{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:38:23Z","timestamp":1771634303855,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.brainresbull.2008.02.026","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T00:41:00Z","timestamp":1206060060000},"page":"27-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states"],"prefix":"10.1016","volume":"77","author":[{"given":"Yun","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changshui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangdong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songniu","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2008.02.026_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.brainresbull.2008.02.026_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00019052-200206000-00021","article-title":"Targeting the host inflammatory response in traumatic spinal cord injury","volume":"15","author":"Bethea","year":"2002","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib3","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1152\/jn.1999.82.3.1590","article-title":"P2X receptor-mediated ionic currents in dorsal root ganglion neurons","volume":"82","author":"Burgard","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/oxfordjournals.bja.a013473","article-title":"P2X receptors in sensory neurones","volume":"84","author":"Burnstock","year":"2000","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1124\/pr.58.1.5","article-title":"Pathophysiology and therapeutic potential of purinergic signaling","volume":"58","author":"Burnstock","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.pharmthera.2005.08.013","article-title":"Purinergic P2 receptors as targets for novel analgesics","volume":"110","author":"Burnstock","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00043.2006","article-title":"Physiology and pathophysiology of purinergic neurotransmission","volume":"87","author":"Burnstock","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib8","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1097\/00001756-199909090-00015","article-title":"Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat","volume":"10","author":"Chen","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainresbull.2008.02.026_bib9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0031-6997(24)01512-6","article-title":"P2X receptors and nociception","volume":"53","author":"Chizh","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neuint.2006.08.017","article-title":"Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1\/TRPV1","volume":"50","author":"Christoph","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib11","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/35039519","article-title":"Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice","volume":"407","author":"Cockayne","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2008.02.026_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0301-0082(01)00005-3","article-title":"P2X receptors in peripheral neurons","volume":"65","author":"Dunn","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuint.2006.09.003","article-title":"LPA-mediated demyelination in ex vivo culture of dorsal root","volume":"50","author":"Fujita","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib14","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuint.2006.12.007","article-title":"Existence of high and low affinity dinucleotides pentaphosphate-induced calcium responses in individual synaptic terminals and lack of correlation with the distribution of P2X1-7 subunits","volume":"50","author":"G\u00f3mez-Villafuertes","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ddr.1119","article-title":"Pharmacological characterization of P2X3 homomeric and heteromeric channels in nociceptive signaling and behavior","author":"Jarvis","year":"2001","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib16","doi-asserted-by":"crossref","first-page":"17179","DOI":"10.1073\/pnas.252537299","article-title":"A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2\/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat","volume":"99","author":"Jarvis","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib17","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1113\/jphysiol.2003.049114","article-title":"Crossing the pain barrier: P2 receptors as targets for novel analgesics","volume":"553","author":"Kennedy","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(99)00114-7","article-title":"Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglion","volume":"263","author":"Li","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.brainres.2003.09.070","article-title":"Effect of tetramethylpyrazine on acute nociception mediated bysignaling of P2X receptor activation in rat","volume":"995","author":"Liang","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2005.01.076","article-title":"Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons","volume":"1040","author":"Liang","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF00433379","article-title":"Logic, truth and language in concepts of pain","volume":"3","author":"Merskrey","year":"1994","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib22","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","article-title":"Molecular physiology of P2X receptors","volume":"82","author":"North","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0304-3959(98)00225-5","article-title":"Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury","volume":"80","author":"Novakovic","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.brainresbull.2008.02.026_bib24","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1248\/cpb.40.954","article-title":"Antiinflammatory effect of tetramethylpyrazine and ferulic acid","volume":"40","author":"Ozaki","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib25","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1002\/1097-0142(19890601)63:11<2266::AID-CNCR2820631135>3.0.CO;2-5","article-title":"Cancer pain, anatomy, physiology, and pharmacology","volume":"63","author":"Payne","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.brainresbull.2008.02.026_bib26","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/35039526","article-title":"Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors","volume":"407","author":"Souslova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2008.02.026_bib27","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1471-4159.2007.04861.x","article-title":"P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain","volume":"103","author":"Tsuda","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib28","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1152\/jn.01171.2002","article-title":"TNP-ATP-resistant P2X ionic currents on the central terminals and somata of rat primary sensory neurons","volume":"89","author":"Tsuzuki","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.bjp.0702319","article-title":"Cell type-specific ATP activated responses in rat dorsal root ganglion neurons","volume":"126","author":"Ueno","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib30","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1073\/pnas.93.15.8063","article-title":"Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry","volume":"93","author":"Vulchanova","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2008.02.026_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0306-4522(01)00377-3","article-title":"Cytotoxic targeting of isolectin IB4-binding sensory neurons","volume":"108","author":"Vulchanova","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2008.02.026_bib32","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.1073\/pnas.0611048104","article-title":"Neuronal somatic ATP release triggers neuron\u2013satellite glial cell communication in dorsal root ganglia","volume":"104","author":"Zhang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923008000956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923008000956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:03:04Z","timestamp":1759780984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923008000956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0361923008000956"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2008.02.026","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2008.02.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}