{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:25:57Z","timestamp":1791213957670,"version":"4.1.0"},"reference-count":164,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.brainresbull.2010.02.013","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T09:44:25Z","timestamp":1267695865000},"page":"7-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["Lipid rafts: Keys to neurodegeneration"],"prefix":"10.1016","volume":"82","author":[{"given":"Cara-Lynne","family":"Schengrund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.brainresbull.2010.02.013_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1471-4159.2007.04713.x","article-title":"Regulation of axonal development by plasma membrane gangliosides","volume":"103","author":"Abad-Rodriguez","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0959-440X(02)00376-7","article-title":"Lubricating cell signaling pathways with gangliosides","volume":"12","author":"Allende","year":"2002","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1600-0404.1995.tb00152.x","article-title":"Association of polyclonal anti-GM1 IgM and anti-neurofilament antibodies with CSF oligoclonal bands in a young with amyotrophic lateral sclerosis","volume":"92","author":"Annunziata","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib4","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1194\/jlr.R800007-JLR200","article-title":"Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease\u2014a review","volume":"49","author":"Ariga","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1022557920150","article-title":"GM1 inhibits amyloid \u03b2-protein-induced cytokine release","volume":"24","author":"Ariga","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000106597","article-title":"Intracerebroventricular administration of GM1 ganglioside to presenile Alzheimer patients","volume":"8","author":"Augustinsson","year":"1997","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10298420290015836","article-title":"Gangliosides prevent excitotoxicity through activation of TrkB receptor","volume":"4","author":"Bachis","year":"2002","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib8","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.neuint.2007.12.001","article-title":"N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice","volume":"52","author":"Baek","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/emboj\/21.5.1031","article-title":"Conversion of raft-associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes","volume":"21","author":"Baron","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib10","doi-asserted-by":"crossref","first-page":"14983","DOI":"10.1074\/jbc.M313061200","article-title":"Squalestatin cures prion-infected neurons and protects against prion neurotoxicity","volume":"279","author":"Bate","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib11","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.neurobiolaging.2007.12.022","article-title":"Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice","volume":"30","author":"Bernardo","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib12","doi-asserted-by":"crossref","first-page":"35119","DOI":"10.1074\/jbc.M505895200","article-title":"Disease-related modifications in tau affect the interaction between Fyn and tau","volume":"280","author":"Bhaskar","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib13","first-page":"301","article-title":"Differences in cerebrospinal fluid gangliosides between \u201cprobable Alzheimer's disease\u201d and normal aging","volume":"4","author":"Blennow","year":"1992","journal-title":"Aging (Milano)"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/sj.ejhg.5201695","article-title":"Parkinson's disease: the LRRK2-G20019S mutation: opening a novel era in Parkinson's disease genetics","volume":"14","author":"Bonifati","year":"2006","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib15","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1172\/JCI112130","article-title":"Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system","volume":"76","author":"Boyles","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0006-291X(82)91769-7","article-title":"GM3 ganglioside induces hamster fibroblast growth inhibition in chemically-defined medium: ganglioside may regulate growth factor receptor function","volume":"106","author":"Bremer","year":"1982","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib17","first-page":"309","article-title":"GPI-anchored proteins and detergent-resistant membrane domains","volume":"27","author":"Brown","year":"1994","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1742-4658.2008.06808.x","article-title":"SREBPs: SREBP function in glia-neuron interactions","volume":"276","author":"Camargo","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib19","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.bbamem.2009.07.019","article-title":"A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells","volume":"1788","author":"Cecchi","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"April (2)","key":"10.1016\/j.brainresbull.2010.02.013_bib20","first-page":"CD004444","article-title":"Gangliosides for acute spinal cord injury","author":"Chinnock","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib21","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1167\/iovs.01-0886","article-title":"Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve","volume":"44","author":"Choi","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3171\/jns.1994.80.1.0097","article-title":"The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury","volume":"80","author":"Constantini","year":"1994","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.nbd.2007.05.003","article-title":"Glycolipid and ganglioside metabolism imbalances in Huntington's disease","volume":"27","author":"Desplats","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib24","series-title":"Gangliosides in Neurological and Neuromuscular Function, Development, and Repair","first-page":"119","article-title":"Ganglioside-induced neurite formation in cultured neuroblastoma cells","author":"Dimpfel","year":"1981"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib25","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1083\/jcb.106.3.821","article-title":"A role for gangliosides in astroglial cell differentiation in vitro","volume":"106","author":"Facci","year":"1988","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1074\/jbc.M109806200","article-title":"Parkin and CASK\/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain","volume":"277","author":"Fallon","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib27","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1046\/j.1471-4159.1997.68062348.x","article-title":"Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA","volume":"68","author":"Farooqui","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib28","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1074\/jbc.270.7.3074","article-title":"Prevention of apoptotic neuronal death by GM1 ganglioside","volume":"270","author":"Ferrari","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib29","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","article-title":"Global prevalence of dementia: a Delphi consensus study","volume":"366","author":"Ferri","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib30","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1523\/JNEUROSCI.1594-04.2004","article-title":"Lipid rafts mediate the synaptic localization of alpha-synuclein","volume":"24","author":"Fortin","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib31","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1471-4159.2000.740582.x","article-title":"Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway","volume":"74","author":"Fryer","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ncb1528","article-title":"Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo","volume":"9","author":"Fulga","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1749-6632.1993.tb23074.x","article-title":"Gangliosides and neurotrophic factors in neurodegenerative diseases: from experimental findings to clinical perspectives","volume":"695","author":"Fusco","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4161\/cib.2.1.7420","article-title":"Akt signaling dynamics in plasma membrane microdomains visualized by FRET-based reporters","volume":"2","author":"Gao","year":"2009","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib35","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1097\/00007632-200112151-00014","article-title":"The Sygen multicenter acute spinal cord injury study","volume":"26","author":"Geisler","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib36","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1056\/NEJM199106273242601","article-title":"Recovery of motor function after spinal-cord injury\u2014a randomized, placebo-controlled trial with GM-1 ganglioside","volume":"324","author":"Geisler","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib37","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1073\/pnas.0407035102","article-title":"Raft lipids as common components of human extracellular amyloid fibrils","volume":"102","author":"Gellermann","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib38","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/glia.20531","article-title":"Glia-induced neuronal differentiation by transcriptional regulation","volume":"55","author":"Goritz","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib39","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.bcp.2006.07.014","article-title":"Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport","volume":"72","author":"Gorria","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1196\/annals.1378.011","article-title":"Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells","volume":"1090","author":"Gorria","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib41","doi-asserted-by":"crossref","first-page":"11302","DOI":"10.1074\/jbc.M801520200","article-title":"Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels","volume":"283","author":"Grimm","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib42","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib43","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1016\/S0021-9258(18)68785-X","article-title":"A novel ganglioside, de-N-acetyl-GM3 (II3)NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth","volume":"263","author":"Hanai","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib44","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/1565","article-title":"Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau","volume":"1","author":"Hardy","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib45","first-page":"35113","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"277","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib46","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/hmg\/ddm013","article-title":"Leucine-rich repeat kinase 2 associates with lipid rafts","volume":"16","author":"Hatano","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib47","doi-asserted-by":"crossref","first-page":"14009","DOI":"10.1074\/jbc.M313828200","article-title":"Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures","volume":"279","author":"Hayashi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00001756-200203250-00004","article-title":"Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice","volume":"13","author":"Hayashi","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib49","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1046\/j.1471-4159.2003.01599.x","article-title":"BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB","volume":"84","author":"Hu","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib50","doi-asserted-by":"crossref","unstructured":"Huntington's Disease Collaborative Research Group, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes, Cell 72 (1993) 971\u2013983.","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib51","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/76615","article-title":"Proteomic analysis of NMDA receptor-adhesion protein signaling complexes","volume":"3","author":"Husi","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1388-1981(00)00042-1","article-title":"Physiology and pathophysiology of sphingolipid metabolism and signaling","volume":"1485","author":"Huwiler","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib53","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jns.2004.11.037","article-title":"Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE3 and 4 and by increasing age","volume":"229\u2013230","author":"Igbavboa","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib54","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1056\/NEJM199812313392707","article-title":"Creutzfeldt-Jakob disease and related transmissible spongiform encephalopathies","volume":"339","author":"Johnson","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib55","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/j.1471-4159.1988.tb01138.x","article-title":"Altered expression of the D1.1 ganglioside in the cerebellum of the Weaver mouse","volume":"51","author":"Johnstone","year":"1988","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib56","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1006\/bbrc.2001.4864","article-title":"The plasma membrane ganglioside sialidase cofractionates with markers of lipid rafts","volume":"283","author":"Kalka","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib57","doi-asserted-by":"crossref","first-page":"36815","DOI":"10.1074\/jbc.M504484200","article-title":"Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro","volume":"280","author":"Kalvodova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib58","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0308-4","article-title":"Amylotrophic lateral sclerosis models and human neuropathology: similarities and differences","volume":"115","author":"Kato","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib59","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nm0309-253","article-title":"Getting a handle on Huntington's disease: the case for cholesterol","volume":"15","author":"Katsuno","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib60","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1074\/jbc.C000847200","article-title":"Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures","volume":"276","author":"Kawai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib61","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib62","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0005-2736(76)90317-5","article-title":"Freeze-fracture ultrastructural alterations induced by filipin, pimaricin, nystatin and amphotericin B in the plasma membranes of Epidermophyton, Saccharomyces and red complex-induced membrane lesions","volume":"455","author":"Kitajima","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1054\/jocn.1999.0194","article-title":"Anti-GM1 ganglioside antibodies: their role in the diagnosis and pathogenesis of immune-mediated motor neuropathies","volume":"7","author":"Kornberg","year":"2000","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib64","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1471-4159.1984.tb12833.x","article-title":"Topographical atlas of the gangliosides of adult human brain","volume":"43","author":"Kracun","year":"1984","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib65","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0021-9258(19)75683-X","article-title":"Regulation of protein kinase C activity by gangliosides","volume":"262","author":"Kreutter","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","article-title":"Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease","volume":"18","author":"Kruger","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib67","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1046\/j.1471-4159.2001.00364.x","article-title":"Parkin is associated with cellular vesicles","volume":"78","author":"Kubo","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib68","doi-asserted-by":"crossref","first-page":"31664","DOI":"10.1074\/jbc.M504894200","article-title":"A combinatorial code for the interaction of alpha-synuclein with membranes","volume":"280","author":"Kubo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib69","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/exnr.2002.8011","article-title":"Elevated levels of neurotrophins in human biceps brachii tissue of amyotrophic lateral sclerosis","volume":"177","author":"Kust","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib70","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0741-8329(95)02045-4","article-title":"Cortical cell plasma membrane alterations after in vitro alcohol exposure: prevention by GM1 ganglioside","volume":"13","author":"Laev","year":"1996","journal-title":"Alcohol"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib71","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neurobiolaging.2003.12.024","article-title":"Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease","volume":"25","author":"Lahiri","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib72","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1020224016830","article-title":"Ganglioside function in calcium homeostasis and signaling","volume":"27","author":"Ledeen","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib73","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0361-9230(94)90251-8","article-title":"Cocaine exposure during pregnancy affects rat neonate and maternal brain glycosphingolipids","volume":"33","author":"Leskawa","year":"1994","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib74","doi-asserted-by":"crossref","first-page":"42782","DOI":"10.1074\/jbc.M101481200","article-title":"Enhancement of epidermal growth factor signaling and activation of Src kinase by gangliosides","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib75","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib76","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1073\/pnas.0600549103","article-title":"Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease","volume":"103","author":"Mahley","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib77","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0022-3565(25)13364-8","article-title":"Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids","volume":"252","author":"Manev","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib78","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib79","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1021\/bi061749a","article-title":"GM1 specifically interacts with alpha-synuclein and inhibits fibrillation","volume":"46","author":"Martinez","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib80","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.semcdb.2008.10.005","article-title":"Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing implications for Alzheimer's disease","volume":"20","author":"Marzolo","year":"2009","journal-title":"Sem. Cell Dev. Biol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib81","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0306-4522(96)00703-8","article-title":"Inhibition by compactin demonstrates a requirement of isoprenoid metabolism for long-term potentiation in rat hippocampal slices","volume":"79","author":"Matthies","year":"1997","journal-title":"Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib82","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.294.5545.1354","article-title":"CNS synaptogenesis promoted by glia-derived cholesterol","volume":"294","author":"Mauch","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib83","doi-asserted-by":"crossref","first-page":"RE15","DOI":"10.1126\/stke.2002.160.re15","article-title":"Regulation of growth factor receptors by gangliosides","volume":"2002","author":"Miljan","year":"2002","journal-title":"Sci. STKE"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib84","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1074\/jbc.M111669200","article-title":"Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides","volume":"277","author":"Miljan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib85","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.1365-2184.2002.00228.x","article-title":"Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1a and GT1b","volume":"35","author":"Mirkin","year":"2002","journal-title":"Cell Prolif."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib86","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/jb\/mvn089","article-title":"Plasma membrane-associated sialidase as a crucial regulator of transmembrane signaling","volume":"144","author":"Miyagi","year":"2008","journal-title":"J. Biochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib87","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2169\/internalmedicine.42.277","article-title":"Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2","volume":"42","author":"Mizutani","year":"2003","journal-title":"Intern. Med."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib88","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1523\/JNEUROSCI.1856-06.2006","article-title":"Protecting motor neurons from toxic insult by antagonism of adenosine A2a and Trk receptors","volume":"26","author":"Mojsilovic-Petrovic","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib89","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1471-4159.2004.02849.x","article-title":"Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains","volume":"92","author":"Molander-Melin","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib90","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1016\/j.febslet.2006.07.053","article-title":"Traffic of prion protein between different compartments on the neuronal surface, and the propagation of prion disease","volume":"580","author":"Morris","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib91","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1073\/pnas.73.4.1034","article-title":"Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness","volume":"73","author":"Moss","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib92","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1023\/A:1020209008169","article-title":"Stable transfection of GM1 synthase gene into GM1-deficient NG108-15 cells, CR-72 cells, rescues the responsiveness of Trk-neurotrophin receptor to its ligand, NGF","volume":"27","author":"Mutoh","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib93","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1073\/pnas.92.11.5087","article-title":"Ganglioside GM1 binds to the Trk protein and regulates receptor function","volume":"92","author":"Mutoh","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib94","doi-asserted-by":"crossref","first-page":"21604","DOI":"10.1074\/jbc.271.35.21604","article-title":"Intracellular trafficking of cholesterol monitored with a cyclodextrin","volume":"271","author":"Neufeld","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib95","doi-asserted-by":"crossref","first-page":"33368","DOI":"10.1074\/jbc.M403816200","article-title":"Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells","volume":"279","author":"Nishio","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib96","doi-asserted-by":"crossref","first-page":"11062","DOI":"10.1073\/pnas.0609621104","article-title":"Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein","volume":"104","author":"Parkin","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib97","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0026-895X(25)11342-4","article-title":"Effect of gangliosides on adenylate cyclase activity in rat cerebral cortical membranes","volume":"15","author":"Partington","year":"1979","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib98","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrn1971","article-title":"Molecular biology of amyotrophic lateral sclerosis: insights from genetics","volume":"7","author":"Pasinelli","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib99","first-page":"29","article-title":"Multifocal motor neuropathy. Serum IgM and anti-GM1 ganglioside antibodies in most patients detected using covalent linkage of GM1 Membrane raft disruption promotes axonogenesis in N2a neuroblastoma cells","volume":"34","author":"Pestronk","year":"1997","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11064-008-9625-9","article-title":"Membrane raft disruption promotes axonogenesis in N2a neuroblastoma cells","volume":"34","author":"Petro","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib101","doi-asserted-by":"crossref","first-page":"39907","DOI":"10.1074\/jbc.M606015200","article-title":"Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation","volume":"281","author":"Pierrot","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib102","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib103","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1023\/A:1020269326825","article-title":"Modulation of neuritogenesis by ganglioside-specific sialiddase (Neu3) in human neuroblastoma NB-1 cells","volume":"27","author":"Proshin","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib104","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","article-title":"Prions","volume":"95","author":"Prusiner","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(78)90749-7","article-title":"Meganeurites and other aberrant processes of neurons in feline GM1-gangliosidosis: a Golgi study","volume":"143","author":"Purpura","year":"1978","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(76)90245-6","article-title":"Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease","volume":"116","author":"Purpura","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib107","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1471-4159.1995.65010347.x","article-title":"GM1 ganglioside activates the high affinity nerve growth factor receptor trkA","volume":"65","author":"Rabin","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib108","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/bj20031348","article-title":"Isolation and characterization of lipid rafts with different properties from RBL-2H3 (rat basophilic leukemia) cells","volume":"380","author":"Radeva","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib109","series-title":"Gangliosides in Neurological and Neuromuscular Function, Development, and Repair","first-page":"xv","article-title":"Introduction to the biochemistry of gangliosides","author":"Rapport","year":"1981"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib110","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0960-9822(01)00394-3","article-title":"Compartmentalization of [beta]-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts","volume":"11","author":"Riddell","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib111","first-page":"1","article-title":"Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease","volume":"2006","author":"Rojo","year":"2006","journal-title":"J. Biomed. Biotech."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib112","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0896-6273(02)00872-3","article-title":"Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders","volume":"35","author":"Ross","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib113","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1073\/pnas.072651899","article-title":"Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2","volume":"99","author":"Rusnati","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib114","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/S0002-9440(10)63439-6","article-title":"Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts","volume":"165","author":"Russelakis-Carneiro","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib115","doi-asserted-by":"crossref","first-page":"27896","DOI":"10.1074\/jbc.M212200200","article-title":"Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice","volume":"278","author":"Sasaki","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib116","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0361-9230(90)90297-D","article-title":"The role(s) of gangliosides in differentiation and repair: a perspective","volume":"24","author":"Schengrund","year":"1990","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib117","doi-asserted-by":"crossref","first-page":"13233","DOI":"10.1016\/S0021-9258(18)51619-7","article-title":"Binding of vibrio cholera toxin and the heat-labile enterotoxin of Escherichia coli to GM1, derivatives of GM1, and nonlipid oligosaccharide polyvalent ligands","volume":"264","author":"Schengrund","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib118","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.256.5058.843","article-title":"Recovery from experimental Parkinsonism in primates with GM1 ganglioside treatment","volume":"256","author":"Schneider","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib119","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1212\/WNL.45.6.1149","article-title":"GM1 ganglioside treatment of Parkinson's disease: an open pilot study of safety and efficacy","volume":"45","author":"Schneider","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib120","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1749-6632.1998.tb09688.x","article-title":"GM1 ganglioside in the treatment of Parkinson's disease","volume":"845","author":"Schneider","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib121","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1242\/jcs.03378","article-title":"Tau impacts on growth-factor stimulated actin remodeling","volume":"120","author":"Sharma","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib122","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/hmg\/ddm054","article-title":"Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain","volume":"16","author":"Shelbourne","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib123","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1093\/hmg\/ddi377","article-title":"Mitochondral import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism","volume":"14","author":"Silvestri","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib124","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1093\/hmg\/ddl398","article-title":"C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine\/threonine kinase activity of PTEN-induced kinase-1","volume":"15","author":"Sim","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib125","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib126","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1073\/pnas.95.11.6460","article-title":"Cholesterol depletion inhibits the generation of \u03b2-amyloid in hippocampal neurons","volume":"95","author":"Simons","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib127","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/ng1460","article-title":"Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation in GM3 synthase","volume":"36","author":"Simpson","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib128","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"Alpha-Synuclein locus triplication causes Parkinson's disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib129","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/11.17.1953","article-title":"Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses","volume":"11","author":"Sipione","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib130","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.1074\/jbc.M110338200","article-title":"Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells","volume":"277","author":"Song","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib131","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1111\/j.1742-4658.2006.05203.x","article-title":"Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells","volume":"273","author":"Sottocornola","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib132","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0165-3806(84)90075-0","article-title":"Ganglioside-mediated enhancement of the cytoskeletal organization and activity in neuro-2a neuroblastoma cells","volume":"315","author":"Spero","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib133","first-page":"519","article-title":"A characteristic ganglioside antibody pattern in the CSF of patients with amyotrophic lateral sclerosis","volume":"58","author":"Stevens","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib134","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to \u03b2-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib135","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1093\/emboj\/cdg344","article-title":"The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein","volume":"22","author":"Sunyach","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib136","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1471-4159.2005.03620.x","article-title":"Interaction of huntingtin fragments with brain membranes\u2013clues to early dysfunction in Huntington's disease","volume":"96","author":"Suopanki","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib137","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-4684-7844-0_2","article-title":"Ganglioside designation","volume":"125","author":"Svennerholm","year":"1980","journal-title":"Adv. Exp. Med."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib138","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000063604","article-title":"Alzheimer disease\u2013effect of continuous intracerebroventricular treatment with GM1 ganglioside and a systematic activation programme","volume":"14","author":"Svennerholm","year":"2002","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib139","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1074\/jbc.M103705200","article-title":"Ganglioside GM3 participates in the pathological conditions of insulin resistance","volume":"277","author":"Tagami","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib140","doi-asserted-by":"crossref","first-page":"28110","DOI":"10.1074\/jbc.M414525200","article-title":"Inhibition of glycosphingolipid biosynthesis reduces secretion of the \u03b2-amyloid precursor protein and amyloid \u03b2-peptide","volume":"280","author":"Tamboli","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib141","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BJ20061736","article-title":"The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein","volume":"402","author":"Taylor","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib142","series-title":"Gangliosides in Neurological and Neuromuscular Function, Development, and Repair","first-page":"225","article-title":"The fate of exogenously administered brain gangliosides","author":"Tettamanti","year":"1981"},{"key":"10.1016\/j.brainresbull.2010.02.013_bib143","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/71366","article-title":"Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles","volume":"2","author":"Thiele","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib144","first-page":"6106","article-title":"Mutant huntingtin and glycogen synthase kinase 3-\u03b2 accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease","volume":"29","author":"Valencia","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib145","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1471-4159.1993.tb03581.x","article-title":"Gangliosides inhibit platelet-derived growth factor-stimulated receptor dimerization in human glioma U-1242MG and Swiss 3T3 cells","volume":"61","author":"Van Brocklyn","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib146","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib147","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF02960920","article-title":"Region distribution of the gangliosides in rat brain after chronic ethanol treatment","volume":"25","author":"Vrbaski","year":"1995","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib148","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1515\/BC.2001.031","article-title":"Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers","volume":"382","author":"Vyas","year":"2001","journal-title":"Biol. Chem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib149","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.4049\/jimmunol.0802981","article-title":"Cross-linking of GM1 by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis","volume":"182","author":"Wang","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib150","doi-asserted-by":"crossref","first-page":"16842","DOI":"10.1073\/pnas.0507360102","article-title":"Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity","volume":"102","author":"West","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib151","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1096\/fj.07-9766com","article-title":"Membrane-bound \u03b2-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism","volume":"22","author":"Williamson","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1006910001869","article-title":"Induction of axon-like and dendrite-like processes in neuroblastoma cells","volume":"27","author":"Wu","year":"1998","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib153","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0165-3806(00)00150-4","article-title":"Comparison of ganglioside profiles in nuclei and whole cells of NG108-15 and NG-CR72 lines: changes in response to different neuritogenic stimul","volume":"126","author":"Wu","year":"2001","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib154","doi-asserted-by":"crossref","first-page":"7447","DOI":"10.1523\/JNEUROSCI.4266-06.2007","article-title":"Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with alpha5beta1 integrin initiates neurite outgrowth","volume":"27","author":"Wu","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib155","doi-asserted-by":"crossref","first-page":"11014","DOI":"10.1523\/JNEUROSCI.3635-05.2005","article-title":"Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1","volume":"25","author":"Wu","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib156","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.febslet.2005.03.013","article-title":"Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides","volume":"579","author":"Yamamoto","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib157","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1471-4159.2005.03444.x","article-title":"Cross-seeding of wild-type and hereditary variant-type amyloid beta-proteins in the presence of gangliosides","volume":"95","author":"Yamamoto","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib158","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1042\/BJ20070090","article-title":"Fucoganglioside alpha-fucosyl(alpha-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis","volume":"407","author":"Yamazake","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib159","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm1095-1062","article-title":"GM1 ganglioside-boound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease","volume":"1","author":"Yanagisawa","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib160","doi-asserted-by":"crossref","first-page":"10793","DOI":"10.1073\/pnas.0602493103","article-title":"Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin","volume":"103","author":"Yang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib161","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1471-4159.1989.tb07308.x","article-title":"Ganglioside modulation of cyclic AMP-dependent kinase and cyclic nucleotide phosphodiesterase in vitro","volume":"53","author":"Yates","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib162","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1111\/j.1742-4658.2009.07057.x","article-title":"Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord","volume":"276","author":"Zhai","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib163","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.240347797","article-title":"Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein CDCrel-1","volume":"97","author":"Zhang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2010.02.013_bib164","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tips.2007.05.001","article-title":"Impact of HMG-CoA reductase inhibition on brain pathology","volume":"28","author":"Zipp","year":"2007","journal-title":"Trends Pharmacol. Sci."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923010000572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923010000572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:07:38Z","timestamp":1759781258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923010000572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":164,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0361923010000572"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2010.02.013","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid rafts: Keys to neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2010.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}