{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:33:37Z","timestamp":1772998417961,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.brainresbull.2010.02.007","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T05:46:24Z","timestamp":1267076784000},"page":"83-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice"],"prefix":"10.1016","volume":"82","author":[{"given":"Vien","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alevtina D.","family":"Zharikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Prokai-Tatrai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Prokai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2010.02.007_bib1","series-title":"Statistics for Experimenters: Design, Innovation, and Discovery","author":"Box","year":"2005"},{"key":"10.1016\/j.brainresbull.2010.02.007_bib2","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","article-title":"Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib3","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1016\/S0021-9258(18)83109-X","article-title":"A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone","volume":"264","author":"Cockle","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/138955706775476019","article-title":"Thyrotropin-releasing hormone analogs","volume":"6","author":"Colsona","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib5","first-page":"145","article-title":"Antagonism of the analeptic activity of thyrotropin-releasing hormone (TRH) by agents which enhance GABA transmission","volume":"55","author":"Cott","year":"1976","journal-title":"Psychopharmacology."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1677\/joe.0.1270445","article-title":"Distribution of pyroglutamylpeptide amides related to thyrotropin-releasing hormone in the central nervous system and periphery of the rat","volume":"127","author":"Del Rio-Garcia","year":"1990","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1476-5381.1991.tb12179.x","article-title":"Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis","volume":"102","author":"Giovannini","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1677\/joe.0.1380137","article-title":"pGlutamylglutamylprolineamide modulation of growth hormone secretion in domestic fowl: antagonism of thyrotrophin-releasing hormone action?","volume":"138","author":"Harvey","year":"1993","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-8993(02)02454-X","article-title":"Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides","volume":"935","author":"Hinkle","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib10","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0024-3205(98)00087-3","article-title":"An update on the CNS actions of TRH and its analogs","volume":"62","author":"Horita","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib11","doi-asserted-by":"crossref","first-page":"16746","DOI":"10.1074\/jbc.M910386199","article-title":"Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides","volume":"275","author":"Kelly","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1677\/joe.0.1530411","article-title":"Urinary excretion of the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in rats","volume":"153","author":"Klootwijk","year":"1997","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib13","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1210\/jcem.82.9.4219","article-title":"High serum levels of the thyrotropin-releasing hormone-like peptide pyroglutamyl-glutamyl-prolineamide in patients with carcinoid tumors","volume":"82","author":"Klootwijk","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0091-3057(01)00555-X","article-title":"Antidepressant effects of thyrotropin-releasing hormone analogues using a rodent model of depression","volume":"70","author":"Lloyd","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib15","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2174\/092986708786242912","article-title":"Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs","volume":"15","author":"Monga","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1254\/fpj.107.237","article-title":"Montirelin hydrate (NS-3), a TRH analog, improved the disturbance of consciousness caused by head concussion and pentobarbital in mice","volume":"107","author":"Mushiroi","year":"1996","journal-title":"Folia Pharmacol. Jpn."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neulet.2006.12.039","article-title":"Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: an in vivo microdialysis study","volume":"415","author":"Nguyen","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0024-3205(74)90359-2","article-title":"Thyrotropin releasing hormone: antagonism of pentobarbital in rodents","volume":"14","author":"Prange","year":"1974","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib19","first-page":"133","article-title":"Central nervous system effects of thyrotropin-releasing hormone and its analogues: opportunities and perspectives for drug discovery and development","volume":"vol. 59","author":"Prokai","year":"2002"},{"key":"10.1016\/j.brainresbull.2010.02.007_bib20","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1021\/jm020531t","article-title":"Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium","volume":"47","author":"Prokai","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0006-8993(02)03251-1","article-title":"Neuropharmacodynamic evaluation of the centrally active thyrotropin-releasing hormone analogue [Leu2]TRH and its chemical brain-targeting system","volume":"952","author":"Prokai","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib22","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0960-894X(03)00081-7","article-title":"Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2","volume":"13","author":"Prokai-Tatrai","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib23","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/S0960-894X(02)00368-2","article-title":"Design, synthesis and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues","volume":"12","author":"Prokai-Tatrai","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib24","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/molecules14020633","article-title":"Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents","volume":"14","author":"Prokai-Tatrai","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.brainresbull.2010.02.007_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1573406053175256","article-title":"A pyridinium-substituted analogue of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents","volume":"2","author":"Prokai-Tatrai","year":"2005","journal-title":"Med. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib26","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1210\/endo-119-6-2519","article-title":"Benzodiazepines inhibit thyrotropin (TSH)-releasing hormone-induced TSH and growth hormone release from perifused rat pituitaries","volume":"119","author":"Roussel","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainresbull.2010.02.007_bib27","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.neuropharm.2007.02.003","article-title":"Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone","volume":"52","author":"Scalabrino","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2010.02.007_bib28","first-page":"469","article-title":"Effects of thyrotropine releasing hormone (TRH) on pentobarbital-induced decrease in cholinergic neuronal activity","volume":"1","author":"Schmidt","year":"1977","journal-title":"Commun. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainresbull.2007.02.012","article-title":"Exploratory neuropharmacological evaluation of a bridged thyrotropin-releasing hormone analogue","volume":"73","author":"Teixido","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2010.02.007_bib30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/263523a0","article-title":"TRH potentiates excitatory actions of acetylcholine on cerebral cortical neurons","volume":"263","author":"Yarbrough","year":"1976","journal-title":"Nature"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923010000511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923010000511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:07:51Z","timestamp":1759781271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923010000511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":30,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0361923010000511"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2010.02.007","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2010.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}