{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:17:27Z","timestamp":1794003447743,"version":"4.8.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":353,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["307687\/2009-0"],"award-info":[{"award-number":["307687\/2009-0"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de Ensino Superior (CAPES)"},{"name":"Funda\u00e7\u00e3o de Apoio a Pesquisa Cient\u00edfica e Tecnol\u00f3gica do Estado de Santa Catarina (FAPESC)","award":["1347\/2010-1"],"award-info":[{"award-number":["1347\/2010-1"]}]},{"name":"Rede Instituto Brasileiro de Neuroci\u00eancia (IBN-Net\/CNPq)"},{"name":"NENASC Project (PRONEX-FAPESC\/CNPq)"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.brainresbull.2013.01.005","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T03:55:28Z","timestamp":1358999728000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice"],"prefix":"10.1016","volume":"95","author":[{"given":"Mauricio P.","family":"Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis L.","family":"Pazini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gatha","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele G.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia S.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2013.01.005_bib0005","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1098\/rstb.2011.0376","article-title":"Transcriptional regulation of the 5-HT1A receptor: implications for mental illness","volume":"367","author":"Albert","year":"2012","journal-title":"Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0010","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/npp.2009.160","article-title":"Chronic creatine supplementation alters depression-like behavior in rodents in a sex-dependent manner","volume":"35","author":"Allen","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0015","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.pbb.2012.03.005","article-title":"Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats","volume":"101","author":"Allen","year":"2012","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0020","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1176\/ajp.2006.163.10.1840b","article-title":"Observed effects of creatine monohydrate in a patient with depression and fibromyalgia","volume":"163","author":"Amital","year":"2006","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0025","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.brainresbull.2008.02.035","article-title":"Functions and effects of creatine in the central nervous system","volume":"76","author":"Andres","year":"2008","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1001\/archpsyc.1994.03950030084009","article-title":"Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors","volume":"51","author":"Artigas","year":"1994","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0035","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0166-2236(96)10037-0","article-title":"Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists","volume":"19","author":"Artigas","year":"1996","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0040","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1476-5381.1996.tb15749.x","article-title":"Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats","volume":"119","author":"Assi\u00e9","year":"1996","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0045","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S1516-44462009000300010","article-title":"Effect of acute administration of ketamine and imipramine on creatine kinase activity in the brain of rats","volume":"31","author":"Assis","year":"2009","journal-title":"Revista Brasileira de Psiquiatria"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/syn.20156","article-title":"The effect of a 5-HT1A receptor agonist on striatal dopamine release","volume":"57","author":"Bantick","year":"2005","journal-title":"Synapse"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0055","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1146\/annurev.bi.54.070185.004151","article-title":"The creatine\u2013creatine phosphate energy shuttle","volume":"54","author":"Bessman","year":"1985","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0060","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuropharm.2007.10.016","article-title":"Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems","volume":"54","author":"Brocardo","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0065","first-page":"16","article-title":"Real-world data on SSRI antidepressant side effects","volume":"6","author":"Cascade","year":"2009","journal-title":"Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.2042-7158.1993.tb05578.x","article-title":"Mesulergine antagonism towards the fluoxetine anti-immobility effect in the forced swimming test in mice","volume":"45","author":"Cesana","year":"1993","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s00213-006-0490-4","article-title":"WAY-100635 is a potent dopamine D4 receptor agonist","volume":"188","author":"Chemel","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/intimm\/dxg027","article-title":"Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors","volume":"15","author":"Clo\u00ebz-Tayarani","year":"2003","journal-title":"International Immunology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0085","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.pnpbp.2008.09.006","article-title":"Interaction of zinc with antidepressants in the tail suspension test","volume":"32","author":"Cunha","year":"2008","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0090","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1177\/0269881112447989","article-title":"Antidepressant-like effect of creatine in mice involves dopaminergic activation","volume":"26","author":"Cunha","year":"2012","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0095","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","article-title":"Brain metabolic alterations in medication-free patients with bipolar disorder","volume":"61","author":"Dager","year":"2004","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0320","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00213-011-2326-0","article-title":"Antidepressant-like effect of artemin in mice: a mechanism for acetyl-l-carnitine activity on depression","volume":"218","author":"Di Cesare Mannelli","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0100","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1523\/JNEUROSCI.2999-05.2005","article-title":"Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action","volume":"25","author":"D\u00edaz-Mataix","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pnpbp.2003.09.030","article-title":"The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression","volume":"28","author":"Dremencov","year":"2004","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pnpbp.2003.11.018","article-title":"Central monoamines and their role in major depression","volume":"28","author":"Elhwuegi","year":"2004","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0115","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0893-133X(01)00395-5","article-title":"Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration","volume":"26","author":"Hensler","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-9-49","article-title":"Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats","volume":"9","author":"Herring","year":"2008","journal-title":"BMC Neuroscience"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainresbull.2005.05.025","article-title":"Involvement of 5-HT1A receptors in the antidepressant-like effect of adenosine in the mouse forced swimming test","volume":"67","author":"Kaster","year":"2005","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0165-0327(92)90099-R","article-title":"Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy","volume":"26","author":"Kato","year":"1992","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainres.2010.05.097","article-title":"Desipramine attenuates forced swim test-induced behavioral and neurochemical alterations in mice: an in vivo(1)H-MRS study at 9.4T","volume":"1348","author":"Kim","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0140","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2010.05.052","article-title":"Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex","volume":"480","author":"Knox","year":"2010","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0145","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jad.2011.07.010","article-title":"Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy study","volume":"135","author":"Kondo","year":"2011","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0150","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0893-133X(99)00100-1","article-title":"Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test","volume":"22","author":"Lopez-Rubalcava","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0155","first-page":"24","article-title":"Behavioral studies of serotonin receptor agonists as antidepressant drugs","volume":"52","author":"Lucki","year":"1991","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0160","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/15622970903131597","article-title":"Creatine transporter expression after antidepressant therapy in rats bred for learned helplessness","volume":"11","author":"Lugenbiel","year":"2010","journal-title":"World Journal of Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0165","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1476-5381.1993.tb12859.x","article-title":"Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors","volume":"108","author":"Luscombe","year":"1993","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0170","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1176\/appi.ajp.2012.12010009","article-title":"A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder","volume":"169","author":"Lyoo","year":"2012","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0175","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.pnpbp.2009.03.004","article-title":"Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system","volume":"33","author":"Machado","year":"2009","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0180","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1741-7015-10-66","article-title":"Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways","volume":"10","author":"Maes","year":"2012","journal-title":"BMC Medicine"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1471-4892(01)00116-3","article-title":"Serotonergic targets in depression","volume":"2","author":"Middlemiss","year":"2002","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0190","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ejphar.2004.07.038","article-title":"The role of monoamines in the actions of established and \u201cnovel\u201d antidepressant agents: a critical review","volume":"500","author":"Millan","year":"2004","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0195","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/tp.2011.58","article-title":"Serotonin 1A receptor-mediated signaling through ERK and PKC\u03b1 is essential for normal synaptogenesis in neonatal mouse hippocampus","volume":"2","author":"Mogha","year":"2012","journal-title":"Translational Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0200","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S1092852900016011","article-title":"Augmentation strategies in the treatment of major depressive disorder. Recent findings and current status of augmentation strategies","volume":"12","author":"Nelson","year":"2007","journal-title":"CNS Spectrums"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0205","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00213-007-0728-9","article-title":"Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test","volume":"192","author":"O\u2019Leary","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0210","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0893-133X(00)00196-2","article-title":"Role of 5-HT1A and 5-HT1B receptors in the mediation of behavior in the forced swim test in mice","volume":"24","author":"O\u2019Neill","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0215","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002130051156","article-title":"Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test","volume":"147","author":"Page","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0220","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4088\/JCP.8157su1c.04","article-title":"Evidence for S-adenosyl-l-methionine (SAM-e) for the treatment of major depressive disorder","volume":"70","author":"Papakostas","year":"2009","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0225","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s11920-003-0085-2","article-title":"S-adenosyl-methionine in depression: a comprehensive review of the literature","volume":"5","author":"Papakostas","year":"2003","journal-title":"Current Psychiatry Reports"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0230","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1017\/S146114570400450X","article-title":"Effects of fluoxetine on dopamine D2 receptors in the human brain: a positron emission tomography study with [11C]raclopride","volume":"7","author":"Penttil\u00e4","year":"2004","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0325","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0163-1047(90)91296-N","article-title":"Acetylcarnitine reduces the immobility of rats in a despair test (constrained swim)","volume":"54","author":"Pulvirenti","year":"1990","journal-title":"Behavioral and Neural Biology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0235","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-2999(96)00772-8","article-title":"The role of 5-HT1A and 5-HT1B receptors in antidepressant drug actions in the mouse forced swimming test","volume":"318","author":"Redrobe","year":"1996","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0240","first-page":"987397","article-title":"Administration of harmine and imipramine alters creatine kinase and mitochondrial respiratory chain activities in the rat brain","author":"Reus","year":"2012","journal-title":"Depression Research and Treatment"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0245","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00702-011-0718-2","article-title":"Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain","volume":"119","author":"Reus","year":"2012","journal-title":"Journal of Neural Transmission"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0250","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0024-3205(01)01498-9","article-title":"Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus","volume":"70","author":"Rodrigues","year":"2002","journal-title":"Life Sciences"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0255","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0304-3940(96)13199-2","article-title":"The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain","volume":"219","author":"Romero","year":"1996","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0260","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.brainresbull.2009.09.007","article-title":"Brain creatine kinase activity is increased by chronic administration of paroxetine","volume":"80","author":"Santos","year":"2009","journal-title":"Brain Research Bulletin"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0265","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0006-3223(03)00064-7","article-title":"S-adenosyl-l-methionine: effects on brain bioenergetic status and transverse relaxation time in healthy subjects","volume":"54","author":"Silveri","year":"2003","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0270","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuint.2012.04.008","article-title":"Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice","volume":"61","author":"Smeland","year":"2012","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0275","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuropharm.2003.08.007","article-title":"8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production","volume":"46","author":"Sprouse","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0280","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-0327(98)00221-3","article-title":"Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects","volume":"51","author":"Stahl","year":"1998","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0285","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0290","first-page":"615","article-title":"Effects of combined administration of 5-HT1A and\/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats","volume":"54","author":"Tatarczynska","year":"2002","journal-title":"Polish Journal of Pharmacology"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0295","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/35072566","article-title":"Research and treatment approaches to depression","volume":"2","author":"Wong","year":"2001","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0300","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0005-2728(92)90096-K","article-title":"Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism","volume":"1102","author":"Wyss","year":"1992","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0305","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0022-3565(25)22522-8","article-title":"Endogenous serotonin stimulates striatal dopamine release in conscious rats","volume":"270","author":"Yadid","year":"1994","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0310","first-page":"109","article-title":"Differential involvement of 5-HT1A and 5-HT1B\/1D receptors in human interferon-alpha-induced immobility in the mouse forced swimming test","volume":"60","author":"Zhang","year":"2010","journal-title":"Arzneimittel-Forschung"},{"key":"10.1016\/j.brainresbull.2013.01.005_bib0315","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.brainres.2004.07.041","article-title":"Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test","volume":"1023","author":"Zomkowski","year":"2004","journal-title":"Brain Research"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923013000063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923013000063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:17:24Z","timestamp":1759781844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923013000063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":65,"alternative-id":["S0361923013000063"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2013.01.005","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2013.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}