{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:21:56Z","timestamp":1783117316423,"version":"3.54.6"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AAG9758 233 349500 4"],"award-info":[{"award-number":["AAG9758 233 349500 4"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM135119"],"award-info":[{"award-number":["T32GM135119"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51OD011106"],"award-info":[{"award-number":["P51OD011106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001395","name":"Wisconsin Alumni Research Foundation Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.brainres.2026.150364","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:49:34Z","timestamp":1777762174000},"page":"150364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer\u2019s disease-like pathology"],"prefix":"10.1016","volume":"1886","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0154-8564","authenticated-orcid":false,"given":"Lauren E.","family":"Sarko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Klaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriya","family":"Bondarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8764-1797","authenticated-orcid":false,"given":"Callista","family":"Secker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7914-763X","authenticated-orcid":false,"given":"Mackenzie S.","family":"Mnuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn M.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Shippy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6507-4989","authenticated-orcid":false,"given":"Tyler K.","family":"Ulland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-0858","authenticated-orcid":false,"given":"Krishanu","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9351-6641","authenticated-orcid":false,"given":"Marina E.","family":"Emborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-2668","authenticated-orcid":false,"given":"Jeanette M.","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2026.150364_b0005","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70051","article-title":"The role of glial cell senescence in Alzheimer\u2019s disease","volume":"169","author":"Alshaebi","year":"2025","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2026.150364_b0010","unstructured":"Alzheimer\u2019s Association, 2025. Alzheimer\u2019s disease facts and figures. Alzheimer\u2019s Association."},{"key":"10.1016\/j.brainres.2026.150364_b0015","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s43587-023-00560-5","article-title":"Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction","volume":"4","author":"Amor","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.brainres.2026.150364_b0020","first-page":"1053","article-title":"Brain region-specific differences in amyloid-\u03b2 plaque composition in 5XFAD mice","volume":"13","author":"Bader","year":"2023","journal-title":"Life (basel)"},{"key":"10.1016\/j.brainres.2026.150364_b0025","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI95145","article-title":"Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives","volume":"128","author":"Baker","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2026.150364_b0030","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2026.150364_b0035","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-024-07516-8","article-title":"Senescent glia link mitochondrial dysfunction and lipid accumulation","volume":"630","author":"Byrns","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2026.150364_b0040","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2026.150364_b0045","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dadm.2014.12.001","article-title":"Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer\u2019s disease","volume":"1","author":"Carlesimo","year":"2015","journal-title":"Alzheimers Dement. (amst.)"},{"key":"10.1016\/j.brainres.2026.150364_b0050","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3233\/JAD-231383","article-title":"Gene association study of the urokinase plasminogen activator and its receptor gene in Alzheimer\u2019s disease","volume":"99","author":"Cetinsoy","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2026.150364_b0055","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2026.150364_b0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.brainres.2026.150364_b0065","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.biopsych.2008.07.024","article-title":"Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease","volume":"65","author":"Cunningham","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2026.150364_b0070","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/glia.20892","article-title":"Microglia and the urokinase plasminogen activator receptor\/uPA system in innate brain inflammation","volume":"57","author":"Cunningham","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2026.150364_b0075","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0736-5748(99)00031-3","article-title":"Localization of urokinase-type plasminogen activator, its receptor, and inhibitors in mouse forebrain during postnatal development","volume":"17","author":"Del Bigio","year":"1999","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2026.150364_b0085","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1523\/JNEUROSCI.2804-19.2020","article-title":"Urokinase-type plasminogen activator protects cerebral cortical neurons from soluble A\u03b2-induced synaptic damage","volume":"40","author":"Diaz","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0090","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1177\/0271678X18783653","article-title":"Urokinase-type plasminogen activator (uPA) protects the tripartite synapse in the ischemic brain via ezrin-mediated formation of peripheral astrocytic processes","volume":"39","author":"Diaz","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2026.150364_b0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1742-2094-11-48","article-title":"Microglia receptors and their implications in the response to amyloid \u03b2 for Alzheimer\u2019s disease pathogenesis","volume":"11","author":"Doens","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2026.150364_b0100","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1523\/JNEUROSCI.20-01-00230.2000","article-title":"The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF-driven differentiation","volume":"20","author":"Farias-Eisner","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0105","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s40478-022-01447-z","article-title":"Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer\u2019s disease","volume":"10","author":"Faridar","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.brainres.2026.150364_b0110","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41597-021-01054-y","article-title":"Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"8","author":"Forner","year":"2021","journal-title":"Sci. Data"},{"key":"10.1016\/j.brainres.2026.150364_b0115","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41467-021-23111-1","article-title":"Transcriptional signature in microglia associated with A\u03b2 plaque phagocytosis","volume":"12","author":"Grubman","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2026.150364_b0120","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.tins.2021.06.007","article-title":"Cellular senescence at the crossroads of inflammation and Alzheimer\u2019s disease","volume":"44","author":"Guerrero","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0125","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainres.2026.150364_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109228","article-title":"Replicative senescence dictates the emergence of disease-associated microglia and contributes to A\u03b2 pathology","volume":"35","author":"Hu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainres.2026.150364_b0135","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.3390\/cancers17203309","article-title":"The urokinase-type plasminogen activator receptor (uPAR) as a mediator of physiological and pathological processes: potential therapeutic strategies","volume":"17","author":"Iftikhar","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.brainres.2026.150364_b0140","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2026.150364_b0145","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11055-025-01752-9","article-title":"Plaur and Plat genes are early upregulated in response to environmental novelty in mouse brain","volume":"55","author":"Klimovich","year":"2025","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.brainres.2026.150364_b0150","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuroscience.2009.06.019","article-title":"Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus","volume":"163","author":"Lahtinen","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2026.150364_b0155","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s41467-023-37304-3","article-title":"An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer\u2019s disease","volume":"14","author":"Lau","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2026.150364_b0160","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00702-010-0433-4","article-title":"The role of microglia in amyloid clearance from the AD brain","volume":"117","author":"Lee","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"Suppl 7","key":"10.1016\/j.brainres.2026.150364_b0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1528-1167.2005.00305.x","article-title":"Disruption of interneuron development","volume":"46","author":"Levitt","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2026.150364_b0170","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/jnr.22419","article-title":"Increased expression of urokinase-type plasminogen activator receptor in the frontal cortex of patients with intractable frontal lobe epilepsy","volume":"88","author":"Liu","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2026.150364_b0175","article-title":"Aging, Cellular Senescence, and Alzheimer\u2019s Disease","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainres.2026.150364_b0180","doi-asserted-by":"crossref","unstructured":"Liu, Y., Chen, J., 2024. Senescence-related genes and proteins in the development of Alzheimer\u2019s disease: evidence from transcriptomic and Mendelian randomization analysis. Front. Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2024.1423725.","DOI":"10.3389\/fnagi.2024.1423725"},{"key":"10.1016\/j.brainres.2026.150364_b0185","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.neuron.2024.01.024","article-title":"Mechanisms of sex differences in Alzheimer\u2019s disease","volume":"112","author":"Lopez-Lee","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2026.150364_b0190","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.brainres.2026.150364_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2025.578552","article-title":"Sugar utilization by microglia in Alzheimer\u2019s disease","volume":"401","author":"Marino","year":"2025","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2026.150364_b0200","doi-asserted-by":"crossref","unstructured":"Marino, K.M., Squirrell, J.M., Chacko, J.V., Watters, J.W., Eliceiri, K.W., Ulland, T.K., 2023. Metabolic response of microglia to amyloid deposition during Alzheimer\u2019s disease progression in a mouse model. bioRxivorg. https:\/\/doi.org\/10.1101\/2023.05.12.540407.","DOI":"10.1101\/2023.05.12.540407"},{"key":"10.1016\/j.brainres.2026.150364_b0205","doi-asserted-by":"crossref","first-page":"E1316","DOI":"10.1073\/pnas.1525466113","article-title":"The adaptive immune system restrains Alzheimer\u2019s disease pathogenesis by modulating microglial function","volume":"113","author":"Marsh","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.brainres.2026.150364_b0210","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.stemcr.2016.12.019","article-title":"HuCNS-SC human NSCs fail to differentiate, form ectopic clusters, and provide no cognitive benefits in a transgenic model of Alzheimer\u2019s disease","volume":"8","author":"Marsh","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.brainres.2026.150364_b0215","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fncel.2020.00016","article-title":"Cellular Senescence in Neurodegenerative Diseases","volume":"14","author":"Mart\u00ednez-Cu\u00e9","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0220","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00018-022-04310-5","article-title":"IL4 stimulated macrophages promote axon regeneration after peripheral nerve injury by secreting uPA to stimulate uPAR upregulated in injured axons","volume":"79","author":"Matsui","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.brainres.2026.150364_b0225","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bbadis.2015.10.011","article-title":"The plasminogen activation system in neuroinflammation","volume":"1862","author":"Mehra","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainres.2026.150364_b0230","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1538\/expanim.58.141","article-title":"Genetic differences among C57BL\/6 substrains","volume":"58","author":"Mekada","year":"2009","journal-title":"Exp. Anim."},{"key":"10.1016\/j.brainres.2026.150364_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102141","article-title":"Cellular senescence in brain aging and neurodegeneration","volume":"93","author":"Melo Dos Santos","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.brainres.2026.150364_b0240","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1074\/jbc.M116.761650","article-title":"Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central nervous System","volume":"292","author":"Merino","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2026.150364_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121959","article-title":"Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins","volume":"293","author":"Metzger","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.brainres.2026.150364_b0250","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.brainres.2026.150364_b0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271651","article-title":"Metabolic differences and differentially expressed genes between C57BL\/6J and C57BL\/6N mice substrains","volume":"17","author":"Nemoto","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.brainres.2026.150364_b0260","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.713726","article-title":"Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing applications: a MODEL-AD Study","volume":"13","author":"Oblak","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0270","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5272014","article-title":"Early detection of A\u03b2 deposition in the 5xFAD mouse by amyloid PET","volume":"2018","author":"Oh","year":"2018","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.brainres.2026.150364_b0275","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/cells12050780","article-title":"Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer\u2019s Disease","volume":"12","author":"Poon","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.brainres.2026.150364_b0280","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1523\/JNEUROSCI.23-02-00622.2003","article-title":"Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction","volume":"23","author":"Powell","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0285","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.780641","article-title":"Soluble urokinase plasminogen activator receptor (suPAR) as a biomarker of systemic chronic inflammation","volume":"12","author":"Rasmussen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.brainres.2026.150364_b0290","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-024-01033-z","article-title":"Therapeutic targeting of senescent cells in the CNS","volume":"23","author":"Riessland","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.brainres.2026.150364_b0295","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-024-00402-3","article-title":"Emerging role of senescent microglia in brain aging-related neurodegenerative diseases","volume":"13","author":"Rim","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.brainres.2026.150364_b0300","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2026.150364_b0305","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.brainres.2026.150364_b0310","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/ejn.14584","article-title":"Urokinase receptor and tissue plasminogen activator as immediate-early genes in pentylenetetrazole-induced seizures in the mouse brain","volume":"51","author":"Shmakova","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0315","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3233\/JAD-210523","article-title":"Sex differences in behavior and molecular pathology in the 5XFAD model","volume":"85","author":"Sil","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainres.2026.150364_b0320","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/brain\/aww016","article-title":"Eliminating microglia in Alzheimer\u2019s mice prevents neuronal loss without modulating amyloid-\u03b2 pathology","volume":"139","author":"Spangenberg","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2026.150364_b0325","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2199-10-75","article-title":"Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells","volume":"10","author":"Stewart","year":"2009","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.brainres.2026.150364_b0330","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1038\/ncomms13180","article-title":"Nlrp12 mutation causes C57BL\/6J strain-specific defect in neutrophil recruitment","volume":"7","author":"Ulland","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2026.150364_b0335","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2026.150364_b0340","doi-asserted-by":"crossref","unstructured":"Walton, C.C., Begelman, D., Nguyen, W., Andersen, J.K., 2020. Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis. Front. Cell. Neurosci 14.","DOI":"10.3389\/fncel.2020.00129"},{"key":"10.1016\/j.brainres.2026.150364_b0345","doi-asserted-by":"crossref","first-page":"14219","DOI":"10.1523\/JNEUROSCI.5309-13.2014","article-title":"Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke","volume":"34","author":"Wu","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2026.150364_b0350","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jphs.2025.01.002","article-title":"C57BL\/6J and C57BL\/6N mice show distinct aging-associated behavioral alterations","volume":"157","author":"Yamada","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2026.150364_b0355","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/s41590-023-01627-6","article-title":"APOE4 impairs the microglial response in Alzheimer\u2019s disease by inducing TGF\u03b2-mediated checkpoints","volume":"24","author":"Yin","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.brainres.2026.150364_b0360","article-title":"A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy","author":"Zhang","year":"2026","journal-title":"Cell"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326002234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326002234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:01:11Z","timestamp":1783116071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326002234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":72,"alternative-id":["S0006899326002234"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150364","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer\u2019s disease-like pathology","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150364"}}