{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:02:36Z","timestamp":1793833356022,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Committee","doi-asserted-by":"publisher","award":["2022ZD045"],"award-info":[{"award-number":["2022ZD045"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.brainres.2025.149662","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T19:00:27Z","timestamp":1745866827000},"page":"149662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["AMPK mediates the anti-ferroptosis effect of acupuncture in cerebral ischemia\u2013reperfusion rats"],"prefix":"10.1016","volume":"1860","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8859-7967","authenticated-orcid":false,"given":"Rong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-8219","authenticated-orcid":false,"given":"Jun-feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.brainres.2025.149662_b0005","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s11011-014-9632-2","article-title":"Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia","volume":"30","author":"Ashabi","year":"2015","journal-title":"Metab. Brain Dis."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0010","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/ana.23817","article-title":"Ceruloplasmin dysfunction and therapeutic potential for parkinson disease","volume":"73","author":"Ayton","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2025.149662_b0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2020.07.026","article-title":"Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell","volume":"160","author":"Bai","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2025.149662_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.822088","article-title":"Mechanism of electroacupuncture against cerebral ischemia-reperfusion injury: reducing inflammatory response and cell pyroptosis by inhibiting NLRP3 and caspase-1","volume":"15","author":"Cai","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"5","key":"10.1016\/j.brainres.2025.149662_b0025","doi-asserted-by":"crossref","first-page":"944","DOI":"10.4103\/1673-5374.297061","article-title":"Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation","volume":"16","author":"Cao","year":"2021","journal-title":"Neural Regen Res."},{"issue":"3","key":"10.1016\/j.brainres.2025.149662_b0030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3390\/antiox9030248","article-title":"Effect of acupuncture on oxidative stress induced by cerebral ischemia-reperfusion injury","volume":"9","author":"Chen","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.brainres.2025.149662_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147216","article-title":"Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53\/SLC7A11-mediated ferroptosis","volume":"1752","author":"Chen","year":"2021","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.brainres.2025.149662_b0040","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.brainres.2025.149662_b0045","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2013from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2025.149662_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.881809","article-title":"Ferroptosis-A novel mechanism with multifaceted actions on stroke","volume":"13","author":"Fang","year":"2022","journal-title":"Front Neurol."},{"key":"10.1016\/j.brainres.2025.149662_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1009169","article-title":"Neuropharmacological efficacy of metformin for stroke in rodents: a meta-analysis of preclinical trials","volume":"13","author":"Fu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.brainres.2025.149662_b0060","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","author":"GBD 2019 Stroke Collaborators","year":"2021","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0065","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of disease study 2021[J]","volume":"23","author":"GBD 2021 Nervous System Disorders Collaborators","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2025.149662_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1388759","article-title":"Acupuncture modulates the AMPK\/PGC-1 signaling pathway to facilitate mitochondrial biogenesis and neural recovery in ischemic stroke rats","volume":"17","author":"Guo","year":"2024","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0075","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/jnc.15807","article-title":"Iron, ferroptosis, and ischemic stroke","volume":"165","author":"Guo","year":"2023","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0080","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149662_b0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3892\/mmr.2020.11704","article-title":"Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury","volume":"23","author":"Jiang","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0090","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.brainres.2025.149662_b0095","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"issue":"2","key":"10.1016\/j.brainres.2025.149662_b0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0105","article-title":"Energy stress inhibits ferroptosis via AMPK","volume":"7","author":"Lee","year":"2020","journal-title":"Mol. Cell Oncol."},{"issue":"11","key":"10.1016\/j.brainres.2025.149662_b0110","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","article-title":"Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.brainres.2025.149662_b0115","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/dna.2019.5097","article-title":"Ferroptosis is involved in diabetes myocardial ischemia\/reperfusion injury through endoplasmic reticulum stress","volume":"39","author":"Li","year":"2020","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.brainres.2025.149662_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155134","article-title":"Targeting ferroptosis with natural products in liver injury: new insights from molecular mechanisms to targeted therapies","volume":"122","author":"Liang","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.brainres.2025.149662_b0125","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.3892\/mmr.2015.4321","article-title":"Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus","volume":"12","author":"Lin","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.brainres.2025.149662_b0130","series-title":"A study on mechanisms of protective function of cluster acupuncture on scalp points on neurological damage and cerebral edema of early stage of cerebral ischemic reperfution in rats","author":"Liu","year":"2008"},{"issue":"34","key":"10.1016\/j.brainres.2025.149662_b0135","doi-asserted-by":"crossref","first-page":"24147","DOI":"10.1074\/jbc.274.34.24147","article-title":"Identification of a hypoxia response element in the transferrin receptor gene","volume":"274","author":"Lok","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.brainres.2025.149662_b0140","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2025.149662_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118305","article-title":"lncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53","volume":"260","author":"Lu","year":"2020","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.brainres.2025.149662_b0150","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.chembiol.2020.10.010","article-title":"Using the oxytosis\/ferroptosis pathway to understand and treat age-associated neurodegenerative diseases","volume":"27","author":"Maher","year":"2020","journal-title":"Cell Chem. Biol."},{"issue":"5","key":"10.1016\/j.brainres.2025.149662_b0155","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/00004647-200205000-00003","article-title":"Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro","volume":"22","author":"Prass","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"7","key":"10.1016\/j.brainres.2025.149662_b0160","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1007\/s12035-015-9389-6","article-title":"Hypoxia-induced iron accumulation in oligodendrocytes mediates apoptosis by eliciting endoplasmic reticulum stress","volume":"53","author":"Rathnasamy","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.brainres.2025.149662_b0165","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.arr.2004.04.001","article-title":"The role of iron neurotoxicity in ischemic stroke","volume":"3","author":"Selim","year":"2004","journal-title":"Ageing Res. Rev."},{"issue":"6270","key":"10.1016\/j.brainres.2025.149662_b0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1126\/science.aab4138","article-title":"Metabolism AMP-activated protein kinase mediates mitochondrial fission in response to energy stress","volume":"351","author":"Toyama","year":"2016","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.brainres.2025.149662_b0175","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1474-4422(22)00519-1","article-title":"Thrombolysis for acute ischaemic stroke: current status and future perspectives","volume":"22","author":"Tsivgoulis","year":"2023","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149662_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2019.151058","article-title":"Mitochondria regulation in ferroptosis","volume":"99","author":"Wang","year":"2020","journal-title":"Eur. J. Cell Biol."},{"issue":"10","key":"10.1016\/j.brainres.2025.149662_b0185","first-page":"1019","article-title":"Effect of \u201cXingnao Kaiqiao\u201d needling on expression of ferroptosis-related factors in rats with cerebral ischemia-reperfusion injury","volume":"49","author":"Wang","year":"2024","journal-title":"Zhen Ci Yan Jiu"},{"issue":"2","key":"10.1016\/j.brainres.2025.149662_b0190","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12031-018-1155-6","article-title":"Ferroptosis, a recent defined form of critical cell death in neurological disorders","volume":"66","author":"Wu","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2025.149662_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.633280","article-title":"The anti-apoptosis effect of single electroacupuncture treatment via suppressing neuronal autophagy in the acute stage of ischemic stroke without infarct alleviation","volume":"15","author":"Xing","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.brainres.2025.149662_b0200","article-title":"Study on the mechanism of AMPK\/mTOR\/ULK1 signalingpathway regulated by electro-acupuncture to improve nervefunction injury in MCAO\/R rats","author":"Xu","year":"2024","journal-title":"Guangzhou Univ. Chin. Med."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0205","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1016\/j.bbrc.2018.08.130","article-title":"Microglia TREM2 is required for electroacupuncture to attenuate neuroinflammation in focal cerebral ischemia\/reperfusion rats","volume":"503","author":"Xu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.brainres.2025.149662_b0210","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bbadis.2011.12.004","article-title":"Hypoxic preconditioning increases iron transport rate in astrocytes","volume":"1822","author":"Yang","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2025.149662_b0215","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4717258","article-title":"Ezetimibe attenuates oxidative stress and neuroinflammation via the AMPK\/Nrf2\/TXNIP pathway after MCAO in rats","volume":"2020","author":"Yu","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"issue":"6","key":"10.1016\/j.brainres.2025.149662_b0220","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1161\/01.STR.0000070841.31224.29","article-title":"Neuroprotection in transient focal cerebral ischemia by combination drug therapy and mild hypothermia: comparison with customary therapeutic regimen","volume":"34","author":"Zausinger","year":"2003","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.brainres.2025.149662_b0225","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s11064-022-03697-8","article-title":"Cell death mechanisms in cerebral ischemia-reperfusion injury","volume":"47","author":"Zhang","year":"2022","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.brainres.2025.149662_b0230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/ijmm.2021.5070","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (Review)","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.brainres.2025.149662_b0235","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1007\/s11064-024-04185-x","article-title":"Electroacupuncture downregulating neuronal ferroptosis in MCAO\/R rats by activating Nrf2\/SLC7A11\/GPX4 Axis","volume":"49","author":"Zhu","year":"2024","journal-title":"Neurochem. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325002215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325002215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:05:51Z","timestamp":1767992751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325002215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":47,"alternative-id":["S0006899325002215"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149662","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMPK mediates the anti-ferroptosis effect of acupuncture in cerebral ischemia\u2013reperfusion rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149662","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149662"}}