Rev. Neurother."},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0360","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00210-022-02322-3","article-title":"Leflunomide abrogates neuroinflammatory changes in a rat model of Alzheimer\u2019s disease: the role of TNF-\u03b1\/NF-\u03baB\/IL-1\u03b2 axis inhibition","volume":"396","author":"Nafea","year":"2023","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.brainres.2025.149573_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2021.102069","article-title":"Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer\u2019s disease","volume":"120","author":"Nandini","year":"2022","journal-title":"J. Chem. Neuroanat."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0370","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41467-024-44853-8","article-title":"Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice","volume":"15","author":"Nguyen","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0375","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0304-3940(86)90629-4","article-title":"Reduced number of [3H] nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains","volume":"72","author":"Nordberg","year":"1986","journal-title":"Neurosci. Lett."},{"issue":"12","key":"10.1016\/j.brainres.2025.149573_b0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029560","article-title":"Levetiracetam reverses synaptic deficits produced by overexpression of SV2A","volume":"6","author":"Nowack","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0385","first-page":"1","article-title":"Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer\u2019s disease mouse model","volume":"7","author":"Nygaard","year":"2015","journal-title":"Alzheimer\u2019s Res. Therapy"},{"issue":"10","key":"10.1016\/j.brainres.2025.149573_b0390","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/jnr.23256","article-title":"Effects of antiparkinsonian agents on \u03b2-amyloid and \u03b1-synuclein oligomer formation in vitro","volume":"91","author":"Ono","year":"2013","journal-title":"J. Neurosci. Res."},{"issue":"11","key":"10.1016\/j.brainres.2025.149573_b0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21113958","article-title":"Human neural stem cells encoding ChAT gene restore cognitive function via acetylcholine synthesis, A\u03b2 elimination, and neuroregeneration in APPswe\/PS1dE9 mice","volume":"21","author":"Park","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0400","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yebeh.2007.08.002","article-title":"Long-term cognitive and mood effects of zonisamide monotherapy in epilepsy patients","volume":"12","author":"Park","year":"2008","journal-title":"Epilepsy Behav."},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0405","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3988\/jcn.2007.3.4.175","article-title":"Long-term efficacy and safety of zonisamide monotherapy in epilepsy patients","volume":"3","author":"Park","year":"2007","journal-title":"J. Clin. Neurol."},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0410","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4236\/aad.2015.43007","article-title":"Activated Caspase-3 and Neurodegeneration and Synaptic Plasticity in Alzheimer\u2019s Disease","volume":"4","author":"P\u0142\u00f3ciennik","year":"2015","journal-title":"Adv. Alzheimer\u2019s Dis."},{"issue":"7","key":"10.1016\/j.brainres.2025.149573_b0415","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1021\/acs.jproteome.1c00180","article-title":"Levetiracetam treatment normalizes levels of presynaptic endocytosis machinery and restores nonamyloidogenic APP processing inAppKnock-in mice","volume":"20","author":"Rao","year":"2021","journal-title":"J. Proteome Res."},{"issue":"10","key":"10.1016\/j.brainres.2025.149573_b0420","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s00702-008-0107-7","article-title":"Effects of cholinesterase inhibitors on rat nicotinic receptor levels in vivo and in vitro","volume":"115","author":"Reid","year":"2008","journal-title":"J. Neural Transm."},{"issue":"8","key":"10.1016\/j.brainres.2025.149573_b0425","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/14656566.2019.1595584","article-title":"An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy","volume":"20","author":"Reimers","year":"2019","journal-title":"Expert Opin. Pharmacother."},{"issue":"6","key":"10.1016\/j.brainres.2025.149573_b0430","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0896-6273(00)80134-8","article-title":"Nicotinic receptors in the development and modulation of CNS synapses","volume":"16","author":"Role","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2025.149573_b0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105378","article-title":"Differential effects of levetiracetam on hippocampal CA1 synaptic plasticity and molecular changes in the dentate gyrus in epileptic rats","volume":"158","author":"Salaka","year":"2022","journal-title":"Neurochem. Int."},{"issue":"42","key":"10.1016\/j.brainres.2025.149573_b0440","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer\u2019s disease model","volume":"109","author":"Sanchez","year":"2012","journal-title":"PNAS"},{"issue":"8","key":"10.1016\/j.brainres.2025.149573_b0445","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1001\/archneurol.2009.130","article-title":"Seizures in Alzheimer disease: who, when, and how common?","volume":"66","author":"Scarmeas","year":"2009","journal-title":"Arch. Neurol."},{"issue":"10284","key":"10.1016\/j.brainres.2025.149573_b0450","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet (london, England)"},{"issue":"6","key":"10.1016\/j.brainres.2025.149573_b0455","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0460","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"AUG","key":"10.1016\/j.brainres.2025.149573_b0465","first-page":"1","article-title":"EGCG nanoparticles attenuate aluminum chloride induced neurobehavioral deficits, beta amyloid and tau pathology in a rat model of Alzheimer\u2019s disease","volume":"10","author":"Singh","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2025.149573_b0470","first-page":"1","article-title":"Morbus Alzheimer and morbus pick; a genetic, clinical and patho-anatomical study","volume":"Suppl. 82","author":"Sjogren","year":"1952","journal-title":"Acta Psychiatr. Neurol. Scand."},{"issue":"10","key":"10.1016\/j.brainres.2025.149573_b0475","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s40263-022-00955-9","article-title":"Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies","volume":"36","author":"Strzelczyk","year":"2022","journal-title":"CNS Drugs"},{"issue":"158","key":"10.1016\/j.brainres.2025.149573_b0480","article-title":"Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer\u2019s disease: In vivo and in vitro studies","volume":"9","author":"Tozlu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.brainres.2025.149573_b0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104779","article-title":"Nicotinic acetylcholine receptors regulate clustering, fusion and acidification of the rat brain synaptic vesicles","volume":"138","author":"Trikash","year":"2020","journal-title":"Neurochem. Int."},{"issue":"8","key":"10.1016\/j.brainres.2025.149573_b0490","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3390\/toxics10080428","article-title":"Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study","volume":"10","author":"Turkez","year":"2022","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0495","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer's disease: causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"The Lancet. Neurology"},{"issue":"11","key":"10.1016\/j.brainres.2025.149573_b0500","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jamaneurol.2021.3310","article-title":"Effect of levetiracetam on cognition in patients with alzheimer disease with and without epileptiform activity: a randomized clinical trial","volume":"78","author":"Vossel","year":"2021","journal-title":"JAMA Neurol."},{"issue":"8","key":"10.1016\/j.brainres.2025.149573_b0505","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1074\/jbc.275.8.5626","article-title":"beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer\u2019s disease pathology","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.brainres.2025.149573_b0510","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1249\/MSS.0000000000002294","article-title":"Effects of Exercise Training on Anxious-Depressive-like Behavior in Alzheimer Rat","volume":"52","author":"Wu","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.brainres.2025.149573_b0515","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.940515","article-title":"Alzheimer's disease and epilepsy: An increasingly recognized comorbidity","volume":"14","author":"Yang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2025.149573_b0520","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.638209","article-title":"Neuroprotective and Angiogenesis Effects of Levetiracetam Following Ischemic Stroke in Rats","volume":"12","author":"Yao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainres.2025.149573_b0525","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijpsycho.2022.05.008","article-title":"Treatment effects on event-related EEG potentials and oscillations in Alzheimer\u2019s disease","volume":"177","author":"Yener","year":"2022","journal-title":"Internat. J. Psychophysiol."},{"issue":"s1","key":"10.1016\/j.brainres.2025.149573_b0530","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.3233\/JAD-161115","article-title":"A Combination of Resveratrol and Curcumin is Effective Against Aluminum Chloride-Induced Neuroinflammation in Rats","volume":"60","author":"Zaky","year":"2017","journal-title":"J. Alzheimer's Dis.: JAD"},{"issue":"1","key":"10.1016\/j.brainres.2025.149573_b0535","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/ene.14043","article-title":"Increased risk of epilepsy in patients registered in the Swedish Dementia Registry","volume":"27","author":"Zelano","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.brainres.2025.149573_b0540","article-title":"Levetiracetam attenuates diabetes-associated cognitive impairment and microglia polarization by suppressing neuroinflammation","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.brainres.2025.149573_b0545","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.nbd.2003.07.006","article-title":"Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease","volume":"14","author":"Zhao","year":"2003","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.brainres.2025.149573_b0550","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.yebeh.2007.10.003","article-title":"Effects of levetiracetam as an add-on therapy on cognitive function and quality of life in patients with refractory partial seizures","volume":"12","author":"Zhou","year":"2008","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainres.2025.149573_b0555","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.2147\/NDT.S117469","article-title":"Baicalein improves behavioral dysfunction induced by Alzheimer\u2019s disease in rats","volume":"12","author":"Zhou","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.brainres.2025.149573_b0560","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12993-015-0069-5","article-title":"Alteration in amyloid \u03b242, phosphorylated tau protein, interleukin 6, and acetylcholine during diabetes-accelerated memory dysfunction in diabetic rats: correlation of amyloid \u03b242 with changes in glucose metabolism","volume":"11","author":"Zhou","year":"2015","journal-title":"Behav. Brain Funct.: BBF"},{"key":"10.1016\/j.brainres.2025.149573_b0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108917","article-title":"The differential effect of levetiracetam on memory and anxiety in rats","volume":"136","author":"Zwierzy\u0144ska","year":"2022","journal-title":"Epilepsy Behav.: e&b"},{"issue":"8","key":"10.1016\/j.brainres.2025.149573_b0570","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.3390\/molecules26082258","article-title":"Cholinergic signaling, neural excitability, and epilepsy","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"4","key":"10.1016\/j.brainres.2025.149573_b0575","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1460-9568.2008.06070.x","article-title":"Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats","volume":"27","author":"Zimmerman","year":"2008","journal-title":"Eur. J. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325001313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325001313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:14:33Z","timestamp":1791648873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325001313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":115,"alternative-id":["S0006899325001313"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149573","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing levetiracetam and zonisamide effects on rivastigmine anti-Alzheimer\u2019s activity in aluminum chloride-induced Alzheimer\u2019s-like disease in rats: Impact on \u03b17 nicotinic acetylcholine receptors and amyloid \u03b2","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149573"}}