{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:16:49Z","timestamp":1774487809669,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.brainresbull.2011.08.001","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T23:47:48Z","timestamp":1312674468000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: Possible implications for the pharmacotherapy of autism spectrum disorders"],"prefix":"10.1016","volume":"86","author":[{"given":"Jessica A.","family":"Burket","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Herndon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin E.","family":"Winebarger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F.","family":"Jacome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen I.","family":"Deutsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2011.08.001_bib0005","unstructured":"American Psychiatric Association, 2000. Diagnostic and Statistical Manual of Mental Disorders, fourth ed., text revision. American Psychiatric Association, Washington, DC."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0010","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1523\/JNEUROSCI.20-21-07871.2000","article-title":"Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus","volume":"20","author":"Awad","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0015","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"Bear","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0190","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0091-3057(02)01012-2","article-title":"Interaction of stress and strain on glutamatergic neurotransmission: relevance to schizophrenia","volume":"74","author":"Billingslea","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbr.2006.06.025","article-title":"BALB\/c mice: low sociability and other phenotypes that may be relevant to autism","volume":"176","author":"Brodkin","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.brainresbull.2010.08.014","article-title":"MK-801, a noncompetitive NMDA receptor antagonist, elicited circling behavior in the genetically-inbred Balb\/c mouse strain","volume":"83","author":"Burket","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.brainresbull.2010.07.006","article-title":"Locomotor activity of the genetically-inbred mouse strain is suppressed by a socially-salient stimulus","volume":"83","author":"Burket","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0035","first-page":"260","article-title":"Stereotypies and tardive dyskinesia: abnormal movements in autistic children","volume":"26","author":"Campbell","year":"1990","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0040","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/356521a0","article-title":"Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation","volume":"356","author":"Chen","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2760","article-title":"Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders","volume":"8","author":"Conn","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tips.2008.10.006","article-title":"Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia","volume":"30","author":"Conn","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0055","first-page":"248","article-title":"Designing mouse behavioral tasks relevant to autistic-like behaviors","volume":"10","author":"Crawley","year":"2004","journal-title":"Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0060","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1750-3639.2007.00096.x","article-title":"Mouse behavioral assays relevant to the symptoms of autism","volume":"17","author":"Crawley","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0065","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/FBP.0b013e3282feb0ac","article-title":"Interaction of N-methyl-d-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm","volume":"19","author":"Darrah","year":"2008","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0070","article-title":"Selective mGluR5 antagonism attenuates the stress-induced reduction of MK-801s antiseizure potency in the genetically inbred Balb\/c mouse","volume":"June","author":"Deutsch","year":"2011","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainresbull.2010.10.006","article-title":"d-Cycloserine improves the impaired sociability of the Balb\/c mouse","volume":"84","author":"Deutsch","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0080","first-page":"255","article-title":"Inbred mouse strains differ in their sensitivity to an antiseizure effect of MK-801","volume":"21","author":"Deutsch","year":"1998","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0085","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0091-3057(96)00347-4","article-title":"Inbred mouse strains differ in sensitivity to popping elicited by MK-801","volume":"57","author":"Deutsch","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0090","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pharmthera.2010.02.008","article-title":"Mechanism-based approaches to treating fragile X","volume":"127","author":"D\u00f6len","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0095","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0028-3908(99)00082-9","article-title":"2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist","volume":"38","author":"Gasparini","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1469-8749.2008.03178.x","article-title":"Motor stereotypies in children with autism and other developmental disorders","volume":"51","author":"Goldman","year":"2008","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0105","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1601-183X.2009.00504.x","article-title":"Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia","volume":"8","author":"Halene","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0110","unstructured":"Jacome, L.F., Burket, J.A., Herndon, A.L., Deutsch, S.I. Genetically-inbred Balb\/c mice differ from outbred Swiss Webster mice on discrete measures of Sociability: relevance to a genetic mouse model of autism spectrum disorders, Autism Res. (in press)."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0115","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainresbull.2010.10.010","article-title":"d-Serine improves dimensions of the sociability deficit of the genetically-inbred Balb\/c mouse strain","volume":"84","author":"Jacome","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00213-008-1196-6","article-title":"Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia","volume":"200","author":"Labrie","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0125","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1523\/JNEUROSCI.21-16-05925.2001","article-title":"Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function","volume":"21","author":"Mannaioni","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1124\/mol.109.059865","article-title":"Glutamatergic (N-methyl-d-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?","volume":"77","author":"Marek","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF02245335","article-title":"d-Cycloserine enhances social behavior in individually-housed mice in the resident-intruder test","volume":"116","author":"McAllister","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0140","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.biopsych.2011.01.026","article-title":"d-Cycloserine Facilitates socially reinforced learning in an animal model relevant to autism spectrum disorders","volume":"70","author":"Modi","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbr.2006.07.030","article-title":"Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains","volume":"176","author":"Moy","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0150","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.euroneuro.2008.06.004","article-title":"Expression of NR1, NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb\/c mouse strain with heightened behavioral sensitivity to MK-801, a noncompetitive NMDA receptor antagonist","volume":"18","author":"Perera","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0155","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0306-4522(01)00297-4","article-title":"Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-d-aspartate responses in medium spiny striatal neurons","volume":"106","author":"Pisani","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0160","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.biopsych.2005.07.026","article-title":"A mouse model system for genetic analysis of sociability: C57BL\/6J versus BALB\/cJ inbred mouse strains","volume":"59","author":"Sankoorikal","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0165","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/npp.2009.201","article-title":"Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP","volume":"35","author":"Silverman","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2010.07.026","article-title":"Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats","volume":"644","author":"Takagi","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0175","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/sj.bjp.0703923","article-title":"Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist","volume":"132","author":"Tatarczy\u0144ska","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0180","first-page":"56","article-title":"MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta","volume":"3","author":"Westmark","year":"2009","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.brainresbull.2011.08.001_bib0185","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.neuropharm.2005.06.004","article-title":"Suppression of two major fragile X syndrome mouse model phenotypes by the mGluR5 antagonist MPEP","volume":"49","author":"Yan","year":"2005","journal-title":"Neuropharmacology"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923011002474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923011002474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:12:11Z","timestamp":1759781531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923011002474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":38,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0361923011002474"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2011.08.001","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: Possible implications for the pharmacotherapy of autism spectrum disorders","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2011.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}