{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T17:29:34Z","timestamp":1782581374625,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.brainres.2025.150014","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:04:51Z","timestamp":1761696291000},"page":"150014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Anticancer properties of new flavonoid lensoside A\u03b2 in combination with temozolomide in an in vitro model of human glioma cells"],"prefix":"10.1016","volume":"1869","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-6490","authenticated-orcid":false,"given":"Aleksandra","family":"Maciejczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Kapral-Piotrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Sumorek-Wiadro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4184-9049","authenticated-orcid":false,"given":"Adrian","family":"Zaj\u0105c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw I.","family":"Gruszecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lemieszek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Wertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-6716","authenticated-orcid":false,"given":"\u0141ukasz","family":"Pecio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"\u017buchowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-5929","authenticated-orcid":false,"given":"Krystyna","family":"Skalicka-Wo\u017aniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017cena","family":"Pawlikowska-Pawl\u0119ga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Hu\u0142as-Stasiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Rzeski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0613-6593","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Rola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-9666","authenticated-orcid":false,"given":"Piotr","family":"Dobrowolski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Jakubowicz-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2025.150014_b0005","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.3390\/molecules25214895","article-title":"Anti-neoplastic potential of flavonoids and polysaccharide phytochemicals in glioblastoma","volume":"25","author":"Atiq","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2025.150014_b0010","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2025.150014_b0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41420-024-01945-0","article-title":"Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma","volume":"10","author":"Cavallo","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.brainres.2025.150014_b0020","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the chou-talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2025.150014_b0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-004-2751-6","article-title":"Molecular mechanisms of glioma cell migration and invasion","volume":"70","author":"Demuth","year":"2004","journal-title":"J. Neurooncol"},{"key":"10.1016\/j.brainres.2025.150014_b0030","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cbi.2010.07.015","article-title":"Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line","volume":"188","author":"Jakubowicz-Gil","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.brainres.2025.150014_b0035","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.taap.2013.10.003","article-title":"Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment","volume":"273","author":"Jakubowicz-Gil","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.brainres.2025.150014_b0040","first-page":"1517","article-title":"Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents","volume":"9","author":"Kikuchi","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.brainres.2025.150014_b0045","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2025.150014_b0050","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.gendis.2016.04.007","article-title":"Temozolomide resistance in glioblastoma multiforme","volume":"3","author":"Lee","year":"2016","journal-title":"Genes Dis."},{"key":"10.1016\/j.brainres.2025.150014_b0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-211-78741-0_1","article-title":"Present and potential future adjuvant issues in high-grade astrocytic glioma treatment","volume":"34","author":"Lefranc","year":"2009","journal-title":"Adv. Tech. Stand. Neurosurg."},{"key":"10.1016\/j.brainres.2025.150014_b0060","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3390\/ijms19041115","article-title":"Migration\/invasion of malignant gliomas and implications for therapeutic treatment","volume":"19","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2025.150014_b0065","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.2174\/092986732639191213095405","article-title":"Flavonoids in health and disease","volume":"26","author":"L\u00f3pez","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainres.2025.150014_b0070","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.3390\/cancers13112637","article-title":"Lensoside a\u03b2 as an adjuvant to the anti-glioma potential of sorafenib","volume":"13","author":"Maciejczyk","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.brainres.2025.150014_b0075","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.fct.2011.04.039","article-title":"Comparative study on antioxidant activity of different varieties of commonly consumed legumes in India","volume":"49","author":"Marathe","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.brainres.2025.150014_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox10020316","article-title":"Health benefits of antioxidative peptides derived from legume proteins with a high amino acid score","volume":"10","author":"Matemu","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.brainres.2025.150014_b0085","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.3390\/ijms25052529","article-title":"Glioblastoma therapy: past, present and future","volume":"25","author":"Obrador","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2025.150014_b0090","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbamem.2013.08.014","article-title":"Characteristics of quercetin interactions with liposomal and vacuolar membranes","volume":"1838","author":"Pawlikowska-Pawl\u0229ga","year":"2014","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.brainres.2025.150014_b0095","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bbamem.2017.10.027","article-title":"Interaction of a quercetin derivative - lensoside A\u03b2 with liposomal membranes","volume":"1860","author":"Pawlikowska-Pawlega","year":"2018","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.brainres.2025.150014_b0100","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.bbamem.2014.04.029","article-title":"Biophysical characterization of genistein-membrane interaction and its correlation with biological effect on cells - the case of EYPC liposomes and human erythrocyte membranes","volume":"1838","author":"Pawlikowska-Pawl\u0229ga","year":"2014","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.brainres.2025.150014_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2022.869713","article-title":"Protein biofortification in lentils (Lens culinaris Medik.) toward human health","volume":"13","author":"Salaria","year":"2022","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.brainres.2025.150014_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-016-0803-2","article-title":"Suppression of RAF\/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells","volume":"14","author":"Shingu","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.brainres.2025.150014_b0115","first-page":"101","article-title":"Phenolic composition and antioxidant potential of grain legume seeds: a review","author":"Singh","year":"2017","journal-title":"Food Res. Int."},{"key":"10.1016\/j.brainres.2025.150014_b0120","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3390\/cells11091479","article-title":"Crosstalk of autophagy and apoptosis","volume":"11","author":"Sorice","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.brainres.2025.150014_b0125","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.3390\/molecules25215192","article-title":"Antiglioma potential of coumarins combined with sorafenib","volume":"25","author":"Sumorek-Wiadro","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2025.150014_b0130","doi-asserted-by":"crossref","first-page":"8814","DOI":"10.1038\/s41598-017-06851-3","article-title":"GADD45A plays a protective role against temozolomide treatment in glioblastoma cells","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2025.150014_b0135","first-page":"1","article-title":"Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.brainres.2025.150014_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/bpa.13062","article-title":"Classification of adult-type diffuse gliomas: impact of the World Health Organization 2021 update","volume":"32","author":"Whitfield","year":"2022","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainres.2025.150014_b0145","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/nu15040797","article-title":"Anticancer mechanism of flavonoids on high-grade adult-type diffuse gliomas","volume":"15","author":"Wong","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.brainres.2025.150014_b0150","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.foodchem.2014.04.014","article-title":"Fatty acid, carotenoid and tocopherol compositions of 20 Canadian lentil cultivars and synergistic contribution to antioxidant activities","volume":"161","author":"Zhang","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.brainres.2025.150014_b0155","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.foodchem.2014.09.144","article-title":"Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on \u03b1-glucosidase and pancreatic lipase","volume":"172","author":"Zhang","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.brainres.2025.150014_b0160","doi-asserted-by":"crossref","first-page":"18152","DOI":"10.3390\/molecules191118152","article-title":"Novel flavonol glycosides from the aerial parts of lentil (Lens culinaris)","volume":"19","author":"Zuchowski","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2025.150014_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules26020497","article-title":"Modulation of oxidative stress and hemostasis by flavonoids from lentil aerial parts","volume":"26","author":"\u017buchowski","year":"2021","journal-title":"Molecules"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325005773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325005773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:52:51Z","timestamp":1778590371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325005773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":33,"alternative-id":["S0006899325005773"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150014","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticancer properties of new flavonoid lensoside A\u03b2 in combination with temozolomide in an in vitro model of human glioma cells","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150014"}}