{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:18:01Z","timestamp":1764688681073,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.brainresbull.2008.01.012","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T10:04:29Z","timestamp":1202897069000},"page":"102-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroprotective effects of sodium orthovanadate after hypoxic-ischemic brain injury in neonatal rats"],"prefix":"10.1016","volume":"76","author":[{"given":"Yangzheng","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay J.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Fratkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2008.01.012_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuint.2005.12.008","article-title":"Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats","volume":"48","author":"Althaus","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-0270(90)90131-X","article-title":"Evaluation of brain damage in rat model of neonatal hypoxic ischemia","volume":"35","author":"Andine","year":"1990","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2008.01.012_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0165-6147(00)89043-4","article-title":"The role of vanadium in the management of diabetes","volume":"16","author":"Brichard","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0959-4388(00)00211-7","article-title":"Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway","volume":"11","author":"Brunet","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1203\/00006450-199508000-00019","article-title":"Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat","volume":"38","author":"Cataltepe","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib6","doi-asserted-by":"crossref","first-page":"32377","DOI":"10.1074\/jbc.273.49.32377","article-title":"CRBE is a regulatory target for the protein kinase Akt\/PKB","volume":"273","author":"Du","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00019052-200204000-00005","article-title":"Perinatal brain injury in the preterm and term newborn","volume":"15","author":"du Plessis","year":"2002","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib8","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1016\/S0021-9258(17)36912-0","article-title":"Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell-free experiments, depending on its oxidation state: possible role of endogenous vanadium in controlling cellular protein tyrosine kinase activity","volume":"269","author":"Elberg","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2003.10.048","article-title":"Treatment with tamoxifen reduces hypoxic-ischemic brain injury in neonatal rats","volume":"484","author":"Feng","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib10","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1038\/sj.onc.1207115","article-title":"PI3K\/Akt and apoptosis: size matters","volume":"22","author":"Franke","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.brainresbull.2008.01.012_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0092-8674(00)81883-8","article-title":"PI3K: downstream AKTion blocks apoptosis","volume":"88","author":"Franke","year":"1977","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2008.01.012_bib12","doi-asserted-by":"crossref","first-page":"31963","DOI":"10.1074\/jbc.M200082200","article-title":"Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase\/Akt pathway and reactive oxygen species","volume":"277","author":"Gao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib13","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/01.WCB.0000085160.71791.3F","article-title":"Neuroprotective effect of post ischemic administration of sodium orthovanadate in rats with transient middle cerebral artery occlusion","volume":"23","author":"Hasegawa","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1124\/jpet.105.096677","article-title":"Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats","volume":"317","author":"Hasegawa","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib15","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1097\/00004647-200111000-00003","article-title":"Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus","volume":"21","author":"Kawano","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.brainres.2003.10.002","article-title":"Tyrosine phosphatase inhibition induces loss of blood\u2013brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways.","volume":"995","author":"Lohmann","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib17","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1124\/jpet.106.104562","article-title":"Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia","volume":"318","author":"Matsumoto","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.cdd.4401768","article-title":"Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53","volume":"13","author":"Morita","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.brainresrev.2005.07.003","article-title":"Apoptosis in perinatal hypoxic-ischemic brain injury: how important is it and should it be inhibited?","volume":"50","author":"Northington","year":"2005","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1203\/01.PDR.0000179381.86809.02","article-title":"Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal rat","volume":"58","author":"Ong","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib21","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1203\/00006450-199004000-00003","article-title":"Reduction of perinatal hypoxic-ischemic brain damage with allopurinol","volume":"27","author":"Palmer","year":"1990","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000085979","article-title":"Hypoxia preconditioning in the brain","volume":"27","author":"Ran","year":"2005","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/43474","article-title":"NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling","volume":"401","author":"Romashkova","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2008.01.012_bib25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neuint.2007.07.005","article-title":"Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress","volume":"52","author":"Shrivastava","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1007075204494","article-title":"Anti-diabetic and toxic effects of vanadium compounds","volume":"206","author":"Srivastava","year":"2000","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib27","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/01.fjc.0000143275.45289.0a","article-title":"A protein tyrosine phosphatase inhibitor accelerates angiogenesis in a rat model of hind limb ischemia","volume":"44","author":"Sugano","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib28","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1203\/00006450-199310000-00029","article-title":"Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat","volume":"34","author":"Yager","year":"1993","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainresbull.2008.01.012_bib29","doi-asserted-by":"crossref","first-page":"9794","DOI":"10.1523\/JNEUROSCI.3163-05.2005","article-title":"Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats","volume":"25","author":"Zhao","year":"2005","journal-title":"J. Neurosci."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923008000051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923008000051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:01:31Z","timestamp":1759780891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923008000051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0361923008000051"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2008.01.012","relation":{},"ISSN":["0361-9230"],"issn-type":[{"type":"print","value":"0361-9230"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effects of sodium orthovanadate after hypoxic-ischemic brain injury in neonatal rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2008.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}