{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:44:00Z","timestamp":1774694640226,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ80730"],"award-info":[{"award-number":["2025JJ80730"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.brainres.2025.150067","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:50:00Z","timestamp":1763765400000},"page":"150067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["IGF2BP2-mediated m6A modification of IGF1R mRNA promotes neuronal senescence and cognitive decline in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"1871","author":[{"given":"Shan","family":"Hui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lemei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.brainres.2025.150067_b0005","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13316","article-title":"Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells","volume":"20","author":"Zhou","year":"2021","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.brainres.2025.150067_b0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"23\u201324","key":"10.1016\/j.brainres.2025.150067_b0015","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.brainres.2025.150067_b0020","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41583-020-0325-z","article-title":"Cellular senescence and Alzheimer disease: the egg and the chicken scenario","volume":"21","author":"Saez-Atienzar","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2025.150067_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2022.111675","article-title":"Cellular senescence in the aging brain: a promising target for neurodegenerative diseases","volume":"204","author":"Sahu","year":"2022","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.brainres.2025.150067_b0035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.brainres.2025.150067_b0040","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"10284","key":"10.1016\/j.brainres.2025.150067_b0045","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0050","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13024-021-00424-9","article-title":"New approaches to symptomatic treatments for Alzheimer's disease","volume":"16","author":"Cummings","year":"2021","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.brainres.2025.150067_b0055","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00015.2020","article-title":"The complexity of Alzheimer's disease: an evolving puzzle","volume":"101","author":"Ferrari","year":"2021","journal-title":"Physiol. Rev."},{"issue":"7288","key":"10.1016\/j.brainres.2025.150067_b0060","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.brainres.2025.150067_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061368","article-title":"Insulin-like growth factor-1 and IGF Binding proteins predict all-cause mortality and morbidity in older adults","volume":"9","author":"Zhang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.brainres.2025.150067_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1203534","article-title":"Decreased IGF1R attenuates senescence and improves function in pancreatic \u03b2-cells","volume":"14","author":"Iwasaki","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.brainres.2025.150067_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.949074","article-title":"Accelerated aging-related transcriptome alterations in neurovascular unit cells in the brain of Alzheimer's disease","volume":"14","author":"Zhao","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"7","key":"10.1016\/j.brainres.2025.150067_b0080","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1093\/brain\/awx132","article-title":"The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons","volume":"140","author":"George","year":"2017","journal-title":"Brain J. Neurol."},{"issue":"7","key":"10.1016\/j.brainres.2025.150067_b0085","article-title":"Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms","volume":"1870","author":"Liu","year":"2024","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.brainres.2025.150067_b0090","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1002\/ctm2.426","article-title":"m(6) a modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization","volume":"11","author":"Lang","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.brainres.2025.150067_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110313","article-title":"IGF2BP2 promotes gastric cancer progression by regulating the IGF1R-RhoA-ROCK signaling pathway","volume":"94","author":"Liu","year":"2022","journal-title":"Cell. Signal."},{"issue":"Pt 2","key":"10.1016\/j.brainres.2025.150067_b0100","article-title":"CircTBCD\/IGF2BP2 complex stabilizes IGF-1R mRNA in an m6A-dependent manner to promote bone metastasis in nasopharyngeal carcinoma","volume":"319","author":"Yang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.brainres.2025.150067_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171515","article-title":"Administration of bovine casein-derived peptide prevents cognitive decline in Alzheimer disease model mice","volume":"12","author":"Min","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0110","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13024-021-00484-x","article-title":"METTL3-dependent RNA m(6)A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events","volume":"16","author":"Zhao","year":"2021","journal-title":"Mol. Neurodegener."},{"issue":"15","key":"10.1016\/j.brainres.2025.150067_b0115","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4103\/0366-6999.186646","article-title":"Amyloid \u03b2 protein aggravates neuronal senescence and cognitive deficits in 5XFAD mouse model of Alzheimer's disease","volume":"129","author":"Wei","year":"2016","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"2","key":"10.1016\/j.brainres.2025.150067_b0120","first-page":"717","article-title":"Ginsenoside Rg1 protects against H2O2\u2011induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons invitro","volume":"43","author":"Xu","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13195-020-00746-8","article-title":"Trichostatin a ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and A\u03b2 clearance in APP\/PS1 mice","volume":"13","author":"Su","year":"2021","journal-title":"Alzheimers Res. Ther."},{"issue":"3","key":"10.1016\/j.brainres.2025.150067_b0130","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2025.13441","article-title":"Multifaceted roles of insulin\u2011like growth factor 2 mRNA binding protein 2 in human cancer (Review)","volume":"31","author":"Shen","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.brainres.2025.150067_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102593","article-title":"The new perspective of Alzheimer's disease research: mechanism and therapeutic strategy of neuronal senescence","volume":"102","author":"Niu","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcb.2022.04.011","article-title":"The heterogeneity of cellular senescence: insights at the single-cell level","volume":"33","author":"Cohn","year":"2023","journal-title":"Trends Cell Biol."},{"issue":"11","key":"10.1016\/j.brainres.2025.150067_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2024.100113","article-title":"The role of p21 in cellular senescence and aging-related diseases","volume":"47","author":"Yan","year":"2024","journal-title":"Mol. Cells"},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0150","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13521","article-title":"Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus","volume":"21","author":"Matias","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.brainres.2025.150067_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1397901","article-title":"Intracerebral inoculation of healthy non-transgenic rats with a single aliquot of oligomeric amyloid-\u03b2 (1-42) profoundly and progressively alters brain function throughout life","volume":"16","author":"Kramer","year":"2024","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2025.150067_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/biom15040543","article-title":"Evaluation of the effects of thymoquinone on RAGE\/NOX4 expressions and brain tissue morphometry in experimental Alzheimer's disease induced by amyloid beta 1-42 peptide","volume":"15","author":"Ate\u015f","year":"2025","journal-title":"Biomolecules"},{"issue":"52","key":"10.1016\/j.brainres.2025.150067_b0165","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1039\/c3cc40779a","article-title":"Exploring the differences between mouse mA\u03b2(1-42) and human hA\u03b2(1-42) for Alzheimer's disease related properties and neuronal cytotoxicity","volume":"49","author":"Lv","year":"2013","journal-title":"Chem. Commun. (Camb)"},{"issue":"7481","key":"10.1016\/j.brainres.2025.150067_b0170","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0175","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s12967-024-06050-5","article-title":"Circ-ITCH promotes the ubiquitination degradation of HOXC10 to facilitate osteogenic differentiation in disuse osteoporosis through stabilizing BRCA1 mRNA via IGF2BP2-mediated m(6)A modification","volume":"23","author":"Zhong","year":"2025","journal-title":"J. Transl. Med."},{"issue":"7397","key":"10.1016\/j.brainres.2025.150067_b0180","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.brainres.2025.150067_b0185","doi-asserted-by":"crossref","first-page":"24086","DOI":"10.18632\/aging.203652","article-title":"Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer's disease","volume":"13","author":"Deng","year":"2021","journal-title":"Aging"},{"issue":"10","key":"10.1016\/j.brainres.2025.150067_b0190","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1093\/nar\/gkx141","article-title":"N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein","volume":"45","author":"Liu","year":"2017","journal-title":"Nucl. Acids Res."},{"issue":"1","key":"10.1016\/j.brainres.2025.150067_b0195","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41467-025-56173-6","article-title":"Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.brainres.2025.150067_b0200","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrg3724","article-title":"Gene expression regulation mediated through reversible m\u2076a RNA methylation","volume":"15","author":"Fu","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"10","key":"10.1016\/j.brainres.2025.150067_b0205","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70076","article-title":"Insulin-like growth factor binding protein 2 drives neurodegeneration in Parkinson's disease: insights from invivo and invitro studies","volume":"30","author":"An","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"17","key":"10.1016\/j.brainres.2025.150067_b0210","doi-asserted-by":"crossref","first-page":"11454","DOI":"10.1021\/acs.jmedchem.2c00844","article-title":"Progress and challenges in targeted protein degradation for neurodegenerative disease therapy","volume":"65","author":"Fang","year":"2022","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.brainres.2025.150067_b0215","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s13205-023-03739-0","article-title":"CircDiaph3 influences PASMC apoptosis by regulating PI3K\/AKT\/mTOR pathway through IGF1R","volume":"13","author":"Liu","year":"2023","journal-title":"3 Biotech"},{"issue":"3","key":"10.1016\/j.brainres.2025.150067_b0220","doi-asserted-by":"crossref","first-page":"E316","DOI":"10.1152\/ajpendo.00369.2011","article-title":"Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus","volume":"302","author":"Tran","year":"2012","journal-title":"Am. J. Phys. Endocrinol. Metab."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325006304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325006304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T22:13:40Z","timestamp":1766096020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325006304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"alternative-id":["S0006899325006304"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150067","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF2BP2-mediated m6A modification of IGF1R mRNA promotes neuronal senescence and cognitive decline in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150067"}}