{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:03:50Z","timestamp":1784135030583,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["40118012"],"award-info":[{"award-number":["40118012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.brainres.2026.150396","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:18:09Z","timestamp":1780298289000},"page":"150396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Early and sustained Intervention with YKB Modulates the Cerebro-Retinal-Synaptic Network to Ameliorate Memory Deficits in Alzheimer\u2019s Disease"],"prefix":"10.1016","volume":"1888","author":[{"given":"Yunjun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxue","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nila","family":"Sayami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-6124","authenticated-orcid":false,"given":"Heng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0353-1436","authenticated-orcid":false,"given":"Ping","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2026.150396_b0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuroscience.2026.01.010","article-title":"A multi-target therapeutic framework for Alzheimer's disease: an integrative mechanistic review","volume":"596","author":"Bajinka","year":"2026","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2026.150396_b0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.mcb.2017.08.010","article-title":"Basement membrane collagen IV: Isolation of functional domains","volume":"143","author":"Boudko","year":"2018","journal-title":"Methods Cell Biol."},{"issue":"24","key":"10.1016\/j.brainres.2026.150396_b0015","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive Review on Alzheimer's Disease: Causes and Treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.brainres.2026.150396_b0020","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/glia.23924","article-title":"Astrocytes in the regulation of cerebrovascular functions","volume":"69","author":"Cohen-Salmon","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.brainres.2026.150396_b0025","doi-asserted-by":"crossref","first-page":"9486","DOI":"10.1038\/s41598-019-45971-w","article-title":"PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment","volume":"9","author":"Coley","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2026.150396_b0030","article-title":"Alzheimer's disease drug development pipeline: 2023","volume":"9","author":"Cummings","year":"2023","journal-title":"Alzheimers Dement (n y)."},{"key":"10.1016\/j.brainres.2026.150396_b0035","article-title":"The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias","volume":"21","author":"Huang","year":"2025","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainres.2026.150396_b0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit coming of Age: a Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2026.150396_b0045","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1586\/ern.11.155","article-title":"Distinguishing Alzheimer's disease from other major forms of dementia","volume":"11","author":"Karantzoulis","year":"2011","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.brainres.2026.150396_b0050","series-title":"Organ-Brain Axis in Alzheimer's Disease: a Systemic Perspective on Pathogenesis and Progression","author":"Kim","year":"2026"},{"key":"10.1016\/j.brainres.2026.150396_b0055","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrn.2017.48","article-title":"Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease","volume":"18","author":"Kisler","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2026.150396_b0060","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature20145","article-title":"Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour","volume":"539","author":"Ma","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2026.150396_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbas.2022.100035","article-title":"Capillary function progressively deteriorates in prodromal Alzheimer's disease: a longitudinal MRI perfusion study","volume":"2","author":"Madsen","year":"2022","journal-title":"Aging Brain."},{"key":"10.1016\/j.brainres.2026.150396_b0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41467-019-13956-y","article-title":"Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow","volume":"11","author":"Marina","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainres.2026.150396_bib106","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2019"},{"key":"10.1016\/j.brainres.2026.150396_b0075","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s43587-023-00410-4","article-title":"Detection and treatment of Alzheimer's disease in its preclinical stage","volume":"3","author":"Rafii","year":"2023","journal-title":"Nat. Aging"},{"issue":"5594","key":"10.1016\/j.brainres.2026.150396_bib107","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer\u2019s disaseas is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.brainres.2026.150396_b0080","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1002\/alz.13086","article-title":"Retinal arterial A\u03b2(40) deposition is linked with tight junction loss and cerebral amyloid angiopathy in MCI and AD patients","volume":"19","author":"Shi","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainres.2026.150396_b0085","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jnr.22227","volume":"88","author":"Sultana","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2026.150396_b0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainres.2026.150396_b0095","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in Early Alzheimer's Disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2026.150396_b0100","unstructured":"World Health Organization, G., 2019. Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. WHO Guidelines Approved by the Guidelines Review Committee., Vol. (Report No.: CC BY-NC-SA 3.0 IGO). World Health Organization, Geneva."},{"key":"10.1016\/j.brainres.2026.150396_b0105","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326002568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326002568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:10:47Z","timestamp":1784131847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326002568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":23,"alternative-id":["S0006899326002568"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150396","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early and sustained Intervention with YKB Modulates the Cerebro-Retinal-Synaptic Network to Ameliorate Memory Deficits in Alzheimer\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150396"}}