{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:55:31Z","timestamp":1791316531014,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2003J011520"],"award-info":[{"award-number":["2003J011520"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.brainres.2026.150562","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:42:25Z","timestamp":1790264545000},"page":"150562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hypoxic bone marrow mesenchymal stem cell-derived exosomes promote neurovascular repair in ischemic stroke with CXCR4-Associated enhancement"],"prefix":"10.1016","volume":"1893","author":[{"given":"Xiaolan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.brainres.2026.150562_b0005","article-title":"Stroke: Epidemiology, Risk Factors","volume":"6","author":"Ren","year":"2025","journal-title":"Signaling Pathways, and Clinical Management. Medcomm"},{"key":"10.1016\/j.brainres.2026.150562_b0010","article-title":"Ferroptosis in ischemic stroke: from a glia-neuron crosstalk perspective","volume":"257","author":"Zhang","year":"2025","journal-title":"Prog. Neurobiol."},{"issue":"12","key":"10.1016\/j.brainres.2026.150562_b0015","doi-asserted-by":"crossref","DOI":"10.1002\/cns.70687","article-title":"Cellular Communication Networks Mediated by Microglia in Ischemic Stroke","volume":"31","author":"Ma","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainres.2026.150562_b0020","article-title":"Flipping the Switch: MeCP2-Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2\/mTOR Axis in Poststroke Neuroinflammation","author":"Zhang","year":"2025","journal-title":"Adv Sci (weinh)"},{"key":"10.1016\/j.brainres.2026.150562_b0025","article-title":"Inhibition of SCD1 attenuates neuroinflammation and brain injury after cerebral ischemia-reperfusion","volume":"111693","author":"Li","year":"2025","journal-title":"Brain Res. Bull."},{"issue":"10","key":"10.1016\/j.brainres.2026.150562_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci15101111","article-title":"Multimodal Neuroprotection in Ischemic Stroke: Emerging Non-Pharmacological Interventions from Bench to Bedside","volume":"15","author":"Cui","year":"2025","journal-title":"Brain Sci."},{"key":"10.1016\/j.brainres.2026.150562_b0035","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbaf109","article-title":"The impact of microstructure and extracellular matrix suspension on the proliferation of bone marrow-derived mesenchymal stem cells for osteochondral defect repair","volume":"12","author":"Stocco","year":"2025","journal-title":"Regen Biomater"},{"key":"10.1016\/j.brainres.2026.150562_b0040","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-025-06468-7","article-title":"Exosomal miR-223-3p from mesenchymal stem cells targets FBXW7 to inhibit intervertebral disc degeneration: mechanism insights","author":"Chen","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.brainres.2026.150562_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110999","article-title":"Stem cell grafts enhance endogenous extracellular vesicle expression in the stroke brain","volume":"214","author":"Brooks","year":"2024","journal-title":"Brain Res. Bull."},{"issue":"9","key":"10.1016\/j.brainres.2026.150562_b0050","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.4239\/wjd.v15.i9.1978","article-title":"Bone marrow-derived mesenchymal stem cell-derived exosome-loaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage","volume":"15","author":"Wang","year":"2024","journal-title":"World J. Diabetes"},{"issue":"7","key":"10.1016\/j.brainres.2026.150562_b0055","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1007\/s12035-023-03301-2","article-title":"Bone Marrow Mesenchymal Stem Cell-Derived Exosomal KLF4 Alleviated Ischemic Stroke through Inhibiting N6-Methyladenosine Modification Level of Drp1 by Targeting lncRNA-ZFAS1","volume":"60","author":"Wang","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.brainres.2026.150562_b0060","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/2211-5463.13142","article-title":"Exosomal HMGB1 derived from hypoxia-conditioned bone marrow mesenchymal stem cells increases angiogenesis via the JNK\/HIF-1\u03b1 pathway","volume":"11","author":"Gao","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.brainres.2026.150562_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1198546","article-title":"Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Neurol."},{"issue":"12","key":"10.1016\/j.brainres.2026.150562_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2025.108481","article-title":"White matter injury in young rats with cerebral palsy: the role of massage in regulating exosomes via the chemokine axis","volume":"34","author":"Yiping","year":"2025","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"14","key":"10.1016\/j.brainres.2026.150562_b0075","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1523\/JNEUROSCI.22-14-05865.2002","article-title":"A dual role for the SDF-1\/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia","volume":"22","author":"Stumm","year":"2002","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.brainres.2026.150562_b0080","doi-asserted-by":"crossref","first-page":"287","DOI":"10.14336\/AD.2017.1112","article-title":"SDF-1\/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in patients with Ischemic Stroke","volume":"9","author":"Zhang","year":"2018","journal-title":"Aging Dis."},{"issue":"6","key":"10.1016\/j.brainres.2026.150562_b0085","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10735-021-10008-y","article-title":"SDF-1\u00a0sreted by mesenchymal stem cells promotes the migration of endothelial progenitor cells via CXCR4\/PI3K\/AKT pathway","volume":"52","author":"Wang","year":"2021","journal-title":"J. Mol. Histol."},{"issue":"1","key":"10.1016\/j.brainres.2026.150562_b0090","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12013-014-0228-6","article-title":"Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K\/Akt and ERK1\/2 pathways","volume":"71","author":"Gao","year":"2015","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.brainres.2026.150562_b0095","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13287-022-02975-0","article-title":"BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1\/M2 macrophage polarization in rats","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.brainres.2026.150562_b0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12031-021-01887-7","article-title":"Zeb2\/Axin2-Enriched BMSC-Derived Exosomes Promote Post-Stroke Functional Recovery by Enhancing Neurogenesis and Neural Plasticity","volume":"72","author":"Wei","year":"2021","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.brainres.2026.150562_b0105","doi-asserted-by":"crossref","first-page":"L537","DOI":"10.1152\/ajplung.00050.2006","article-title":"Hyperoxia modulates TGF-beta\/BMP signaling in a mouse model of bronchopulmonary dysplasia","volume":"292","author":"Alejandre-Alc\u00e1zar","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"12","key":"10.1016\/j.brainres.2026.150562_b0110","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1007\/s12035-021-02565-w","article-title":"Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Attenuate Blood-Spinal Cord Barrier Disruption via the TIMP2\/MMP Pathway after Acute Spinal Cord Injury","volume":"58","author":"Xin","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.brainres.2026.150562_b0115","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1007\/s12035-024-04507-8","article-title":"Exosomal MiR-653-3p Alleviates Hypoxic-Ischemic Brain damage via the TRIM21\/p62\/Nrf2\/CYLD Axis","volume":"62","author":"Shu","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.brainres.2026.150562_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107235","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2","volume":"32","author":"Wang","year":"2023","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"10","key":"10.1016\/j.brainres.2026.150562_b0125","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1007\/s12035-024-04056-0","article-title":"Exosomes from Hypoxia-treated Mesenchymal Stem Cells: Promoting Neuroprotection in Ischemic Stroke through miR-214-3p\/PTEN Mechanism","volume":"61","author":"Wu","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.brainres.2026.150562_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030468","article-title":"Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration","volume":"20","author":"Ciullo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2026.150562_b0135","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12951-023-02098-5","article-title":"Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia-reperfusion injury via mTOR\/ULK1\/FUNDC1 pathways","volume":"21","author":"Deng","year":"2023","journal-title":"J Nanobiotechnology"},{"issue":"7","key":"10.1016\/j.brainres.2026.150562_b0140","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/jnen\/nlac037","article-title":"Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling","volume":"81","author":"Cai","year":"2022","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2026.150562_b0145","first-page":"541","article-title":"Hypoxia preconditioned MSC exosomes attenuate high-altitude cerebral edema via the miR-125a-5p\/RTEF-1 axis to protect vascular endothelial cells","volume":"52","author":"Zuo","year":"2025","journal-title":"Bioact. Mater."},{"issue":"Pt 1","key":"10.1016\/j.brainres.2026.150562_b0150","article-title":"Extracellular vesicles from hypoxia preconditioned bone marrow mesenchymal stem cell improve peri-implant osteogenesis under type 2 diabetes condition","volume":"388","author":"Cao","year":"2025","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.brainres.2026.150562_b0155","doi-asserted-by":"crossref","first-page":"40737","DOI":"10.31083\/FBL40737","article-title":"Ferroptosis in Neurovascular Unit of Ischemic Stroke: Multidimensional Regulatory Mechanisms and Targeted Interventions","volume":"30","author":"Wang","year":"2025","journal-title":"Front Biosci (landmark Ed)"},{"issue":"Pt A","key":"10.1016\/j.brainres.2026.150562_b0160","article-title":"Network pharmacology and molecular docking reveal the multi-target mechanisms of Paeoniae Radix Rubra in functional angiogenesis: Synergistic regulation of ADAM10-NOTCH and VEGFR2-PI3K\/AKT signaling","volume":"355","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.brainres.2026.150562_b0165","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.4103\/NRR.NRR-D-24-01456","article-title":"Neuroinflammation strokes the brain: a double-edged sword in ischemic stroke","volume":"21","author":"Lombardozzi","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainres.2026.150562_b0170","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/jrms.jrms_341_22","article-title":"Neuroprotective effect of ischemic postconditioning against hyperperfusion and its mechanisms of neuroprotection","volume":"29","author":"Bagheri","year":"2024","journal-title":"J. Res. Med. Sci."},{"issue":"1","key":"10.1016\/j.brainres.2026.150562_b0175","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/NRR.NRR-D-24-00879","article-title":"Enhanced neurogenesis after ischemic stroke: the interplay between endogenous and exogenous stem cells","volume":"21","author":"Geng","year":"2025","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.brainres.2026.150562_b0180","doi-asserted-by":"crossref","first-page":"630","DOI":"10.2174\/1570159X19666210806163352","article-title":"The Role of Stem Cells in the Therapy of Stroke","volume":"20","author":"Ejma","year":"2022","journal-title":"Curr. Neuropharmacol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326004245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326004245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:48:21Z","timestamp":1791316101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326004245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S0006899326004245"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150562","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxic bone marrow mesenchymal stem cell-derived exosomes promote neurovascular repair in ischemic stroke with CXCR4-Associated enhancement","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150562"}}