{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:23:05Z","timestamp":1778588585517,"version":"3.51.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.brainresbull.2011.03.013","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T14:16:24Z","timestamp":1303136184000},"page":"171-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice"],"prefix":"10.1016","volume":"88","author":[{"given":"Zubeyde","family":"Bayram-Weston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B.","family":"Dunnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2011.03.013_bib0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ar.1090940210","article-title":"Estimation of nuclear population from microtome sections","author":"Abercrombie","year":"1946","journal-title":"Anatomical Records"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0010","series-title":"Huntington's Disease","author":"Bates","year":"2002"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0330","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.brainresbull.2011.03.013","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in the R6\/1 transgenic mouse","volume":"88","author":"Bayram-Weston","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0320","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainresbull.2011.05.005","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 transgenic mice","volume":"88","author":"Bayram-Weston","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0325","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainresbull.2011.03.014","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh(CAG)150 Huntington's disease knock-in mouse","volume":"88","author":"Bayram-Weston","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0030","article-title":"Longitudinal analysis of the behavioural phenotype in Hdh(Q92) Huntington's disease knock-in mice","author":"Brooks","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0035","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nn0802-711","article-title":"Mutant huntingtin goes straight to the heart","volume":"5","author":"Cattaneo","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0040","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0045","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0896-6273(95)90346-1","article-title":"Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons","volume":"14","author":"DiFiglia","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0050","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0055","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1523\/JNEUROSCI.17-09-03052.1997","article-title":"Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum","volume":"17","author":"Ferrante","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0060","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1097\/00001756-199806010-00028","article-title":"Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset","volume":"9","author":"Gourfinkel-An","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0065","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0070","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0075","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1523\/JNEUROSCI.19-07-02522.1999","article-title":"Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology","volume":"19","author":"Gutekunst","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00005072-199501000-00013","article-title":"Early loss of neostriatal striosome neurons in Huntington's disease","volume":"54","author":"Hedreen","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0085","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","article-title":"A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration","volume":"23","author":"Hodgson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0090","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/hmg\/2.12.2069","article-title":"Characterization and localization of the Huntington disease gene product","volume":"2","author":"Hoogeveen","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0095","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/sj.embor.7400250","article-title":"Huntingtin and the molecular pathogenesis of Huntington's disease \u2013 fourth in molecular medicine review series 1","volume":"5","author":"Landles","year":"2004","journal-title":"Embo Rep."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0100","doi-asserted-by":"crossref","first-page":"8808","DOI":"10.1074\/jbc.M109.075028","article-title":"Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease","volume":"285","author":"Landles","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1097-4547(19991115)58:4<515::AID-JNR5>3.0.CO;2-F","article-title":"Enhanced sensitivity to N-methyl-d-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease","volume":"58","author":"Levine","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0110","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/hmg\/8.7.1227","article-title":"Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice","volume":"8","author":"Li","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/78054","article-title":"Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity","volume":"25","author":"Li","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0120","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molmed.2003.08.006","article-title":"Huntington's disease: a synaptopathy?","volume":"9","author":"Li","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington's disease","volume":"10","author":"Lin","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0130","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/hmg\/ddl125","article-title":"Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice","volume":"15","author":"Lloret","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0135","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/hmg\/7.9.1355","article-title":"A cellular model that recapitulates major pathogenic steps of Huntington's disease","volume":"7","author":"Lunkes","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005072-199902000-00003","article-title":"Distribution of inclusions in neuronal nuclei and dystrophic neurites in Huntington disease brain","volume":"58","author":"Maat-Schieman","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.10776","article-title":"Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats","volume":"465","author":"Menalled","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0150","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/hmg\/ddl092","article-title":"Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease","volume":"15","author":"Milnerwood","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0155","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1023\/A:1010887421592","article-title":"Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation","volume":"29","author":"Morton","year":"2000","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0160","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0092-8674(00)80464-X","article-title":"Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse","volume":"91","author":"Ordway","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0165","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0170","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/2510","article-title":"Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA","volume":"20","author":"Reddy","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0166-2236(99)01415-0","article-title":"Recent advances in understanding the pathogenesis of Huntington's disease","volume":"22","author":"Reddy","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0180","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1073\/pnas.85.15.5733","article-title":"Differential loss of striatal projection neurons in Huntington disease","volume":"85","author":"Reiner","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0185","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/cne.21515","article-title":"R6\/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice","volume":"505","author":"Reiner","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0190","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-510X(83)90053-9","article-title":"Nuclear membrane indentations in Huntington's chorea","volume":"61","author":"Roos","year":"1983","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0195","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/jnnp.48.5.422","article-title":"Neuronal distribution in the putamen in Huntington's disease","volume":"48","author":"Roos","year":"1985","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0200","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1212\/01.WNL.0000065888.88988.6E","article-title":"Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis","volume":"60","author":"Rosas","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0205","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0896-6273(00)80405-5","article-title":"Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?","volume":"19","author":"Ross","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0210","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ana.410420411","article-title":"Huntingtin localization in brains of normal and Huntington's disease patients","volume":"42","author":"Sapp","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0092-8674(00)81782-1","article-title":"Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions","volume":"95","author":"Saudou","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0220","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0896-6273(95)90345-3","article-title":"Widespread expression of Huntington's disease gene (IT15) protein product","volume":"14","author":"Sharp","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0225","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1093\/hmg\/11.23.2815","article-title":"HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis","volume":"11","author":"Singaraja","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(00)81743-2","article-title":"Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?","volume":"95","author":"Sisodia","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0235","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0240","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/00005072-197404000-00008","article-title":"Studies on brain biopsies of patients with Huntington's chorea","volume":"33","author":"Tellez-Nagel","year":"1974","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0245","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0250","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1460-9568.2007.05307.x","article-title":"The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease","volume":"25","author":"Trueman","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0255","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bbr.2008.01.020","article-title":"Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT)","volume":"189","author":"Trueman","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0260","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbr.2009.05.006","article-title":"Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease","volume":"203","author":"Trueman","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0265","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1128\/MCB.24.18.8195-8209.2004","article-title":"Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro","volume":"24","author":"Trushina","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0270","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1073\/pnas.110078997","article-title":"Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease","volume":"97","author":"Turmaine","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0275","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nbd.2006.12.010","article-title":"Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain","volume":"26","author":"Van Raamsdonk","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0280","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0285","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0290","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1091\/mbc.12.5.1393","article-title":"Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation","volume":"12","author":"Waelter","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0295","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1326-4-11","article-title":"Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction","volume":"4","author":"Weiss","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0300","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/8.1.115","article-title":"Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse","volume":"8","author":"Wheeler","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0305","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/hmg\/9.4.503","article-title":"Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice","volume":"9","author":"Wheeler","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0310","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng1297-404","article-title":"Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion","volume":"17","author":"White","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.013_bib0315","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)80623-6","article-title":"Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease","volume":"101","author":"Yamamoto","year":"2000","journal-title":"Cell"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923011001018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923011001018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:13:17Z","timestamp":1759781597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923011001018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":63,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0361923011001018"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2011.03.013","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2011.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}