{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:17:21Z","timestamp":1790896641364,"version":"4.1.0"},"reference-count":169,"publisher":"Elsevier BV","issue":"4-5","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.brainresbull.2009.06.014","type":"journal-article","created":{"date-parts":[[2009,7,2]],"date-time":"2009-07-02T05:37:50Z","timestamp":1246513070000},"page":"315-325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Prevention of age-associated dementia"],"prefix":"10.1016","volume":"80","author":[{"given":"M. Hasan","family":"Mohajeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Leuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2009.06.014_bib1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1083\/jcb.200404149","article-title":"Neuronal membrane cholesterol loss enhances amyloid peptide generation","volume":"167","author":"Abad-Rodriguez","year":"2004","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2202-9-28","article-title":"Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically","volume":"9","author":"Agca","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease","volume":"1","author":"Arnold","year":"1991","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/85525","article-title":"Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy","volume":"7","author":"Bacskai","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib5","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1523\/JNEUROSCI.22-18-07873.2002","article-title":"Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy","volume":"22","author":"Bacskai","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/78682","article-title":"Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease","volume":"6","author":"Bard","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib7","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1471-4159.2005.03578.x","article-title":"Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms","volume":"96","author":"Bentahir","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00394-005-0583-6","article-title":"How should we measure nutrition-induced improvements in memory?","volume":"44","author":"Benton","year":"2005","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.neuroscience.2005.03.026","article-title":"Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus","volume":"133","author":"Berchtold","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/jnr.10256","article-title":"Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum","volume":"68","author":"Berchtold","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib11","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1523\/JNEUROSCI.22-08-03234.2002","article-title":"Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis","volume":"22","author":"Boncristiano","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib12","doi-asserted-by":"crossref","first-page":"16941","DOI":"10.1074\/jbc.M000937200","article-title":"Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia","volume":"275","author":"Brazil","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy","volume":"10","author":"Bu","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","article-title":"Tau protein isoforms, phosphorylation and role in neurodegenerative disorders","volume":"33","author":"Buee","year":"2000","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib15","doi-asserted-by":"crossref","first-page":"14088","DOI":"10.1073\/pnas.96.24.14088","article-title":"Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid","volume":"96","author":"Calhoun","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1460-9568.2005.04253.x","article-title":"Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease","volume":"22","author":"Calon","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2004.08.013","article-title":"Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model","volume":"43","author":"Calon","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib18","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/sj.mp.4001516","article-title":"Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits","volume":"9","author":"Chacon","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/415462a","article-title":"Nerve inflammation halts trial for Alzheimer's drug","volume":"415","author":"Check","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/35050103","article-title":"A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease","volume":"408","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib21","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/nm1123","article-title":"Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation","volume":"10","author":"Cheng","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","article-title":"Treatment with a copper\u2013zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice","volume":"30","author":"Cherny","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib23","doi-asserted-by":"crossref","first-page":"21562","DOI":"10.1074\/jbc.M100710200","article-title":"Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695","volume":"276","author":"Chishti","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nm0197-67","article-title":"Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice","volume":"3","author":"Citron","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib25","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1073\/pnas.0400266101","article-title":"Cardiovascular fitness, cortical plasticity, and aging","volume":"101","author":"Colcombe","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib26","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/sj.emboj.7600938","article-title":"The role of seladin-1\/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo","volume":"25","author":"Crameri","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib27","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1002\/j.1460-2075.1985.tb04132.x","article-title":"Image reconstruction of the Alzheimer paired helical filament","volume":"4","author":"Crowther","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib28","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.52.6.1158","article-title":"The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease","volume":"52","author":"Delacourte","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib29","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1212\/WNL.59.3.398","article-title":"Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease","volume":"59","author":"Delacourte","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib30","doi-asserted-by":"crossref","first-page":"8850","DOI":"10.1073\/pnas.151261398","article-title":"Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease","volume":"98","author":"DeMattos","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib31","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1523\/JNEUROSCI.5384-05.2006","article-title":"Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology","volume":"26","author":"Deng","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib32","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1523\/JNEUROSCI.5980-08.2009","article-title":"A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses","volume":"29","author":"Deshpande","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib33","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1523\/JNEUROSCI.20-17-06452.2000","article-title":"Aging increased amyloid peptide and caused amyloid plaques in brain of old APP\/V717I transgenic mice by a different mechanism than mutant presenilin1","volume":"20","author":"Dewachter","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0531-5565(00)00149-2","article-title":"Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP\/London mice","volume":"35","author":"Dewachter","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nn842","article-title":"Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model","volume":"5","author":"Dodart","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib36","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1111\/j.1460-9568.2004.03643.x","article-title":"An in vitro and in vivo study of early deficits in associative learning in transgenic mice that over-express a mutant form of human APP associated with Alzheimer's disease","volume":"20","author":"Dominguez-del-Toro","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib37","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/383710a0","article-title":"Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1","volume":"383","author":"Duff","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib38","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1074\/jbc.C200642200","article-title":"Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme","volume":"278","author":"Eckman","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib39","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1212\/WNL.46.6.1592","article-title":"Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience. Part XV","volume":"46","author":"Ellis","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib40","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.0230450100","article-title":"Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo","volume":"100","author":"Farris","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1750-3639.2004.tb00493.x","article-title":"Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease","volume":"14","author":"Ferrer","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1474-4422(04)00767-7","article-title":"An active and socially integrated lifestyle in late life might protect against dementia","volume":"3","author":"Fratiglioni","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib43","doi-asserted-by":"crossref","first-page":"11455","DOI":"10.1073\/pnas.97.21.11455","article-title":"Immunization against Alzheimer's beta-amyloid plaques via EFRH phage administration","volume":"97","author":"Frenkel","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/brain\/awg031","article-title":"Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57\/BL6 mice","volume":"126","author":"Furlan","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/JAD-2006-9S316","article-title":"Mice as models: transgenic approaches and Alzheimer's disease","volume":"9","author":"Games","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib47","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.febslet.2005.01.002","article-title":"Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo","volume":"579","author":"Gaugler","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib48","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nm0798-827","article-title":"Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity","volume":"4","author":"Geula","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib49","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neurobiolaging.2005.04.017","article-title":"Common mechanisms of amyloid oligomer pathogenesis in degenerative disease","volume":"27","author":"Glabe","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib50","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib51","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","article-title":"Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau","volume":"85","author":"Goedert","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-4-8","article-title":"The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease","volume":"4","author":"Golde","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib53","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nm0908-894","article-title":"Hope in Alzheimer's fight emerges from unexpected places","volume":"14","author":"Gura","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib54","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1001\/archneur.60.8.1119","article-title":"Alzheimer disease in the US population: prevalence estimates using the 2000 census","volume":"60","author":"Hebert","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib55","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nn1302","article-title":"Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis","volume":"7","author":"Herzig","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib56","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/nm783","article-title":"Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease","volume":"8","author":"Hock","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib57","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0896-6273(03)00294-0","article-title":"Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease","volume":"38","author":"Hock","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib58","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","article-title":"Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial","volume":"372","author":"Holmes","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib60","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0896-6273(95)90107-8","article-title":"Age-related CNS disorder and early death in transgenic FVB\/N mice overexpressing Alzheimer amyloid precursor proteins","volume":"15","author":"Hsiao","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib61","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-2005-871241","article-title":"Clioquinol treatment in familiar early onset of Alzheimer's disease: a case report","volume":"38","author":"Ibach","year":"2005","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib62","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jnr.10390","article-title":"Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging","volume":"70","author":"Iwata","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib63","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.1059946","article-title":"Metabolic regulation of brain Abeta by neprilysin","volume":"292","author":"Iwata","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/72237","article-title":"Identification of the major Abeta1\u201342-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition","volume":"6","author":"Iwata","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib65","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0925-4439(00)00033-8","article-title":"Transgenic mouse models of Alzheimer's disease","volume":"1502","author":"Janus","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib66","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0197-4580(00)00107-X","article-title":"Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes","volume":"21","author":"Janus","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib67","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/35050110","article-title":"A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease","volume":"408","author":"Janus","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib68","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000089919","article-title":"Mental, physical and social components in leisure activities equally contribute to decrease dementia risk","volume":"21","author":"Karp","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ana.21475","article-title":"Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden","volume":"65","author":"Kellner","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib70","first-page":"85","article-title":"Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention","volume":"13","author":"Kidd","year":"2008","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib71","doi-asserted-by":"crossref","first-page":"89S","DOI":"10.1007\/BF02982595","article-title":"Alzheimer's disease\u2014the ways of prevention","volume":"12","author":"Kivipelto","year":"2008","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib72","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0404.2006.00685.x","article-title":"Cholesterol as a risk factor for Alzheimer's disease\u2014epidemiological evidence","volume":"185","author":"Kivipelto","year":"2006","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib73","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000076666","article-title":"Immunization of mice with an A\u03b2-Hsp70 vaccine elicits anti-A\u03b2 antibodies and increased cerebral A\u03b2-levels","volume":"1","author":"Koller","year":"2004","journal-title":"Neurodeg. Dis."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib74","doi-asserted-by":"crossref","first-page":"6331","DOI":"10.1523\/JNEUROSCI.22-15-06331.2002","article-title":"Reversible memory loss in a mouse transgenic model of Alzheimer's disease","volume":"22","author":"Kotilinek","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib75","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/22682","article-title":"Ageing, fitness and neurocognitive function","volume":"400","author":"Kramer","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib76","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/humu.20336","article-title":"Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40","volume":"27","author":"Kumar-Singh","year":"2006","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib77","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/1389450033346957","article-title":"A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease","volume":"4","author":"Lahiri","year":"2003","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib78","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000093478","article-title":"Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study","volume":"22","author":"Laitinen","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib79","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/archneur.58.3.498","article-title":"Physical activity and risk of cognitive impairment and dementia in elderly persons","volume":"58","author":"Laurin","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib80","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1073\/pnas.092034699","article-title":"Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice","volume":"99","author":"Lee","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib81","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/ana.20592","article-title":"Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies","volume":"58","author":"Lee","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib82","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","article-title":"Neurodegenerative tauopathies","volume":"24","author":"Lee","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib83","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0896-6273(03)00787-6","article-title":"Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death","volume":"40","author":"Leissring","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib84","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib85","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/78078","article-title":"Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein","volume":"25","author":"Lewis","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib86","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/334359a0","article-title":"Structure and elasticity of microtubule-associated protein tau","volume":"334","author":"Lichtenberg","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib87","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1471-4159.2007.05064.x","article-title":"Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools","volume":"104","author":"Lichtlen","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2009.01.010","article-title":"New functions of cholesterol binding proteins","volume":"303","author":"Liu","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib89","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1002\/jnr.21074","article-title":"Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo","volume":"84","author":"Madani","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib90","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/ana.20494","article-title":"Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease","volume":"57","author":"Maruyama","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib91","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1002\/j.1460-2075.1985.tb04000.x","article-title":"Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels","volume":"4","author":"Masters","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib92","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib93","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/bies.20630","article-title":"The underestimated potential of the immune system in prevention of Alzheimer's disease pathology","volume":"29","author":"Mohajeri","year":"2007","journal-title":"Bioessays"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib94","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000080981","article-title":"Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo","volume":"1","author":"Mohajeri","year":"2004","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib95","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s11064-009-9919-6","article-title":"Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis","volume":"34","author":"Mohajeri","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib96","doi-asserted-by":"crossref","first-page":"35460","DOI":"10.1074\/jbc.M202899200","article-title":"Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo","volume":"277","author":"Mohajeri","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib97","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/35050116","article-title":"A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease","volume":"408","author":"Morgan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib98","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","article-title":"High-level neuronal expression of abeta 1\u201342 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation","volume":"20","author":"Mucke","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib99","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm840","article-title":"Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report","volume":"9","author":"Nicoll","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib100","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.febslet.2006.04.088","article-title":"Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia","volume":"580","author":"Obeid","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib101","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neurobiolaging.2003.08.012","article-title":"Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease","volume":"24","author":"Oddo","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib102","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib103","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.nbd.2006.04.013","article-title":"Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP\/PS1 transgenic mice","volume":"23","author":"Oksman","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib104","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.4049\/jimmunol.176.11.7071","article-title":"Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera","volume":"176","author":"O\u2019Nuallain","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1212\/01.WNL.0000073623.84147.A8","article-title":"Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization","volume":"61","author":"Orgogozo","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib106","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/archneur.60.1.29","article-title":"Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism","volume":"60","author":"Papassotiropoulos","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib107","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0896-6273(00)80187-7","article-title":"Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor","volume":"17","author":"Paresce","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib108","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1096\/fj.01-0841fje","article-title":"Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide","volume":"16","author":"Permanne","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib109","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.1078259","article-title":"Cerebral hemorrhage after passive anti-Abeta immunotherapy","volume":"298","author":"Pfeifer","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib110","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.nbd.2006.08.003","article-title":"Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit","volume":"24","author":"Poirier","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib111","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nn0403-345","article-title":"Alzheimer's disease: the cholesterol connection","volume":"6","author":"Puglielli","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib112","doi-asserted-by":"crossref","first-page":"S196","DOI":"10.1016\/j.jalz.2007.04.021","article-title":"IVIg contains antibodies against oligomers and fibrils of beta amyloid","volume":"3","author":"Relkin","year":"2007","journal-title":"Alzheimer Dement."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib113","article-title":"18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease","author":"Relkin","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib114","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1750-3639.2002.tb00449.x","article-title":"Sporadic and familial cerebral amyloid angiopathies","volume":"12","author":"Revesz","year":"2002","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib115_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1055\/s-2006-931548","article-title":"Clioquinol treatment in familiar early onset of Alzheimer's disease","volume":"39","author":"Ritchie","year":"2006","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib115_2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-2005-871241","volume":"38","author":"Ibach","year":"2005","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib116","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/hmg\/10.12.1317","article-title":"BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics","volume":"10","author":"Roberds","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib117","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.neurobiolaging.2003.12.020","article-title":"Lessons from the AN 1792 Alzheimer vaccine: lest we forget","volume":"25","author":"Robinson","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(03)00067-4","article-title":"Causative and susceptibility genes for Alzheimer's disease: a review","volume":"61","author":"Rocchi","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib119","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-0404.2006.00688.x","article-title":"Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease","volume":"185","author":"Rockwood","year":"2006","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib120","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib121","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1076-7460.2007.06696.x","article-title":"Cardiovascular risk factors for Alzheimer's disease","volume":"16","author":"Rosendorff","year":"2007","journal-title":"Am. J. Geriatr. Cardiol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib122","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ng1718","article-title":"APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy","volume":"38","author":"Rovelet-Lecrux","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib123","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1474-4422(05)70198-8","article-title":"Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease","volume":"4","author":"Rovio","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib124","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/gps.1755","article-title":"Work-related physical activity and the risk of dementia and Alzheimer's disease","volume":"22","author":"Rovio","year":"2007","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib125","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0197-4580(98)00033-5","article-title":"Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid","volume":"19","author":"Saido","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib126","series-title":"Metabolism and Alzheimer's Disease","author":"Saido","year":"2003"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib127","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0896-6273(04)00182-5","article-title":"Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration","volume":"42","author":"Saura","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib128","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1001\/archneur.63.12.noc60109","article-title":"Mediterranean diet, Alzheimer disease, and vascular mediation","volume":"63","author":"Scarmeas","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib129","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/ana.20854","article-title":"Mediterranean diet and risk for Alzheimer's disease","volume":"59","author":"Scarmeas","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib130","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nrn938","article-title":"Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning","volume":"3","author":"Schenk","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib131","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib132","doi-asserted-by":"crossref","first-page":"6787","DOI":"10.1523\/JNEUROSCI.2377-07.2008","article-title":"Immunotherapy reduces vascular amyloid-beta in PDAPP mice","volume":"28","author":"Schroeter","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib133","doi-asserted-by":"crossref","first-page":"24290","DOI":"10.1016\/S0021-9258(19)51080-8","article-title":"Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure","volume":"269","author":"Schweers","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib134","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2008.02.016","article-title":"Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior","volume":"192","author":"Selkoe","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib135","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.1038\/399a023","article-title":"Translating cell biology into therapeutic advances in Alzheimer's disease","volume":"399","author":"Selkoe","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib136","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1474-4422(02)00023-6","article-title":"Dosing in phase II trial of Alzheimer's vaccine suspended","volume":"1","author":"Senior","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib137","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0306-4522(01)00315-3","article-title":"Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus","volume":"107","author":"Shen","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib138","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0092-8674(00)80244-5","article-title":"Skeletal and CNS defects in presenilin-1-deficient mice","volume":"89","author":"Shen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib139","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib140","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer's amyloid-ss(1\u201340) peptide from brain by LDL receptor-related protein-1 at the blood\u2013brain barrier","volume":"106","author":"Shibata","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib141","series-title":"Aging with Grace: What the Nun Study Teaches Us About Leading Longer, Healthier, and More Meaningful Lives","author":"Snowdon","year":"2002"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib142","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm0798-822","article-title":"Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy","volume":"4","author":"Soto","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib143","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1749-6632.2002.tb04838.x","article-title":"Cholesterol and cognition: rationale for the AD cholesterol-lowering treatment trial and sex-related differences in beta-amyloid accumulation in the brains of spontaneously hypercholesterolemic Watanabe rabbits","volume":"977","author":"Sparks","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib144","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0264-410X(02)00464-4","article-title":"The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol","volume":"21","author":"Spooner","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib145","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0002-9440(10)65423-5","article-title":"Association of microglia with amyloid plaques in brains of APP23 transgenic mice","volume":"154","author":"Stalder","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib146","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/156720509787313899","article-title":"Cholesterol in Alzheimer's disease: unresolved questions","volume":"6","author":"Stefani","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib147","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Sturchler-Pierrat","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib148","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.autrev.2008.03.007","article-title":"Natural human antibodies to amyloid beta peptide","volume":"7","author":"Szabo","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib149","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1006\/nbdi.2001.0427","article-title":"Effects of exercise on gene-expression profile in the rat hippocampus","volume":"8","author":"Tong","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib150","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000105156","article-title":"Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches","volume":"4","author":"Van Broeck","year":"2007","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib151","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng1292-335","article-title":"Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3","volume":"2","author":"Van Broeckhoven","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib152","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0002-9440(10)64644-5","article-title":"Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons","volume":"157","author":"Van Dorpe","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib153","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1111\/j.1471-4159.2007.04689.x","article-title":"Oxysterols, cholesterol homeostasis, and Alzheimer disease","volume":"102","author":"Vaya","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib154","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1089\/10445490152717578","article-title":"beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe\/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology","volume":"20","author":"Vehmas","year":"2001","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib155","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib156","doi-asserted-by":"crossref","first-page":"15330","DOI":"10.1074\/jbc.M512574200","article-title":"Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4933-1-2","article-title":"The immunotherapy of Alzheimer's disease","volume":"1","author":"Weksler","year":"2004","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib158","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0531-5565(02)00029-3","article-title":"Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals","volume":"37","author":"Weksler","year":"2002","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib159","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(08)70090-5","article-title":"Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial","volume":"7","author":"Wilcock","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib160","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1523\/JNEUROSCI.21-05-01619.2001","article-title":"Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy","volume":"21","author":"Winkler","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib161","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1083\/jcb.100.6.1905","article-title":"Subunit structure of paired helical filaments in Alzheimer's disease","volume":"100","author":"Wischik","year":"1985","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib162","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(08)70170-4","article-title":"Amyloid-beta immunisation for Alzheimer's disease","volume":"7","author":"Wisniewski","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib163","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1001\/archneur.60.1.16","article-title":"Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer disease","volume":"60","author":"Wolozin","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib164","doi-asserted-by":"crossref","first-page":"12876","DOI":"10.1074\/jbc.M311652200","article-title":"Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation","volume":"279","author":"Wong","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng799","article-title":"Small changes in expression affect predisposition to tumorigenesis","volume":"30","author":"Yan","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2009.06.014_bib166","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1072545","article-title":"Allelic variation in human gene expression","volume":"297","author":"Yan","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib167","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0171-2985(99)80044-8","article-title":"Immune response against heat shock proteins in infectious diseases","volume":"201","author":"Zugel","year":"1999","journal-title":"Immunobiology"},{"key":"10.1016\/j.brainresbull.2009.06.014_bib168","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1073\/pnas.0701096104","article-title":"Attenuation of neuroinflammation and Alzheimer's disease pathology by liver \u00d7 receptors","volume":"104","author":"Zelcer","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923009002044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923009002044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:07:18Z","timestamp":1759781238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923009002044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":169,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0361923009002044"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2009.06.014","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevention of age-associated dementia","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2009.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}