{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:15:52Z","timestamp":1793722552105,"version":"4.6.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2023H071"],"award-info":[{"award-number":["LH2023H071"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008858","name":"Heilongjiang Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474289"],"award-info":[{"award-number":["82474289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.brainres.2025.150069","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:33:25Z","timestamp":1763771605000},"page":"150069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Tongqiao huoxue decoction and its components promote angiogenesis and treat ischemic stroke via glycolysis-enhanced VEGF-A\/VEGFR2 pathway"],"prefix":"10.1016","volume":"1870","author":[{"given":"Gongda","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2173-089X","authenticated-orcid":false,"given":"Peiliang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10260","key":"10.1016\/j.brainres.2025.150069_b0005","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0140-6736(20)31363-5","article-title":"Stroke systems of care in high-income countries: what is optimal?","volume":"396","author":"Langhorne","year":"2020","journal-title":"Lancet"},{"issue":"24","key":"10.1016\/j.brainres.2025.150069_b0010","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa1515510","article-title":"Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke","volume":"374","author":"Anderson","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.brainres.2025.150069_b0015","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/cvr\/cvq105","article-title":"Vascular endothelial growth factors and vascular permeability","volume":"87","author":"Bates","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.brainres.2025.150069_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/S0003-4975(99)00680-3","article-title":"Thoracic surgery directors association award. Angiogenesis in transmyocardial revascularization: comparison of laser versus mechanical punctures","volume":"68","author":"Chu","year":"1999","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.brainres.2025.150069_b0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11936-007-0014-5","article-title":"The role of angiogenesis in damage and recovery from ischemic stroke","volume":"9","author":"Arenillas","year":"2007","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"issue":"9","key":"10.1016\/j.brainres.2025.150069_b0030","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1161\/01.STR.25.9.1794","article-title":"Role of angiogenesis in patients with cerebral ischemic stroke","volume":"25","author":"Krupinski","year":"1994","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.brainres.2025.150069_b0035","first-page":"469","article-title":"Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis","volume":"39","author":"Shibuya","year":"2006","journal-title":"J. Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.brainres.2025.150069_b0040","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.brainres.2025.150069_b0045","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41401-023-01061-2","article-title":"Angiogenesis after ischemic stroke","volume":"44","author":"Fang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainres.2025.150069_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114693","article-title":"Tongqiao huoxue decoction for the treatment of acute ischemic stroke: A systematic review and meta-analysis","volume":"283","author":"Zhou","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.brainres.2025.150069_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148247","article-title":"Tongqiao Huoxue decoction alleviates neurological impairment following ischemic stroke via the PTGS2\/NF-kappa B axis","volume":"1805","author":"Zhou","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2025.150069_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154437","article-title":"Study on the mechanism of Tong-Qiao-Huo-Xue decoction regulating apoptosis via ASK1\/MKK4\/JNK pathway in MCAO\/R rats","volume":"106","author":"Yuan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainres.2025.150069_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114450","article-title":"Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia","volume":"367","author":"Deng","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2025.150069_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1395167","article-title":"Promotion of mature angiogenesis in ischemic stroke by Taohong Siwu decoction through glycolysis activation","volume":"15","author":"Tang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.brainres.2025.150069_b0075","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s11011-025-01707-6","article-title":"Promotion of angiogenesis in cerebral infarction by Tongqiao Huoxue Decoction through activation of glycolysis","volume":"40","author":"Li","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.brainres.2025.150069_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115475","article-title":"Proteomics on the role of muscone in the \u201cconsciousness-restoring resuscitation\u201d effect of musk on ischemic stroke","volume":"296","author":"Han","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.brainres.2025.150069_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110563","article-title":"The intranasal administration of Carthamus tinctorius L. extract\/phospholipid complex in the treatment of cerebral infarction via the TNF-\u03b1\/MAPK pathway","volume":"130","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainres.2025.150069_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156966","article-title":"Activation of BDNF-TrkB-PI3K-AKT signaling pathway by Tong-Qiao-Huo-Xue Decoction facilitates nerve regeneration and mitigates cerebral ischemia-reperfusion injury","volume":"145","author":"Peng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainres.2025.150069_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115585","article-title":"Tong-Qiao-Huo-Xue decoction activates PI3K\/Akt\/mTOR pathway to reduce BMECs autophagy after cerebral ischemia\/reperfusion injury","volume":"298","author":"Hua","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.brainres.2025.150069_b0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4149\/endo_2014_01_35","article-title":"Glucose transport in brain - effect of inflammation","volume":"48","author":"Jurcovicova","year":"2014","journal-title":"Endocr. Regul."},{"key":"10.1016\/j.brainres.2025.150069_b0105","first-page":"32","article-title":"The prognostic value of the lactate concentration and lactate\/pyruvate ratio in cerebrospinal fluid following acute cerebral circulatory disorders","volume":"2","author":"Raudam","year":"1976","journal-title":"Vopr. Neirokhir."},{"issue":"11","key":"10.1016\/j.brainres.2025.150069_b0110","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1038\/sj.jcbfm.9600521","article-title":"Supply and demand in cerebral energy metabolism: the role of nutrient transporters","volume":"27","author":"Simpson","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"11","key":"10.1016\/j.brainres.2025.150069_b0115","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/jnr.23998","article-title":"Near-critical GLUT1 and Neurodegeneration","volume":"95","author":"Barros","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.brainres.2025.150069_b0120","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","article-title":"Endothelial\/pericyte interactions","volume":"97","author":"Armulik","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.brainres.2025.150069_b0125","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fneur.2019.00571","article-title":"Cortical microinfarcts and white matter connectivity in memory clinic patients","volume":"10","author":"Ferro","year":"2019","journal-title":"Front. Neurol."},{"issue":"12","key":"10.1016\/j.brainres.2025.150069_b0130","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/1570159X18666200720173316","article-title":"Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke","volume":"18","author":"Yang","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"5","key":"10.1016\/j.brainres.2025.150069_b0135","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s11596-012-1025-3","article-title":"Over-expression of VEGF in marrow stromal cells promotes angiogenesis in rats with cerebral infarction via the synergistic effects of VEGF and Ang-2","volume":"32","author":"Lai","year":"2012","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci."},{"issue":"5","key":"10.1016\/j.brainres.2025.150069_b0140","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/ATVBAHA.119.313692","article-title":"Partial inhibition of glycolysis reduces atherogenesis independent of intraplaque neovascularization in mice","volume":"40","author":"Perrotta","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7653","key":"10.1016\/j.brainres.2025.150069_b0145","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature22322","article-title":"FGF-dependent metabolic control of vascular development","volume":"545","author":"Yu","year":"2017","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.brainres.2025.150069_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0113-2","article-title":"Lactate potentiates angiogenesis and neurogenesis in experimental intracerebral hemorrhage","volume":"50","author":"Zhou","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"8","key":"10.1016\/j.brainres.2025.150069_b0155","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1089\/ars.2007.1674","article-title":"Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms","volume":"9","author":"Hunt","year":"2007","journal-title":"Antioxid. Redox Signal."},{"issue":"10","key":"10.1016\/j.brainres.2025.150069_b0160","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm.2016.87","article-title":"Mechanisms and regulation of endothelial VEGF receptor signalling","volume":"17","author":"Simons","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.brainres.2025.150069_b0165","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1593\/neo.11948","article-title":"The effect of bevacizumab on human malignant melanoma cells with functional VEGF\/VEGFR2 autocrine and intracrine signaling loops","volume":"14","author":"Adamcic","year":"2012","journal-title":"Neoplasia"},{"issue":"16","key":"10.1016\/j.brainres.2025.150069_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/cells12162054","article-title":"A systematic compilation of human SH3 domains: A versatile superfamily in cellular signaling","volume":"12","author":"Mehrabipour","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.brainres.2025.150069_b0175","series-title":"Regulation of tight junction barrier function by phospholipase C","author":"Klein","year":"2007"},{"issue":"694","key":"10.1016\/j.brainres.2025.150069_b0180","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abc6612","article-title":"Emerging roles of PLC\u03b31 in endothelial biology","volume":"14","author":"Chen","year":"2021","journal-title":"Sci. Signal."},{"issue":"11","key":"10.1016\/j.brainres.2025.150069_b0185","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1074\/jbc.M109955200","article-title":"Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice","volume":"277","author":"Liao","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.brainres.2025.150069_b0190","first-page":"3556","article-title":"RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells","volume":"128","author":"Hoeppner","year":"2015","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.brainres.2025.150069_b0195","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/10739680802220323","article-title":"VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6","volume":"15","author":"Hamdollah Zadeh","year":"2008","journal-title":"Microcirculation"},{"issue":"11","key":"10.1016\/j.brainres.2025.150069_b0200","doi-asserted-by":"crossref","first-page":"21211","DOI":"10.1002\/jcp.28727","article-title":"GRP94 promotes muscle differentiation by inhibiting the PI3K\/AKT\/mTOR signaling pathway","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.brainres.2025.150069_b0205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnmol.2011.00051","article-title":"PI3K\/AKT\/mTOR Pathway in Angiogenesis","volume":"4","author":"Karar","year":"2011","journal-title":"Front. Mol. Neurosci."},{"issue":"5","key":"10.1016\/j.brainres.2025.150069_b0210","first-page":"6489","article-title":"Adenosine induces intrinsic apoptosis via the PI3K\/Akt\/mTOR signaling pathway in human pharyngeal squamous carcinoma FaDu cells","volume":"15","author":"Choi","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.brainres.2025.150069_b0215","article-title":"Endothelial cell integrin \u03b16 regulates vascular remodeling through the PI3K\/Akt-eNOS-VEGFA Axis after stroke","author":"Wang","year":"2025","journal-title":"Neurosci. Bull."},{"issue":"11","key":"10.1016\/j.brainres.2025.150069_b0220","first-page":"3485","article-title":"MiRNA-26a promotes angiogenesis in a rat model of cerebral infarction via PI3K\/AKT and MAPK\/ERK pathway","volume":"22","author":"Liang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.brainres.2025.150069_b0225","first-page":"3411","article-title":"TSLP\/TSLPR promote angiogenesis following ischemic stroke via activation of the PI3K\/AKT pathway","volume":"17","author":"Yu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.brainres.2025.150069_b0230","article-title":"PI3K\/Akt\/mTOR pathway and its role in cancer therapeutics: are we making headway?","volume":"12","author":"Peng","year":"2022","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.brainres.2025.150069_b0235","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1747-4949.2012.00818.x","article-title":"Collateral perfusion: time for novel paradigms in cerebral ischemia","volume":"7","author":"Liebeskind","year":"2012","journal-title":"Int. J. Stroke"},{"issue":"6","key":"10.1016\/j.brainres.2025.150069_b0240","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.brainres.2025.150069_b0245","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2025.150069_b0250","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pneurobio.2013.11.004","article-title":"Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials","volume":"115","author":"Liu","year":"2014","journal-title":"Prog. Neurobiol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325006328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899325006328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:26:24Z","timestamp":1775147184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899325006328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":50,"alternative-id":["S0006899325006328"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150069","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tongqiao huoxue decoction and its components promote angiogenesis and treat ischemic stroke via glycolysis-enhanced VEGF-A\/VEGFR2 pathway","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2025.150069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150069"}}