{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:32:22Z","timestamp":1787067142660,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202940"],"award-info":[{"award-number":["81202940"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Research Foundation of ministry of Health & United Fujian Provincial Health and Education Project for Tacking the Key Research","award":["WKJ-FJ-31"],"award-info":[{"award-number":["WKJ-FJ-31"]}]},{"name":"Promotion Program for Young and Middle-aged Teacher in Science and Technology Research of Huaqiao University","award":["ZQN-PY218"],"award-info":[{"award-number":["ZQN-PY218"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.brainresbull.2015.03.006","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T08:02:45Z","timestamp":1428566565000},"page":"62-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Hippocampal BDNF signaling restored with chronic asiaticoside treatment in depression-like mice"],"prefix":"10.1016","volume":"114","author":[{"given":"Liu","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Long","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Hao","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2015.03.006_bib0005","doi-asserted-by":"crossref","first-page":"26496","DOI":"10.1155\/2007\/26496","article-title":"Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation","volume":"2007","author":"Alme","year":"2007","journal-title":"Neural Plast."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0091-3057(01)00599-8","article-title":"Intra and interstrain differences in models of behavioral despair","volume":"70","author":"Bai","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2008.03.023","article-title":"Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments","volume":"1211","author":"Balu","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0025","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1139\/jpn.0414","article-title":"Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors","volume":"29","author":"Bourin","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"issue":"Pt C","key":"10.1016\/j.brainresbull.2015.03.006_bib0030","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuropharm.2013.08.012","article-title":"BDNF regulation of synaptic structure, function, and plasticity","volume":"76","author":"Bramham","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0035","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2006.08.009","article-title":"Role of neurotrophic factors in depression","volume":"7","author":"Castren","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.neuro.31.060407.125618","article-title":"Neurocognitive mechanisms in depression: implications for treatment","volume":"32","author":"Clark","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0050","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","article-title":"A molecular and cellular theory of depression","volume":"54","author":"Duman","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0055","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0060","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.neuroscience.2005.12.058","article-title":"Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone","volume":"139","author":"Dwivedi","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0065","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1017\/S1461145709990575","article-title":"Aberrant extracellular signal-regulated kinase (ERK)1\/2 signalling in suicide brain: role of ERK kinase 1 (MEK1)","volume":"12","author":"Dwivedi","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0070","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chroma.2008.04.024","article-title":"Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins","volume":"1193","author":"Jia","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.03.058","article-title":"Endogenous neurogenesis in the hippocampus of developing rat after intrauterine infection","volume":"1459","author":"Jiang","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0080","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Kessler","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pharmthera.2007.07.001","article-title":"Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies","volume":"117","author":"Kozisek","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0090","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0095","doi-asserted-by":"crossref","first-page":"e26153","DOI":"10.1371\/journal.pone.0026153","article-title":"Cysteamine attenuates the decreases in TrkB protein levels and the anxiety\/depression-like behaviors in mice induced by corticosterone treatment","volume":"6","author":"Kutiyanawalla","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4306\/pi.2010.7.4.231","article-title":"The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment","volume":"7","author":"Lee","year":"2010","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0105","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.phymed.2012.08.002","article-title":"Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model","volume":"19","author":"Lee","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0115","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1017\/S1461145710001082","article-title":"Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine","volume":"14","author":"Li","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0120","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.neuroscience.2008.06.043","article-title":"Coordinate action of pre- and postsynaptic brain-derived neurotrophic factor is required for AMPAR trafficking and acquisition of in vitro classical conditioning","volume":"155","author":"Li","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0125","doi-asserted-by":"crossref","first-page":"10884","DOI":"10.1073\/pnas.95.18.10884","article-title":"Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons","volume":"95","author":"Li","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.pbb.2008.01.020","article-title":"Antidepressant-like effect of asiaticoside in mice","volume":"89","author":"Liang","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0135","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.pnpbp.2010.07.033","article-title":"Differential regulation of neurotrophin S100B and BDNF in two rat models of depression","volume":"34","author":"Luo","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0140","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nn1971","article-title":"New insights into BDNF function in depression and anxiety","volume":"10","author":"Martinowich","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0145","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1152\/jn.1998.79.1.496","article-title":"Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus","volume":"79","author":"Messaoudi","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0150","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(00)80853-3","article-title":"Essential role for TrkB receptors in hippocampus-mediated learning","volume":"24","author":"Minichiello","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0155","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1248\/bpb.26.474","article-title":"Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test","volume":"26","author":"Nakazawa","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0160","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","article-title":"Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments","volume":"15","author":"Nibuya","year":"1995","journal-title":"J. Neurosci."},{"issue":"Pt C","key":"10.1016\/j.brainresbull.2015.03.006_bib0165","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.neuropharm.2013.04.011","article-title":"Synaptic regulation of affective behaviors; role of BDNF","volume":"76","author":"Ninan","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0170","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.psyneuen.2008.09.015","article-title":"Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling","volume":"34","author":"O\u2019Leary","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"Suppl. 6","key":"10.1016\/j.brainresbull.2015.03.006_bib0175","first-page":"5","article-title":"The societal costs of chronic major depression","volume":"62","author":"Pincus","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0185","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejphar.2008.10.055","article-title":"Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system","volume":"602","author":"Posser","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0195","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1523\/JNEUROSCI.19-12-04972.1999","article-title":"Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice","volume":"19","author":"Pozzo-Miller","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0200","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.4103\/1673-5374.137574","article-title":"Neuroprotective effects of Asiaticoside","volume":"9","author":"Qi","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0205","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/14728222.12.6.705","article-title":"Targeting TrkB neurotrophin receptor to treat depression","volume":"12","author":"Rantamaki","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0210","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","article-title":"Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression","volume":"22","author":"Shirayama","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0215","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1472-6882-12-103","article-title":"Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study","volume":"12","author":"Somboonwong","year":"2012","journal-title":"BMC Compl. Altern. Med."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0220","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mp.2009.67","article-title":"Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis","volume":"15","author":"Taliaz","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0225","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1523\/JNEUROSCI.5275-11.2012","article-title":"Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF","volume":"32","author":"Valente","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0230","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jnr.20077","article-title":"Exercise induces BDNF and synapsin I to specific hippocampal subfields","volume":"76","author":"Vaynman","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0235","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/ptr.4838","article-title":"Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1","volume":"27","author":"Wan","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0240","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural\u2013neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0250","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.neuint.2007.01.006","article-title":"The role of c-AMP-dependent protein kinase in spinal cord and post synaptic dorsal column neurons in a rat model of visceral pain","volume":"50","author":"Wu","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0255","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1017\/S1461145709990733","article-title":"Fuzi polysaccharide-1 produces antidepressant-like effects in mice","volume":"13","author":"Yan","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0260","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1503\/jpn.130169","article-title":"BDNF\u2013ERK\u2013CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice","volume":"39","author":"Yi","year":"2014","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0265","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.phymed.2010.01.008","article-title":"Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide\/d-galactosamine in mice","volume":"17","author":"Zhang","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0270","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S1461145713001661","article-title":"Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats","volume":"17","author":"Zhang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0275","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2010.09.095","article-title":"Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat","volume":"1366","author":"Zhang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2015.03.006_bib0280","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1503\/jpn.120228","article-title":"Glycine site N-methyl-d-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats","volume":"38","author":"Zhu","year":"2013","journal-title":"J. Psychiatry Neurosci."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036192301500060X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036192301500060X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:21:40Z","timestamp":1759782100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036192301500060X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":55,"alternative-id":["S036192301500060X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2015.03.006","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal BDNF signaling restored with chronic asiaticoside treatment in depression-like mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2015.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}