{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:07:16Z","timestamp":1768770436749,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul (FAPERGS)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.brainresbull.2016.02.004","type":"journal-article","created":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T21:18:02Z","timestamp":1454793482000},"page":"169-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats"],"prefix":"10.1016","volume":"121","author":[{"given":"Ana Paula K.","family":"Riffel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica A.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo Q.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a","family":"Horst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u00edna","family":"Scheid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Kolberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane","family":"Bell\u00f3-Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wania A.","family":"Partata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2016.02.004_bib0005","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.redox.2014.01.006","article-title":"Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy","volume":"18","author":"Areti","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0015","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.freeradbiomed.2005.10.051","article-title":"Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation","volume":"40","author":"Bruno","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0020","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1073\/pnas.0702854104","article-title":"Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0025","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0014-4886(82)90234-5","article-title":"An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks","volume":"77","author":"De Medinaceli","year":"1982","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0035","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.numecd.2011.03.002","article-title":"Vitamin E differentially affects short term exercise induced changes in oxidative stress, lipids, and inflammatory markers","volume":"22","author":"Garelnabi","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejphar.2015.05.038","article-title":"Gabapentin inhibits the activity of the rat excitatory glutamate transporter 3 expressed in Xenopus oocytes","volume":"762","author":"Gil","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s11064-006-9058-2","article-title":"Neuropathic pain modifies antioxidant activity in rat spinal cord","volume":"31","author":"Guedes","year":"2006","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0050","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases: the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0055","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0060","first-page":"753","article-title":"Banafshe HR. Gabapentin enhances anti-nociceptive effects of morphine on heat cold, and mechanical hyperalgesia in a rat model of neuropathic pain","volume":"17","author":"Hamidi","year":"2014","journal-title":"Iran J. Basic Med. Sci."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0065","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbrc.2012.01.031","article-title":"Vitamin E is a MIF inhibitor","volume":"418","author":"Hedge","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2009.00801.x","article-title":"Animal models of neuropathic pain","volume":"25","author":"Jaggi","year":"2011","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0075","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/BF02536169","article-title":"Lipid hydroperoxide measurement by oxidation of Fe2+ in the presence of xylenol orange: comparison with the TBA assay and an iodometric method","volume":"26","author":"Jiang","year":"1991","journal-title":"Lipids"},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0080","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3344\/kjp.2013.26.2.209","article-title":"Can Vitamin C be used as an adjuvant for managing postoperative pain? A short literature review","volume":"26","author":"Kiabi","year":"2013","journal-title":"Korean J. Pain"},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0085","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3344\/kjp.2012.25.4.238","article-title":"Antinociceptive effects of intraperitoneal and intrathecal vitamin E in the rat formalin test","volume":"25","author":"Kim","year":"2012","journal-title":"Korean J. Pain"},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.aanat.2009.02.007","article-title":"Experimental models of peripheral neuropathic pain based on traumatic nerve injuries\u2014an anatomical perspective","volume":"191","author":"Klus\u00e1kov\u00e1","year":"2009","journal-title":"Ann. Anat."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0095","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s12272-013-0057-y","article-title":"Implications and mechanism of action of gabapentin in neuropathic pain","volume":"36","author":"Kukkar","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0100","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1440-1681.2010.05356.x","article-title":"Effect of tocopheryl phosphate on key biomarkers of inflammation: implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model","volume":"37","author":"Libinaki","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0029240","article-title":"Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury","volume":"6","author":"Lu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0110","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/practneurol-2013-000536","article-title":"Neuropathic pain: diagnosis and treatment","volume":"13","author":"Magrinelli","year":"2013","journal-title":"Pract. Neurol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0115","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2006.8.1941","article-title":"Redox control of neural function: background, mechanisms, and significance","volume":"8","author":"Maher","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0120","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1734-1140(10)70281-4","article-title":"Early co-administration of vitamin E acetate and methylcobalamin improves thermal hyperalgesia and motor nerve conduction velocity following sciatic nerve crush injury in rats","volume":"62","author":"Morani","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0125","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.lfs.2009.02.014","article-title":"Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats","volume":"84","author":"Nakazato-Imasato","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0130","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10863-013-9524-x","article-title":"Vitamin E modulates oxidative stress and protein kinase C activator (PMA)-induced TRPM2 channel gate in dorsal root ganglion of rats","volume":"45","author":"Naziro\u011flu","year":"2013","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0135","doi-asserted-by":"crossref","first-page":"12577","DOI":"10.1523\/JNEUROSCI.2206-07.2007","article-title":"Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate","volume":"27","author":"Nelson","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0140","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1744-8069-8-8","article-title":"Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury","volume":"8","author":"Okubo","year":"2012","journal-title":"Mol. Pain"},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0145","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1179\/1476830512Y.0000000019","article-title":"Ascorbic acid, alpha-tocopherol, and beta-carotene reduce oxidative stress and proinflammatory cytokines in mononuclear cells of Alzheimer's disease patients","volume":"15","author":"Oliveira","year":"2012","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0150","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4097\/kjae.2013.65.5.442","article-title":"Antiallodynic effects of vitamin C and vitamin E in chronic post-ischemia pain rat model","volume":"65","author":"Park","year":"2013","journal-title":"Korean J. Anesthesiol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0155","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-2236(99)01543-X","article-title":"Ascorbate regulation and its neuroprotective role in the brain","volume":"23","author":"Rice","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1744-9081-10-19","article-title":"The neural mobilization technique modulates the expression of endogenous opioids in the periaqueductal gray and improves muscle strength and mobility in rats with neuropathic pain","volume":"10","author":"Santos","year":"2014","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0165","first-page":"CS58","article-title":"Intravenous administration of vitamin C in the treatment of herpetic neuralgia: two case reports","volume":"16","author":"Schencking","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0170","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fphar.2015.00104","article-title":"Opioid-induced hyperalgesia in chronic pain patients and the mitigating effects of gabapentin","volume":"6","author":"Stoicea","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0175","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00424-003-1104-1","article-title":"Sodium-dependent ascorbic acid transporter family SLC23","volume":"447","author":"Takanaga","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0180","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/ptr.4635","article-title":"Neuroprotective effect of vitamin e isoforms against chronic alcohol-induced peripheral neurotoxicity: possible involvement of oxidative nitrodative stress","volume":"26","author":"Tiwari","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0185","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.freeradbiomed.2011.05.017","article-title":"Vitamins C and E: Beneficial effects from a mechanistic perspective","volume":"51","author":"Traber","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0190","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: redefinition and a grading system for clinical and research purposes","volume":"70","author":"Treede","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0195","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.nutres.2013.07.001","article-title":"\u03b1-Tocopherol, ascorbic acid, and \u03b2-carotene protect against oxidative stress but reveal no direct influence on p53 expression in rats subjected to stress","volume":"33","author":"Warzyniak","year":"2013","journal-title":"Nutr. Res."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0200","doi-asserted-by":"crossref","first-page":"382S","DOI":"10.1093\/jn\/131.2.382S","article-title":"Vitamin E and macrophage cyclooxygenase regulation in the aged","volume":"131","author":"Wu","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0205","doi-asserted-by":"crossref","first-page":"e19529","DOI":"10.5812\/aapm.19529","article-title":"Ascorbic acid interaction with analgesic effect of morphine and tramadol in mice","volume":"4","author":"Zeraati","year":"2014","journal-title":"Anesth. Pain Med."},{"key":"10.1016\/j.brainresbull.2016.02.004_bib0210","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(99)00376-3","article-title":"High rat food vitamin E content improves nerve function in streptozotocin-diabetic rats","volume":"376","author":"van Dam","year":"1999","journal-title":"Eur. J. Pharmacol."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036192301630017X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036192301630017X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:23:54Z","timestamp":1759782234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036192301630017X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":42,"alternative-id":["S036192301630017X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.02.004","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}