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Soc."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0370","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/01.WNL.0000098878.47789.BD","article-title":"NEST-HD Consortium, Profile of cognitive progression in early Huntington's disease","volume":"61","author":"Ho","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0375","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1601-183X.2007.00350.x","article-title":"Brain gene expression correlates with changes in behavior in the R6\/1 mouse model of Huntington's disease","volume":"7","author":"Hodges","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0380","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","article-title":"A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration","volume":"23","author":"Hodgson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0385","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.134.3483.943","article-title":"Progressive ratio as a measure of reward strength","volume":"134","author":"Hodos","year":"1961","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0390","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1901\/jeab.1963.6-387","article-title":"Effects of increment size and reinforcer volume on progressive ratio performance","volume":"6","author":"Hodos","year":"1963","journal-title":"J. Exp. Anal. Behav."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0395","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1098\/rstb.2007.2063","article-title":"Action selection and refinement in subcortical loops through basal ganglia and cerebellum","volume":"362","author":"Houk","year":"2007","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0400","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/cercor\/5.2.95","article-title":"Distributed modular architectures linking basal ganglia, cerebellum, and cerebral cortex: their role in planning and controlling action","volume":"5","author":"Houk","year":"1995","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0405","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1046\/j.1460-9568.1999.00701.x","article-title":"Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype","volume":"11","author":"Humby","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0410","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group","volume":"11","year":"1996","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0415","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0420","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s00213-003-1551-6","article-title":"Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine","volume":"170","author":"Isles","year":"2003","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0425","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1037\/h0056632","article-title":"Studies of cerebral function in primates. IV. The effect of frontal lobe lesions on the delayed alternation habit in monkeys","volume":"23","author":"Jacobsen","year":"1937","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0430","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/hmg\/ddq063","article-title":"An ovine transgenic Huntington's disease model","volume":"19","author":"Jacobsen","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0435","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/jnnp.56.11.1169","article-title":"A comparative study of simple and choice reaction time in Parkinson's, Huntington's and cerebellar disease","volume":"56","author":"Jahanshahi","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0440","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archneur.1988.00520310079021","article-title":"Presymptomatic neuropsychological impairment in Huntington's disease","volume":"45","author":"Jason","year":"1988","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0445","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jneumeth.2007.03.008","article-title":"An operant serial implicit learning task (SILT) in rats: task acquisition, performance and the effects of striatal lesions","volume":"163","author":"Jay","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0450","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.nbd.2005.12.014","article-title":"Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats","volume":"22","author":"Kantor","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0455","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1073\/pnas.0911805107","article-title":"Dopamine D2 receptor density in the limbic striatum is related to implicit but not explicit movement sequence learning","volume":"107","author":"Karabanov","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0460","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1037\/0097-7403.22.4.447","article-title":"Cyclic responding by pigeons on the peak timing procedure","volume":"22","author":"Kirkpatrick-Steger","year":"1996","journal-title":"J. Exp. Psychol. Anim. Behav. Process."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0465","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/archneur.56.5.563","article-title":"Longitudinal cognitive and motor changes among presymptomatic Huntington disease gene carriers","volume":"56","author":"Kirkwood","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0470","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0028-3932(91)90085-M","article-title":"Procedural learning is impaired in Huntington's disease: evidence from the serial reaction time task","volume":"29","author":"Knopman","year":"1991","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0475","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.273.5280.1399","article-title":"A neostriatal habit learning system in humans","volume":"273","author":"Knowlton","year":"1996","journal-title":"Science"},{"issue":"Suppl. 2","key":"10.1016\/j.brainresbull.2011.03.015_bib0480","first-page":"317","article-title":"Comprehensive neurotoxicity assessment","volume":"104","author":"Kulig","year":"1996","journal-title":"Environ. 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Neuropsychol."},{"issue":"Pt 7","key":"10.1016\/j.brainresbull.2011.03.015_bib0495","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","article-title":"Evidence for specific cognitive deficits in preclinical Huntington's disease","volume":"121","author":"Lawrence","year":"1998","journal-title":"Brain"},{"issue":"Pt 5","key":"10.1016\/j.brainresbull.2011.03.015_bib0500","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/brain\/119.5.1633","article-title":"Executive and mnemonic functions in early Huntington's disease","volume":"119","author":"Lawrence","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0505","series-title":"Neuropsychological Assessment","author":"Lezak","year":"2004"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0510","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","article-title":"The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies","volume":"2","author":"Li","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0515","doi-asserted-by":"crossref","first-page":"10428","DOI":"10.1523\/JNEUROSCI.19-23-10428.1999","article-title":"Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation","volume":"19","author":"Lione","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0520","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/hmg\/ddl125","article-title":"Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice","volume":"15","author":"Lloret","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0525","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1162\/089892998562762","article-title":"Coupled temporal memories in Parkinson's disease: a dopamine-related dysfunction","volume":"10","author":"Malapani","year":"1998","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0530","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0535","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1901\/jeab.1996.65-173","article-title":"A computer touch-screen apparatus for training visual discriminations in rats","volume":"65","author":"Markham","year":"1996","journal-title":"J. Exp. Anal. Behav."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0540","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1001\/archneur.64.1.116","article-title":"Specific psychiatric manifestations among preclinical Huntington disease mutation carriers","volume":"64","author":"Marshall","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0545","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2006.06.031","article-title":"Neuroanatomical localization of an internal clock: a functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems","volume":"1109","author":"Meck","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0550","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/brcg.2001.1313","article-title":"Dissecting the brain's internal clock: how frontal-striatal circuitry keeps time and shifts attention","volume":"48","author":"Meck","year":"2002","journal-title":"Brain Cogn."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0555","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.conb.2008.08.002","article-title":"Cortico-striatal representation of time in animals and humans","volume":"18","author":"Meck","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0560","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nbd.2009.05.007","article-title":"Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models","volume":"35","author":"Menalled","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0565","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0165-6147(00)01884-8","article-title":"Mouse models of Huntington's disease","volume":"23","author":"Menalled","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0570","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nmeth1006-767","article-title":"Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system","volume":"3","author":"Morton","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0575","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/cercor\/6.3.470","article-title":"The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task","volume":"6","author":"Muir","year":"1996","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0580","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.neuroscience.2003.08.053","article-title":"Molecular and behavioral analysis of the R6\/1 Huntington's disease transgenic mouse","volume":"122","author":"Naver","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0585","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1093\/hmg\/ddl394","article-title":"Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease","volume":"15","author":"Nguyen","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0590","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s002210050016","article-title":"Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia","volume":"130","author":"Page","year":"2000","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0595","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington's disease decades before diagnosis: the Predict-HD study","volume":"79","author":"Paulsen","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0600","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/1097-4679(199501)51:1<48::AID-JCLP2270510109>3.0.CO;2-E","article-title":"Discrimination of cortical from subcortical dementias on the basis of memory and problem-solving tests","volume":"51","author":"Paulsen","year":"1995","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0605","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1212\/WNL.57.4.658","article-title":"Clinical markers of early disease in persons near onset of Huntington's disease","volume":"57","author":"Paulsen","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0610","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jns.2005.07.007","article-title":"Executive dysfunction in early stages of Huntington's disease is associated with striatal and insular atrophy: a neuropsychological and voxel-based morphometric study","volume":"239","author":"Peinemann","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0615","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/mds.870050202","article-title":"Huntington's disease in Venezuela: 7 years of follow-up on symptomatic and asymptomatic individuals","volume":"5","author":"Penney","year":"1990","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0620","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/13803390600726829","article-title":"Impairments in source memory for olfactory and visual stimuli in preclinical and clinical stages of Huntington's disease","volume":"29","author":"Pirogovsky","year":"2007","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0625","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00335558008248231","article-title":"Orienting of attention","volume":"32","author":"Posner","year":"1980","journal-title":"Q. J. Exp. Psychol."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0630","first-page":"313","article-title":"Cognitive neuropsychology and the problem of selective attention","volume":"39","author":"Posner","year":"1987","journal-title":"Electroencephalogr. Clin. Neurophysiol. Suppl."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0635","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1037\/0097-7403.24.1.15","article-title":"Scalar expectancy theory and peak-interval timing in humans","volume":"24","author":"Rakitin","year":"1998","journal-title":"J. Exp. Psychol. Anim. Behav. Process."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0640","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/ilar.48.4.356","article-title":"Animal models of Huntington's disease","volume":"48","author":"Ramaswamy","year":"2007","journal-title":"ILAR J."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0645","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/2510","article-title":"Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA","volume":"20","author":"Reddy","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0650","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00213-002-1154-7","article-title":"The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry","volume":"163","author":"Robbins","year":"2002","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0655","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0166-4328(89)80143-3","article-title":"Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes","volume":"35","author":"Robbins","year":"1989","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0660","first-page":"13","article-title":"Methods for assessing attention and stimulus control in the rat","volume":"vol. 1","author":"Robbins","year":"1993"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0665","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1037\/0735-7044.115.4.799","article-title":"Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance","volume":"115","author":"Rogers","year":"2001","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0670","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/jnnp.56.1.98","article-title":"Duration of illness in Huntington's disease is not related to age at onset","volume":"56","author":"Roos","year":"1993","journal-title":"J. Neurol. Neurosurg. 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Disord."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0695","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1037\/a0018905","article-title":"Self-paced timing detects and tracks change in prodromal Huntington disease","volume":"24","author":"Rowe","year":"2010","journal-title":"Neuropsychology"},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0700","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbr.2009.04.034","article-title":"Detection of early behavioral markers of Huntington's disease in R6\/2 mice employing an automated social home cage","volume":"203","author":"Rudenko","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0705","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1098\/rstb.1999.0447","article-title":"Transgenic models of Huntington's disease","volume":"354","author":"Sathasivam","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0710","doi-asserted-by":"crossref","first-page":"9195","DOI":"10.1074\/jbc.M607865200","article-title":"Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model","volume":"282","author":"Schiffer","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0715","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/mds.22692","article-title":"Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease","volume":"25","author":"Schneider","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainresbull.2011.03.015_bib0720","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF00237708","article-title":"Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study","volume":"37","author":"Schwarcz","year":"1979","journal-title":"Exp. 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