{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:35:33Z","timestamp":1790674533033,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.brainresbull.2012.01.012","type":"journal-article","created":{"date-parts":[[2012,2,4]],"date-time":"2012-02-04T10:47:42Z","timestamp":1328352462000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease"],"prefix":"10.1016","volume":"87","author":[{"given":"Renata P.","family":"Lerner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz del Carmen G.","family":"Trejo Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunni","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Fran\u00e7oise","family":"Chesselet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam A.","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2012.01.012_bib0005","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/brain\/119.6.2085","article-title":"Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease","volume":"119","author":"Antonini","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0010","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainresbull.2006.10.028","article-title":"Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease","volume":"72","author":"Aylward","year":"2007","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0015","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.2010.208264","article-title":"Longitudinal change in regional brain volumes in prodromal Huntington disease","volume":"82","author":"Aylward","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0020","doi-asserted-by":"crossref","first-page":"e6908","DOI":"10.1371\/journal.pone.0006908","article-title":"Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion","volume":"4","author":"Azdad","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0025","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1073\/pnas.120166397","article-title":"Severe deficiencies in dopamine signalling in presymptomatic Huntington's disease mice","volume":"97","author":"Bibb","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0030","doi-asserted-by":"crossref","first-page":"16685","DOI":"10.1073\/pnas.0707842104","article-title":"A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6\/2 transgenic mouse","volume":"104","author":"Chopra","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0035","doi-asserted-by":"crossref","first-page":"e00036","DOI":"10.1042\/AN20100007","article-title":"Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease","volume":"2","author":"Cummings","year":"2010","journal-title":"ASN Neuro"},{"issue":"Suppl. 3","key":"10.1016\/j.brainresbull.2012.01.012_bib0040","doi-asserted-by":"crossref","first-page":"S251","DOI":"10.1016\/S1353-8020(08)70012-9","article-title":"Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism","volume":"13","author":"Deutch","year":"2007","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0045","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1523\/JNEUROSCI.11-12-03877.1991","article-title":"Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry","volume":"11","author":"Ferrante","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0050","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0055","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-2-8","article-title":"Pathological cell\u2013cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease","volume":"2","author":"Gu","year":"2007","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuron.2005.03.025","article-title":"Pathological cell\u2013cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice","volume":"46","author":"Gu","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0070","series-title":"The Mouse Nervous System","first-page":"752","article-title":"Mouse models of mental illness and neurological disease: Huntington's disease","author":"Hickey","year":"2012"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2008.08.041","article-title":"Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice","volume":"157","author":"Hickey","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0080","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1471-4159.2002.00804.x","article-title":"The role of dopamine in motor symptoms in the R6\/2 transgenic mouse model of Huntington's disease","volume":"81","author":"Hickey","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mcn.2011.10.007","article-title":"Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease","volume":"49","author":"Hickey","year":"2012","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0090","article-title":"Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function","volume":"3","author":"Ho Kim","year":"2011","journal-title":"ASN Neuro"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0095","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0100","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0006-8993(89)91686-7","article-title":"Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age","volume":"503","author":"Ingham","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0105","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1523\/JNEUROSCI.18-12-04732.1998","article-title":"Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway","volume":"18","author":"Ingham","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0110","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ajmg.10500","article-title":"Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile-X knockout mice","volume":"111","author":"Irwin","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0115","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1471-4159.2006.03762.x","article-title":"Dopamine release is severely compromised in the R6\/2 mouse model of Huntington's disease","volume":"97","author":"Johnson","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0120","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1523\/JNEUROSCI.5687-08.2009","article-title":"Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease","volume":"29","author":"Joshi","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0125","doi-asserted-by":"crossref","first-page":"e00060","DOI":"10.1042\/AN20110009","article-title":"Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function","volume":"3","author":"Kim","year":"2011","journal-title":"ASN Neuro"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0130","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ana.410220318","article-title":"Elevated serotonin and reduced dopamine in subregionally divided Huntington's disease striatum","volume":"22","author":"Kish","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0135","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","article-title":"Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington's disease transgenic mice","volume":"86","author":"Klapstein","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0140","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1523\/JNEUROSCI.21-23-09112.2001","article-title":"Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease","volume":"21","author":"Laforet","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0145","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/WNF.0b013e3181ebb285","article-title":"Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington's disease","volume":"33","author":"Lundin","year":"2010","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0150","first-page":"93","article-title":"Neurotransmitters and their receptors in the basal ganglia","volume":"60","author":"McGeer","year":"1993","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0155","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1212\/WNL.32.6.640","article-title":"Huntington chorea is not associated with hyperactivity of nigrostriatal dopaminergic neurons: studies in postmortem tissues and in rats with kainic acid lesions","volume":"32","author":"Melamed","year":"1982","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0160","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.10776","article-title":"Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats","volume":"465","author":"Menalled","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0165","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.neuroscience.2007.06.044","article-title":"Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons","volume":"149","author":"Neely","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0170","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington's disease decades before diagnosis: the Predict-HD study","volume":"79","author":"Paulsen","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0175","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0180","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/hmg\/ddn428","article-title":"Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models","volume":"18","author":"Phan","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0185","first-page":"79","article-title":"Characterization of brain dopaminergic receptors in Huntington's disease","volume":"2","author":"Reisine","year":"1978","journal-title":"Commun. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0190","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0024-3205(77)90111-4","article-title":"Alterations in dopaminergic receptors in Huntington's disease","volume":"21","author":"Reisine","year":"1977","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0195","doi-asserted-by":"crossref","first-page":"11557","DOI":"10.1073\/pnas.0504984102","article-title":"Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome","volume":"102","author":"Restivo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0200","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1212\/01.wnl.0000174432.87383.87","article-title":"Regional cortical thinning in preclinical Huntington disease and its relationship to cognition","volume":"65","author":"Rosas","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0205","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.neuroimage.2009.10.015","article-title":"Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical disconnection","volume":"49","author":"Rosas","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0210","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1212\/WNL.58.5.695","article-title":"Regional and progressive thinning of the cortical ribbon in Huntington's disease","volume":"58","author":"Rosas","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0215","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/mds.20979","article-title":"Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures","volume":"21","author":"Rosas","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0220","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0225","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/35000576","article-title":"Motor disorder in Huntington's disease begins as a dysfunction in error feedback control","volume":"403","author":"Smith","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0230","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuroscience.2005.01.007","article-title":"Evidence of a breakdown of corticostriatal connections in Parkinson's disease","volume":"132","author":"Stephens","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0235","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0240","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis","volume":"10","author":"Tabrizi","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0245","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1523\/JNEUROSCI.1396-07.2007","article-title":"Dopaminergic signaling and striatal neurodegeneration in Huntington's disease","volume":"27","author":"Tang","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0250","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/ddq548","article-title":"In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons","volume":"20","author":"Thomas","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2012.01.012_bib0255","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1212\/01.wnl.0000176071.08694.cc","article-title":"Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease","volume":"65","author":"van Oostrom","year":"2005","journal-title":"Neurology"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923012000226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923012000226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:12:58Z","timestamp":1759781578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923012000226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0361923012000226"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2012.01.012","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2012.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}