{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:51:28Z","timestamp":1786985488492,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.brainresbull.2010.04.004","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T04:26:21Z","timestamp":1271219181000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Histaminergic and cholinergic neuron systems in the impairment of human thermoregulation during motion sickness"],"prefix":"10.1016","volume":"82","author":[{"given":"Gerard","family":"Nobel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Tribukait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor B.","family":"Mekjavic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Eiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2010.04.004_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2265.1983.tb02986.x","article-title":"Effect of meclastine, a selective H1 receptor antagonist, upon ACTH release","volume":"19","author":"Allolio","year":"1983","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/01.CIR.73.6.1145","article-title":"Effects of vasopressin on the circulation and its baroreflex control in healthy men","volume":"73","author":"Aylward","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00019052-200002000-00005","article-title":"Motion sickness","volume":"13","author":"Bles","year":"2000","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib4","series-title":"Agard Conference Proceedings 541","article-title":"Effect of seasickness on aircrew student survivor ability after ditching in cold water","author":"Bohemier","year":"1993"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib5","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1152\/japplphysiol.01064.2005","article-title":"Neuronal basis of Hammel's model for set-point thermoregulation","volume":"100","author":"Boulant","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF01900386","article-title":"Temperature changes following microinjection of histamine into the thermoregulatory centers of the rat","volume":"26","author":"Brezenoff","year":"1970","journal-title":"Experientia"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(02)00830-9","article-title":"The human hippocampus and spatial and episodic memory","volume":"35","author":"Burgess","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0361-9230(01)00463-4","article-title":"Coriolis-induced cutaneous blood flow increase in the forearm and calf","volume":"54","author":"Cheung","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0163-7258(83)90006-2","article-title":"Brain and pituitary peptides in thermoregulation","volume":"22","author":"Clark","year":"1983","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib10","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0306-4522(84)90001-0","article-title":"Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain: brainstem","volume":"12","author":"Cortes","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1249\/00005768-199104000-00008","article-title":"Additive effects of caffeine and cold water during submaximal leg exercise","volume":"23","author":"Doubt","year":"1991","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib12","first-page":"821","article-title":"Hormonal changes after parabolic flight: implications on the development of motion sickness","volume":"61","author":"Drummer","year":"1990","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib13","first-page":"57","article-title":"A discrete mode of the antipyretic action of AVP, alpha-MSH and ACTH","volume":"41","author":"Ehymayed","year":"1992","journal-title":"Physiol. Res."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib14","first-page":"541","article-title":"Motion sickness decreases arterial pressure and therefore acceleration tolerance","volume":"76","author":"Eiken","year":"2005","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib15","first-page":"53","article-title":"Increased secretion of growth hormone, prolactin, antidiuretic hormone, and cortisol induced by the stress of motion sickness","volume":"49","author":"Eversmann","year":"1978","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0006-8993(75)90360-1","article-title":"Localization of vasopressin in discrete areas of the rat hypothalamus","volume":"93","author":"George","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib17","unstructured":"F. Golden, M., Essentials of Sea Survival, Human Kinetics, New York, 2002."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jrnms-59-5","article-title":"Death after rescue from immersion in cold water","volume":"59","author":"Golden","year":"1973","journal-title":"J. R. Nav. Med. Serv."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/026988110101500311","article-title":"The effects of dimenhydrinate, cinnarizine and transdermal scopolamine on performance","volume":"15","author":"Gordon","year":"2001","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib20","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1152\/ajplegacy.1944.141.2.172","article-title":"Cold sweating in motion sickness","volume":"141","author":"Hemingway","year":"1944","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib22","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1172\/JCI114182","article-title":"Vasopressin-mediated forearm vasodilation in normal humans. Evidence for a vascular vasopressin V2 receptor","volume":"84","author":"Hirsch","year":"1989","journal-title":"J. Clin. Invest."},{"issue":"Pt 2","key":"10.1016\/j.brainresbull.2010.04.004_bib23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3109\/00016489509125280","article-title":"Vestibular modulation of the septo-hippocampal cholinergic system of rats","volume":"Suppl. 520","author":"Horii","year":"1995","journal-title":"Acta Otolaryngol."},{"issue":"Suppl. 1","key":"10.1016\/j.brainresbull.2010.04.004_bib24","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1007\/PL00014148","article-title":"Effects of the antihistaminergic drugs diphenhydramine and zolantidine on vestibular-induced hypothalamic neuronal activity in the guinea pig","volume":"256","author":"Inokuchi","year":"1999","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0304-3940(83)90055-1","article-title":"Interaction of cholecystokinin with vasoactive intestinal peptide in body shaking response to ice-water immersion in rats","volume":"40","author":"Katsuura","year":"1983","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib26","first-page":"1158","article-title":"Endocrine correlates of susceptibility to motion sickness","volume":"56","author":"Kohl","year":"1985","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0031-9384(89)90266-7","article-title":"Responses of hypothalamic paraventricular neurons in vitro to norepinephrine and other feeding-relevant agents","volume":"46","author":"Kow","year":"1989","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib28","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1113\/jphysiol.2008.159103","article-title":"Neurotransmitters and peptides: whispered secrets and public announcements","volume":"586","author":"Leng","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib29","series-title":"Airmen Against the sea. An Analysis of Sea Survival Experiences","author":"Llano","year":"1955"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1469-7793.2001.00619.x","article-title":"Motion sickness potentiates core cooling during immersion in humans","volume":"535","author":"Mekjavic","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib31","first-page":"89","article-title":"Does the effect of AVP on hypothalamic neurones support its proposed role in endogenous antipyresis?","volume":"41","author":"Moravec","year":"1992","journal-title":"Physiol. Res."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib32","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2165\/00003088-200645060-00001","article-title":"Transdermal scopolamine for prevention of motion sickness: clinical pharmacokinetics and therapeutic applications","volume":"45","author":"Nachum","year":"2006","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00421-006-0217-6","article-title":"Motion sickness increases the risk of accidental hypothermia","volume":"98","author":"Nobel","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.autneu.2006.07.010","article-title":"Endocrine correlates of acute nausea and vomiting","volume":"129","author":"Otto","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0306-4522(81)90240-2","article-title":"The distribution of histamine H1-receptors in the rat brain: an autoradiographic study","volume":"6","author":"Palacios","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib36","series-title":"Motion Sickness","author":"Reason","year":"1975"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-8993(99)01468-7","article-title":"Colocalization of VIP with AVP in neurons of the human paraventricular, supraoptic and suprachiasmatic nucleus","volume":"832","author":"Romijn","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib38","doi-asserted-by":"crossref","first-page":"816","DOI":"10.2741\/1277","article-title":"Endogenous antipyretics: neuropeptides and glucocorticoids","volume":"9","author":"Roth","year":"2004","journal-title":"Front. Biosci."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib39","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/ki.1979.189","article-title":"Influence of the emetic reflex on vasopressin release in man","volume":"16","author":"Rowe","year":"1979","journal-title":"Kidney Int."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00000542-199009000-00027","article-title":"Skin-surface temperature gradients correlate with fingertip blood flow in humans","volume":"73","author":"Rubinstein","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainresbull.2010.04.004_bib41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1152\/jappl.2001.90.1.67","article-title":"Orthostatic intolerance and motion sickness after parabolic flight","volume":"90","author":"Schlegel","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1991.71.1.1","article-title":"Histaminergic transmission in the mammalian brain","volume":"71","author":"Schwartz","year":"1991","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib43","first-page":"837","article-title":"Effect of vestibular Coriolis reaction on respiration and blood-flow changes in man","volume":"39","author":"Sinha","year":"1968","journal-title":"Aerosp. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib44","first-page":"995","article-title":"Serum levels of eleven steroid hormones following motion sickness","volume":"56","author":"Stalla","year":"1985","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib45","first-page":"A270","article-title":"Pharmacological interventions for motion sickness: cardiovascular effects","volume":"58","author":"Sunahara","year":"1987","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib46","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/00016489309126205","article-title":"Neuropharmacology of motion sickness and emesis. A review","volume":"501","author":"Takeda","year":"1993","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib47","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2741\/2174","article-title":"Corticotropin-releasing hormone and the blood\u2013brain-barrier","volume":"12","author":"Theoharides","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib48","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainresbull.2009.06.012","article-title":"Effects of anti-histaminic and anti-cholinergic substances on human thermoregulation during cold provocation","volume":"81","author":"Tribukait","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0304-3940(89)90095-5","article-title":"Effects of histamine on thermosensitive neurons in rat preoptic slice preparations","volume":"102","author":"Tsai","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib50","first-page":"579","article-title":"Histaminergic response to Coriolis stimulation: implication for transdermal scopolamine therapy of motion sickness","volume":"63","author":"Wang","year":"1992","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib51","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1152\/jappl.1987.63.2.589","article-title":"Metabolic and hormonal responses in theophylline-increased cold resistance in males","volume":"63","author":"Wang","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.brainresbull.2010.04.004_bib52","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1113\/jphysiol.2004.071779","article-title":"H1 but not H2 histamine receptor activation contributes to the rise in skin blood flow during whole body heating in humans","volume":"560","author":"Wong","year":"2004","journal-title":"J. Physiol."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923010000717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923010000717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:07:32Z","timestamp":1759781252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923010000717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":52,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0361923010000717"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2010.04.004","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histaminergic and cholinergic neuron systems in the impairment of human thermoregulation during motion sickness","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2010.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}