{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:59:56Z","timestamp":1790729996041,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173388"],"award-info":[{"award-number":["82173388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.brainres.2026.150561","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:32:50Z","timestamp":1790177570000},"page":"150561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MYH gene family associated with high mortality risk in elderly glioma patients with frontal lobe primary site"],"prefix":"10.1016","volume":"1893","author":[{"given":"Pengfei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.brainres.2026.150561_b0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-022-01513-z","article-title":"Glioma targeted therapy: insight into future of molecular approaches","volume":"21","author":"Yang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"18","key":"10.1016\/j.brainres.2026.150561_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e37712","article-title":"Clinical sequencing reveals diagnostic, therapeutic, and prognostic biomarkers for adult-type diffuse gliomas","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.brainres.2026.150561_b0015","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13287-018-0977-z","article-title":"Current status and potential challenges of mesenchymal stem cell-based therapy for malignant gliomas","volume":"9","author":"Zhang","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.brainres.2026.150561_b0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pharmthera.2015.05.005","article-title":"Glioblastoma multiforme: Pathogenesis and treatment","volume":"152","author":"Alifieris","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2026.150561_b0025","doi-asserted-by":"crossref","unstructured":"Schwartzbaum J A, Fisher J L, Aldape K D, et al. Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol, 2006,2(9): 494-503, 1-516.","DOI":"10.1038\/ncpneuro0289"},{"key":"10.1016\/j.brainres.2026.150561_b0030","doi-asserted-by":"crossref","unstructured":"Rathore S, Mohan S, Bakas S, et al. Multi-institutional noninvasive in vivo characterization of Idh, 1p\/19q, and Egfrviii in glioma using neuro-Cancer Imaging Phenomics Toolkit (neuro-CAPTK). Neurooncol Adv, 2020,2(Suppl 4): iv22-iv34.","DOI":"10.1093\/noajnl\/vdaa128"},{"key":"10.1016\/j.brainres.2026.150561_b0035","doi-asserted-by":"crossref","unstructured":"Horbinski C, Berger T, Packer R J, et al. Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours. Nat Rev Neurol, 2022,18(9): 515-529.","DOI":"10.1038\/s41582-022-00679-w"},{"issue":"8","key":"10.1016\/j.brainres.2026.150561_b0040","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 Who Classification of Tumors of the Central Nervous System: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"issue":"6","key":"10.1016\/j.brainres.2026.150561_b0045","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1212\/CON.0000000000001352","article-title":"Adult-type Diffuse Gliomas","volume":"29","author":"de la Fuente","year":"2023","journal-title":"Continuum (Minneap Minn)"},{"key":"10.1016\/j.brainres.2026.150561_b0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jocn.2017.10.041","article-title":"Patient and treatment factors associated with survival among pediatric glioblastoma patients: A Surveillance, Epidemiology, and End Results study","volume":"47","author":"Lam","year":"2018","journal-title":"J. Clin. Neurosci."},{"issue":"12","key":"10.1016\/j.brainres.2026.150561_b0055","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jocn.2014.05.011","article-title":"Prognosis by tumor location in adults with intracranial ependymomas","volume":"21","author":"Sayegh","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.brainres.2026.150561_b0060","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1016\/j.wneu.2018.01.055","article-title":"Correlation Between Tumor Location and Clinical Properties of Glioblastomas in Frontal and Temporal Lobes","volume":"112","author":"Li","year":"2018","journal-title":"World Neurosurg."},{"issue":"6","key":"10.1016\/j.brainres.2026.150561_b0065","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S1470-2045(23)00185-7","article-title":"The prognosis of patients with small cell carcinoma of the cervix: a retrospective study of the Seer database and a Chinese multicentre registry","volume":"24","author":"Chu","year":"2023","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.brainres.2026.150561_b0070","unstructured":"Surveillance, Epidemiology, and End Results (Seer) Program (www.seer.cancer.gov) Seer*Stat Database: Incidence - Seer Research Data, 17 Registries, Nov 2023 Sub (2000-2021) - Linked To County Attributes - Time Dependent (1990-2022) Income\/Rurality, 1969-2022 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, released April 2024, based on the November 2023 submission[Z]."},{"issue":"3","key":"10.1016\/j.brainres.2026.150561_b0075","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s11060-022-04114-4","article-title":"Sex as a prognostic factor in adult-type diffuse gliomas: an integrated clinical and molecular analysis according to the 2021 Who classification","volume":"159","author":"Kim","year":"2022","journal-title":"J. Neurooncol"},{"issue":"2","key":"10.1016\/j.brainres.2026.150561_b0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11060-024-04656-9","article-title":"Revisiting prognostic factors of gliomatosis cerebri in adult-type diffuse gliomas","volume":"168","author":"Shin","year":"2024","journal-title":"J. Neurooncol"},{"key":"10.1016\/j.brainres.2026.150561_b0085","first-page":"10","volume":"14","author":"Grochans","year":"2022","journal-title":"Epidemiology of Glioblastoma Multiforme-Literature Review. Cancers (Basel)"},{"key":"10.1016\/j.brainres.2026.150561_b0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.wneu.2017.06.126","article-title":"Clinical and Molecular Prognostic Factors for Long-Term Survival of Patients with Glioblastomas in Single-Institutional Consecutive Cohort","volume":"106","author":"Nakagawa","year":"2017","journal-title":"World Neurosurg."},{"issue":"1","key":"10.1016\/j.brainres.2026.150561_b0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/neuonc\/nos268","article-title":"Relationship of glioblastoma multiforme to the subventricular zone is associated with survival","volume":"15","author":"Jafri","year":"2013","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.brainres.2026.150561_b0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1748-717X-9-95","article-title":"A comparison of long-term survivors and short-term survivors with glioblastoma, subventricular zone involvement: a predictive factor for survival?","volume":"9","author":"Adeberg","year":"2014","journal-title":"Radiat. Oncol."},{"issue":"6967","key":"10.1016\/j.brainres.2026.150561_b0105","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1136\/bmj.309.6967.1480","article-title":"Confounding and Simpson's paradox","volume":"309","author":"Julious","year":"1994","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.brainres.2026.150561_b0110","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","article-title":"Eano guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.brainres.2026.150561_b0115","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJMoa0808710","article-title":"Idh1 and Idh2 mutations in gliomas","volume":"360","author":"Yan","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.brainres.2026.150561_b0120","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11060-015-1798-x","article-title":"Age-associated brain regions in gliomas: a volumetric analysis","volume":"123","author":"Wang","year":"2015","journal-title":"J. Neurooncol"},{"issue":"34","key":"10.1016\/j.brainres.2026.150561_b0125","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1200\/JCO.2010.33.8715","article-title":"Evidence for sequenced molecular evolution of Idh1 mutant glioblastoma from a distinct cell of origin","volume":"29","author":"Lai","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.brainres.2026.150561_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116118","article-title":"Myh9: A key protein involved in tumor progression and virus-related diseases","volume":"171","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.brainres.2026.150561_b0135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tibs.2019.11.003","article-title":"The Cytoskeleton as Regulator of Cell Signaling Pathways","volume":"45","author":"Moujaber","year":"2020","journal-title":"Trends Biochem. Sci"},{"issue":"6","key":"10.1016\/j.brainres.2026.150561_b0140","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.celrep.2017.07.032","article-title":"The Epithelial Circumferential Actin Belt Regulates Yap\/Taz through Nucleocytoplasmic Shuttling of Merlin","volume":"20","author":"Furukawa","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.brainres.2026.150561_b0145","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1091\/mbc.e16-06-0467","article-title":"Opposing roles for distinct Linc complexes in regulation of the small Gtpase RhoA","volume":"28","author":"Thakar","year":"2017","journal-title":"Mol. Biol. Cell"},{"issue":"9","key":"10.1016\/j.brainres.2026.150561_b0150","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1073\/pnas.1809683116","article-title":"Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging","volume":"116","author":"Chang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"10.1016\/j.brainres.2026.150561_b0155","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1007\/s00018-019-03153-x","article-title":"Death for life: a path from apoptotic signaling to tissue-scale effects of apoptotic epithelial extrusion","volume":"76","author":"Gagliardi","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.brainres.2026.150561_b0160","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.cellsig.2014.04.007","article-title":"Microtubule dynamics regulates Akt signaling via dynactin p150","volume":"26","author":"Jo","year":"2014","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.brainres.2026.150561_b0165","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41467-018-04121-y","article-title":"Tak1 activation of alpha-Tat1 and microtubule hyperacetylation control Akt signaling and cell growth","volume":"9","author":"Shah","year":"2018","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.brainres.2026.150561_b0170","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a023234","article-title":"Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells","volume":"9","author":"Bachir","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"5","key":"10.1016\/j.brainres.2026.150561_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050434","article-title":"Rho Gtpases-Emerging Regulators of Glucose Homeostasis and Metabolic Health","volume":"8","author":"Moller","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.brainres.2026.150561_b0180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ceb.2018.08.003","article-title":"Regulation of actin dynamics by Pi(4,5)P(2) in cell migration and endocytosis","volume":"56","author":"Senju","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"issue":"10","key":"10.1016\/j.brainres.2026.150561_b0185","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.tcb.2017.06.004","article-title":"Tensins: Bridging Amp-Activated Protein Kinase with Integrin Activation","volume":"27","author":"Georgiadou","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.brainres.2026.150561_b0190","doi-asserted-by":"crossref","first-page":"10029","DOI":"10.1038\/ncomms10029","article-title":"A molecular ruler regulates cytoskeletal remodelling by the Rho kinases","volume":"6","author":"Truebestein","year":"2015","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.brainres.2026.150561_b0195","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111961","article-title":"Dna damage repair kinase Dna-Pk and cgas synergize to induce cancer-related inflammation in glioblastoma","volume":"42","author":"Taffoni","year":"2023","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.brainres.2026.150561_b0200","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41419-025-08226-3","article-title":"Lmna-Prkdc axis enhances Dna repair and promotes chemoresistance in glioblastoma","volume":"17","author":"Saathoff","year":"2025","journal-title":"Cell Death Dis."},{"issue":"15","key":"10.1016\/j.brainres.2026.150561_b0205","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1158\/0008-5472.CAN-08-1079","article-title":"Targeting cancer stem cells through L1cam suppresses glioma growth","volume":"68","author":"Bao","year":"2008","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.brainres.2026.150561_b0210","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/emboj.2011.10","article-title":"L1cam regulates Dna damage checkpoint response of glioblastoma stem cells through Nbs1","volume":"30","author":"Cheng","year":"2011","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.brainres.2026.150561_b0215","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1158\/1078-0432.CCR-18-2946","article-title":"Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma","volume":"25","author":"Indira Chandran","year":"2019","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.brainres.2026.150561_b0220","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s11658-025-00806-7","article-title":"Microrna strand ratio disarray promotes temozolomide resistance in glioblastoma","volume":"30","author":"Shen","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"8","key":"10.1016\/j.brainres.2026.150561_b0225","first-page":"2480","article-title":"Death-associated protein 3 (Dap-3) is overexpressed in invasive glioblastoma cells in vivo and in glioma cell lines with induced motility phenotype in vitro","volume":"7","author":"Mariani","year":"2001","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.brainres.2026.150561_b0230","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.71142","article-title":"High Alg1 Expression Is Correlated With Poor Prognosis and the Immune Microenvironment in Glioma","volume":"30","author":"Li","year":"2026","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.brainres.2026.150561_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156174","article-title":"Mettl1 drives glioma progression by promoting N7-methylguanosine (m7G) modification of glycolysis-related enzyme Pgk1","volume":"274","author":"Fan","year":"2025","journal-title":"Pathol. Res. Pract."},{"issue":"8","key":"10.1016\/j.brainres.2026.150561_b0240","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1002\/jcp.30277","article-title":"Circular Rna circhectd1 facilitates glioma progression by regulating the miR-296-3p\/Slc10A7 axis","volume":"236","author":"Li","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.brainres.2026.150561_b0245","article-title":"Suppression of Glioblastoma Proliferation by Inducing Oxidative Stress via Modulation of Txndc12 Expression","author":"Zhang","year":"2024","journal-title":"International Journal of Cancer Management"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326004233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326004233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:52:13Z","timestamp":1790729533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326004233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":49,"alternative-id":["S0006899326004233"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150561","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MYH gene family associated with high mortality risk in elderly glioma patients with frontal lobe primary site","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150561"}}