{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:45:24Z","timestamp":1778694324901,"version":"3.51.4"},"reference-count":83,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.brainresbull.2008.07.002","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T05:39:38Z","timestamp":1217569178000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Activity of protein kinase C is important for 3\u03b1,5\u03b1-THP's actions at dopamine type 1-like and\/or GABAA receptors in the ventral tegmental area for lordosis of rats"],"prefix":"10.1016","volume":"77","author":[{"given":"Cheryl A.","family":"Frye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia A.","family":"Walf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2008.07.002_bib1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1124\/jpet.105.086140","article-title":"Contributions of the mitogen-activated protein kinase and protein kinase C cascades in spatial learning and memory mediated by the nucleus accumbens","volume":"314","author":"Alvarez-Jaimes","year":"2005","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1017\/S146114570400478X","article-title":"Signal transduction abnormalities in melancholic depression","volume":"8","author":"Akin","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000054374","article-title":"Allopregnanolone-induced modification of presynaptic basal and K+-induced [3H]-norepinephrine efflux from rat cortical slices during the estrous cycle","volume":"68","author":"Belmar","year":"1998","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0031-9384(81)90019-6","article-title":"Facilitation of lordosis behavior in the ovariectomized estrogen primed rat by dibutyryl cAMP","volume":"26","author":"Beyer","year":"1988","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0165-6147(00)01979-9","article-title":"Nicotine addiction: the possible role of functional upregulation","volume":"23","author":"Buisson","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/hbeh.1997.1413","article-title":"A potential role of cyclic GMP in the regulation of lordosis behavior of female rats","volume":"32","author":"Chu","year":"1997","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0090-6980(95)00107-7","article-title":"Arachidonic acid inhibits hCG-stimulated progesterone production by corpora lutea of primates: potential mechanism of action","volume":"50","author":"Ciereszko","year":"1995","journal-title":"Prostaglandins"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/frne.1999.0188","article-title":"Neurosteroids: biosynthesis and function of these novel neuromodulators","volume":"21","author":"Compagnone","year":"2000","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0031-9384(89)90347-8","article-title":"Facilitation of sexual receptivity by hypothalamic and midbrain implants of progesterone in female hamsters","volume":"46","author":"DeBold","year":"1989","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/archpsyc.64.3.327","article-title":"The role of dopamine in the pathophysiology of depression","volume":"64","author":"Dunlop","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1176\/appi.ajp.159.1.66","article-title":"[(3)H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims","volume":"159","author":"Dwivedi","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib12","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1523\/JNEUROSCI.20-09-03067.2000","article-title":"Neurosteroid modulation of GABA IPSCs is phosphorylation dependent","volume":"20","author":"Fancsik","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-0173(01)00119-9","article-title":"The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents","volume":"37","author":"Frye","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/hbeh.2001.1674","article-title":"The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents","volume":"40","author":"Frye","year":"2001","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(92)90233-Y","article-title":"Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus","volume":"578","author":"Frye","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0091-3057(92)90044-G","article-title":"Muscimol facilitates sexual receptivity in hamsters when infused into the ventral tegmentum","volume":"42","author":"Frye","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1006\/hbeh.1996.0069","article-title":"Progestins can have a membrane-mediated action in rat midbrain for facilitation of sexual receptivity","volume":"30","author":"Frye","year":"1996","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(92)90233-Y","article-title":"Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus","volume":"578","author":"Frye","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0091-3057(93)90308-G","article-title":"Bicuculline infused into the hamster ventral tegmentum inhibits, while sodium valproate facilitates, sexual receptivity","volume":"46","author":"Frye","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0166-4328(00)00242-4","article-title":"Anti-sense oligonucleotides, for progestin receptors in the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats","volume":"115","author":"Frye","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1530\/rep.1.01208","article-title":"Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5\u03b1-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex","volume":"133","author":"Frye","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000068338","article-title":"Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmental area","volume":"77","author":"Frye","year":"2003","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib23","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-2826.2003.01047.x","article-title":"Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behavior of cycling or hormone-primed hamsters","volume":"15","author":"Frye","year":"2001","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00213-004-2001-9","article-title":"In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters","volume":"178","author":"Frye","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1196\/annals.1286.004","article-title":"Fluoxetine may influence lordosis of rats through effects on midbrain 3\u03b1,5\u03b1-THP concentrations","volume":"1007","author":"Frye","year":"2001","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000096051","article-title":"Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats","volume":"83","author":"Frye","year":"2007","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neuroscience.2005.06.015","article-title":"3\u03b1-hydroxy-5\u03b1-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors","volume":"138","author":"Frye","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1037\/0735-7044.120.2.281","article-title":"Rats bred for high versus low anxiety responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3\u03b1,5\u03b1-THP levels as adults","volume":"120","author":"Frye","year":"2006","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0166-4328(99)00020-0","article-title":"GABAA, D1, and D5, but not progestin receptor, antagonist and anti-sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis","volume":"103","author":"Frye","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib30","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1046\/j.1365-2826.2001.00731.x","article-title":"Ventral tegmental area infusions of inhibitors of the biosynthesis and metabolism of 3\u03b1,5\u03b1-THP attenuate lordosis of hormone-primed and behavioural oestrous rats and hamsters","volume":"13","author":"Frye","year":"2001","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.pbb.2004.03.024","article-title":"Hippocampal 3\u03b1,5\u03b1-THP may alter depressive behavior of pregnant and lactating rats","volume":"78","author":"Frye","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib32","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2826.2007.01580.x","article-title":"In the ventral tegmental area, progestins\u2019 membrane-mediated actions for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C","volume":"19","author":"Frye","year":"2007","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib33","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.steroids.2008.01.020","article-title":"Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways","volume":"73","author":"Frye","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.yhbeh.2006.04.001","article-title":"In the ventral tegmental area progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABAA receptors","volume":"50","author":"Frye","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbr.2006.05.014","article-title":"Progestins\u2019 effects on sexual behavior of female rats and hamsters involving D1 and GABAA receptors in the ventral tegmental area may be G-protein-dependent","volume":"172","author":"Frye","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.yhbeh.2006.03.006","article-title":"Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area","volume":"50","author":"Frye","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.pbb.2004.04.014","article-title":"Progestins\u2019 actions in the VTA to facilitate lordosis involve dopamine-like type 1 and 2 receptors","volume":"78","author":"Frye","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib38","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.yhbeh.2005.08.011","article-title":"Differential effect of kinase A and C blockers on lordosis facilitation by progesterone and its metabolites in ovariectomized estrogen-primed rats","volume":"49","author":"Gonzalez-Flores","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib39","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1210\/en.2004-0823","article-title":"Regulation of lordosis by cyclic 3\u2032,5\u2032-guanosine monophosphate, progesterone, and its 5\u03b1-reduced metabolites involves mitogen-activated protein kinase","volume":"145","author":"Gonzalez-Flores","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib40","doi-asserted-by":"crossref","first-page":"13512","DOI":"10.1073\/pnas.96.23.13512","article-title":"Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes","volume":"96","author":"Griffin","year":"1999","journal-title":"PNAS"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0031-9384(71)90120-X","article-title":"Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat","volume":"7","author":"Hardy","year":"1971","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(84)90299-3","article-title":"Modulation of the GABA receptor complex by a steroid anesthetic","volume":"323","author":"Harrison","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib43","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1095\/biolreprod.104.037721","article-title":"Involvement of protein kinase C and cyclic adenosine 3\u2032,5\u2032-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells","volume":"73","author":"Jo","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0925-4773(97)00122-6","article-title":"Progesterone acts through protein kinase C to remodel the cytoplasm as the amphibian oocyte becomes the fertilization-competent egg","volume":"67","author":"Johnson","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib45","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0006-291X(87)91009-6","article-title":"Calcium-dependent phosphorylation of the amphibian oocyte plasma membrane: an early event in initiating the meiotic divisions","volume":"147","author":"Kostellow","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0006-8993(94)91295-5","article-title":"Activation of protein kinase C in the hypothalamic ventromedial nucleus or the midbrain central gray facilitates lordosis","volume":"660","author":"Kow","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0166-4328(97)00189-7","article-title":"Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system","volume":"92","author":"Kow","year":"1998","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib48","first-page":"135","article-title":"Inhibition of noradrenaline release by 5\u03b1-progestins in cerebral cortex slices","volume":"26","author":"Kubli-Garfias","year":"1983","journal-title":"Proc. Western Pharmacol. Soc."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02088174","article-title":"Neurosteroid modulation of native and recombinant GABAA receptors","volume":"16","author":"Lambert","year":"1996","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jsbmb.2007.09.019","article-title":"Integration of progesterone receptor action with rapid signaling events in breast cancer models","volume":"108","author":"Lange","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-2999(84)90205-X","article-title":"Progesterone and estrogens in rat brain: modulation of GABA (gamma-aminobutyric acid) receptor activity","volume":"103","author":"Maggi","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib52","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.2422758","article-title":"Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor","volume":"232","author":"Majewska","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib53","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1126\/science.287.5455.1053","article-title":"Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice","volume":"287","author":"Mani","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib54","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1017\/S1092852900008579","article-title":"Is obsessive-compulsive disorder caused by a second-messenger imbalance?","volume":"6","author":"Marazziti","year":"2001","journal-title":"CNS Spectrums"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib55","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0306-4530(01)00076-2","article-title":"Decreased inhibitory activity of PKC in OCD patients after six months of treatment","volume":"27","author":"Marazziti","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib56","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1037\/h0035941","article-title":"Further analysis of sensory inattention following lateral hypothalamic damage in rats","volume":"86","author":"Marshall","year":"1974","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-5198(19)30781-4","article-title":"Neuroactive neurosteroids as endogenous effectors for the sigma1 (sigma1) receptor: pharmacological evidence and therapeutic opportunities","volume":"81","author":"Maurice","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib58","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1095\/biolreprod56.3.569","article-title":"Amino acid neurotransmitter receptor\/chloride channels of mammalian sperm and the acrosome reaction","volume":"56","author":"Meizel","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib59","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0091-3057(89)90572-8","article-title":"Phorbol esters and forskolin infused into midbrain central gray facilitate lordosis","volume":"34","author":"Mobbs","year":"1989","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib60","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1046\/j.1365-2826.2002.00860.x","article-title":"Functional cooperation between neurosteroids and D2 dopamine antagonists on KCl-evoked [3H]noradrenaline release: modulation by calcium channel blockers","volume":"14","author":"Monnet","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib61","first-page":"5","article-title":"The neurobiology of depression: inroads to treatment and new drug discovery","volume":"66","author":"Nemeroff","year":"2005","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib62","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0893-133X(01)00327-X","article-title":"Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients","volume":"26","author":"Pandey","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib63","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0026-895X(25)08656-0","article-title":"3\u03b1-Hydroxy-5\u03b1-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons","volume":"46","author":"Park-Chung","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib64","series-title":"The Rat Brain","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib65","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.1365-2826.2006.01488.x","article-title":"In the ventral tegmental area, cAMP mediates progesterone's actions at dopamine type 1 receptors for lordosis of rats and hamsters","volume":"18","author":"Petralia","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib66","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000082752","article-title":"In the ventral tegmental area, G-proteins and cAMP mediate the neurosteroid 3\u03b1,5\u03b1-THP's actions at dopamine type 1 receptors for lordosis of rats","volume":"80","author":"Petralia","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib67","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2826.2005.01342.x","article-title":"Inhibiting biosynthesis and\/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus","volume":"17","author":"Petralia","year":"2005","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib68","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000100510","article-title":"In the ventral tegmental area, progestins\u2019 membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A","volume":"84","author":"Petralia","year":"2006","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib69","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/hbeh.1999.1562","article-title":"Appetitive and consummatory sexual behaviors of female rats in bilevel chambers. II. Patterns of estrus termination following vaginocervical stimulation","volume":"37","author":"Pfaus","year":"2000","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib70","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3940(02)01106-0","article-title":"Antidepressant effects on kinase gene expression patterns in rat brain","volume":"334","author":"Rausch","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib71","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1095\/biolreprod44.3.404","article-title":"Activity of phospholipase C and release of prostaglandin F2 alpha by endometrial tissue from ovariectomized ewes receiving progesterone and estradiol","volume":"44","author":"Raw","year":"1991","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(97)01294-6","article-title":"Chronic neurosteroid treatment prevents the development of morphine tolerance and attenuates abstinence behavior in mice","volume":"337","author":"Reddy","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib73","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0026-895X(25)13052-6","article-title":"Estrogen increases adrenergic- but not cholinergic-mediated production of inositol phosphates in rabbit uterus","volume":"32","author":"Riemer","year":"1987","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib74","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1073\/pnas.86.8.2923","article-title":"Brain phospholipase C isozymes: differential mRNA localizations by in situ hybridisation","volume":"86","author":"Ross","year":"1989","journal-title":"PNAS"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib75","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.yfrne.2006.02.003","article-title":"Gonadal steroid regulation of mood: the lessons of premenstrual syndrome","volume":"27","author":"Rubinow","year":"2006","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib76","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0166-2236(99)01399-5","article-title":"Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives","volume":"22","author":"Rupprecht","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib77","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.phrs.2006.09.007","article-title":"PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice","volume":"54","author":"Smith","year":"2006","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2005.02.013","article-title":"Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area","volume":"161","author":"Sumida","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib79","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0022-3565(24)29431-3","article-title":"Metabotropic neurosteroid\/sigma-receptor involved in stimulation of nociceptor endings of mice","volume":"298","author":"Ueda","year":"2001","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib80","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00213-005-0201-6","article-title":"Relevance of endogenous 3\u03b1-reduced neurosteroids to depression and antidepressant action","volume":"186","author":"Uzunova","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2008.07.002_bib81","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0018-506X(89)90073-1","article-title":"Actions of RU 38486 on progesterone facilitation and sequential inhibition of rat estrous behavior: correlation with neural progestin receptor levels","volume":"23","author":"Vathy","year":"1989","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib82","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0024-3205(92)90095-7","article-title":"Analgesic effects of intrathecally-administered 3\u03b1-hydroxy-5\u03b1-pregnan-20-one in a rat mechanical visceral pain model","volume":"50","author":"Winfree","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2008.07.002_bib83","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0006-8993(98)00644-1","article-title":"Neurosteroid modulation of recombinant ionotropic glutamate receptors","volume":"803","author":"Yaghoubi","year":"1998","journal-title":"Brain Res."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923008002463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923008002463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:03:10Z","timestamp":1759780990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923008002463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":83,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0361923008002463"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2008.07.002","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activity of protein kinase C is important for 3\u03b1,5\u03b1-THP's actions at dopamine type 1-like and\/or GABAA receptors in the ventral tegmental area for lordosis of rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2008.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}