{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:03:06Z","timestamp":1777366986525,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471281"],"award-info":[{"award-number":["82471281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["HAB202317"],"award-info":[{"award-number":["HAB202317"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.brainres.2026.150280","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T17:37:26Z","timestamp":1773941846000},"page":"150280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dopaminergic neurons in the dorsal raphe nucleus are involved in the regulation of memory impairment in chronic pain"],"prefix":"10.1016","volume":"1882","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-150X","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-5646","authenticated-orcid":false,"given":"Chenglan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6384-8234","authenticated-orcid":false,"given":"Fuhai","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2026.150280_b0005","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev-psych-020223-124335","article-title":"Psychological Flexibility, Chronic Pain, and Health","volume":"75","author":"McCracken","year":"2024","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.brainres.2026.150280_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bandc.2025.106305","article-title":"The effect of chronic pain on memory: a systematic review and meta-analysis exploring the impact of nociceptive, neuropathic and nociplastic pain","volume":"187","author":"Kelly","year":"2025","journal-title":"Brain Cogn."},{"issue":"8","key":"10.1016\/j.brainres.2026.150280_b0015","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1001\/jamainternmed.2017.1622","article-title":"Association between Persistent Pain and memory Decline and Dementia in a Longitudinal Cohort of Elders","volume":"177","author":"Whitlock","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.brainres.2026.150280_b0020","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4217593","article-title":"Current Understanding of the Neural Circuitry in the Comorbidity of Chronic Pain and anxiety","volume":"2022","author":"Chen","year":"2022","journal-title":"Neural Plast."},{"key":"10.1016\/j.brainres.2026.150280_b0025","article-title":"Louren\u00e7o da Silva M., Resende Torres da Silva J. Infralimbic medial prefrontal cortex alters electroacupuncture effect in animals with neuropathic chronic pain","volume":"424","author":"Leite","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2026.150280_b0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnbeh.2017.00031","article-title":"Role of the Lateral Habenula in Pain-Associated Depression","volume":"11","author":"Li","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.brainres.2026.150280_b0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jocn.2024.03.034","article-title":"Insular cortex involvement in migraine patients with chronic pain: a volumetric radiological and clinical study","volume":"123","author":"Mammadkhanli","year":"2024","journal-title":"J. Clin. Neurosci."},{"issue":"12","key":"10.1016\/j.brainres.2026.150280_b0040","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1111\/cns.14328","article-title":"Electroacupuncture alleviates mechanical allodynia and anxiety-like behaviors induced by chronic neuropathic pain via regulating rostral anterior cingulate cortex-dorsal raphe nucleus neural circuit","volume":"29","author":"Xu","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"10","key":"10.1016\/j.brainres.2026.150280_b0045","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci14100982","article-title":"Role of the Dorsal Raphe Nucleus in Pain Processing","volume":"14","author":"Zhang","year":"2024","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.brainres.2026.150280_b0050","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1038\/s41467-023-40860-3","article-title":"A glutamatergic DRN-VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2026.150280_b0055","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuroscience.2023.03.019","article-title":"Preoperative Pain Facilitates Postoperative Cognitive Dysfunction via Periaqueductal Gray Matter-Dorsal Raphe Circuit","volume":"524","author":"Deng","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2026.150280_b0060","doi-asserted-by":"crossref","unstructured":"Choi J. E., Choi D. I., Lee J., Kim J., Kim M. J., Hong I., Jung H., Sung Y., Kim J. I., Kim T., Yu N. K., Lee S. H., Choe H. K., Koo J. W., Kim J. H., Kaang B. K. Synaptic ensembles between raphe and D(1)R-containing accumbens shell neurons underlie postisolation sociability in males. Sci Adv 2022 8(41):eabo7527. https:\/\/doi:10.1126\/sciadv.abo7527.","DOI":"10.1126\/sciadv.abo7527"},{"issue":"8036","key":"10.1016\/j.brainres.2026.150280_b0065","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41586-024-07819-w","article-title":"Dopamine-mediated interactions between short- and long-term memory dynamics","volume":"634","author":"Huang","year":"2024","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.brainres.2026.150280_b0070","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41593-018-0174-5","article-title":"Dorsal tegmental dopamine neurons gate associative learning of fear","volume":"21","author":"Groessl","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.brainres.2026.150280_b0075","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuron.2020.02.009","article-title":"The Raphe Dopamine System Controls the Expression of Incentive memory","volume":"106","author":"Lin","year":"2020","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.brainres.2026.150280_b0080","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1021\/acschemneuro.8b00594","article-title":"Sex-Dependent Modulation of anxiety and Fear by 5-HT(1A) Receptors in the Bed Nucleus of the Stria Terminalis","volume":"10","author":"Marcinkiewcz","year":"2019","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.brainres.2026.150280_b0085","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nlm.2016.10.008","article-title":"5-HT2C receptors in the BNST are necessary for the enhancement of fear learning by selective serotonin reuptake inhibitors","volume":"136","author":"Pelrine","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"issue":"1","key":"10.1016\/j.brainres.2026.150280_b0090","first-page":"e209","article-title":"A role for the extended amygdala in the fear-enhancing effects of acute selective serotonin reuptake inhibitor treatment. Transl","volume":"3","author":"Ravinder","year":"2013","journal-title":"Psychiatry"},{"issue":"5","key":"10.1016\/j.brainres.2026.150280_b0095","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tins.2021.01.002","article-title":"The Raphe Dopamine System: Roles in Salience Encoding, memory Expression, and Addiction","volume":"44","author":"Lin","year":"2021","journal-title":"Trends Neurosci."},{"issue":"8","key":"10.1016\/j.brainres.2026.150280_b0100","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.pain.2013.03.002","article-title":"Evidence for working memory deficits in chronic pain: a systematic review and meta-analysis","volume":"154","author":"Berryman","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2026.150280_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2021.673962","article-title":"Cognition and Pain: a Review","volume":"12","author":"Khera","year":"2021","journal-title":"Front. Psychol."},{"issue":"3","key":"10.1016\/j.brainres.2026.150280_b0110","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3233\/JAD-200960","article-title":"The potential Contribution of Chronic Pain and Common Chronic Pain Conditions to subsequent Cognitive Decline, New Onset Cognitive Impairment, and Incident Dementia: a Systematic Review and Conceptual Model for Future Research","volume":"78","author":"Innes","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2026.150280_b0115","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.2147\/JIR.S379093","article-title":"Normalization of Neuroinflammation: a New Strategy for Treatment of Persistent Pain and Memory\/Emotional Deficits in Chronic Pain","volume":"15","author":"Liu","year":"2022","journal-title":"J. Inflamm. Res."},{"issue":"2","key":"10.1016\/j.brainres.2026.150280_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12020132","article-title":"Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM)","volume":"12","author":"Baraniuk","year":"2022","journal-title":"Brain Sci."},{"issue":"3","key":"10.1016\/j.brainres.2026.150280_b0125","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14335","article-title":"Modulatory effects of acupuncture on raphe nucleus-related brain circuits in patients with chronic neck pain: A randomized neuroimaging trial","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci Ther"},{"issue":"11","key":"10.1016\/j.brainres.2026.150280_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115636","article-title":"Activation of Pedunculopontine Tegmental Nucleus Alleviates the Pain Induced by the Lesion of Midbrain DAergic Neurons","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"10","key":"10.1016\/j.brainres.2026.150280_b0135","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/s41593-019-0468-2","article-title":"A neural circuit for comorbid depressive symptoms in chronic pain","volume":"22","author":"Zhou","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2026.150280_b0140","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/j.pain.0000000000003362","article-title":"Activation of GABAergic neurons in the dorsal raphe nucleus alleviates hyperalgesia induced by ovarian hormone withdrawal","volume":"166","author":"Wu","year":"2025","journal-title":"Pain"},{"key":"10.1016\/j.brainres.2026.150280_b0145","doi-asserted-by":"crossref","unstructured":"Yu W., Pati D., Pina M. M., Schmidt K. T., Boyt K. M., Hunker A. C., Zweifel L. S., McElligott Z. A., Kash T. L. Periaqueductal gray\/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors. Neuron 2021 109(8):1365-80.e5. https:\/\/doi:10.1016\/j.neuron.2021.03.001.","DOI":"10.1016\/j.neuron.2021.03.001"},{"issue":"1","key":"10.1016\/j.brainres.2026.150280_b0150","first-page":"408","article-title":"Dorsal raphe DAergic neurons target CaMKII(+) neurons in dorsal bed nucleus of the stria terminalis for mediating depression-related behaviors. Transl","volume":"14","author":"Wang","year":"2024","journal-title":"Psychiatry"},{"key":"10.1016\/j.brainres.2026.150280_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2019.109730","article-title":"Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety","volume":"96","author":"Donner","year":"2020","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.brainres.2026.150280_b0160","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1523\/JNEUROSCI.1944-20.2020","article-title":"Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear memory consolidation in mice","volume":"41","author":"Bruzsik","year":"2021","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.brainres.2026.150280_b0165","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1101\/lm.044206.116","article-title":"Role of the bed nucleus of the stria terminalis in aversive learning and memory","volume":"24","author":"Goode","year":"2017","journal-title":"Learn. Mem."},{"issue":"14","key":"10.1016\/j.brainres.2026.150280_b0170","doi-asserted-by":"crossref","first-page":"8104","DOI":"10.1073\/pnas.1915501117","article-title":"Bed nuclei of the stria terminalis modulate memory consolidation via glucocorticoid-dependent and -independent circuits","volume":"117","author":"Lingg","year":"2020","journal-title":"PNAS"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326001393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326001393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:04:21Z","timestamp":1777363461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326001393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":34,"alternative-id":["S0006899326001393"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150280","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dopaminergic neurons in the dorsal raphe nucleus are involved in the regulation of memory impairment in chronic pain","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150280"}}