{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:48:03Z","timestamp":1791330483559,"version":"4.3.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.brainresbull.2012.07.010","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T12:16:51Z","timestamp":1343996211000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neonatal tricyclic antidepressant clomipramine treatment reduces the spike-wave discharge activity of the adult WAG\/Rij rat"],"prefix":"10.1016","volume":"89","author":[{"given":"Zsolt","family":"Kov\u00e1cs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Czurk\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin A.","family":"K\u00e9kesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2012.07.010_bib0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biopsych.2006.09.023","article-title":"Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports","volume":"62","author":"Alper","year":"2007","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0010","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbr.2007.08.020","article-title":"Neonatal clomipramine induced endogenous depression in rats is associated with learning impairment in adulthood","volume":"187","author":"Bhagya","year":"2008","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1460-9568.1991.tb00083.x","article-title":"Noradrenergic control of thalamic oscillation: the role of alpha-2 receptors","volume":"3","author":"Buzs\u00e1ki","year":"1991","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0020","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0149-7634(05)80005-3","article-title":"Absence epilepsy and the level of vigilance in rats of the WAG\/Rij strain","volume":"15","author":"Coenen","year":"1991","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0025","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1023\/A:1026179013847","article-title":"Genetic animal models for absence epilepsy: a review of the WAG\/Rij strain of rats","volume":"33","author":"Coenen","year":"2003","journal-title":"Behavior Genetics"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0030","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0920-1211(91)90055-K","article-title":"Spike-wave discharges and sleep\u2013wake states in rats with absence epilepsy","volume":"9","author":"Drinkenburg","year":"1991","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0035","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0091-3057(96)00276-6","article-title":"Decreased hypothalamic serotonin levels in adult rats treated neonatally with clomipramine","volume":"55","author":"Feenstra","year":"1996","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0040","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0197-0186(00)00120-0","article-title":"8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance","volume":"38","author":"Filakovszky","year":"2001","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0045","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0006-8993(97)00657-4","article-title":"Neonatal treatments with the serotonin uptake inhibitors clomipramine and zimelidine, but not the noradrenaline uptake inhibitor desipramine, disrupt sleep patterns in adult rats","volume":"768","author":"Frank","year":"1997","journal-title":"Brain Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0050","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(98)00801-4","article-title":"The 5-HT1A agonist 8-OH-DPAT increases the number of spike-wave discharges in a genetic rat model of absence epilepsy","volume":"807","author":"Gerber","year":"1998","journal-title":"Brain Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0055","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF02247474","article-title":"Inhibition of REM sleep by ipsapirone a 5HT1A agonist, in normal volunteers","volume":"116","author":"Gillin","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0060","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.bjp.0707253","article-title":"Tricyclic antidepressant pharmacology and therapeutic drug interactions updated","volume":"151","author":"Gillman","year":"2007","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0065","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0361-9230(94)00247-X","article-title":"Sleep\u2013waking cycle in chronic rat preparations with brain stem transected at the caudopontine level","volume":"36","author":"Gottesmann","year":"1995","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0070","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2004.01.072","article-title":"Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG\/Rij rat model of absence epilepsy","volume":"359","author":"Graf","year":"2004","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0075","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0014-2999(98)00349-5","article-title":"Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor","volume":"352","author":"Hansen","year":"1998","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0080","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0014-4886(03)00352-2","article-title":"5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy","volume":"184","author":"Jakus","year":"2003","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-2999(95)00272-M","article-title":"Modulation of rat neocortical high-voltage spindle activity by 5-HT1\/5-HT2 receptor subtype specific drugs","volume":"282","author":"J\u00e4k\u00e4l\u00e4","year":"1995","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0920-1211(95)00097-6","article-title":"Lack of hippocampal involvement in a rat model of petit mal epilepsy","volume":"23","author":"Kandel","year":"1996","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0095","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.eplepsyres.2010.02.011","article-title":"Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG\/Rij rats","volume":"90","author":"Kov\u00e1cs","year":"2010","journal-title":"Epilepsy Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0100","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neuroscience.2006.02.023","article-title":"Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo\/Rijswijk rats","volume":"140","author":"Kov\u00e1cs","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0105","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0110","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.euroneuro.2007.05.004","article-title":"Limitations of current medical treatments for depression: disturbed circadian rhythms as a possible therapeutic target","volume":"17","author":"Lader","year":"2007","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.physbeh.2006.09.020","article-title":"Propagation of spike and wave activity to the medial prefrontal cortex and dorsal raphe nucleus of WAG\/Rij rats","volume":"90","author":"L\u00f6rincz","year":"2007","journal-title":"Physiology and Behavior"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/sj.npp.1300823","article-title":"Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry","volume":"31","author":"Maciag","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0125","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00001756-199503000-00024","article-title":"Electrophysiological activity of raphe dorsalis serotoninergic neurones in a possible model of endogenous depression","volume":"6","author":"Maudhuit","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3940(02)00725-5","article-title":"Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood","volume":"330","author":"Mavanji","year":"2002","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0135","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1523\/JNEUROSCI.22-04-01480.2002","article-title":"Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats","volume":"22","author":"Meeren","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0140","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0014-2999(87)90690-X","article-title":"Effects of drugs affecting noradrenergic neurotransmission in rats with spontaneous petit mal-like seizures","volume":"135","author":"Micheletti","year":"1987","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.brainresbull.2006.03.008","article-title":"The brain 5HTergic response to an acute sound stress in rats with generalized (absence and audiogenic) epilepsy","volume":"69","author":"Midzyanovskaya","year":"2006","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1254\/jphs.10156FP","article-title":"Serotonergic modulation of absence-like seizures in Groggy rats: a novel rat model of absence epilepsy","volume":"114","author":"Ohno","year":"2010","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0160","series-title":"The Rat Brain Stereotaxic Coordinates","year":"1997"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0165","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0091-3057(95)02023-3","article-title":"Effects of a D2 receptor agonist RO 41-9067 alone and with clonidine on sleep parameters in the rat","volume":"53","author":"Python","year":"1996","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0170","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0387-7604(95)00040-I","article-title":"Reduction of seizure frequency with clomipramine in patients with complex partial seizures","volume":"17","author":"Sakakihara","year":"1995","journal-title":"Brain and Development"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0175","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.pnpbp.2010.11.010","article-title":"The WAG\/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression","volume":"35","author":"Sarkisova","year":"2011","journal-title":"Progress in Neuro-psychopharmacology & Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2005.07.024","article-title":"Behavioral characteristics of WAG\/Rij rats susceptible and non-susceptible to audiogenic seizures","volume":"166","author":"Sarkisova","year":"2006","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0185","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1528-1167.2009.02260.x","article-title":"Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms","volume":"51","author":"Sarkisova","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0190","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0166-4328(03)00090-1","article-title":"Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG\/Rij rats with genetic absence epilepsy","volume":"144","author":"Sarkisova","year":"2003","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0195","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/S1388-2457(00)00397-7","article-title":"Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation","volume":"111","author":"Shouse","year":"2000","journal-title":"Clinical Neurophysiology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0200","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0006-8993(89)91453-4","article-title":"Mechanisms of seizure suppression during rapid-eye-movement (REM) sleep in cats","volume":"505","author":"Shouse","year":"1989","journal-title":"Brain Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0205","series-title":"Principles and Practice of Sleep Medicine","first-page":"125","article-title":"Brain stem mechanisms generating REM sleep","author":"Siegel","year":"1994"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0210","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.brainresbull.2004.11.004","article-title":"Reduction of adrenergic neurotransmission with clonidine aggravates spike-wave seizures and alters activity in the cortex and the thalamus in WAG\/Rij rats","volume":"64","author":"Sitnikova","year":"2005","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0215","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/ana.410370204","article-title":"Basic mechanisms of generalized absence seizures","volume":"37","author":"Snead","year":"1995","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0220","series-title":"Principles and Practice of Sleep Medicine","first-page":"105","article-title":"Brain electrical activity and sensory processing during waking and sleep states","author":"Steriade","year":"1994"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0225","doi-asserted-by":"crossref","first-page":"217","DOI":"10.31887\/DCNS.2006.8.2\/mthase","article-title":"Depression and sleep: pathophysiology and treatment","volume":"8","author":"Thase","year":"2006","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0230","article-title":"Does antiepileptogenesis affects sleep in genetic epileptic rats?","author":"Van Luijtelaar","year":"2011","journal-title":"International Journal of Psychophysiology"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0235","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1023\/A:1020992314534","article-title":"Alterations in the levels of monoamines in discrete brain regions of clomipramine-induced animal model of endogenous depression","volume":"24","author":"Vijayakumar","year":"1999","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0240","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0149-7634(05)80164-2","article-title":"A new animal model of endogenous depression: a summary of present findings","volume":"14","author":"Vogel","year":"1990","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.brainresbull.2012.07.010_bib0245","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0006-8993(93)91773-L","article-title":"Decreased raphe unit activity in a rat model of endogenous depression","volume":"611","author":"Yavari","year":"1993","journal-title":"Brain Research"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923012001797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923012001797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:13:48Z","timestamp":1759781628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923012001797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":49,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0361923012001797"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2012.07.010","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal tricyclic antidepressant clomipramine treatment reduces the spike-wave discharge activity of the adult WAG\/Rij rat","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2012.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}