{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:06:19Z","timestamp":1790445979831,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NIH","award":["DA009815"],"award-info":[{"award-number":["DA009815"]}]},{"name":"NIH","award":["DA035608"],"award-info":[{"award-number":["DA035608"]}]},{"name":"Pennsylvania Department of Health, Commonwealth Universal Research Enhancements SAP#","award":["4100055576"],"award-info":[{"award-number":["4100055576"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.brainresbull.2015.10.008","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T14:45:56Z","timestamp":1445611556000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Early avoidance of a heroin-paired taste-cue and subsequent addiction-like behavior in rats"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-0356","authenticated-orcid":false,"given":"Christopher B.","family":"Jenney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Petko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Ebersole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian V. Nzinkeu","family":"Njatcha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teddy O.","family":"Uzamere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-6211","authenticated-orcid":false,"given":"Danielle N.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia S.","family":"Grigson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Levenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2015.10.008_bib0005","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: change in hedonic set point","volume":"282","author":"Ahmed","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0010","series-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR","author":"American Psychiatric Association, A.P.A.T.F.o.D.-IV","year":"2000"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1037\/1064-1297.2.3.244","article-title":"Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey","volume":"2","author":"Anthony","year":"1994","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0020","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.physbeh.2013.02.017","article-title":"Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats","volume":"112\u2013113","author":"Cason","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0025","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.1099020","article-title":"Evidence for addiction-like behavior in the rat","volume":"305","author":"Deroche-Gamonet","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0030","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/FBP.0b013e3283644d15","article-title":"Escalation of drug self-administration as a hallmark of persistent addiction liability","volume":"24","author":"Edwards","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1037\/a0015033","article-title":"Overexpression of DeltaFosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice","volume":"123","author":"Freet","year":"2009","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0040","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1037\/0735-7044.116.2.321","article-title":"Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards","volume":"116","author":"Grigson","year":"2002","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0045","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1037\/0735-7044.121.6.1234","article-title":"Once is too much: conditioned changes in accumbens dopamine following a single saccharin\u2013morphine pairing","volume":"121","author":"Grigson","year":"2007","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0050","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1186\/1471-2164-15-874","article-title":"Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression","volume":"15","author":"Herrero-Turrion","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0055","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1037\/bne0000069","article-title":"Greater avoidance of a heroin-paired taste cue is associated with greater escalation of heroin self-administration in rats","volume":"129","author":"Imperio","year":"2015","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2202-11-33","article-title":"Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence","volume":"11","author":"Jin","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0065","doi-asserted-by":"crossref","first-page":"8476","DOI":"10.1523\/JNEUROSCI.22-19-08476.2002","article-title":"Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor","volume":"22","author":"Kabbani","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0070","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1176\/appi.ajp.2007.05030503","article-title":"Stress, dysregulation of drug reward pathways, and the transition to drug dependence","volume":"164","author":"Koob","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0075","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pbb.2008.03.019","article-title":"Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior","volume":"90","author":"Kuntz","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0080","doi-asserted-by":"crossref","first-page":"e698","DOI":"10.1371\/journal.pone.0000698","article-title":"Intense sweetness surpasses cocaine reward","volume":"2","author":"Lenoir","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0085","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/npp.2013.17","article-title":"Extended heroin access increases heroin choices over a potent nondrug alternative","volume":"38","author":"Lenoir","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0090","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/adb.12134","article-title":"Drug versus sweet reward: greater attraction to and preference for sweet versus drug cues","volume":"20","author":"Madsen","year":"2015","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0095","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0100","doi-asserted-by":"crossref","first-page":"e67608","DOI":"10.1371\/journal.pone.0067608","article-title":"MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens","volume":"8","author":"Petko","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0105","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1037\/a0025759","article-title":"A history of bingeing on fat enhances cocaine seeking and taking","volume":"125","author":"Puhl","year":"2011","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/FBP.0b013e32834eb060","article-title":"Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue","volume":"23","author":"Puhl","year":"2012","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0115","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1038\/tp.2012.11","article-title":"Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability","volume":"2","author":"Shumay","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0120","unstructured":"Tacelosky, D.M., et al., in press. Low expression of D2R and Wntless correlates with high motivation for heroin. Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0125","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1523\/JNEUROSCI.5261-12.2013","article-title":"Predominance of D2 receptors in mediating dopamine\u2019s effects in brain metabolism: effects of alcoholism","volume":"33","author":"Volkow","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0130","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1126\/science.1257748","article-title":"Both Positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats","volume":"191","author":"Wise","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0135","unstructured":"World Health Organization, 2015. Facts and figures. Retrieved October 23, 2015 from www.who.int\/substance_abuse\/facts\/en\/."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0140","unstructured":"World Health Organization, 2015. Information sheet on opioid overdose. Retrieved October 23, 2015 from www.who.int\/substance_abuse\/information-sheet\/en\/."},{"key":"10.1016\/j.brainresbull.2015.10.008_bib0145","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.devcel.2007.12.004","article-title":"Wnt signaling requires retromer-dependent recycling of MIG-14\/Wntless in Wnt-producing cells","volume":"14","author":"Yang","year":"2008","journal-title":"Dev. Cell"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923015300460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923015300460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:22:33Z","timestamp":1759782153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923015300460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":29,"alternative-id":["S0361923015300460"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2015.10.008","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early avoidance of a heroin-paired taste-cue and subsequent addiction-like behavior in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2015.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}