{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:40:53Z","timestamp":1777628453989,"version":"3.51.4"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Secretariat of Science Humanities Technology and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.brainres.2026.150233","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T14:57:39Z","timestamp":1772377059000},"page":"150233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reversal of chronic restraint-induced HPA axis dysregulation and depressive-like behaviour by chronic escitalopram treatment in rats: involvement of SERT"],"prefix":"10.1016","volume":"1880","author":[{"given":"Shiv","family":"Shanker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeshu","family":"Saroj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Manjarrez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-9794","authenticated-orcid":false,"given":"Pedro","family":"L\u00f3pez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-4382","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Terr\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2026.150233_b0005","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.euroneuro.2006.08.009","article-title":"Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat","volume":"17","author":"Abumaria","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0010","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00213-004-2011-7","article-title":"Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey","volume":"178","author":"Anderson","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbr.2014.06.040","article-title":"Behavioural and transcriptional effects of escitalopram in the chronic escape deficit model of depression","volume":"272","author":"Benatti","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2026.150233_b0020","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.psyneuen.2017.10.011","article-title":"Molecular changes associated with escitalopram response in a stress-based model of depression","volume":"87","author":"Benatti","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2026.150233_b0030","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1523\/JNEUROSCI.22-15-06766.2002","article-title":"Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter","volume":"22","author":"Benmansour","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150233_b0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12031-007-0065-9","article-title":"Molecular pathways associated with stress resilience and drug resistance in the chronic mild stress rat model of depression: a gene expression study","volume":"33","author":"Bergstr\u00f6m","year":"2007","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainres.2026.150233_b0040","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00213-010-2054-x","article-title":"Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression","volume":"214","author":"Bhagya","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0045","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.jcp.0000161500.58266.90","article-title":"Activity of citalopram on adenosine and serotonin circulating levels in depressed patients","volume":"25","author":"Blardi","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0006-3223(98)00114-0","article-title":"Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive-compulsive disorder responses","volume":"44","author":"Blier","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tem.2008.01.009","article-title":"Dissociation of ACTH and glucocorticoids","volume":"19","author":"Bornstein","year":"2008","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.brainres.2026.150233_b0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12035-013-8413-y","article-title":"Downregulation of serotonergic gene expression in the raphe nuclei of the midbrain under chronic social defeat stress in male mice","volume":"48","author":"Boyarskikh","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2026.150233_b0065","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87958","article-title":"PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease","volume":"1","author":"Bram","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.brainres.2026.150233_b0070","first-page":"343","article-title":"Effect of antidepressant drugs on the hypothalamic-pituitary-adrenal axis activity and glucocorticoid receptor function","volume":"54","author":"Budziszewska","year":"2002","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188043","article-title":"Escitalopram and NHT normalized stress-induced anhedonia and molecular neuroadaptations in a mouse model of depression","volume":"12","author":"Burstein","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2026.150233_b0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1176\/ajp.128.1.31","article-title":"Adrenal cortical activity in depressive illness","volume":"128","author":"Carpenter","year":"1971","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0085","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/sj.bjp.0705800","article-title":"Effects of chronic treatment with escitalopram or citalopram on extracellular 5-HT in the prefrontal cortex of rats: role of 5-HT1A receptors","volume":"142","author":"Ceglia","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0090","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14014","article-title":"Sex differences in peripheral monoamine transmitter and related hormone levels in chronic stress mice with a depression-like phenotype","volume":"10","author":"Chen","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.brainres.2026.150233_b0095","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pnpbp.2012.05.018","article-title":"Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex","volume":"39","author":"Chiba","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0100","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1124\/mol.56.3.552","article-title":"Pharmacological and molecular characterization of 5-hydroxytryptamine(7) receptors in the rat adrenal gland","volume":"56","author":"Contesse","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0105","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1210\/jc.2004-2476","article-title":"Abnormal sensitivity of cortisol-producing adrenocortical adenomas to serotonin: in vivo and in vitro studies","volume":"90","author":"Contesse","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2026.150233_b0110","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuroscience.2005.06.068","article-title":"Chronic mild stress impact: are females more vulnerable?","volume":"135","author":"Dalla","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2026.150233_b0115","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/sj.bjp.0705538","article-title":"Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice","volume":"140","author":"David","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0120","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1176\/ajp.150.4.656","article-title":"Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression","volume":"150","author":"De Bellis","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0125","doi-asserted-by":"crossref","first-page":"7483","DOI":"10.3390\/ijms22147483","article-title":"Escitalopram targets oxidative stress, caspase-3, BDNF and MeCP2 in the hippocampus and frontal cortex of a rat model of depression induced by chronic unpredictable mild stress","volume":"22","author":"Dionisie","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2026.150233_bib436","doi-asserted-by":"crossref","first-page":"113640","DOI":"10.1016\/j.physbeh.2021.113640","article-title":"Sucrose solution concentration and the intermittent access induced consumption increase","volume":"243","author":"Eikelboom","year":"2022","journal-title":"Physiol Behav"},{"key":"10.1016\/j.brainres.2026.150233_b0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(01)02495-8","article-title":"Repeated experience of social defeats increases serotonin transporter and monoamine oxidase A mRNA levels in raphe nuclei of male mice","volume":"321","author":"Filipenko","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2026.150233_b0135","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.euroneuro.2012.05.013","article-title":"Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response","volume":"23","author":"Frokjaer","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0140","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neuropharm.2013.03.013","article-title":"Sensitization of restraint-induced corticosterone secretion after chronic restraint in rats: involvement of 5-HT7 receptors","volume":"71","author":"Garc\u00eda-Iglesias","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0145","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/sj.npp.1300201","article-title":"Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression","volume":"28","author":"Gartside","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0150","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4088\/JCP.v61n1002","article-title":"How fast are antidepressants?","volume":"61","author":"Gelenberg","year":"2000","journal-title":"J. Clin. Psychiatry"},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2026.150233_b0155","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/01.psy.0000163456.22154.d2","article-title":"Hypercortisolemia and depression","volume":"67","author":"Gillespie","year":"2005","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.brainres.2026.150233_b0160","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1017\/S1461145711000484","article-title":"Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study","volume":"15","author":"Guiard","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0165","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S2215-0366(17)30015-9","article-title":"How do antidepressants work? New perspectives for refining future treatment approaches","volume":"4","author":"Harmer","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0170","doi-asserted-by":"crossref","first-page":"R250","DOI":"10.1152\/ajpregu.00361.2014","article-title":"Chronic and acute effects of stress on energy balance: are there appropriate animal models?","volume":"308","author":"Harris","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.brainres.2026.150233_b0175","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1176\/ajp.142.8.911","article-title":"Diagnostic categorization of psychiatric disturbance in Cushing\u2019s syndrome","volume":"142","author":"Haskett","year":"1985","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0180","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0197-0186(00)00043-7","article-title":"Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study","volume":"38","author":"H\u00e9bert","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2026.150233_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172730","article-title":"Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways","volume":"865","author":"Hern\u00e1ndez-Aquino","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1176\/ajp.153.1.93","article-title":"Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects","volume":"153","author":"Heuser","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0195","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0028-3908(97)00050-6","article-title":"WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor","volume":"36","author":"Hjorth","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0200","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/edrv-17-2-187","article-title":"Antidepressants and hypothalamic-pituitary-adrenocortical regulation","volume":"17","author":"Holsboer","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.brainres.2026.150233_b0205","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1042\/bst0290728","article-title":"Structure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter","volume":"29","author":"Horschitz","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.brainres.2026.150233_b0210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s002130100737","article-title":"Reduction in basal afternoon plasma ACTH during early treatment of depression with fluoxetine","volume":"156","author":"Inder","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0215","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0091-3057(82)90053-3","article-title":"Animal model of depression: pharmacological sensitivity of a hedonic deficit","volume":"16","author":"Katz","year":"1982","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1016\/j.brainres.2026.150233_b0220","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1192\/bjp.142.1.16","article-title":"Cushing\u2019s syndrome and depression\u2013a prospective study of 26 patients","volume":"142","author":"Kelly","year":"1983","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0225","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1176\/appi.ajp.157.8.1243","article-title":"Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the \u201ckindling\u201d hypothesis","volume":"157","author":"Kendler","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"Suppl 15","key":"10.1016\/j.brainres.2026.150233_b0230","first-page":"12","article-title":"Gender differences in depression: implications for treatment","volume":"58","author":"Kornstein","year":"1997","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0235","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00213-015-4194-5","article-title":"Escitalopram reversed the traumatic stress-induced depressed and anxiety-like symptoms but not the deficits of fear memory","volume":"233","author":"Lin","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0240","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archpsyc.1981.01780290105011","article-title":"Side effects of corticosteroid therapy. Psychiatric aspects","volume":"38","author":"Ling","year":"1981","journal-title":"Arch. Gen, Psych."},{"key":"10.1016\/j.brainres.2026.150233_b0245","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1210\/jcem-61-3-429","article-title":"The 24-hour profile of adrenocorticotropin and cortisol in major depressive illness","volume":"61","author":"Linkowski","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2026.150233_b0250","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41380-019-0474-5","article-title":"Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0255","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1055\/s-2007-1014405","article-title":"Psychiatric phenomenology in Cushing\u2019s disease","volume":"25","author":"Loosen","year":"1992","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0260","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/156720208786413406","article-title":"Chronic mild stress paradigm reduces sweet food intake in rats without affecting brain derived neurotrophic factor protein levels","volume":"5","author":"Lucca","year":"2008","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.brainres.2026.150233_b0265","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0031-9384(94)90055-8","article-title":"Effects of chronic stress on food intake in rats: influence of stressor intensity and duration of daily exposure","volume":"55","author":"Mart\u00ed","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2026.150233_b0270","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0275","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-0773.2001.880511.x","article-title":"Escitalopram (S-enantiomer of citalopram): clinical efficacy and onset of action predicted from a rat model","volume":"88","author":"Montgomery","year":"2001","journal-title":"Pharmacol. Toxicol."},{"issue":"Suppl 1","key":"10.1016\/j.brainres.2026.150233_b0280","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1016\/S0306-4530(97)00021-8","article-title":"Antiglucocorticoid therapies in major depression: a review","volume":"22","author":"Murphy","year":"1997","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2026.150233_b0285","first-page":"102","article-title":"Comparison of corticosterone responses to acute stress in mice following different serial blood collection methods","volume":"61","author":"Musillo","year":"2025","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.brainres.2026.150233_b0290","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00213-005-0034-3","article-title":"Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response","volume":"181","author":"Nikisch","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0295","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/art.11249","article-title":"Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"48","author":"Ota","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.brainres.2026.150233_b0300","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0006-3223(01)01145-3","article-title":"Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine","volume":"50","author":"Owens","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0305","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02688691","article-title":"Gender differences in acute and chronic stress in Wistar Kyoto (WKY) rats","volume":"34","author":"Par\u00e9","year":"1999","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"10.1016\/j.brainres.2026.150233_b0310","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02740603","article-title":"Gender specificity in the neural regulation of the response to stress: new leads from classical paradigms","volume":"16","author":"Patchev","year":"1998","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2026.150233_b0315","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0003-2697(83)90375-5","article-title":"High-performance liquid chromatographic determination of indoleamines, dopamine, and norepinephrine in rat brain with fluorometric detection","volume":"128","author":"Peat","year":"1983","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2026.150233_b0320","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0169-328X(89)90031-4","article-title":"Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures","volume":"6","author":"Pepin","year":"1989","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2026.150233_bib437","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.euroneuro.2023.08.496","article-title":"Sucrose preference test: A systematic review of protocols for the assessment of anhedonia in rodents","volume":"77","author":"Primo","year":"2023","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.brainres.2026.150233_b0325","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1523\/JNEUROSCI.17-01-00045.1997","article-title":"Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression","volume":"17","author":"Qian","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150233_b0330","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41398-019-0416-7","article-title":"PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model","volume":"9","author":"Reisinger","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0335","unstructured":"Rihmer, Z., Dome, P., Katona, C., 2022. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacol Hung 24, 120\u2013125."},{"key":"10.1016\/j.brainres.2026.150233_b0340","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.npp.1300003","article-title":"Fluvoxamine reduces responsiveness of HPA axis in adult female BPD patients with a history of sustained childhood abuse","volume":"28","author":"Rinne","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0345","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fnagi.2016.00315","article-title":"Evidence of Tau hyperphosphorylation and dystrophic microglia in the common marmoset","volume":"8","author":"Rodriguez-Callejas","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2026.150233_b0350","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archpsyc.1970.01750040001001","article-title":"Cortisol production in depressive illness. A clinical and biochemical clarification","volume":"23","author":"Sachar","year":"1970","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0355","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/archpsyc.1973.01750310011002","article-title":"Disrupted 24-hour patterns of cortisol secretion in psychotic depression","volume":"28","author":"Sachar","year":"1973","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0360","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1046\/j.1471-4159.1997.68062618.x","article-title":"Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine\/threonine phosphatases","volume":"68","author":"Sakai","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2026.150233_b0365","doi-asserted-by":"crossref","DOI":"10.1139\/cjpp-2019-0080","article-title":"Effect of chronic corticosterone treatment on expression and distribution of serotonin 5-HT7 receptors in rat adrenal glands","author":"Saroj","year":"2019","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainres.2026.150233_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2024.107219","article-title":"Expression of tryptophan hydroxylase in rat adrenal glands: upregulation of TPH2 by chronic stress","volume":"171","author":"Saroj","year":"2025","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainres.2026.150233_b0375","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2004.11.003","article-title":"Cytokines and major depression","volume":"29","author":"Schiepers","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150233_b0380","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/mcne.1997.0619","article-title":"Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland","volume":"9","author":"Schroeter","year":"1997","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2026.150233_b0385","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neulet.2018.12.033","article-title":"Effects of escitalopram and ibuprofen on a depression-like phenotype induced by chronic stress in rats","volume":"696","author":"Seo","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2026.150233_b0390","article-title":"Chronic restraint stress induces serotonin transporter expression in the rat adrenal glands","volume":"110935","author":"Shanker","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.brainres.2026.150233_b0395","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000182736","article-title":"Course of depression in Cushing\u2019s syndrome: response to treatment and comparison with Graves\u2019 disease","volume":"39","author":"Sonino","year":"1993","journal-title":"Horm. Res."},{"key":"10.1016\/j.brainres.2026.150233_b0400","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000064426","article-title":"Adrenal splanchnic innervation modulates adrenal cortical responses to dehydration stress in rats","volume":"76","author":"Ulrich-Lai","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2026.150233_b0405","doi-asserted-by":"crossref","first-page":"R1138","DOI":"10.1152\/ajpregu.2000.279.3.R1138","article-title":"Single exposure to stressors causes long-lasting, stress-dependent reduction of food intake in rats","volume":"279","author":"Vall\u00e8s","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.brainres.2026.150233_b0410","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/257495a0","article-title":"Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain","volume":"257","author":"Vetulani","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2026.150233_b0415","doi-asserted-by":"crossref","first-page":"E421","DOI":"10.1208\/aapsj070242","article-title":"Serotonin transporters: implications for antidepressant drug development","volume":"7","author":"White","year":"2005","journal-title":"AAPS J."},{"key":"10.1016\/j.brainres.2026.150233_b0420","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainres.2026.150233_b0425","first-page":"247","article-title":"Antiglucocorticoid strategies in hypercortisolemic states","volume":"28","author":"Wolkowitz","year":"1992","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.brainres.2026.150233_b0430","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neuint.2013.09.019","article-title":"Gender differences in CMS and the effects of antidepressant venlafaxine in rats","volume":"63","author":"Xing","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2026.150233_b0435","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/jnc.12055","article-title":"Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner","volume":"123","author":"Zhang","year":"2012","journal-title":"J. Neurochem."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326000910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326000910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:46:55Z","timestamp":1777427215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326000910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":88,"alternative-id":["S0006899326000910"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150233","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reversal of chronic restraint-induced HPA axis dysregulation and depressive-like behaviour by chronic escitalopram treatment in rats: involvement of SERT","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150233"}}