{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:03:26Z","timestamp":1784945006468,"version":"3.55.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["946666"],"award-info":[{"award-number":["946666"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03 AG081865"],"award-info":[{"award-number":["R03 AG081865"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.brainres.2025.149999","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:55:20Z","timestamp":1761353720000},"page":"149999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Evaluating AT1R expression and the effects of renin-angiotensin system inhibition in a mouse model of cerebral amyloid angiopathy"],"prefix":"10.1016","volume":"1869","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6662-0970","authenticated-orcid":false,"given":"Natalia","family":"Motzko Noto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-9183","authenticated-orcid":false,"given":"Lisa S.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-2136","authenticated-orcid":false,"given":"Robert C.","family":"Speth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.brainres.2025.149999_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15092290","article-title":"Therapeutic implications of renin-angiotensin system modulators in Alzheimer's dementia","volume":"15","author":"Ababei","year":"2023","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.brainres.2025.149999_b0010","doi-asserted-by":"crossref","first-page":"16917","DOI":"10.3390\/ijms140816917","article-title":"ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer's disease","volume":"14","author":"AbdAlla","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.brainres.2025.149999_b0015","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","article-title":"Role of brain renin angiotensin system in neurodegeneration: an update","volume":"27","author":"Abiodun","year":"2020","journal-title":"Saudi J Biol Sci."},{"key":"10.1016\/j.brainres.2025.149999_b0020","unstructured":"AbuHasan, Q., V. Reddy and W. Siddiqui (2025). Neuroanatomy, Amygdala. StatPearls. Treasure Island (FL), StatPearls Publishing Copyright \u00a9 2025, StatPearls Publishing LLC."},{"issue":"9","key":"10.1016\/j.brainres.2025.149999_b0025","doi-asserted-by":"crossref","DOI":"10.1148\/rg.230009","article-title":"Amyloid-related imaging abnormalities in Alzheimer disease treated with anti-amyloid-\u03b2 therapy","volume":"43","author":"Agarwal","year":"2023","journal-title":"Radiographics"},{"key":"10.1016\/j.brainres.2025.149999_b0030","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1471-4159.1982.tb07930.x","article-title":"Angiotensin converting enzyme in Alzheimer's disease: increased activity in caudate nucleus and cortical areas","volume":"38","author":"Arregui","year":"1982","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.brainres.2025.149999_b0035","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/1073858418824256","article-title":"The striatum's role in executing rational and irrational economic behaviors","volume":"25","author":"Bamford","year":"2019","journal-title":"Neuroscientist"},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0008-6363(99)00015-2","article-title":"Chronic AT1 receptor blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival","volume":"43","author":"Bastien","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.brainres.2025.149999_b0045","unstructured":"Bear, M. H., V. Reddy and P. C. Bollu (2025). Neuroanatomy, Hypothalamus. StatPearls. Treasure Island (FL), StatPearls Publishing Copyright \u00a9 2025, StatPearls Publishing LLC."},{"issue":"8","key":"10.1016\/j.brainres.2025.149999_b0050","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s10571-012-9862-y","article-title":"Six commercially available angiotensin II AT(1) receptor antibodies are non-specific","volume":"32","author":"Benicky","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.brainres.2025.149999_b0055","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/HYPERTENSIONAHA.113.01743","article-title":"Circulating angiotensin ii gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood\u2013brain barrier","volume":"63","author":"Biancardi","year":"2014","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.brainres.2025.149999_b0060","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1113\/JP271584","article-title":"Compromised blood-brain barrier permeability: novel mechanism by which circulating angiotensinII signals to sympathoexcitatory centres during hypertension","volume":"594","author":"Biancardi","year":"2016","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2011.7.1.1","article-title":"Cerebral amyloid angiopathy: a systematic review","volume":"7","author":"Biffi","year":"2011","journal-title":"J Clin Neurol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0070","article-title":"Renin angiotensin system in cognitive function and dementia","volume":"2013","author":"Bodiga","year":"2013","journal-title":"Asian J. Neurosci."},{"issue":"8","key":"10.1016\/j.brainres.2025.149999_b0075","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00210-018-1522-4","article-title":"No answer to the lack of specificity: mouse monoclonal antibody targeting the angiotensin II type 1 receptor AT(1) fails to recognize its target","volume":"391","author":"Bouressam","year":"2018","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0080","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1476-5381.2012.02036.x","article-title":"Sexual dimorphism in rodent models of hypertension and atherosclerosis","volume":"167","author":"Bubb","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2025.149999_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2023.102489","article-title":"Astrocytic AT1R deficiency ameliorates A\u03b2-induced cognitive deficits and synaptotoxicity through \u03b2-arrestin2 signaling","volume":"228","author":"Chen","year":"2023","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2025.149999_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.117425","article-title":"Cerebral amyloid angiopathy and related inflammatory disorders","volume":"424","author":"Chwalisz","year":"2021","journal-title":"J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.brainres.2025.149999_b0095","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11906-022-01183-8","article-title":"Sex differences in the Prevalence, Outcomes and Management of Hypertension","volume":"24","author":"Connelly","year":"2022","journal-title":"Curr. Hypertens. Rep."},{"issue":"9","key":"10.1016\/j.brainres.2025.149999_b0100","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/biom12091169","article-title":"Renin-a in the Subfornical organ plays a critical role in the maintenance of salt-sensitive hypertension","volume":"12","author":"Cooper","year":"2022","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.brainres.2025.149999_b0105","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/gerona\/glab376","article-title":"Higher angiotensin II Type 1 Receptor levels and activity in the postmortem brains of older persons with Alzheimer's dementia","volume":"77","author":"Cosarderelioglu","year":"2022","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"981","key":"10.1016\/j.brainres.2025.149999_b0110","article-title":"Brain renin\u2013angiotensin system at the intersect of physical and cognitive frailty","volume":"14","author":"Cosarderelioglu","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainres.2025.149999_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2023.120866","article-title":"Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment","volume":"454","author":"Cozza","year":"2023","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-8993(98)00930-5","article-title":"Changes in angiotensin II receptor in dopamine-rich regions of the mouse brain with age and ethanol consumption","volume":"816","author":"Daubert","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2025.149999_b0125","article-title":"Measuring blood pressure in mice using volume pressure recording, a tail-cuff method","volume":"27","author":"Daugherty","year":"2009","journal-title":"J. Vis. Exp."},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0130","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00429-014-0943-1","article-title":"Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system","volume":"221","author":"de Kloet","year":"2016","journal-title":"Brain Struct. Funct."},{"issue":"9","key":"10.1016\/j.brainres.2025.149999_b0135","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jacc.2017.07.724","article-title":"Cerebral amyloid angiopathy: diagnosis, clinical implications, and management strategies in atrial fibrillation","volume":"70","author":"DeSimone","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"17","key":"10.1016\/j.brainres.2025.149999_b0140","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172728","article-title":"Role of Microglia and astrocytes in Alzheimer's disease: from neuroinflammation to Ca(2+) homeostasis dysregulation","volume":"11","author":"Di Benedetto","year":"2022","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.brainres.2025.149999_b0145","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1161\/HYPERTENSIONAHA.111.00943","article-title":"Lack of specificity of commercial antibodies leads to misidentification of angiotensin type-1 receptor protein","volume":"61","author":"Elliott","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.brainres.2025.149999_b0150","doi-asserted-by":"crossref","unstructured":"Fekete \u00c9, M., J. Gomez, M. Ghobrial, K. Kaminski, P. C. Muskus, C. R. Boychuk, A. Hantke Guixa, I. Vazirabad, M. Xie, A. Ganiyu, D. Golosova, N. M. Mathieu, Y. B. Wang, K. T. Lu, K. K. Wackman, D. T. Brozoski, G. C. Mouradian, M. R. Hodges, J. L. Segar, J. L. Grobe, C. D. Sigmund and P. Nakagawa (2025). Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus. Hypertension. 82(2): 282-292.","DOI":"10.1161\/HYPERTENSIONAHA.124.23740"},{"key":"10.1016\/j.brainres.2025.149999_b0155","unstructured":"Fountain, J. H., Lappin, S. L., 2021. Physiology, Renin Angiotensin System. StatPearls. Treasure Island (FL), StatPearls Publishing Copyright \u00a9 2021, StatPearls Publishing LLC."},{"key":"10.1016\/j.brainres.2025.149999_b0160","unstructured":"Franklin, K. B. J. and G. Paxinos (1997). The Mouse Brain in Stereotaxic Coordinates. San Diego, Academic Press."},{"issue":"3","key":"10.1016\/j.brainres.2025.149999_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.166037","article-title":"New drug targets for hypertension: a literature review","volume":"1867","author":"Gao","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.brainres.2025.149999_b0170","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fphar.2018.00440","article-title":"Targeting renin-angiotensin system against Alzheimer's disease","volume":"9","author":"Gebre","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.brainres.2025.149999_b0175","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/0024-3205(84)90611-8","article-title":"Autoradiographic localization of angiotensin II receptors in the rat brainstem","volume":"34","author":"Gehlert","year":"1984","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/HYPERTENSIONAHA.108.124511","article-title":"Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension","volume":"53","author":"Gonzalez-Villalobos","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.brainres.2025.149999_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101612","article-title":"Targeting brain renin-angiotensin system for the prevention and treatment of Alzheimer's disease: past, present and future","volume":"77","author":"Gouveia","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0190","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/beee9a88-80e1-4332-ac02-c1845beaa71b","article-title":"Correction: commercially available angiotensin II AT receptor antibodies are nonspecific","volume":"9","author":"Hafko","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-2999(98)00134-4","article-title":"Characterization and distribution of angiotensin II receptor subtypes in the mouse brain","volume":"348","author":"Hauser","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0200","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/HYPERTENSIONAHA.112.203679","article-title":"Lack of specificity of commercial antibodies leads to misidentification of Angiotensin type 1 receptor protein","volume":"61","author":"Herrera","year":"2013","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.brainres.2025.149999_b0205","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1161\/HYPERTENSIONAHA.111.00982","article-title":"Response to lack of specificity of commercial antibodies leads to misidentification of angiotensin type-1 receptor protein","volume":"61","author":"Herrera","year":"2013","journal-title":"Hypertension"},{"issue":"10\u201311","key":"10.1016\/j.brainres.2025.149999_b0210","first-page":"1795","article-title":"Isorenin in dog brain and other tissues","volume":"6","author":"Husain","year":"1984","journal-title":"Clin. Exp. Hypertens. A"},{"issue":"3","key":"10.1016\/j.brainres.2025.149999_b0215","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3390\/ijms19030876","article-title":"Within the Brain: the renin angiotensin system","volume":"19","author":"Jackson","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2025.149999_b0220","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-161265","article-title":"Angiotensin-III is increased in Alzheimer's disease in association with amyloid-beta and tau pathology","author":"Kehoe","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"12","key":"10.1016\/j.brainres.2025.149999_b0225","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tins.2009.07.006","article-title":"Angiotensins in Alzheimer's disease - friend or foe?\u201c","volume":"32","author":"Kehoe","year":"2009","journal-title":"Trends Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2025.149999_b0230","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1474-4422(07)70077-7","article-title":"Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease?","volume":"6","author":"Kehoe","year":"2007","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.brainres.2025.149999_b0235","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac245","article-title":"Blood-brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy","volume":"4","author":"Kozberg","year":"2022","journal-title":"Brain Commun."},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0240","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/physiolgenomics.00131.2003","article-title":"Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model","volume":"16","author":"Lavoie","year":"2004","journal-title":"Physiol. Genomics"},{"issue":"6","key":"10.1016\/j.brainres.2025.149999_b0245","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1210\/en.2003-0150","article-title":"Minireview: overview of the renin-angiotensin system\u2013an endocrine and paracrine system","volume":"144","author":"Lavoie","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainres.2025.149999_b0250","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1137197","article-title":"Neuroprotective effect of angiotensin II receptor blockers on the risk of incident Alzheimer's disease: a nationwide population-based cohort study","volume":"15","author":"Lee","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.brainres.2025.149999_b0255","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209715","article-title":"Blood pressure, antihypertensive use, and late-life alzheimer and non-Alzheimer dementia risk: an individual participant data meta-analysis","volume":"103","author":"Lennon","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2025.149999_b0260","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/290635","article-title":"The prorenin and (pro)renin receptor: new players in the brain renin-angiotensin system?\u201c","volume":"2012","author":"Li","year":"2012","journal-title":"Int. J. Hypertens."},{"issue":"52866","key":"10.1016\/j.brainres.2025.149999_b0265","article-title":"Receptor autoradiography protocol for the localized visualization of angiotensin II receptors","volume":"112","author":"Linares","year":"2016","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0270","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/HYPERTENSIONAHA.119.12675","article-title":"Evolution of a new class of antihypertensive drugs: targeting the brain renin-angiotensin system","volume":"75","author":"Llorens-Cortes","year":"2020","journal-title":"Hypertension"},{"issue":"18","key":"10.1016\/j.brainres.2025.149999_b0275","doi-asserted-by":"crossref","first-page":"10139","DOI":"10.3390\/ijms221810139","article-title":"Brain renin\u2013angiotensin system as novel and potential therapeutic target for Alzheimer\u2019s disease","volume":"22","author":"Loera-Valencia","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.brainres.2025.149999_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14081667","article-title":"Telmisartan tablets repackaged into dose administration aids: physicochemical stability under tropical conditions","volume":"14","author":"Ma","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.brainres.2025.149999_b0285","article-title":"Sex differences in a murine model of cerebral amyloid angiopathy","volume":"14","author":"Maniskas","year":"2021","journal-title":"Brain Behav Immun Health."},{"issue":"4","key":"10.1016\/j.brainres.2025.149999_b0290","doi-asserted-by":"crossref","first-page":"260","DOI":"10.5114\/pjp.2013.39334","article-title":"The development of cerebral amyloid angiopathy in cerebral vessels. a review with illustrations based upon own investigated post mortem cases","volume":"64","author":"Mendel","year":"2013","journal-title":"Pol. J. Pathol."},{"issue":"6","key":"10.1016\/j.brainres.2025.149999_b0295","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/HYPERTENSIONAHA.116.07914","article-title":"How does angiotensin activate hypothalamic neurons essential for controlling sympathetic activity and blood pressure?\u201c","volume":"68","author":"Mendelowitz","year":"2016","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.brainres.2025.149999_b0300","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1073\/pnas.81.5.1575","article-title":"Autoradiographic localization of angiotensin II receptors in rat brain","volume":"81","author":"Mendelsohn","year":"1984","journal-title":"PNAS"},{"key":"10.1016\/j.brainres.2025.149999_b0305","doi-asserted-by":"crossref","unstructured":"Menon, R., T. S\u00fc\u00df, V. E. d. M. Oliveira, I. D. Neumann, Bludau, A., 2022. Neurobiology of the lateral septum: regulation of social behavior. Trends Neurosci.. 45(1) 27\u201340.","DOI":"10.1016\/j.tins.2021.10.010"},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0310","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2990.2007.00885.x","article-title":"Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy","volume":"34","author":"Miners","year":"2008","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"9","key":"10.1016\/j.brainres.2025.149999_b0315","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/hr.2009.110","article-title":"Effects of angiotensin II receptor blockers on dementia","volume":"32","author":"Mogi","year":"2009","journal-title":"Hypertens. Res."},{"issue":"3","key":"10.1016\/j.brainres.2025.149999_b0320","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2008.08.032","article-title":"Telmisartan prevented cognitive decline partly due to PPAR-gamma activation","volume":"375","author":"Mogi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2025.149999_b0325","doi-asserted-by":"crossref","unstructured":"Motzko Noto, N., Restrepo, Y.M., Hernandez, A., Vogel, C., Pulido-Correa, V., Moen, S., Bonetti, J., Chiduruppa, V., Speth, R.C., Robison, L.S., 2025. Telmisartan and lisinopril show potential benefits in rescuing cognitive-behavioral function despite limited improvements in neuropathological outcomes in Tg-SwDI mice. bioRxiv: 2025.2004.2023.650226.","DOI":"10.1101\/2025.04.23.650226"},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0330","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13195-021-00778-8","article-title":"The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE \u03b54 carrier status","volume":"13","author":"Ouk","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.brainres.2025.149999_b0335","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nbd.2018.03.007","article-title":"Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's disease","volume":"114","author":"Paul","year":"2018","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0340","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/hr.2010.235","article-title":"ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease","volume":"34","author":"Rabelo","year":"2011","journal-title":"Hypertens. Res."},{"issue":"13","key":"10.1016\/j.brainres.2025.149999_b0345","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jacc.2024.01.030","article-title":"Risk of dementia during antihypertensive drug therapy intheelderly","volume":"83","author":"Rea","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0350","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/jcbfm.2015.88","article-title":"Ischemic brain injury in cerebral amyloid angiopathy","volume":"36","author":"Reijmer","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"21","key":"10.1016\/j.brainres.2025.149999_b0355","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1042\/CS20220261","article-title":"CGP42112: the full AT2 receptor agonist and its role in the renin-angiotensin-aldosterone system: no longer misunderstood","volume":"136","author":"Restrepo","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"issue":"6","key":"10.1016\/j.brainres.2025.149999_b0360","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2174\/0929866527666191230103739","article-title":"Renin-angiotensin system and Alzheimer's disease pathophysiology: from the potential interactions to therapeutic perspectives","volume":"27","author":"Ribeiro","year":"2020","journal-title":"Protein Pept. Lett."},{"issue":"3","key":"10.1016\/j.brainres.2025.149999_b0365","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030843","article-title":"Environmental enrichment: disentangling the influence of novelty, social, and physical activity on cerebral amyloid angiopathy in a transgenic mouse model","volume":"21","author":"Robison","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0370","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12974-019-1534-0","article-title":"Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy","volume":"16","author":"Robison","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2025.149999_b0375","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuroscience.2020.05.024","article-title":"Impaired amyloid beta clearance and brain microvascular dysfunction are present in the Tg-SwDI mouse model of Alzheimer's disease","volume":"440","author":"Rosas-Hernandez","year":"2020","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0380","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s40263-015-0230-6","article-title":"Antihypertensive drugs, prevention of cognitive decline and dementia: a systematic review of observational studies, randomized controlled trials and meta-analyses, with discussion of potential mechanisms","volume":"29","author":"Rouch","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2025.149999_b0385","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-2999(90)90457-H","article-title":"Angiotensin II receptor subtypes in the rat brain","volume":"186","author":"Rowe","year":"1990","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.brainres.2025.149999_b0390","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s11357-020-00231-y","article-title":"Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets","volume":"42","author":"Royea","year":"2020","journal-title":"Geroscience"},{"key":"10.1016\/j.brainres.2025.149999_b0395","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.643357","article-title":"Taxifolin: a potential therapeutic agent for cerebral amyloid angiopathy","volume":"12","author":"Saito","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0400","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/HYPERTENSIONAHA.122.18085","article-title":"Hypertension, neurovascular dysfunction, and cognitive impairment","volume":"80","author":"Santisteban","year":"2023","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0405","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physrev.00023.2016","article-title":"The ACE2\/angiotensin-(1-7)\/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7)","volume":"98","author":"Santos","year":"2018","journal-title":"Physiol. Rev."},{"issue":"23","key":"10.1016\/j.brainres.2025.149999_b0410","doi-asserted-by":"crossref","first-page":"R1111","DOI":"10.1016\/j.cub.2014.10.023","article-title":"The HYPOTHALAMUS","volume":"24","author":"Saper","year":"2014","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.brainres.2025.149999_b0415","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0197-4580(00)00259-1","article-title":"Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia","volume":"22","author":"Savaskan","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2025.149999_b0420","doi-asserted-by":"crossref","unstructured":"Schroevers, J. L., M. P. Hoevenaar-Blom, W. B. Busschers, M. Hollander, W. A. Van Gool, E. Richard, J. W. Van Dalen and E. P. Moll van Charante (2024). Antihypertensive medication classes and risk of incident dementia in primary care patients: a longitudinal cohort study in the Netherlands. The Lancet Regional Health \u2013 Europe. 42.","DOI":"10.1016\/j.lanepe.2024.100927"},{"issue":"5","key":"10.1016\/j.brainres.2025.149999_b0425","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1113\/expphysiol.2008.041988","article-title":"Characterization of a functional (pro)renin receptor in rat brain neurons","volume":"93","author":"Shan","year":"2008","journal-title":"Exp. Physiol."},{"issue":"21","key":"10.1016\/j.brainres.2025.149999_b0430","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12216792","article-title":"Anti-amyloid therapy, AD, and ARIA: untangling the role of CAA","volume":"12","author":"Sin","year":"2023","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0435","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/1470320312459977","article-title":"Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible involvement of PPAR-gamma agonistic property","volume":"14","author":"Singh","year":"2013","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"issue":"13","key":"10.1016\/j.brainres.2025.149999_b0440","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinternmed.2009.175","article-title":"Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study","volume":"169","author":"Sink","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.brainres.2025.149999_b0445","doi-asserted-by":"crossref","unstructured":"Speth, R. C. (2022). Renin-Angiotensin-Aldosterone System. Comprehensive Pharmacology. T. Kenakin, Elsevier. 4: 528-569.","DOI":"10.1016\/B978-0-12-820472-6.00160-2"},{"key":"10.1016\/j.brainres.2025.149999_b0450","first-page":"275","article-title":"Radiolabeling of Angiotensin peptides","volume":"51","author":"Speth","year":"2001","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.brainres.2025.149999_b0455","first-page":"1749","article-title":"Localization of angiotensin receptors in the canine CNS","volume":"6","author":"Speth","year":"1984","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.brainres.2025.149999_b0460","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.3201232","article-title":"Astrocytes synthesize angiotensinogen in brain","volume":"242","author":"Stornetta","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.brainres.2025.149999_b0465","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1016\/S0021-9258(17)39310-9","article-title":"A rat brain isozyme of angiotensin-converting enzyme: unique specificity for amidated peptide substrates","volume":"260","author":"Strittmatter","year":"1985","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.brainres.2025.149999_b0470","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/STROKEAHA.121.036873","article-title":"Vessels sing their ARIAs: the role of vascular amyloid in the age of aducanumab","volume":"53","author":"Sveikata","year":"2022","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.brainres.2025.149999_b0475","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/CIRCRESAHA.116.303587","article-title":"Hypertension: renin-angiotensin-aldosterone system alterations","volume":"116","author":"Te Riet","year":"2015","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.brainres.2025.149999_b0480","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/HYPERTENSIONAHA.109.136879","article-title":"Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation","volume":"54","author":"Tsukuda","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.brainres.2025.149999_b0485","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-7030-8_6","article-title":"Measuring blood pressure using a noninvasive tail cuff method in mice","volume":"1614","author":"Wang","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.brainres.2025.149999_b0490","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1161\/STROKEAHA.110.583948","article-title":"Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-gamma activation in mice with chronic cerebral hypoperfusion","volume":"41","author":"Washida","year":"2010","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.brainres.2025.149999_b0495","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","article-title":"Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease","volume":"18","author":"Weller","year":"2008","journal-title":"Brain Pathol."},{"issue":"6","key":"10.1016\/j.brainres.2025.149999_b0500","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/HYPERTENSIONAHA.109.138677","article-title":"Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin","volume":"54","author":"Xu","year":"2009","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.brainres.2025.149999_b0505","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3233\/JAD-130758","article-title":"Cerebral microvascular rather than parenchymal amyloid-\u03b2 protein pathology promotes early cognitive impairment in transgenic mice","volume":"38","author":"Xu","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"10","key":"10.1016\/j.brainres.2025.149999_b0510","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1212\/WNL.0b013e3182a35228","article-title":"Antihypertensive drugs decrease risk of Alzheimer disease: ginkgo evaluation of memory study","volume":"81","author":"Yasar","year":"2013","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.brainres.2025.149999_b0515","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1161\/HYPERTENSIONAHA.124.22980","article-title":"Sex differences in hypertension and its management throughout life","volume":"81","author":"Yeo","year":"2024","journal-title":"Hypertension"},{"issue":"14","key":"10.1016\/j.brainres.2025.149999_b0520","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1073\/pnas.85.14.5339","article-title":"Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain","volume":"85","author":"Young","year":"1988","journal-title":"PNAS"},{"key":"10.1016\/j.brainres.2025.149999_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109460","article-title":"Central amygdala angiotensin type 1 receptor (Agtr1) expressing neurons contribute to fear extinction","volume":"229","author":"Yu","year":"2023","journal-title":"Neuropharmacology"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325005621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325005621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:56:50Z","timestamp":1778590610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325005621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":105,"alternative-id":["S0006899325005621"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149999","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating AT1R expression and the effects of renin-angiotensin system inhibition in a mouse model of cerebral amyloid angiopathy","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.149999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149999"}}