{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:09:02Z","timestamp":1778638142403,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Finep","doi-asserted-by":"publisher","award":["04.16.0054.02"],"award-info":[{"award-number":["04.16.0054.02"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["INCT 408474\/2024-6"],"award-info":[{"award-number":["INCT 408474\/2024-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023563","name":"INCT-INPD CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023563","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/09207-3"],"award-info":[{"award-number":["2019\/09207-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2024\/04617-7"],"award-info":[{"award-number":["2024\/04617-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/03297-3"],"award-info":[{"award-number":["2022\/03297-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/07904-4"],"award-info":[{"award-number":["2023\/07904-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/08287-3"],"award-info":[{"award-number":["2019\/08287-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/02413-1"],"award-info":[{"award-number":["2017\/02413-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/13112-8"],"award-info":[{"award-number":["2019\/13112-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/00527-8"],"award-info":[{"award-number":["2022\/00527-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/01107-7"],"award-info":[{"award-number":["2020\/01107-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/50963-4"],"award-info":[{"award-number":["2011\/50963-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.brainres.2025.149640","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:29:54Z","timestamp":1744478994000},"page":"149640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Long-term treatment with haloperidol modulates angiotensin I-converting enzyme (ACE) activity in transgenic animal model with construct validity for schizophrenia studies"],"prefix":"10.1016","volume":"1859","author":[{"given":"William Y.","family":"Oyadomari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thays C.","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2205-5291","authenticated-orcid":false,"given":"Leonardo","family":"Basso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio C.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o V.","family":"Nani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian A.F.","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.brainres.2025.149640_b0005","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18495","article-title":"The potential role of brain renin-angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?","volume":"28","author":"Al-Qahtani","year":"2024","journal-title":"J Cell Mol Med."},{"issue":"10","key":"10.1016\/j.brainres.2025.149640_b0010","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1111\/ejn.16312","article-title":"Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications","volume":"59","author":"Basmadjian","year":"2024","journal-title":"Eur J Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0015","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/npp.2010.225","article-title":"Angiotensin II AT1 receptor blockade ameliorates brain inflammation","volume":"36","author":"Benicky","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"10.1016\/j.brainres.2025.149640_b0020","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3390\/jcm13072112","article-title":"Cognitive effects of reducing first-generation antipsychotic dose compared to switching to ziprasidone in long-stay patients with schizophrenia","volume":"13","author":"Bogers","year":"2024","journal-title":"J Clin Med."},{"issue":"7","key":"10.1016\/j.brainres.2025.149640_b0025","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/s41380-018-0133-2","article-title":"Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness","volume":"24","author":"Bradshaw","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbr.2011.06.026","article-title":"Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats","volume":"225","author":"Calzavara","year":"2011","journal-title":"Behav Brain Res."},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0035","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/schbul\/sbn006","article-title":"Neuroleptic drugs revert the contextual fear conditioning deficit presented by spontaneously hypertensive rats: a potential animal model of emotional context processing in schizophrenia?","volume":"35","author":"Calzavara","year":"2009","journal-title":"Schizophr Bull."},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0040","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/nprot.2006.306","article-title":"A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay","volume":"1","author":"Carmona","year":"2006","journal-title":"Nat Protoc."},{"issue":"3","key":"10.1016\/j.brainres.2025.149640_b0045","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/cvr\/cvac110","article-title":"Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects","volume":"119","author":"Carnovale","year":"2023","journal-title":"Cardiovasc Res."},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0050","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1038\/s41467-023-41130-y","article-title":"Dopamine regulates decision thresholds in human reinforcement learning in males","volume":"14","author":"Chakroun","year":"2023","journal-title":"Nature Communications"},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0055","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/jnc.15918","article-title":"Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response","volume":"166","author":"Christoff","year":"2023","journal-title":"J Neurochem."},{"key":"10.1016\/j.brainres.2025.149640_b0060","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13229-024-00602-8","article-title":"Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms","volume":"15","author":"Courchesne","year":"2024","journal-title":"Mol Autism."},{"key":"10.1016\/j.brainres.2025.149640_b0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jad.2018.10.001","article-title":"Oligopeptidases activity in bipolar disorder: Ndel1 and angiotensin I converting enzyme","volume":"244","author":"Dal Mas","year":"2019","journal-title":"J Affect Disord."},{"issue":"5","key":"10.1016\/j.brainres.2025.149640_b0075","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/acps.12799","article-title":"The effect of adjunctive telmisartan treatment on psychopathology and cognition in patients with schizophrenia","volume":"136","author":"Fan","year":"2017","journal-title":"Acta Psychiatr Scand."},{"issue":"1\u20133","key":"10.1016\/j.brainres.2025.149640_b0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.schres.2015.01.044","article-title":"ACE I\/D genotype-related increase in ACE plasma activity is a better predictor for schizophrenia diagnosis than the genotype alone","volume":"164","author":"Gadelha","year":"2015","journal-title":"Schizophr Res."},{"issue":"12","key":"10.1016\/j.brainres.2025.149640_b0085","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.181","article-title":"Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia","volume":"5","author":"Gadelha","year":"2015","journal-title":"Transl Psychiatry."},{"issue":"7","key":"10.1016\/j.brainres.2025.149640_b0090","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.3390\/ijms25073995","article-title":"Neuroinflammation in neurodegenerative disorders: current knowledge and therapeutic implications","volume":"25","author":"Giri","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0095","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1002\/cpns.68","article-title":"Haloperidol-induced preclinical tardive dyskinesia model in rats","volume":"88","author":"Guzen","year":"2019","journal-title":"Curr Protoc Neurosci."},{"key":"10.1016\/j.brainres.2025.149640_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1345349","article-title":"Microglia-neuron interactions in schizophrenia","volume":"18","author":"Hartmann","year":"2024","journal-title":"Front Cell Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0105","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.mcn.2010.04.006","article-title":"Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth","volume":"44","author":"Hayashi","year":"2010","journal-title":"Molecular and Cellular Neurosciences."},{"issue":"10","key":"10.1016\/j.brainres.2025.149640_b0110","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1073\/pnas.0500330102","article-title":"Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1","volume":"102","author":"Hayashi","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.brainres.2025.149640_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2020.110099","article-title":"Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial","volume":"68","author":"Hollinger","year":"2021","journal-title":"J Clin Anesth."},{"key":"10.1016\/j.brainres.2025.149640_b0120","unstructured":"Jamovi. The Jamovi Project [Computer Software]. 2021. Available online: https:\/\/www.jamovi.org."},{"key":"10.1016\/j.brainres.2025.149640_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2021.638519","article-title":"The renin-angiotensin system modulates dopaminergic neurotransmission: a new player on the scene","volume":"13","author":"Kobiec","year":"2021","journal-title":"Front Synaptic Neurosci."},{"issue":"2","key":"10.1016\/j.brainres.2025.149640_b0130","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4161\/pri.18989","article-title":"Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies","volume":"6","author":"Korth","year":"2012","journal-title":"Prion."},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41531-024-00650-0","article-title":"Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission","volume":"10","author":"Lage","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"issue":"7","key":"10.1016\/j.brainres.2025.149640_b0140","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.pnpbp.2011.06.003","article-title":"Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine","volume":"35","author":"Levin","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"issue":"7","key":"10.1016\/j.brainres.2025.149640_b0145","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s10038-019-0597-1","article-title":"Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia","volume":"64","author":"Liu","year":"2019","journal-title":"J Hum Genet."},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0150","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41398-018-0228-1","article-title":"DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness","volume":"8","author":"Malavasi","year":"2018","journal-title":"Transl Psychiatry"},{"issue":"9","key":"10.1016\/j.brainres.2025.149640_b0155","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/hmg\/9.9.1415","article-title":"Disruption of two novel genes by a translocation co-segregating with schizophrenia","volume":"9","author":"Millar","year":"2000","journal-title":"Hum Mol Genet."},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0160","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41386-022-01492-1","article-title":"The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia","volume":"48","author":"Moya","year":"2023","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"10.1016\/j.brainres.2025.149640_b0165","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/ijnp\/pyaa050","article-title":"A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?","volume":"23","author":"Nani","year":"2020","journal-title":"Int J Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0170","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/0269881119897562","article-title":"Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity","volume":"34","author":"Nani","year":"2020","journal-title":"J Psychopharmacol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/15622975.2019.1583372","article-title":"ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants","volume":"21","author":"Nani","year":"2020","journal-title":"World J Biol Psychiatry"},{"issue":"4288","key":"10.1016\/j.brainres.2025.149640_b0180","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.191908","article-title":"Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents","volume":"196","author":"Ondetti","year":"1977","journal-title":"Science."},{"key":"10.1016\/j.brainres.2025.149640_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176573","article-title":"Angiotensin-converting enzyme inhibition prevents l-dopa-induced dyskinesia in a 6-ohda-induced mouse model of Parkinson's disease","volume":"973","author":"Park","year":"2024","journal-title":"Eur J Pharmacol."},{"issue":"12","key":"10.1016\/j.brainres.2025.149640_b0190","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/pcn.13594","article-title":"Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis","volume":"77","author":"Pils","year":"2023","journal-title":"Psychiatry Clin Neurosci."},{"issue":"9","key":"10.1016\/j.brainres.2025.149640_b0195","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/ntr\/ntx088","article-title":"Evidence of Altered Brain Responses to Nicotine in an Animal Model of Attention Deficit\/Hyperactivity Disorder","volume":"19","author":"Poirier","year":"2017","journal-title":"Nicotine Tob Res."},{"issue":"3","key":"10.1016\/j.brainres.2025.149640_b0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001331","article-title":"Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects","volume":"7","author":"Pramparo","year":"2011","journal-title":"PLoS Genet."},{"issue":"2","key":"10.1016\/j.brainres.2025.149640_b0205","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jnc.15806","article-title":"Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders","volume":"166","author":"Santiago","year":"2023","journal-title":"J Neurochem."},{"issue":"3","key":"10.1016\/j.brainres.2025.149640_b0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00702-022-02567-5","article-title":"Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors","volume":"130","author":"Schmitt","year":"2023","journal-title":"J Neural Transm (Vienna)"},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0215","doi-asserted-by":"crossref","first-page":"10182","DOI":"10.1038\/s41598-022-14102-3","article-title":"Social anhedonia as a Disrupted-in-Schizophrenia 1-dependent phenotype","volume":"12","author":"Seidisarouei","year":"2022","journal-title":"Sci Rep."},{"key":"10.1016\/j.brainres.2025.149640_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2014.05.005","article-title":"Nicotine-stimulated release of [3H]norepinephrine is reduced in the hippocampus of an animal model of attention-deficit\/hyperactivity disorder, the spontaneously hypertensive rat","volume":"1572","author":"Sterley","year":"2014","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.brainres.2025.149640_b0225","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4300\/JGME-D-12-00156.1","article-title":"Using effect size-or why the P value is not enough","volume":"4","author":"Sullivan","year":"2012","journal-title":"J Grad Med Educ."},{"issue":"4","key":"10.1016\/j.brainres.2025.149640_b0230","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/1470320313515038","article-title":"Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat","volume":"16","author":"Thakur","year":"2015","journal-title":"J Renin Angiotensin Aldosterone Syst."},{"issue":"11","key":"10.1016\/j.brainres.2025.149640_b0235","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/mp.2015.194","article-title":"Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits","volume":"21","author":"Trossbach","year":"2016","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0240","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-023-02665-y","article-title":"Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations","volume":"147","author":"Tsai","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2025.149640_b0245","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuroscience.2022.04.013","article-title":"Disrupted-in-schizophrenia 1 protein misassembly impairs cognitive flexibility and social behaviors in a transgenic rat model","volume":"493","author":"Wang","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2025.149640_b0250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pnpbp.2017.10.008","article-title":"Gene polymorphisms of DISC1 is associated with schizophrenia: Evidence from a meta-analysis","volume":"81","author":"Wang","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.brainres.2025.149640_b0255","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0022-3565(25)11077-X","article-title":"Effect of chronic haloperidol treatment on stimulated synaptic overflow of dopamine in the rat striatum","volume":"261","author":"Wiedemann","year":"1992","journal-title":"The Journal of Pharmacology and Experimental Therapeutics."},{"issue":"3","key":"10.1016\/j.brainres.2025.149640_b0260","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.pharep.2013.11.002","article-title":"Telmisartan attenuates cognitive impairment caused by chronic stress in rats","volume":"66","author":"Wincewicz","year":"2014","journal-title":"Pharmacol Rep."},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0265","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-3565(25)28878-4","article-title":"Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme)","volume":"177","author":"Yang","year":"1971","journal-title":"J Pharmacol Exp Ther."},{"key":"10.1016\/j.brainres.2025.149640_b0270","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbr.2014.04.035","article-title":"Autism-related behavioral phenotypes in an inbred rat substrain","volume":"269","author":"Zhang-James","year":"2014","journal-title":"Behav Brain Res."},{"issue":"1","key":"10.1016\/j.brainres.2025.149640_b0275","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12974-023-02901-y","article-title":"Noteworthy perspectives on microglia in neuropsychiatric disorders","volume":"20","author":"Zhu","year":"2023","journal-title":"J Neuroinflammation."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325001994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325001994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:17:02Z","timestamp":1778635022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325001994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":55,"alternative-id":["S0006899325001994"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149640","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term treatment with haloperidol modulates angiotensin I-converting enzyme (ACE) activity in transgenic animal model with construct validity for schizophrenia studies","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149640"}}