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Neurosci."},{"issue":"4","key":"10.1016\/j.brainres.2026.150478_b0345","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s12264-014-1454-4","article-title":"Non-apoptotic role of caspase-3 in synapse refinement","volume":"30","author":"Wang","year":"2014","journal-title":"Neurosci. Bull."},{"issue":"4","key":"10.1016\/j.brainres.2026.150478_b0350","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0091-6773(76)90901-9","article-title":"Open-field behavior in muroid rodents","volume":"17","author":"Wilson","year":"1976","journal-title":"Behav. Biol."},{"key":"10.1016\/j.brainres.2026.150478_b0355","unstructured":"World Health Organization, 2023. Osteoarthritis. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/osteoarthritis."},{"key":"10.1016\/j.brainres.2026.150478_b0360","unstructured":"World Health Organization, 2024. Ageing and health. https:\/\/www.who.int\/news-room\/fact- sheets\/detail\/ageing-and-health."},{"issue":"3","key":"10.1016\/j.brainres.2026.150478_b0365","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tins.2016.01.006","article-title":"Neural mechanisms underlying anxiety\u2013chronic pain interactions","volume":"39","author":"Zhuo","year":"2016","journal-title":"Trends Neurosci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326003409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326003409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:11:38Z","timestamp":1788797498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326003409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":73,"alternative-id":["S0006899326003409"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150478","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-dependent neuronal loss and apoptotic signaling in the anterior cingulate and anterior insular cortices associated with anxio-depressive-like behaviors in a late-stage monoiodoacetate mouse model of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). 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