{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:03:57Z","timestamp":1779771837627,"version":"3.53.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.brainres.2025.149878","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T15:43:06Z","timestamp":1754667786000},"page":"149878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Acori Tatarinowii Rhizoma inhibited neuroinflammation in Alzheimer\u2019s disease rats by modulating the intestinal flora"],"prefix":"10.1016","volume":"1865","author":[{"given":"Liquan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-0071","authenticated-orcid":false,"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2025.149878_b0005","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ebiom.2019.08.042","article-title":"Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion","volume":"47","author":"Agrimi","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.brainres.2025.149878_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1477187","article-title":"Gut microbiota mediated T cells regulation and autoimmune diseases","volume":"15","author":"Bhutta","year":"2024","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","article-title":"Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2's q2-feature-classifier plugin","volume":"6","author":"Bokulich","year":"2018","journal-title":"J Microbiome."},{"issue":"10","key":"10.1016\/j.brainres.2025.149878_b0020","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-\u03b2 and tau in Alzheimer's disease","volume":"23","author":"Busche","year":"2020","journal-title":"J Nature Euroscience."},{"issue":"2","key":"10.1016\/j.brainres.2025.149878_b0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1039\/D3FO04806C","article-title":"Integrated gut microbiome and metabolome analysis reveals the inhibition effect of Lactobacillus plantarum CBT against colorectal cancer","volume":"15","author":"Chen","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.brainres.2025.149878_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.993615","article-title":"Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer's mouse model","volume":"14","author":"Chu","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2025.149878_b0035","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.trci.2018.03.009","article-title":"Alzheimer's disease drug development pipeline: 2018","volume":"4","author":"Cummings","year":"2018","journal-title":"J Alzheimer's Dementia."},{"key":"10.1016\/j.brainres.2025.149878_b0040","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jpsychires.2020.06.032","article-title":"Gut microbiota changes in patients with autism spectrum disorders","volume":"129","author":"Ding","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.brainres.2025.149878_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118676","article-title":"Volatile oil from Acori graminei Rhizoma affected the synaptic plasticity of rats with tic disorders by modulating dopaminergic and glutamatergic systems","volume":"335","author":"Feng","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.brainres.2025.149878_b0050","doi-asserted-by":"crossref","first-page":"395","DOI":"10.31083\/ph.2020.0492","article-title":"Acori tatarinowii rhizoma extract ameliorates Alzheimer's pathological syndromes by repairing myelin injury and lowering Tau phosphorylation in mice","volume":"75","author":"Fu","year":"2020","journal-title":"Pharmazie"},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0055","doi-asserted-by":"crossref","first-page":"23184","DOI":"10.1038\/s41598-024-73700-5","article-title":"Turicibacter and Catenibacterium as potential biomarkers in autism spectrum disorders","volume":"14","author":"Gerges","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/nu16010016","article-title":"Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic factor, Inflammatory Biomarkers, Oxidative stress and Cognitive Function in patients with Alzheimer's Dementia: a 12-Week Randomized, Double-Blind Active-Controlled Study","volume":"16","author":"Hsu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.brainres.2025.149878_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1004765","article-title":"Soybean isoflavones modulate gut microbiota to benefit the health weight and metabolism","volume":"12","author":"Huang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.brainres.2025.149878_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110990","article-title":"Acorus tatarinowii oils exert protective effects on microglia-mediated inflammatory injury via restoring gut microbiota composition in experimental stroke rats","volume":"213","author":"Huang","year":"2024","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0075","doi-asserted-by":"crossref","first-page":"477","DOI":"10.18632\/aging.203826","article-title":"Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis","volume":"14","author":"Hung","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.brainres.2025.149878_b0080","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211023474","article-title":"Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy","volume":"30","author":"Hur","year":"2021","journal-title":"Cell Transplant."},{"issue":"2","key":"10.1016\/j.brainres.2025.149878_b0085","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/gutjnl-2018-317431","article-title":"Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model","volume":"69","author":"Kim","year":"2020","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.brainres.2025.149878_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9071451","article-title":"A Microencapsulated Mixture of Eugenol and Garlic Tincture Supplementation Mitigates the effect of Necrotic Enteritis on Intestinal Integrity and increases Goblet Cells in Broilers","volume":"9","author":"Kumar","year":"2021","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer's disease","volume":"25","author":"Lane","year":"2018","journal-title":"J European Journal of Neurology."},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0100","first-page":"40","article-title":"Antidepressant effect of water decoction of Rhizoma acori tatarinowii in the behavioural despair animal models of depression","volume":"24","author":"Li","year":"2001","journal-title":"Journal of Chinese Medicinal Materials."},{"issue":"20","key":"10.1016\/j.brainres.2025.149878_b0105","article-title":"Eugenol, a Major Component of Clove Oil, Attenuates Adiposity, and Modulates Gut Microbiota in High-Fat Diet-Fed mice","volume":"66","author":"Li","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.brainres.2025.149878_b0110","article-title":"5-Heptadecylresorcinol, a Biomarker for whole Grain Rye Consumption, Ameliorates Cognitive Impairments and Neuroinflammation in APP\/PS1 Transgenic mice","volume":"64","author":"Liu","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"issue":"43","key":"10.1016\/j.brainres.2025.149878_b0115","doi-asserted-by":"crossref","first-page":"12717","DOI":"10.1021\/acs.jafc.1c04687","article-title":"Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP\/PS1 mice: the Mediating Role of the Gut-Brain Axis","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-022-02393-2","article-title":"Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"190","key":"10.1016\/j.brainres.2025.149878_b0125","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.24976\/Discov.Med.202436190.196","article-title":"Exosomes, Endosomes, and Caveolae as encouraging Targets with favorable Gut Microbiota for the innovative Treatment of Alzheimer's Diseases","volume":"36","author":"Nakashima","year":"2024","journal-title":"Discov. Med."},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0130","doi-asserted-by":"crossref","first-page":"15454","DOI":"10.1038\/s41598-022-19502-z","article-title":"Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats","volume":"12","author":"Nguyen","year":"2022","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.brainres.2025.149878_b0135","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s43587-022-00311-y","article-title":"Intermittent fasting protects against Alzheimer's disease in mice by altering metabolism through remodeling of the gut microbiota","volume":"2","author":"Pan","year":"2022","journal-title":"Nat. Aging"},{"issue":"2","key":"10.1016\/j.brainres.2025.149878_b0140","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2282790","article-title":"Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP\/PS1 mice","volume":"15","author":"Qian","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.brainres.2025.149878_b0145","article-title":"Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease","volume":"14","author":"Qiu","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2025.149878_b0150","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2128605","article-title":"Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production","volume":"14","author":"Sugiyama","year":"2022","journal-title":"Gut Microbes"},{"issue":"11","key":"10.1016\/j.brainres.2025.149878_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28114525","article-title":"Acorus tatarinowii Schott: a Review of its Botany, Traditional Uses, Phytochemistry, and Pharmacology","volume":"28","author":"Wang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2025.149878_b0160","article-title":"The relationship between Alzheimer's disease and intestinal microflora structure and inflammatory factors","volume":"14","author":"Wang","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"10","key":"10.1016\/j.brainres.2025.149878_b0165","article-title":"Blend of Cinnamaldehyde, Eugenol, and Capsicum Oleoresin improved Rumen Health of Lambs Fed High-Concentrate Diet as Revealed by Fermentation Characteristics, Epithelial Gene Expression, and Bacterial Community","volume":"13","author":"Wang","year":"2023","journal-title":"Animals (basel)"},{"issue":"10","key":"10.1016\/j.brainres.2025.149878_b0170","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41422-019-0216-x","article-title":"Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression","volume":"29","author":"Wang","year":"2019","journal-title":"J Cell Research."},{"key":"10.1016\/j.brainres.2025.149878_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1090526","article-title":"Acori Tatarinowii Rhizoma: a comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity","volume":"14","author":"Wen","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.brainres.2025.149878_b0180","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1007\/s11064-022-03784-w","article-title":"Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones","volume":"47","author":"Wu","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2025.149878_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.689629","article-title":"Electroacupuncture Improves M2 Microglia Polarization and Glia Anti-inflammation of Hippocampus in Alzheimer's Disease","volume":"15","author":"Xie","year":"2021","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2025.149878_b0190","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/febs.16344","article-title":"Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise","volume":"290","author":"Yin","year":"2023","journal-title":"FEBS J."},{"key":"10.1016\/j.brainres.2025.149878_b0195","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6630795","article-title":"Uncovering the protective Mechanism of the Volatile Oil of Acorus tatarinowii against Acute Myocardial Ischemia Injury using Network Pharmacology and Experimental Validation","volume":"2021","author":"Zang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.brainres.2025.149878_b0200","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuroscience.2020.12.026","article-title":"Alpha-asarone Improves Cognitive Function of APP\/PS1 mice and reducing A\u03b2(42,) P-tau and Neuroinflammation, and Promoting Neuron Survival in the Hippocampus","volume":"458","author":"Zeng","year":"2021","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.brainres.2025.149878_b0205","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2271613","article-title":"Gut microbiome-targeted therapies for Alzheimer's disease","volume":"15","author":"Zhang","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.brainres.2025.149878_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105376","article-title":"Natural volatile oils derived from herbal medicines: a promising therapy way for treating depressive disorder","volume":"164","author":"Zhang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainres.2025.149878_b0215","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbrc.2023.05.075","article-title":"Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota","volume":"670","author":"Zhao","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.brainres.2025.149878_b0220","doi-asserted-by":"crossref","first-page":"197","DOI":"10.31083\/j.jin2311197","article-title":"Molecular Insights into Tau Pathology and its Therapeutic strategies in Alzheimer's Disease","volume":"23","author":"Zhou","year":"2024","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.brainres.2025.149878_b0225","doi-asserted-by":"crossref","DOI":"10.29219\/fnr.v65.5496","article-title":"Dietary lactoferrin has differential effects on gut microbiota in young versus middle-aged APPswe\/PS1dE9 transgenic mice but no effects on cognitive function","volume":"65","author":"Zhou","year":"2021","journal-title":"Food Nutr. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932500441X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000689932500441X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:27:20Z","timestamp":1779769640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000689932500441X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":45,"alternative-id":["S000689932500441X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149878","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acori Tatarinowii Rhizoma inhibited neuroinflammation in Alzheimer\u2019s disease rats by modulating the intestinal flora","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149878"}}