{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:51:27Z","timestamp":1786985487293,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2021\/09768-5"],"award-info":[{"award-number":["2021\/09768-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2021\/05299-0"],"award-info":[{"award-number":["2021\/05299-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/00980-7"],"award-info":[{"award-number":["2023\/00980-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2020\/16320-8"],"award-info":[{"award-number":["2020\/16320-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/11274-6"],"award-info":[{"award-number":["2023\/11274-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306580\/2023-3"],"award-info":[{"award-number":["306580\/2023-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306418\/2023-1"],"award-info":[{"award-number":["306418\/2023-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.brainres.2025.149829","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:04:38Z","timestamp":1752566678000},"page":"149829","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Testosterone modulates respiratory control but does not exert neuroprotective effects in a Parkinson\u2019s disease model"],"prefix":"10.1016","volume":"1864","author":[{"given":"Yasmin C.","family":"Aquino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-9780","authenticated-orcid":false,"given":"Luiz F.","family":"Pedr\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-8296","authenticated-orcid":false,"given":"Thiago S.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Falquetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20133","key":"10.1016\/j.brainres.2025.149829_b0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0304-3940(88)90659-3","article-title":"Reproductive hormones control striatal tyrosine hydroxylase activity in the male rat","volume":"95","author":"Abreu","year":"1988","journal-title":"Neurosci. Lett."},{"issue":"13","key":"10.1016\/j.brainres.2025.149829_b0010","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1096\/fj.04-1495fje","article-title":"Estrogen exerts neuroprotective effects via membrane estrogen receptors and rapid Akt\/NOS activation","volume":"18","author":"Alexaki","year":"2004","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.brainres.2025.149829_b0015","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The epidemiology of Parkinson's disease: risk factors and prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"The Lancet. Neurology"},{"issue":"21","key":"10.1016\/j.brainres.2025.149829_b0020","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1073\/pnas.84.21.7788","article-title":"Progesterone stimulates respiration through a central nervous system steroid receptor-mediated mechanism in cat","volume":"84","author":"Bayliss","year":"1987","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.brainres.2025.149829_b0025","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.steroids.2007.02.003","article-title":"Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications","volume":"72","author":"Brann","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.brainres.2025.149829_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148586","article-title":"TNFR1-mediated neuroinflammation is necessary for respiratory deficits observed in 6-hydroxydopamine mouse model of Parkinso\u0144s Disease","volume":"1822","author":"Cabral","year":"2024","journal-title":"Brain Res."},{"issue":"10","key":"10.1016\/j.brainres.2025.149829_b0035","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.parkreldis.2011.02.018","article-title":"Parkinson's disease: the non-motor issues","volume":"17","author":"Chaudhuri","year":"2011","journal-title":"Parkinsonism Relat. Disord."},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2047-9158-4-1","article-title":"Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis","volume":"4","author":"Chen","year":"2015","journal-title":"Translational neurodegeneration"},{"issue":"3","key":"10.1016\/j.brainres.2025.149829_b0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/andr.12187","article-title":"Androgen deprivation therapy did not increase the risk of Alzheimer's and Parkinson's disease in patients with prostate cancer","volume":"4","author":"Chung","year":"2016","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/joa.13407","article-title":"Androgen receptors in areas of the spinal cord and brainstem: A study in adult male cats","volume":"239","author":"Coolen","year":"2021","journal-title":"J. Anat."},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0055","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.1038\/s41598-024-61733-9","article-title":"Analysis of androgen receptor expression and activity in the mouse brain","volume":"14","author":"Dart","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2025.149829_b0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2015.11.026","article-title":"Role of sex hormones in hypercapnia-induced activation of the locus coeruleus in female and male rats","volume":"313","author":"de Carvalho","year":"2016","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.brainres.2025.149829_b0065","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"de Lau","year":"2006","journal-title":"The Lancet. Neurology"},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0070","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1164\/ajrccm.162.1.9907008","article-title":"Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey","volume":"162","author":"de Marco","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.brainres.2025.149829_b0075","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.pbb.2004.08.015","article-title":"Circulating androgens enhance sensitivity to testosterone self-administration in male hamsters","volume":"79","author":"DiMeo","year":"2004","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1016\/j.brainres.2025.149829_b0080","doi-asserted-by":"crossref","unstructured":"do Rego, J. L., Seong, J. Y., Burel, D., Leprince, J., Luu-The, V., Tsutsui, K., Tonon, M. C., Pelletier, G., & Vaudry, H. (2009). Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides. Frontiers in neuroendocrinology, 30(3), 259\u2013301. doi: 10.1016\/j.yfrne.2009.05.006.","DOI":"10.1016\/j.yfrne.2009.05.006"},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1542\/peds.16.1.81","article-title":"A barometric method for measuring ventilation in newborn infants","volume":"16","author":"Drorbaugh","year":"1955","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.brainres.2025.149829_b0090","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1210\/en.2019-00114","article-title":"Androgens Enhance Adult Hippocampal Neurogenesis in Males but Not Females in an Age-Dependent Manner","volume":"160","author":"Duarte-Guterman","year":"2019","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.brainres.2025.149829_b0095","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/mds.10537","article-title":"Survival time, mortality, and cause of death in elderly patients with Parkinson's disease: a 9-year follow-up","volume":"18","author":"Fall","year":"2003","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"5","key":"10.1016\/j.brainres.2025.149829_b0100","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1113\/expphysiol.2013.077073","article-title":"Testosterone potentiates the hypoxic ventilatory response of adult male rats subjected to neonatal stress","volume":"99","author":"Fournier","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.brainres.2025.149829_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2019.110543","article-title":"Sex differences in breathing. Comparative biochemistry and physiology","volume":"238","author":"Gargaglioni","year":"2019","journal-title":"Part A, Molecular & integrative physiology"},{"key":"10.1016\/j.brainres.2025.149829_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2018.02.013","article-title":"Androgens and androgen receptor: Above and beyond","volume":"465","author":"Gibson","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.brainres.2025.149829_b0115","doi-asserted-by":"crossref","unstructured":"Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., Blackman, M. R., & Baltimore Longitudinal Study of Aging (2001). Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. The Journal of clinical endocrinology and metabolism, 86(2), 724\u2013731. doi: 10.1210\/jcem.86.2.7219.","DOI":"10.1210\/jcem.86.2.7219"},{"issue":"2","key":"10.1016\/j.brainres.2025.149829_b0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euroneuro.2012.04.013","article-title":"Testosterone in the brain: neuroimaging findings and the potential role for neuropsychopharmacology","volume":"23","author":"H\u00f6fer","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"11","key":"10.1016\/j.brainres.2025.149829_b0125","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1210\/en.2013-1242","article-title":"Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells","volume":"154","author":"Holmes","year":"2013","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.brainres.2025.149829_b0130","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1210\/en.2015-1738","article-title":"Effects of Oxidative Stress and Testosterone on Pro-Inflammatory Signaling in a Female Rat Dopaminergic Neuronal Cell Line","volume":"157","author":"Holmes","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2025.149829_b0135","series-title":"Good and bad testosterone","first-page":"235","article-title":"The aging man and testosterone","author":"Huhtaniemi","year":"2024"},{"issue":"4","key":"10.1016\/j.brainres.2025.149829_b0140","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2826.2010.01965.x","article-title":"Androgen decreases dopamine neurone survival in rat midbrain","volume":"22","author":"Johnson","year":"2010","journal-title":"J. Neuroendocrinol."},{"issue":"2","key":"10.1016\/j.brainres.2025.149829_b0145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/mds.26098","article-title":"Increasing age-adjusted male-to-female incidence ratio of Parkinson's disease","volume":"30","author":"Kaasinen","year":"2015","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"29","key":"10.1016\/j.brainres.2025.149829_b0150","doi-asserted-by":"crossref","first-page":"20843","DOI":"10.1074\/jbc.M112.443556","article-title":"Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase","volume":"288","author":"Khasnavis","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.brainres.2025.149829_b0155","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/BF00412468","article-title":"Uber die Wirkung von Cortison und Testosteron auf die Atmung [Effect of cortisone and testosterone on respiration]","volume":"257","author":"Koepchen","year":"1953","journal-title":"Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere"},{"key":"10.1016\/j.brainres.2025.149829_b0160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.psyneuen.2017.10.007","article-title":"Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats","volume":"87","author":"Kokras","year":"2018","journal-title":"Psychoneuroendocrinology"},{"issue":"24","key":"10.1016\/j.brainres.2025.149829_b0165","doi-asserted-by":"crossref","first-page":"10735","DOI":"10.1523\/JNEUROSCI.18-24-10735.1998","article-title":"Perinatal gonadectomy exerts regionally selective, lateralized effects on the density of axons immunoreactive for tyrosine hydroxylase in the cerebral cortex of adult male rats","volume":"18","author":"Kritzer","year":"1998","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.brainres.2025.149829_b0170","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.maturitas.2009.03.008","article-title":"Mechanism of androgen receptor action","volume":"63","author":"Li","year":"2009","journal-title":"Maturitas"},{"key":"10.1016\/j.brainres.2025.149829_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1498756","article-title":"Global, regional, national epidemiology and trends of Parkinson's disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021","volume":"16","author":"Luo","year":"2025","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1530\/JOE-20-0257","article-title":"The role of testosterone in the respiratory and thermal responses to hypoxia and hypercapnia in rats","volume":"247","author":"Marques","year":"2020","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.brainres.2025.149829_b0185","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jchemneu.2010.07.006","article-title":"Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus","volume":"40","author":"Meydan","year":"2010","journal-title":"J. Chem. Neuroanat."},{"issue":"11","key":"10.1016\/j.brainres.2025.149829_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111251","article-title":"Sleep-related respiratory disruptions and laterodorsal tegmental nucleus in a mouse model of Parkinson's disease","volume":"27","author":"Miranda","year":"2024","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jocn.2005.02.014","article-title":"Testosterone improves motor function in Parkinson's disease","volume":"13","author":"Mitchell","year":"2006","journal-title":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia"},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0306-4522(02)00578-X","article-title":"Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females","volume":"116","author":"Murray","year":"2003","journal-title":"Neuroscience"},{"issue":"6 Suppl","key":"10.1016\/j.brainres.2025.149829_b0205","first-page":"120","article-title":"Sexual differentiation of the brain: role of testosterone and its active metabolites","volume":"27","author":"Negri-Cesi","year":"2004","journal-title":"J. Endocrinol. Invest."},{"issue":"6","key":"10.1016\/j.brainres.2025.149829_b0210","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/j.1471-4159.2005.03318.x","article-title":"Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection","volume":"94","author":"Nguyen","year":"2005","journal-title":"J. Neurochem."},{"issue":"27","key":"10.1016\/j.brainres.2025.149829_b0215","volume":"183","author":"Nielsen","year":"2021","journal-title":"Ugeskr. Laeger"},{"issue":"5","key":"10.1016\/j.brainres.2025.149829_b0220","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archneur.59.5.807","article-title":"Refractory nonmotor symptoms in male patients with Parkinson disease due to testosterone deficiency: a common unrecognized comorbidity","volume":"59","author":"Okun","year":"2002","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0225","first-page":"165","article-title":"Testosterone deficiency in a Parkinson's disease clinic: results of a survey","volume":"75","author":"Okun","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"5","key":"10.1016\/j.brainres.2025.149829_b0230","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1113\/EP087507","article-title":"Respiratory disturbances in a mouse model of Parkinson's disease","volume":"104","author":"Oliveira","year":"2019","journal-title":"Exp. Physiol."},{"issue":"4","key":"10.1016\/j.brainres.2025.149829_b0235","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41443-023-00662-z","article-title":"Bilateral orchiectomy deteriorates the structure and function of seminal vesicles in a rat model","volume":"36","author":"Ongun","year":"2024","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.brainres.2025.149829_b0240","doi-asserted-by":"crossref","unstructured":"Ostatn\u00edkov\u00e1, D., Lakato\u0161ov\u00e1, S., Babkov\u00e1, J., Hodosy, J., & Celec, P. (2020). Testosterone and the brain: from cognition to autism. Physiological research, 69(Suppl 3), S403\u2013S419. doi: 10.33549\/physiolres.934592.","DOI":"10.33549\/10.33549\/physiolres.934592"},{"issue":"9","key":"10.1016\/j.brainres.2025.149829_b0245","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.brainres.2025.149829_b0250","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/mds.26060","article-title":"Mortality in Parkinson's disease: a 38-year follow-up study","volume":"30","author":"Pinter","year":"2015","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"key":"10.1016\/j.brainres.2025.149829_b0255","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"Poewe","year":"2017","journal-title":"Parkinson disease. Nature reviews. Disease primers"},{"issue":"2\u20133","key":"10.1016\/j.brainres.2025.149829_b0260","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.resp.2011.09.012","article-title":"Abnormal ventilatory control in Parkinson's disease\u2013further evidence for non-motor dysfunction","volume":"179","author":"Seccombe","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"5","key":"10.1016\/j.brainres.2025.149829_b0265","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/cns.12538","article-title":"Neuroprotective Role of Steroidal Sex Hormones: An Overview","volume":"22","author":"Siddiqui","year":"2016","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0270","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/cne.902940107","article-title":"Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study","volume":"294","author":"Simerly","year":"1990","journal-title":"J. Comp. Neurol."},{"issue":"10","key":"10.1016\/j.brainres.2025.149829_b0275","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/dneu.20457","article-title":"Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats","volume":"67","author":"Spritzer","year":"2007","journal-title":"Dev. Neurobiol."},{"issue":"12","key":"10.1016\/j.brainres.2025.149829_b0280","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12550","article-title":"Neonatal maternal separation opposes the facilitatory effect of castration on the respiratory response to hypercapnia of the adult male rat: Evidence for the involvement of the medial amygdala","volume":"29","author":"Tenorio-Lopes","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainres.2025.149829_b0285","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuroscience.2015.03.048","article-title":"Respiratory deficits in a rat model of Parkinson's disease","volume":"297","author":"Tuppy","year":"2015","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.brainres.2025.149829_b0290","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1096-9861(19960617)370:1<71::AID-CNE7>3.0.CO;2-I","article-title":"Distribution and steroid hormone regulation of aromatase mRNA expression in the forebrain of adult male and female rats: a cellular-level analysis using in situ hybridization","volume":"370","author":"Wagner","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2025.149829_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2016.03.003","article-title":"Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate","volume":"78","author":"Wang","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainres.2025.149829_b0300","doi-asserted-by":"crossref","unstructured":"White, D. P., Schneider, B. K., Santen, R. J., McDermott, M., Pickett, C. K., Zwillich, C. W., & Weil, J. V. (1985). Influence of testosterone on ventilation and chemosensitivity in male subjects. Journal of applied physiology (Bethesda, Md.: 1985), 59(5), 1452\u20131457. doi: 10.1152\/jappl.1985.59.5.1452.","DOI":"10.1152\/jappl.1985.59.5.1452"},{"key":"10.1016\/j.brainres.2025.149829_b0305","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1202459","article-title":"Testosterone Upregulates the Expression of Mitochondrial ND1 and ND4 and Alleviates the Oxidative Damage to the Nigrostriatal Dopaminergic System in Orchiectomized Rats","volume":"2017","author":"Yan","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.brainres.2025.149829_b0310","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000094553","article-title":"Degeneration in the Brains of Parkinson\u2019s Disease Patients","volume":"3","author":"Zhang","year":"2004","journal-title":"Neuroembryology and Aging"},{"issue":"11","key":"10.1016\/j.brainres.2025.149829_b0315","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.18632\/aging.103265","article-title":"Testosterone enhances mitochondrial complex V function in the substantia nigra of aged male rats","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.brainres.2025.149829_b0320","doi-asserted-by":"crossref","unstructured":"Zhou, X. S., Shahabuddin, S., Zahn, B. R., Babcock, M. A., & Badr, M. S. (2000). Effect of gender on the development of hypocapnic apnea\/hypopnea during NREM sleep. Journal of applied physiology (Bethesda, Md. : 1985), 89(1), 192\u2013199. doi: 10.1152\/jappl.2000.89.1.192.","DOI":"10.1152\/jappl.2000.89.1.192"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325003907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325003907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:21:02Z","timestamp":1777105262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325003907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":64,"alternative-id":["S0006899325003907"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149829","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testosterone modulates respiratory control but does not exert neuroprotective effects in a Parkinson\u2019s disease model","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149829","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149829"}}