{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:49:05Z","timestamp":1791920945054,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,10,10]],"date-time":"2027-10-10T00:00:00Z","timestamp":1823126400000},"content-version":"am","delay-in-days":313,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25KJ048305"],"award-info":[{"award-number":["25KJ048305"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27931"],"award-info":[{"award-number":["23K27931"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K0853503"],"award-info":[{"award-number":["23K0853503"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025019","name":"Support for Pioneering Research Initiated by the Next Generation","doi-asserted-by":"publisher","award":["PH8D240001"],"award-info":[{"award-number":["PH8D240001"]}],"id":[{"id":"10.13039\/501100025019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007807","name":"Japan Science Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ym0123122"],"award-info":[{"award-number":["JP23ym0123122"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bk0104134"],"award-info":[{"award-number":["JP23bk0104134"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.brainres.2026.150572","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:59:57Z","timestamp":1790866797000},"page":"150572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mesenchymal stem cell transplantation improves motor recovery accompanied by region-specific transcriptomic responses following intracerebral hemorrhage in rats"],"prefix":"10.1016","volume":"1893","author":[{"given":"Yushan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-6320","authenticated-orcid":false,"given":"Yuichiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7828-937X","authenticated-orcid":false,"given":"Yuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Kawabori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7381-7096","authenticated-orcid":false,"given":"Erika","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-3656","authenticated-orcid":false,"given":"Takako S.","family":"Chikenji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-0516","authenticated-orcid":false,"given":"Miki","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-2246","authenticated-orcid":false,"given":"Hiroshi","family":"Maejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.brainres.2026.150572_b0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/biologics5040037","article-title":"Mesenchymal stem cells and their derivatives: old problems and new possibilities in regenerative medicine for neurological diseases","volume":"5","author":"Akhmetzyanova","year":"2025","journal-title":"Biologics"},{"issue":"11","key":"10.1016\/j.brainres.2026.150572_b0010","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.brainres.2026.150572_b0015","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1523\/JNEUROSCI.4477-10.2011","article-title":"Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons","volume":"31","author":"Cuesto","year":"2011","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.brainres.2026.150572_b0020","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201912098","article-title":"A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy","volume":"219","author":"Fracchiolla","year":"2020","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.brainres.2026.150572_b0025","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3390\/cells13110939","article-title":"Administration of human-derived mesenchymal stem cells activates locally stimulated endogenous neural progenitors and reduces neurological dysfunction in mice after ischemic stroke","volume":"13","author":"Fujiwara","year":"2024","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.brainres.2026.150572_b0030","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-025-03582-5","article-title":"Targeting hypercoagulability in ischemic stroke modulates fibrin-driven microglial polarization via JAK-STAT pathway","volume":"22","author":"Guan","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2026.150572_b0035","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2019.01.033","article-title":"Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains","volume":"297","author":"Hettiaratchi","year":"2019","journal-title":"J. Control. Release"},{"issue":"10","key":"10.1016\/j.brainres.2026.150572_b0040","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.526","article-title":"Mesenchymal stem cell\u2010based treatments for stroke, neural trauma, and heat stroke","volume":"6","author":"Hsuan","year":"2016","journal-title":"Brain and Behavior"},{"key":"10.1016\/j.brainres.2026.150572_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136344","article-title":"Combined treatment with exercise and \u03b15GABAAR inhibitor promotes motor function recovery after intracerebral hemorrhage","volume":"766","author":"Inoue","year":"2022","journal-title":"Neurosci. Lett."},{"issue":"12","key":"10.1016\/j.brainres.2026.150572_b0050","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-083959","article-title":"Phase I\/II trial of intracerebral transplantation of autologous bone marrow stem cells combined with recombinant peptide scaffold for patients with chronic intracerebral haemorrhage: a study protocol","volume":"14","author":"Kawabori","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.brainres.2026.150572_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/732742","article-title":"MSCs: delivery routes and engraftment, cell-targeting strategies, and immune modulation","volume":"2013","author":"Kean","year":"2013","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.brainres.2026.150572_b0060","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1044\/1092-4388(2008\/018)","article-title":"Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage","volume":"51","author":"Kleim","year":"2008","journal-title":"J. Speech Lang. Hear. Res."},{"issue":"1","key":"10.1016\/j.brainres.2026.150572_b0065","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ymthe.2024.12.006","article-title":"Modified human mesenchymal stromal\/stem cells restore cortical excitability after focal ischemic stroke in rats","volume":"33","author":"Klein","year":"2025","journal-title":"Mol. Ther."},{"issue":"7","key":"10.1016\/j.brainres.2026.150572_b0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-05034-x","article-title":"Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?","volume":"13","author":"Kou","year":"2022","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.brainres.2026.150572_b0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/brainsci5020165","article-title":"Growth factors for the treatment of ischemic brain injury (growth factor treatment)","volume":"5","author":"Larpthaveesarp","year":"2015","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.brainres.2026.150572_b0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1742-2094-10-103","article-title":"Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage","volume":"10","author":"Lei","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2026.150572_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00928","article-title":"Characterization of axon damage, neurological deficits, and histopathology in two experimental models of intracerebral hemorrhage","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Neurosci."},{"issue":"10","key":"10.1016\/j.brainres.2026.150572_b0085","doi-asserted-by":"crossref","DOI":"10.4103\/NRR.NRR-D-24-00568","article-title":"PI3K\/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives","volume":"20","author":"Liu","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainres.2026.150572_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149569","article-title":"Skilled reaching training combined with pharmacological inhibition of histone deacetylases potentiated motor recovery after intracerebral hemorrhage in a synergic manner","volume":"1856","author":"Liu","year":"2025","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.brainres.2026.150572_b0100","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.brainres.2026.150572_b0105","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/bioinformatics\/btp053","article-title":"Testing significance relative to a fold-change threshold is a TREAT","volume":"25","author":"Mccarthy","year":"2009","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.brainres.2026.150572_b0110","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI60560","article-title":"Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12","volume":"122","author":"Montenegro","year":"2012","journal-title":"J. Clin. Investig."},{"issue":"12","key":"10.1016\/j.brainres.2026.150572_b0115","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrn2735","article-title":"Plasticity during stroke recovery: from synapse to behaviour","volume":"10","author":"Murphy","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.brainres.2026.150572_b0120","doi-asserted-by":"crossref","first-page":"10772","DOI":"10.1038\/s41598-020-67460-1","article-title":"Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer\u2019s disease model by increasing the expression of microRNA-146a in hippocampus","volume":"10","author":"Nakano","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainres.2026.150572_b0125","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2005"},{"issue":"2","key":"10.1016\/j.brainres.2026.150572_b0130","first-page":"207","article-title":"WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome","volume":"128","author":"Proikas-Cezanne","year":"2015","journal-title":"J. Cell Sci."},{"issue":"9","key":"10.1016\/j.brainres.2026.150572_b0135","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","article-title":"Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential","volume":"41","author":"Song","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2026.150572_b0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbr.2015.12.003","article-title":"Running exercise enhances motor functional recovery with inhibition of dendritic regression in the motor cortex after collagenase-induced intracerebral hemorrhage in rats","volume":"300","author":"Takamatsu","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2026.150572_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/8521922","article-title":"Intracerebral transplantation of mesenchymal stromal cell compounded with recombinant peptide scaffold against chronic intracerebral hemorrhage model","volume":"2022","author":"Takamiya","year":"2022","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.brainres.2026.150572_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2021.103691","article-title":"GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons","volume":"118","author":"Tanaka","year":"2022","journal-title":"Mol. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.brainres.2026.150572_b0155","doi-asserted-by":"crossref","DOI":"10.1093\/neuros\/nyy179","article-title":"Persistent metabolic disturbance in the perihemorrhagic zone despite a normalized cerebral blood flow following surgery for intracerebral hemorrhage","volume":"84","author":"Tobieson","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2026.150572_b0160","doi-asserted-by":"crossref","unstructured":"Tom\u00e9, D., Martins, L. F., Aroso, M., Santos, H., Costa, R. O., Afonso, J. L., Serra, S. C., Aguiar, P., Duarte, C. B., Pe\u00e7a, J., Pinheiro, P. S., Salgado, A. J., & Almeida, R. D. (2025). Mesenchymal stromal cell secretome-induced synaptogenesis is mediated by thrombospondin-1. iScience, 28(9), 113401. Doi: 10.1016\/j.isci.2025.113401.","DOI":"10.1016\/j.isci.2025.113401"},{"issue":"12","key":"10.1016\/j.brainres.2026.150572_b0170","doi-asserted-by":"crossref","DOI":"10.4103\/1673-5374.313049","article-title":"SOCS1\/JAK2\/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses","volume":"16","author":"Wang","year":"2021","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.brainres.2026.150572_b0165","doi-asserted-by":"crossref","DOI":"10.4103\/bc.bc_177_24","article-title":"Advances in intracerebral hemorrhage management: a comprehensive review","volume":"12","author":"Wang","year":"2026","journal-title":"Brain Circulation"},{"issue":"8","key":"10.1016\/j.brainres.2026.150572_b0175","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/CIRCRESAHA.111.243147","article-title":"Mesenchymal stem cells","volume":"109","author":"Williams","year":"2011","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.brainres.2026.150572_b0180","doi-asserted-by":"crossref","DOI":"10.1186\/s42466-021-00120-5","article-title":"Prognostication after intracerebral hemorrhage: a review","volume":"3","author":"Witsch","year":"2021","journal-title":"Neurol. Res. Pract."},{"key":"10.1016\/j.brainres.2026.150572_b0185","first-page":"207","article-title":"Delayed and remote effects of focal cortical infarctions: secondary damage and reactive plasticity","volume":"73","author":"Witte","year":"1997","journal-title":"Adv. Neurol."},{"issue":"3","key":"10.1016\/j.brainres.2026.150572_b0190","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.1103","article-title":"Risk Factors associated with mortality and neurologic disability after intracerebral hemorrhage in a racially and ethnically diverse cohort","volume":"5","author":"Woo","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"5","key":"10.1016\/j.brainres.2026.150572_b0195","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.3390\/ijms23052550","article-title":"Mesenchymal stem cells: therapeutic mechanisms for stroke","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326004348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899326004348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:20:13Z","timestamp":1791919213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899326004348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":39,"alternative-id":["S0006899326004348"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150572","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cell transplantation improves motor recovery accompanied by region-specific transcriptomic responses following intracerebral hemorrhage in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2026.150572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150572"}}