{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T02:21:33Z","timestamp":1783563693192,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.brainresbull.2014.02.004","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T12:01:10Z","timestamp":1393243270000},"page":"54-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Baicalein ameliorated the upregulation of striatal glutamatergic transmission in the mice model of Parkinson's disease"],"prefix":"10.1016","volume":"103","author":[{"given":"Xinhong","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunju","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianrong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiqian","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2014.02.004_bib0005","doi-asserted-by":"crossref","first-page":"e6908","DOI":"10.1371\/journal.pone.0006908","article-title":"Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion","volume":"4","author":"Azdad","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0010","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1042\/BST0380493","article-title":"Synaptic dysfunction in Parkinson's disease","volume":"38","author":"Bagetta","year":"2010","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0015","doi-asserted-by":"crossref","first-page":"17921","DOI":"10.1523\/JNEUROSCI.2664-12.2012","article-title":"Rebalance of striatal NMDA\/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease","volume":"32","author":"Bagetta","year":"2012","journal-title":"Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0020","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1124\/jpet.108.148908","article-title":"Rewarding morphine-induced synaptic function of delta-opioid receptors on central glutamate synapses","volume":"329","author":"Bie","year":"2009","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0025","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11481-013-9435-y","article-title":"Neural and immune mechanisms in the pathogenesis of Parkinson's disease","volume":"8","author":"Blandini","year":"2013","journal-title":"Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/glia.22595","article-title":"Microglial TNF-alpha mediates enhancement of dopaminergic degeneration by brain angiotensin","volume":"62","author":"Borrajo","year":"2014","journal-title":"Glia"},{"issue":"Pt 2","key":"10.1016\/j.brainresbull.2014.02.004_bib0035","first-page":"433","article-title":"Electrophysiology of dopamine-denervated striatal neurons. Implications for Parkinson's disease","volume":"116","author":"Calabresi","year":"1993","journal-title":"Brain: A Journal of Neurology"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0040","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S1474-4422(10)70218-0","article-title":"Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap","volume":"9","author":"Calabresi","year":"2010","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0045","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1152\/jn.1999.82.6.3575","article-title":"Unilateral dopamine denervation blocks corticostriatal LTP","volume":"82","author":"Centonze","year":"1999","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0050","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1523\/JNEUROSCI.1840-08.2008","article-title":"Differential excitability and modulation of striatal medium spiny neuron dendrites","volume":"28","author":"Day","year":"2008","journal-title":"Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0055","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1007\/s10753-013-9703-2","article-title":"Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and NF-kappaB-dependent pathways","volume":"36","author":"Fan","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0060","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.1709304","article-title":"Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition","volume":"252","author":"Hollmann","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0065","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/jnr.23307","article-title":"Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model by downregulating the activations of nuclear factor-kappaB, ERK, and JNK","volume":"92","author":"Lee","year":"2014","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0070","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00702-004-0213-0","article-title":"Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons","volume":"112","author":"Li","year":"2005","journal-title":"Journal of Neural Transmission"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0075","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2741\/232","article-title":"Neuroinflammation and cell therapy for Parkinson's disease","volume":"3","author":"Li","year":"2011","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tins.2007.01.006","article-title":"Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death","volume":"30","author":"Liu","year":"2007","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/aps.2013.128","article-title":"Exendin-4 ameliorates oxidized-LDL-induced inhibition of macrophage migration in vitro via the NF-kappaB pathway","volume":"35","author":"Ma","year":"2014","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0090","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1152\/jn.1993.70.4.1451","article-title":"Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus","volume":"70","author":"Manabe","year":"1993","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0095","doi-asserted-by":"crossref","first-page":"a008870","DOI":"10.1101\/cshperspect.a008870","article-title":"Clinical approach to Parkinson's disease: features, diagnosis, and principles of management","volume":"2","author":"Massano","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1471-4159.2011.07608.x","article-title":"Reduced calcium\/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice","volume":"120","author":"Moriguchi","year":"2012","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The role of inflammatory and oxidative stress mechanisms in the pathogenesis of parkinson's disease: focus on astrocytes","volume":"49","author":"Niranjan","year":"2014","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0110","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00011-013-0639-7","article-title":"Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK\/STATs activation and ROS production","volume":"62","author":"Qi","year":"2013","journal-title":"Inflammation Research: Official Journal of the European Histamine Research Society"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0115","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.fct.2013.10.025","article-title":"5,6,7-Trimethoxyflavone suppresses pro-inflammatory mediators in lipopolysaccharide-induced RAW 264. 7 macrophages and protects mice from lethal endotoxin shock","volume":"62","author":"Rim","year":"2013","journal-title":"Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0120","doi-asserted-by":"crossref","first-page":"e38113","DOI":"10.1371\/journal.pone.0038113","article-title":"Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease","volume":"7","author":"Roy","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0125","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuropharm.2013.07.020","article-title":"Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models","volume":"75","author":"Tai","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0130","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.nbd.2010.10.013","article-title":"Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism","volume":"41","author":"Warre","year":"2011","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0135","doi-asserted-by":"crossref","first-page":"e569","DOI":"10.1038\/cddis.2013.86","article-title":"Inhibition of 12\/15-lipoxygenase by baicalein induces microglia PPARbeta\/delta: a potential therapeutic role for CNS autoimmune disease","volume":"4","author":"Xu","year":"2013","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0140","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2013.11.051","article-title":"Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice","volume":"259","author":"Yabuki","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2014.02.004_bib0145","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1167\/iovs.08-2642","article-title":"Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy","volume":"50","author":"Yang","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923014000239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923014000239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:20:20Z","timestamp":1759782020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923014000239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":29,"alternative-id":["S0361923014000239"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2014.02.004","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalein ameliorated the upregulation of striatal glutamatergic transmission in the mice model of Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2014.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}