{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:04:57Z","timestamp":1790694297260,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.brainresbull.2011.10.001","type":"journal-article","created":{"date-parts":[[2011,10,12]],"date-time":"2011-10-12T15:52:59Z","timestamp":1318434779000},"page":"199-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease"],"prefix":"10.1016","volume":"88","author":[{"given":"Peter","family":"Giles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn","family":"Elliston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma V.","family":"Higgs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Dunnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2011.10.001_bib0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainresbull.2011.03.014","article-title":"Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse","volume":"88","author":"Bayram-Weston","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1750-1326-3-17","article-title":"Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease","volume":"3","author":"Benn","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0020","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1093\/hmg\/ddi340","article-title":"Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease","volume":"14","author":"Benn","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0260","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.brainresbull.2011.07.021","article-title":"Gene expression and behaviour in mouse models of Huntington's disease","volume":"88","author":"Bowles","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0030","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.brainresbull.2010.05.004","article-title":"Longitudinal analysis of the behavioural phenotype in Hdh((CAG)150) Huntington's disease knock-in mice","volume":"88","author":"Brooks","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0035","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.brainresbull.2006.02.011","article-title":"Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease","volume":"69","author":"Brooks","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0040","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/77528","article-title":"Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease","volume":"6","author":"Chen","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0045","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuron.2010.12.035","article-title":"Huntington's disease: can mice lead the way to treatment?","volume":"69","author":"Crook","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0050","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbr.2011.02.030","article-title":"Differential gene expression profiling in the mouse brain during motor skill learning: focus on the striatum structure","volume":"221","author":"D\u2019Amours","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0055","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/nar\/gkq1323","article-title":"Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference","volume":"39","author":"de Mezer","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3727\/000000003783992234","article-title":"Mouse Huntington's disease homolog mRNA levels: variation and allele effects","volume":"11","author":"Dixon","year":"2004","journal-title":"Gene Expr."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.nbd.2008.10.009","article-title":"CAG repeat lengths > or =335 attenuate the phenotype in the R6\/2 Huntington's disease transgenic mouse","volume":"33","author":"Dragatsis","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0070","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nature09231","article-title":"Brain function and chromatin plasticity","volume":"465","author":"Dulac","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0075","doi-asserted-by":"crossref","first-page":"e17119","DOI":"10.1371\/journal.pone.0017119","article-title":"Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats","volume":"6","author":"Duzdevich","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0080","doi-asserted-by":"crossref","first-page":"9418","DOI":"10.1523\/JNEUROSCI.23-28-09418.2003","article-title":"Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice","volume":"23","author":"Ferrante","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0085","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1074\/jbc.M410210200","article-title":"Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease","volume":"280","author":"Gardian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0095","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.brainresrev.2008.12.001","article-title":"The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease","volume":"59","author":"Gil","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0092-8674(02)01074-7","article-title":"Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure","volume":"111","author":"Guan","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2005.01.024","article-title":"Early behavioral deficits in R6\/2 mice suitable for use in preclinical drug testing","volume":"20","author":"Hickey","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0110","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1073\/pnas.0437870100","article-title":"Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease","volume":"100","author":"Hockly","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0115","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1601-183X.2007.00350.x","article-title":"Brain gene expression correlates with changes in behavior in the R6\/1 mouse model of Huntington's disease","volume":"7","author":"Hodges","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0120","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0125","doi-asserted-by":"crossref","unstructured":"J.C. Jacobsen, C.S. Bawden, S.R. Rudiger, C.J. McLaughlan, S.J. Reid, H.J. Waldvogel, M.E. MacDonald, J.F. Gusella, S.K. Walker, J.M. Kelly, G.C. Webb, R.L. Faull, M.I. Rees, R.G. Snell, An ovine transgenic Huntington's disease model, Hum. Mol. Genet. 19 (2010) 1873\u20131882.","DOI":"10.1093\/hmg\/ddq063"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0130","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1523\/JNEUROSCI.5667-07.2008","article-title":"Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation","volume":"28","author":"Kim","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0135","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/hmg\/ddm133","article-title":"Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage","volume":"16","author":"Kuhn","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0140","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00018-006-6026-6","article-title":"Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation","volume":"63","author":"Levenson","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0145","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","article-title":"The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies","volume":"2","author":"Li","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0150","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington's disease","volume":"10","author":"Lin","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0155","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0160","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0165","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrg2828","article-title":"Mechanisms of trinucleotide repeat instability during human development","volume":"11","author":"McMurray","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0170","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nbd.2008.11.015","article-title":"Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6\/2 mice","volume":"33","author":"Morton","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0175","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1460-9568.2005.03895.x","article-title":"A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease","volume":"21","author":"Morton","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0180","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1172","article-title":"Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6\/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model","volume":"2","author":"Quinti","year":"2010","journal-title":"PLoS Curr."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0185","doi-asserted-by":"crossref","first-page":"19176","DOI":"10.1073\/pnas.0606373103","article-title":"ESET\/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease","volume":"103","author":"Ryu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0190","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/hmg\/ddm078","article-title":"Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models","volume":"16","author":"Sadri-Vakili","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0195","series-title":"Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments","author":"Smyth","year":"2004"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0200","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/hmg\/ddm064","article-title":"Modulation of nucleosome dynamics in Huntington's disease","volume":"16","author":"Stack","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0205","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1371\/journal.pgen.0030059","article-title":"Conservation of regional gene expression in mouse and human brain","volume":"3","author":"Strand","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0210","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1523\/JNEUROSCI.2461-07.2007","article-title":"Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration","volume":"27","author":"Strand","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0215","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0220","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0225","doi-asserted-by":"crossref","first-page":"15564","DOI":"10.1073\/pnas.0804249105","article-title":"The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice","volume":"105","author":"Thomas","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0230","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1460-9568.2007.05307.x","article-title":"The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease","volume":"25","author":"Trueman","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0235","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/hmg\/ddg075","article-title":"Transgenic rat model of Huntington's disease","volume":"12","author":"von Horsten","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0240","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0361-9230(03)00141-2","article-title":"Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation","volume":"61","author":"Wood","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0245","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainresbull.2006.11.004","article-title":"The HdhQ150\/Q150 knock-in mouse model of HD and the R6\/2 exon 1 model develop comparable and widespread molecular phenotypes","volume":"72","author":"Woodman","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0250","doi-asserted-by":"crossref","first-page":"9923","DOI":"10.1073\/pnas.1002757107","article-title":"Analysis of factorial time-course microarrays with application to a clinical study of burn injury","volume":"107","author":"Zhou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2011.10.001_bib0255","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/hmg\/ddi014","article-title":"Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1","volume":"14","author":"Zucker","year":"2005","journal-title":"Hum. Mol. Genet."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923011002954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923011002954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:13:35Z","timestamp":1759781615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923011002954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":51,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0361923011002954"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2011.10.001","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2011.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}