{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:51:28Z","timestamp":1786985488331,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.brainres.2025.150008","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:00:35Z","timestamp":1761930035000},"page":"150008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The underlying mechanism of Erbai decoction on Parkinson\u2019s disease rats: a behavioral and pathological study"],"prefix":"10.1016","volume":"1870","author":[{"given":"Li","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2025.150008_b0005","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2017.10.379","article-title":"Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis","volume":"115","author":"Calabrese","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainres.2025.150008_b0010","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/mdc3.12545","article-title":"Parkinson's Disease Biomarkers: where are we and where do we go next?","volume":"4","author":"Chahine","year":"2017","journal-title":"Mov Disord Clin Pract."},{"key":"10.1016\/j.brainres.2025.150008_b0015","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41419-018-0722-7","article-title":"Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T alpha-synuclein model of Parkinson's disease","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.brainres.2025.150008_b0020","doi-asserted-by":"crossref","first-page":"13942","DOI":"10.1021\/acs.jafc.1c04190","article-title":"Rotenone-Induced Neurodegeneration is Enabled by a p38-Parkin-ROS Signaling Feedback Loop","volume":"69","author":"Chen","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.brainres.2025.150008_b0025","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5186252","article-title":"Inhibition of miR-421 Preserves Mitochondrial Function and Protects against Parkinson's Disease Pathogenesis via Pink1\/Parkin-Dependent Mitophagy","volume":"2022","author":"Dong","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.brainres.2025.150008_b0030","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/cns.13805","article-title":"Neuroprotective effects of curcumin on the cerebellum in a rotenone-induced Parkinson's Disease Model","volume":"28","author":"Fikry","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainres.2025.150008_b0035","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1007\/s13277-014-2060-4","article-title":"The prognostic value of autophagy-related markers beclin-1 and microtubule-associated protein light chain 3B in cancers: a systematic review and meta-analysis","volume":"35","author":"He","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.brainres.2025.150008_b0040","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.redox.2016.12.008","article-title":"Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function","volume":"11","author":"Hwang","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.brainres.2025.150008_b0045","first-page":"1144","article-title":"Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death","volume":"1813","author":"Kuznetsov","year":"2011","journal-title":"BBA"},{"key":"10.1016\/j.brainres.2025.150008_b0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2005.8.3","article-title":"Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging","volume":"8","author":"Lemasters","year":"2005","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.brainres.2025.150008_b0055","article-title":"Er-Bai-Tang decoction improved the movement disorders and neuronal injury in the Parkinson's disease model rats via decreasing p38 MAPK pathway and improving the composition of intestinal flora","volume":"37","author":"Li","year":"2023","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.brainres.2025.150008_b0060","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s12031-018-1179-y","article-title":"Knockdown of miR-372 Inhibits Nerve Cell Apoptosis Induced by Spinal Cord Ischemia\/Reperfusion Injury via Enhancing Autophagy by Up-regulating Beclin-1","volume":"66","author":"Li","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2025.150008_b0065","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/acupmed-2016-011342","article-title":"Effectiveness and safety of acupuncture combined with Madopar for Parkinson's disease: a systematic review with meta-analysis","volume":"35","author":"Liu","year":"2017","journal-title":"Acupunct. Med."},{"key":"10.1016\/j.brainres.2025.150008_b0070","doi-asserted-by":"crossref","DOI":"10.1177\/09603271221125928","article-title":"Tricin attenuates cerebral ischemia\/reperfusion injury through inhibiting nerve cell autophagy, apoptosis and inflammation by regulating the PI3K\/Akt pathway","volume":"41","author":"Liu","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.brainres.2025.150008_b0075","article-title":"Kisspeptin preserves mitochondrial function by inducing mitophagy and autophagy in aging rat brain hippocampus and human neuronal cell line","volume":"1868","author":"Mattam","year":"2021","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2025.150008_b0080","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/26506","article-title":"A protein conjugation system essential for autophagy","volume":"395","author":"Mizushima","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2025.150008_b0085","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0006-8993(73)90290-4","article-title":"Isolated removal of hypothalamic or other brain nuclei of the rat","volume":"59","author":"Palkovits","year":"1973","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2025.150008_b0090","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neulet.2015.06.030","article-title":"Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats","volume":"600","author":"Pan","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2025.150008_b0095","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00702-025-02893-4","article-title":"Levodopa treatment: impacts and mechanisms throughout Parkinson's disease progression","volume":"132","author":"Riederer","year":"2025","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.brainres.2025.150008_b0100","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2025.150008_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1880221","article-title":"Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in italian elderly","volume":"13","author":"Tavella","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.brainres.2025.150008_b0110","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s11064-018-2568-x","article-title":"Ulk1\/FUNDC1 Prevents Nerve Cells from Hypoxia-Induced Apoptosis by Promoting Cell Autophagy","volume":"43","author":"Wang","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2025.150008_b0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.gde.2017.01.016","article-title":"PINK1\/Parkin mitophagy and neurodegeneration-what do we really know in vivo?","volume":"44","author":"Whitworth","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.brainres.2025.150008_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.690138","article-title":"Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in mice Treated by High-Fat Diet","volume":"8","author":"Zheng","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.brainres.2025.150008_b0125","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325005712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325005712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:26:18Z","timestamp":1775147178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325005712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"alternative-id":["S0006899325005712"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150008","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The underlying mechanism of Erbai decoction on Parkinson\u2019s disease rats: a behavioral and pathological study","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150008"}}