{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:43:07Z","timestamp":1786365787473,"version":"build-2736575974"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital of Sichuan University","doi-asserted-by":"publisher","award":["ZYGD23032"],"award-info":[{"award-number":["ZYGD23032"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital of Sichuan University","doi-asserted-by":"publisher","award":["ZYGD22003"],"award-info":[{"award-number":["ZYGD22003"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20393"],"award-info":[{"award-number":["U21A20393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.brainres.2025.149885","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T23:12:55Z","timestamp":1754953975000},"page":"149885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Single-cell transcriptome analysis reveals dysregulation of microglial iron homeostasis in temporal lobe epilepsy"],"prefix":"10.1016","volume":"1865","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-4289","authenticated-orcid":false,"given":"Zihua","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jierui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-4125","authenticated-orcid":false,"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2025.149885_b0005","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1101\/gr.271205.120","article-title":"A graph neural network model to estimate cell-wise metabolic flux using single-cell RNA-seq data","volume":"31","author":"Alghamdi","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.brainres.2025.149885_b0010","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fnagi.2019.00351","article-title":"Regional distributions of iron, copper and zinc and their relationships with glia in a normal aging mouse model","volume":"11","author":"Ashraf","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0015","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022863","article-title":"Glutamatergic mechanisms associated with seizures and epilepsy","volume":"5","author":"Barker-Haliski","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.brainres.2025.149885_b0020","article-title":"Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy","author":"Belaidi","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2025.149885_b0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13024-020-00408-1","article-title":"Glycosphingolipids and neuroinflammation in Parkinson's disease","volume":"15","author":"Belarbi","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainres.2025.149885_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.601193","article-title":"Iron metabolism and ferroptosis in epilepsy","volume":"14","author":"Chen","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0035","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41593-023-01288-6","article-title":"Lipid-accumulated reactive astrocytes promote disease progression in epilepsy","volume":"26","author":"Chen","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0040","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.15252\/embj.201489293","article-title":"Chronic exposure to TGF\u03b21 regulates myeloid cell inflammatory response in an IRF7-dependent manner","volume":"33","author":"Cohen","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2025.149885_b0045","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2025.149885_b0050","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis","volume":"1","author":"Donovan","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.brainres.2025.149885_b0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/epi.16423","article-title":"Impaired vigilance networks in temporal lobe epilepsy: Mechanisms and clinical implications","volume":"61","author":"Englot","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2025.149885_b0060","doi-asserted-by":"crossref","first-page":"979","DOI":"10.12688\/f1000research.73600.1","article-title":"Doublet identification in single-cell sequencing data using scDblFinder","volume":"10","author":"Germain","year":"2021","journal-title":"F1000Res."},{"key":"10.1016\/j.brainres.2025.149885_b0065","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1528-1167.2005.11505.x","article-title":"Increased expression of ferritin, an iron-storage protein, in specific regions of the parahippocampal cortex of epileptic rats","volume":"46","author":"Gorter","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2025.149885_b0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11481-007-9090-2","article-title":"Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl\/Mer family of tyrosine kinases","volume":"3","author":"Grommes","year":"2008","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.brainres.2025.149885_b0075","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.brainres.2025.149885_b0080","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.aax0249","article-title":"Single-cell transcriptional diversity is a hallmark of developmental potential","volume":"367","author":"Gulati","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.brainres.2025.149885_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2019.05.013","article-title":"Altered expression of signaling pathways regulating neuronal excitability in hippocampal tissue of temporal lobe epilepsy patients with low and high seizure frequency","volume":"155","author":"Hammer","year":"2019","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2025.149885_b0090","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2025.149885_b0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jneuroim.2016.07.017","article-title":"Increased expression of interleukin 17 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy","volume":"298","author":"He","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2025.149885_b0100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/glia.24265","article-title":"Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy","volume":"71","author":"Henning","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2025.149885_b0105","doi-asserted-by":"crossref","DOI":"10.3390\/cells7040026","article-title":"Microglia after seizures and in epilepsy","volume":"7","author":"Hiragi","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.brainres.2025.149885_b0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jphs.2019.12.008","article-title":"The solute carrier transporters and the brain: physiological and pharmacological implications","volume":"15","author":"Hu","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.brainres.2025.149885_b0115","doi-asserted-by":"crossref","first-page":"D870","DOI":"10.1093\/nar\/gkac947","article-title":"CellMarker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data","volume":"51","author":"Hu","year":"2023","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.brainres.2025.149885_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1173694","article-title":"The role of dendritic spines in epileptogenesis","volume":"17","author":"Jean","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0125","doi-asserted-by":"crossref","first-page":"D853","DOI":"10.1093\/nar\/gkac816","article-title":"Cell taxonomy: a curated repository of cell types with multifaceted characterization","volume":"51","author":"Jiang","year":"2023","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.brainres.2025.149885_b0130","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s40478-020-00999-2","article-title":"Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients","volume":"8","author":"Jiang","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.brainres.2025.149885_b0135","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2025.149885_b0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40478-021-01126-5","article-title":"Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients","volume":"9","author":"Kenkhuis","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.brainres.2025.149885_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101436","article-title":"NFE2L1-mediated proteasome function protects from ferroptosis","volume":"57","author":"Kotschi","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.brainres.2025.149885_b0150","doi-asserted-by":"crossref","first-page":"e1442","DOI":"10.1038\/cddis.2014.390","article-title":"Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation","volume":"5","author":"Kovac","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2025.149885_b0155","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fncel.2019.00414","article-title":"Fractalkine modulates microglia metabolism in brain ischemia","volume":"13","author":"Lauro","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0160","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41380-023-02399-z","article-title":"Iron imbalance in neurodegeneration","volume":"29","author":"Levi","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2025.149885_b0165","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1073\/pnas.0913192107","article-title":"Binding and uptake of H-ferritin are mediated by human transferrin receptor-1","volume":"107","author":"Li","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.brainres.2025.149885_b0170","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.brainres.2025.149885_b0175","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/ars.2007.1893","article-title":"Intracellular iron transport and storage: from molecular mechanisms to health implications","volume":"10","author":"MacKenzie","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainres.2025.149885_b0180","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41593-024-01600-y","article-title":"Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-\u03b2 pathology","volume":"27","author":"Mancuso","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0185","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41467-025-56124-1","article-title":"The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions","volume":"16","author":"Martins-Ferreira","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2025.149885_b0190","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer's disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2025.149885_b0195","doi-asserted-by":"crossref","first-page":"9529","DOI":"10.1073\/pnas.1219004110","article-title":"GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin","volume":"110","author":"Meyer","year":"2013","journal-title":"PNAS"},{"key":"10.1016\/j.brainres.2025.149885_b0200","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s41588-021-00894-z","article-title":"Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease","volume":"53","author":"Morabito","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2025.149885_b0205","article-title":"hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data","volume":"3","author":"Morabito","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.brainres.2025.149885_b0210","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/BF02964604","article-title":"Biochemical pathogenesis of post-traumatic epilepsy","volume":"25","author":"Mori","year":"1990","journal-title":"Pavlov. J. Biol. Sci."},{"key":"10.1016\/j.brainres.2025.149885_b0215","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.brainres.2025.149885_b0220","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/jnc.14906","article-title":"Iron potentiates microglial interleukin-1\u03b2 secretion induced by amyloid-\u03b2","volume":"154","author":"Nnah","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2025.149885_b0225","unstructured":"Ogun, A.S., Joy, N.V., Valentine, M., 2024. Biochemistry, heme synthesis. In: StatPearls. StatPearls Publishing Copyright \u00a9 2024, StatPearls Publishing LLC., Treasure Island (FL)."},{"key":"10.1016\/j.brainres.2025.149885_b0230","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1038\/s41467-020-19737-2","article-title":"Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease","volume":"11","author":"Olah","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2025.149885_b0235","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s40478-022-01453-1","article-title":"High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy","volume":"10","author":"Pai","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.brainres.2025.149885_b0240","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41423-023-01074-1","article-title":"Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection","volume":"20","author":"Pinho","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.brainres.2025.149885_b0245","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-immunol-093019-110159","article-title":"Microglia and central nervous system-associated macrophages-from origin to disease modulation","volume":"39","author":"Prinz","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.brainres.2025.149885_b0250","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41419-022-04917-3","article-title":"Dysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming","volume":"13","author":"Qiu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2025.149885_b0255","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.brainres.2025.149885_b0260","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fncel.2015.00419","article-title":"Ion dynamics during seizures","volume":"9","author":"Raimondo","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0265","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00429-021-02428-z","article-title":"Clinical phenotype modulates brain's myelin and iron content in temporal lobe epilepsy","volume":"227","author":"Roggenhofer","year":"2022","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainres.2025.149885_b0270","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.freeradbiomed.2013.02.002","article-title":"Mitochondrial involvement and oxidative stress in temporal lobe epilepsy","volume":"62","author":"Rowley","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2025.149885_b0275","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41593-022-01221-3","article-title":"Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration","volume":"26","author":"Ryan","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0280","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.arr.2004.02.001","article-title":"Brain iron deposition and the free radical-mitochondrial theory of ageing","volume":"3","author":"Schipper","year":"2004","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.brainres.2025.149885_b0285","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.brainres.2025.149885_b0290","doi-asserted-by":"crossref","DOI":"10.1177\/17562864221138147","article-title":"The overlapping relationship among depression, anxiety, and somatic symptom disorder and its impact on the quality of life of people with epilepsy","volume":"15","author":"Shen","year":"2022","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.brainres.2025.149885_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123214","article-title":"Brain inflammation induces alterations in glycosaminoglycan metabolism and subsequent changes in CS-4S and hyaluronic acid","volume":"230","author":"Silva","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.brainres.2025.149885_b0300","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics","volume":"19","author":"Street","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.brainres.2025.149885_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102248","article-title":"The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy","volume":"96","author":"Su","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.brainres.2025.149885_b0310","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41587-021-01091-3","article-title":"Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data","volume":"40","author":"Sun","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.brainres.2025.149885_b0315","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1016\/j.cell.2023.08.037","article-title":"Human microglial state dynamics in Alzheimer's disease progression","volume":"186","author":"Sun","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2025.149885_b0320","doi-asserted-by":"crossref","first-page":"15837","DOI":"10.1074\/jbc.M111.286633","article-title":"Evolutionarily conserved paired immunoglobulin-like receptor \u03b1 (PILR\u03b1) domain mediates its interaction with diverse sialylated ligands","volume":"287","author":"Sun","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2025.149885_b0325","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.brainres.2025.149885_b0330","article-title":"A review of the epidemiology of temporal lobe epilepsy","volume":"2012","author":"T\u00e9llez-Zenteno","year":"2012","journal-title":"Epilepsy Res. Treat."},{"key":"10.1016\/j.brainres.2025.149885_b0335","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.brainres.2025.149885_b0340","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1212\/WNL.0000000000004840","article-title":"Progranulin: functions and neurologic correlations","volume":"90","author":"Townley","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2025.149885_b0345","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jnc.12244","article-title":"Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells","volume":"126","author":"Urrutia","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2025.149885_b0350","article-title":"Inflaming the brain with iron","volume":"10","author":"Urrutia","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.brainres.2025.149885_b0355","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable SCENIC workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainres.2025.149885_b0360","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41593-023-01353-0","article-title":"Local translation in microglial processes is required for efficient phagocytosis","volume":"26","author":"Vasek","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0365","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41582-022-00727-5","article-title":"Astrocytes in the initiation and progression of epilepsy","volume":"18","author":"Vezzani","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2025.149885_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132707","article-title":"Fluorescent probe disclosing hydroxyl radical generation in mitochondria and nucleoli of cells during ferroptosis","volume":"373","author":"Wang","year":"2022","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.brainres.2025.149885_b0375","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s11064-008-9841-3","article-title":"Posttraumatic epilepsy: hemorrhage, free radicals and the molecular regulation of glutamate","volume":"34","author":"Willmore","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2025.149885_b0380","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1038\/s41467-019-11738-0","article-title":"Metabolic landscape of the tumor microenvironment at single cell resolution","volume":"10","author":"Xiao","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2025.149885_b0385","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fnagi.2020.00110","article-title":"Microglia and Wnt pathways: prospects for inflammation in Alzheimer's disease","volume":"12","author":"Yang","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2025.149885_b0390","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.brainres.2025.149885_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102032","article-title":"Metabolic reprogramming and polarization of microglia in Parkinson's disease: Role of inflammasome and iron","volume":"90","author":"Yu","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.brainres.2025.149885_b0400","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1002\/alz.12943","article-title":"Does Alzheimer's disease with mesial temporal lobe epilepsy represent a distinct disease subtype?","volume":"19","author":"Zawar","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainres.2025.149885_b0405","doi-asserted-by":"crossref","first-page":"W180","DOI":"10.1093\/nar\/gkad444","article-title":"FLUXestimator: a webserver for predicting metabolic flux and variations using transcriptomics data","volume":"51","author":"Zhang","year":"2023","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.brainres.2025.149885_b0410","doi-asserted-by":"crossref","first-page":"23771","DOI":"10.1038\/srep23771","article-title":"Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2025.149885_b0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.03.003","article-title":"Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage","volume":"178","author":"Zhu","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2025.149885_b0420","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/nan.12596","article-title":"Chronic activation of anti-oxidant pathways and iron accumulation in epileptogenic malformations","volume":"46","author":"Zimmer","year":"2020","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainres.2025.149885_b0425","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00401-021-02348-6","article-title":"Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy","volume":"142","author":"Zimmer","year":"2021","journal-title":"Acta Neuropathol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325004482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325004482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:28:45Z","timestamp":1779769725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325004482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":85,"alternative-id":["S0006899325004482"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149885","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell transcriptome analysis reveals dysregulation of microglial iron homeostasis in temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149885"}}