{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:36:43Z","timestamp":1791020203600,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2022\\u201304813"],"award-info":[{"award-number":["RGPIN-2022\\u201304813"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","award":["1238\/2022 \/88881.707895\/2022\\u201301"],"award-info":[{"award-number":["1238\/2022 \/88881.707895\/2022\\u201301"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Quebec Health Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"Quebec Research Fund Nature and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["AFF_173514"],"award-info":[{"award-number":["AFF_173514"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000735","name":"University of Cambridge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.brainres.2026.150187","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:18:55Z","timestamp":1770164335000},"page":"150187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Ghrelin-based interventions in preclinical models of Parkinson\u2019s disease: a systematic review"],"prefix":"10.1016","volume":"1876","author":[{"given":"Henrique Jos\u00e9","family":"Cavalcanti Bezerra Gouveia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-6438","authenticated-orcid":false,"given":"Osmar Henrique","family":"dos Santos-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Frasnelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-0845","authenticated-orcid":false,"given":"Alexandre","family":"Fisette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaci Pereira","family":"dos Santos J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Ant\u00f4nio","family":"da Silva Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eul\u00e1lia Rebeca","family":"da Silva-Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Elisa","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Manh\u00e3es de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2026.150187_bib326","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson disease-associated cognitive impairment","volume":"7","author":"Aarsland","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.brainres.2026.150187_b0005","doi-asserted-by":"crossref","first-page":"14057","DOI":"10.1523\/JNEUROSCI.3890-09.2009","article-title":"Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism","volume":"29","author":"Andrews","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150187_b0010","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of parkinson disease","volume":"323","author":"Armstrong","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.brainres.2026.150187_b0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/gast.2001.22158","article-title":"Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin","volume":"120","author":"Asakawa","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.brainres.2026.150187_b0020","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/jnc.13576","article-title":"Acylated but not des-acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson\u2019s disease","volume":"137","author":"Bayliss","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2026.150187_b0025","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1523\/JNEUROSCI.4373-15.2016","article-title":"Ghrelin-AMPK signaling mediates the neuroprotective effects of calorie restriction in Parkinson\u2019s disease","volume":"36","author":"Bayliss","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150187_b0030","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1016\/j.parkreldis.2008.04.015","article-title":"The 6-hydroxydopamine model: News from the past","volume":"14","author":"Blandini","year":"2008","journal-title":"Parkinson. Relat. Disord."},{"key":"10.1016\/j.brainres.2026.150187_b0035","doi-asserted-by":"crossref","DOI":"10.3233\/JPD-191683","article-title":"Parkinson\u2019s disease in women and men: what\u2019s the difference?","author":"Cerri","year":"2019","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.brainres.2026.150187_b0040","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"Non-motor symptoms of Parkinson\u2019s disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2026.150187_b0045","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1139\/Y10-010","article-title":"Methods for detecting autophagy and determining autophagy-induced cell death","volume":"88","author":"Chen","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150187_b0050","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0006-291X(84)91293-2","article-title":"Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase","volume":"120","author":"Chiba","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2026.150187_bib327","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2018.09.029","article-title":"Ghrelin agonist HM01 attenuates chemotherapy-induced neurotoxicity in rodent models","volume":"840","author":"Chiorazzi","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150187_b0055","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/mds.30162","article-title":"Update on treatments for Parkinson\u2019s disease motor fluctuations \u2013 an international parkinson and movement disorder society evidence\u2010based medicine review","volume":"40","author":"de Bie","year":"2025","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainres.2026.150187_b0060","doi-asserted-by":"crossref","DOI":"10.1042\/NS20220063","article-title":"Cytokine activity in Parkinson\u2019s disease","volume":"7","author":"Dzamko","year":"2023","journal-title":"Neuronal Signal"},{"key":"10.1016\/j.brainres.2026.150187_b0065","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1091\/mbc.e06-05-0402","article-title":"Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells","volume":"18","author":"Filigheddu","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.brainres.2026.150187_b0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-018-1034-3","article-title":"A survey of subjective constipation in Parkinson\u2019s disease patients in shanghai and literature review","volume":"18","author":"Gan","year":"2018","journal-title":"BMC Neurol."},{"key":"10.1016\/j.brainres.2026.150187_b0075","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1093\/ajcn\/86.5.1486","article-title":"Prospective study of dietary pattern and risk of Parkinson disease","volume":"86","author":"Gao","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.brainres.2026.150187_b0080","doi-asserted-by":"crossref","DOI":"10.1111\/ane.12796","article-title":"Gender differences in Parkinson\u2019s disease: a clinical perspective","author":"Georgiev","year":"2017","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.brainres.2026.150187_b0085","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41531-025-01066-0","article-title":"Fasting and postprandial Ghrelin levels in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"11","author":"Gouveia","year":"2025","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.brainres.2026.150187_b0090","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.celrep.2018.11.026","article-title":"Ghrelin enhances food odor conditioning in healthy humans: an fMRI Study","volume":"25","author":"Han","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2026.150187_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.586302","article-title":"Acylated ghrelin is protective against 6-OHDA-induced neurotoxicity by regulating autophagic flux","volume":"11","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150187_b0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41531-023-00511-2","article-title":"Gastrointestinal disorders in Parkinson\u2019s disease and other Lewy body diseases","volume":"9","author":"Hirayama","year":"2023","journal-title":"NPJ Parkinsons. Dis."},{"key":"10.1016\/j.brainres.2026.150187_b0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE\u2019s risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Method."},{"key":"10.1016\/j.brainres.2026.150187_b0110","first-page":"297","article-title":"Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson\u2019s disease","volume":"46","author":"Jellinger","year":"1995","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.brainres.2026.150187_b0115","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.expneurol.2008.05.006","article-title":"Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra","volume":"212","author":"Jiang","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2026.150187_b0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-017-1788-5","article-title":"Parkinson\u2019s disease: experimental models and reality","volume":"135","author":"Jiang","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2026.150187_b0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neurobiolaging.2021.01.011","article-title":"Early low-dose ghrelin intervention via miniosmotic pumps could protect against the progressive dopaminergic neuron loss in Parkinson\u2019s disease mice","volume":"101","author":"Jiao","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2026.150187_b0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neubiorev.2016.12.010","article-title":"The neurological effects of ghrelin in brain diseases: beyond metabolic functions","volume":"73","author":"Jiao","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2026.150187_b0135","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1111\/nmo.12459","article-title":"New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson\u2019s disease","volume":"26","author":"Karasawa","year":"2014","journal-title":"Neurogastroenterol. Motility"},{"key":"10.1016\/j.brainres.2026.150187_b0140","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.parkreldis.2019.12.006","article-title":"Sex differences in smoking, alcohol consumption, and risk of Parkinson\u2019s disease: a nationwide cohort study","volume":"71","author":"Kim","year":"2020","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2026.150187_b0145","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1523\/JNEUROSCI.4346-04.2005","article-title":"Matrix Metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia","volume":"25","author":"Kim","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150187_b0150","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2026.150187_b0155","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2026.150187_b0160","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3748\/wjg.v25.i5.539","article-title":"Contribution of ghrelin to functional gastrointestinal disorders\u2019 pathogenesis","volume":"25","author":"Koutouratsas","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.brainres.2026.150187_b0165","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/WNF.0000000000000051","article-title":"Sex differences in the pharmacokinetics of levodopa in elderly patients with parkinson disease","volume":"37","author":"Kumagai","year":"2014","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.brainres.2026.150187_b0170","doi-asserted-by":"crossref","DOI":"10.1042\/NS20210026","article-title":"Animal models of Parkinson\u2019s disease: a guide to selecting the optimal model for your research","volume":"5","author":"Lama","year":"2021","journal-title":"Neuronal Signal"},{"key":"10.1016\/j.brainres.2026.150187_b0175","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ymeth.2004.10.010","article-title":"The ER chaperone and signaling regulator GRP78\/BiP as a monitor of endoplasmic reticulum stress","volume":"35","author":"Lee","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.brainres.2026.150187_b0180","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.archger.2015.08.004","article-title":"Association between cigarette smoking and Parkinson\u2019s disease: a meta-analysis","volume":"61","author":"Li","year":"2015","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.brainres.2026.150187_b0185","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/45257","article-title":"Induction of autophagy and inhibition of tumorigenesis by beclin 1","volume":"402","author":"Liang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2026.150187_b0190","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203020","article-title":"Ghrelin bridges DMV neuropathology and gi dysfunction in the early stages of Parkinson\u2019s disease","volume":"9","author":"Liu","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.brainres.2026.150187_b0195","first-page":"001","article-title":"Guidelines for Parkinson\u2019s disease management part II: consensus from the movement disorders scientific department of the Brazilian Academy of Neurology \u2013 non-motor symptoms","volume":"83","author":"Maia","year":"2025","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.brainres.2026.150187_b0200","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1089\/ars.2011.4033","article-title":"Toxin models of mitochondrial dysfunction in Parkinson\u2019s disease","volume":"16","author":"Martinez","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainres.2026.150187_b0205","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev-physiol-021113-170310","article-title":"The central nervous system sites mediating the orexigenic actions of ghrelin","volume":"76","author":"Mason","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.brainres.2026.150187_b0210","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1006\/bbrc.2000.3568","article-title":"Ghrelin stimulates gastric acid secretion and motility in rats","volume":"276","author":"Masuda","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2026.150187_b0215","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","article-title":"Autophagy suppresses tumorigenesis through elimination of p62","volume":"137","author":"Mathew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2026.150187_b0220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3233\/JPD-2011-11023","article-title":"MPTP mouse models of Parkinson\u2019s disease: an update","volume":"1","author":"Meredith","year":"2011","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.brainres.2026.150187_b0225","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2019.00013","article-title":"Multiple beneficial effects of ghrelin agonist, HM01 on homeostasis alterations in 6-hydroxydopamine model of Parkinson\u2019s disease in male rats","volume":"13","author":"Minalyan","year":"2019","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.brainres.2026.150187_b0230","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12640-009-9037-x","article-title":"Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6- etrahydropyridine mouse model of Parkinson\u2019s disease by blocking microglial activation","volume":"15","author":"Moon","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2026.150187_b0235","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.envint.2017.04.010","article-title":"Occupational pesticide use and Parkinson\u2019s disease in the Parkinson environment gene (PEG) study","volume":"107","author":"Narayan","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.brainres.2026.150187_b0240","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.3390\/biom13101435","article-title":"Autophagy in Parkinson\u2019s disease","volume":"13","author":"Nechushtai","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.brainres.2026.150187_b0245","doi-asserted-by":"crossref","DOI":"10.1172\/JCI39920","article-title":"Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice","author":"Porporato","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.brainres.2026.150187_b0250","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1749-6632.2003.tb07476.x","article-title":"The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson\u2019s disease","volume":"991","author":"Przedborski","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2026.150187_b0255","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/42867","article-title":"Double identity for proteins of the Bcl-2 family","volume":"387","author":"Reed","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2026.150187_b0260","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1007\/s10571-022-01282-9","article-title":"Acyl-ghrelin attenuates neurochemical and motor deficits in the 6-OHDA model of Parkinson\u2019s disease","volume":"43","author":"Rees","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2026.150187_b0265","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.parkreldis.2019.01.003","article-title":"Effect of subthalamic deep brain stimulation on posture in Parkinson\u2019s disease: a blind computerized analysis","volume":"62","author":"Roediger","year":"2019","journal-title":"Parkinson. Relat. Disord."},{"key":"10.1016\/j.brainres.2026.150187_b0270","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/JPD-120130","article-title":"Neuronal expression of familial Parkinson\u2019s disease A53T \u03b1-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice","volume":"3","author":"Rothman","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.brainres.2026.150187_b0275","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/jcph.1096","article-title":"MAO-B and COMT genetic variations associated with levodopa treatment response in patients with Parkinson\u2019s disease","volume":"58","author":"Sampaio","year":"2018","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150187_bib328","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.3285","article-title":"The Neurocognitive Effects of Ghrelin-induced Signaling on the Hippocampus: A Promising Approach to Alzheimer\u2019s Disease","author":"Seminara","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.brainres.2026.150187_b0280","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neubiorev.2016.11.021","article-title":"Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways","volume":"73","author":"Stievenard","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2026.150187_b0285","doi-asserted-by":"crossref","unstructured":"Su, D., Cui, Y., He, C., Yin, P., Bai, R., Zhu, J., Lam, J.S.T., Zhang, J., Yan, R., Zheng, X., Wu, J., Zhao, D., Wang, A., Zhou, M., Feng, T., 2025. Projections for prevalence of Parkinson\u2019s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021. BMJ e080952. doi:10.1136\/bmj-2024-080952.","DOI":"10.1136\/bmj-2024-080952"},{"key":"10.1016\/j.brainres.2026.150187_b0290","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.beem.2014.02.006","article-title":"Mitochondrial UCP2 in the central regulation of metabolism","volume":"28","author":"Toda","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2026.150187_b0295","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1212\/WNL.54.12.2292","article-title":"Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations","volume":"54","author":"Tsang","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.brainres.2026.150187_b0300","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"issue":"Suppl","key":"10.1016\/j.brainres.2026.150187_b0305","first-page":"7","article-title":"Life style risks of Parkinson\u2019s disease: association between decreased water intake and constipation","volume":"251","author":"Ueki","year":"2004","journal-title":"J. Neurol."},{"key":"10.1016\/j.brainres.2026.150187_b0310","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.051633998","article-title":"Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease","volume":"98","author":"Vila","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2026.150187_bib329","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3390\/ijms18050986","article-title":"Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors","volume":"18","author":"Villars","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2026.150187_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147023","article-title":"Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis","volume":"1746","author":"Wang","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2026.150187_bib330","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14561","article-title":"The ghrelin agonist, HM01 activates central vagal and enteric cholinergic neurons and reverses gastric inflammatory and ileus responses in rats","volume":"35","author":"Yuan","year":"2023","journal-title":"Neurogastroenterology Motil."},{"key":"10.1016\/j.brainres.2026.150187_bib331","article-title":"Potential role of ghrelin in neuroprotection and cognitive function: implications for diabetic cognitive impairment","volume":"13","author":"Zhang","year":"2025","journal-title":"PeerJ"},{"key":"10.1016\/j.brainres.2026.150187_b0320","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/cne.20823","article-title":"Expression of ghrelin receptor mRNA in the rat and the mouse brain","volume":"494","author":"Zigman","year":"2006","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.brainres.2026.150187_b0325","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/mdc3.13584","article-title":"Gender differences in the prevalence of Parkinson\u2019s disease","volume":"10","author":"Zirra","year":"2023","journal-title":"Mov. .disord. Clin. Pract."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326000454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326000454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:02:43Z","timestamp":1789646563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326000454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":71,"alternative-id":["S0006899326000454"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150187","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin-based interventions in preclinical models of Parkinson\u2019s disease: a systematic review","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150187"}}