{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:20:19Z","timestamp":1792718419144,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.brainresbull.2016.03.013","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T11:32:26Z","timestamp":1458732746000},"page":"27-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"special_numbering":"C","title":["Memantine ameliorates autistic behavior, biochemistry &amp; blood brain barrier impairments in rats"],"prefix":"10.1016","volume":"124","author":[{"given":"Hariom","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupesh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2016.03.013_bib0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12640-011-9264-9","article-title":"Effect of aspartame on oxidative stress and monoamine neurotransmitter levels in lipopolysaccharide-treated mice","volume":"21","author":"Abdel-Salam","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0010","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000362645","article-title":"The ketogenic diet modifies social and metabolic alterations identified in the Pre-VPA model of autism spectrum disorder","volume":"36","author":"Ahn","year":"2014","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0015","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/npp.2015.26","article-title":"Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice","volume":"40","author":"Aida","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0020","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/0748233713475517","article-title":"The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats","volume":"31","author":"Al-Hazmi","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0025","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0030","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pnpbp.2015.02.009","article-title":"NMDA receptor activation regulates sociability by its effect on mTOR signaling activity","volume":"60","author":"Burket","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.coph.2014.11.008","article-title":"NMDA receptor subunit mutations in neurodevelopmental disorders","volume":"20","author":"Burnashev","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0040","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1523\/JNEUROSCI.5182-14.2015","article-title":"Idiosyncratic brain activation patterns are associated with poor social comprehension in autism","volume":"35","author":"Byrge","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1471-4159.2011.07189.x","article-title":"Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism","volume":"117","author":"Chauhan","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0050","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nn.3927","article-title":"Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression","volume":"18","author":"Chung","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0055","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1002\/gps.938","article-title":"The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence","volume":"18","author":"Danysz","year":"2003","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0060","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1074\/jbc.M607483200","article-title":"A beta oligomers induce neuronal oxidative stress through an N-methyl-d-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine","volume":"282","author":"De Felice","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0065","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbi.2013.12.004","article-title":"Intestinal inflammation in a murine model of autism spectrum disorders","volume":"37","author":"de Theije","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0070","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12974-014-0189-0","article-title":"GABAergic\/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders","volume":"11","author":"El-Ansary","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2012.06.044","article-title":"N-Methyl-d-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats","volume":"691","author":"\u00c9rces","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0080","first-page":"1302","article-title":"PET and SPECT scans in autistic children","volume":"143","author":"Galuska","year":"2002","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0085","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.psychres.2010.12.030","article-title":"Memantine reduces mania-like symptoms in animal models","volume":"188","author":"Gao","year":"2011","journal-title":"Psychiatry Res."},{"issue":"November (6)","key":"10.1016\/j.brainresbull.2016.03.013_bib0090","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.neuropharm.2012.07.028","article-title":"Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3\u03b2\/\u03b2-catenin pathway","volume":"63","author":"Go","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0095","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bj2560311a","article-title":"The resistance of transferrin, lactoferrin and caeruloplasmin to oxidative damage","volume":"256","author":"Halliwell","year":"1988","journal-title":"Biochem. J"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0100","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.ridd.2014.03.037","article-title":"Sleep patterns in children with and without autism spectrum disorders: developmental comparisons","volume":"35","author":"Hodge","year":"2014","journal-title":"Res. Dev. Disabil."},{"issue":"June","key":"10.1016\/j.brainresbull.2016.03.013_bib0105","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s12035-014-8767-9","article-title":"Memantine alleviates brain injury and neurobehavioral deficits after experimental subarachnoid hemorrhage","volume":"51","author":"Huang","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0110","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/15376516.2013.821567","article-title":"Toxicity of valproic acid in isolated rat liver mitochondria","volume":"23","author":"Jafarian","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"issue":"5","key":"10.1016\/j.brainresbull.2016.03.013_bib0115","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/glia.22781","article-title":"Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes?","volume":"63","author":"Ju","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0120","article-title":"Hydrogen sulfide ameliorates homocysteine-induced Alzheimer's disease-like pathology, blood-brain barrier disruption, and synaptic disorder","author":"Kamat","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnmol.2015.00017","article-title":"Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors","volume":"8","author":"Kang","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.toxlet.2010.12.018","article-title":"The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats","author":"Kim","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0135","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5487\/TR.2013.29.3.173","article-title":"GIT abnormalities induced by Pre-VPA exposure in rat offspring","volume":"29","author":"Kim","year":"2013","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0140","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12035-013-8535-2","article-title":"Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring","volume":"49","author":"Kim","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0145","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000108590","article-title":"Dual action of nitric oxide in the pathogenesis of ischemia\/reperfusion-induced mucosal injury in mouse stomach","volume":"75","author":"Kobata","year":"2007","journal-title":"Digestion"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2015.10.052","article-title":"Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood-brain barrier impairments in rats","volume":"1630","author":"Kumar","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0155","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuint.2015.10.007","article-title":"Benefits of agomelatine in behavioral, neurochemical and blood-brain barrier alterations in prenatal valproic acid induced autism spectrum disorder","volume":"91","author":"Kumar","year":"2015","journal-title":"Neurochem. Int."},{"issue":"9","key":"10.1016\/j.brainresbull.2016.03.013_bib0160","doi-asserted-by":"crossref","first-page":"e107129","DOI":"10.1371\/journal.pone.0107129","article-title":"Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury","volume":"9","author":"Kysenius","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0165","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(13)61539-1","article-title":"Autism","volume":"383","author":"Lai","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coph.2014.10.007","article-title":"NMDA receptor dysfunction in autism spectrum disorders","volume":"20","author":"Lee","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0175","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrd1958","article-title":"Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond","volume":"5","author":"Lipton","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2013.11.031","article-title":"The protective effect of HET0016 on brain edema and blood-brain barrier dysfunction after cerebral ischemia\/reperfusion","volume":"1544","author":"Liu","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0185","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/aur.1338","article-title":"Altered peripheral and central inflammatory responses in a mouse model of autism","volume":"7","author":"Lucchina","year":"2014","journal-title":"Autism Res."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0190","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jneumeth.2010.12.013","article-title":"Comparison Evans blue injection routes: intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model","volume":"195","author":"Manaenko","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0195","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1759-1961.2012.00032.x","article-title":"Effects of prolonged treatment with memantine in the MRL model of CNS lupus","volume":"3","author":"Marcinko","year":"2012","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0200","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.npp.1301453","article-title":"Abnormal fear conditioning and amygdala processing in an animal model of autism","volume":"33","author":"Markram","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0205","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10802-012-9668-x","article-title":"Anxiety sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders","volume":"41","author":"Mazurek","year":"2013","journal-title":"J. Abnorm. Child Psychol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0210","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbr.2014.01.008","article-title":"Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: similarities to autism spectrum disorders","volume":"263","author":"Merali","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-510X(95)00309-P","article-title":"NMDA- and endothelin-1-induced increases in blood-brain barrier permeability quantitated with Lucifer yellow","volume":"136","author":"Miller","year":"1996","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0220","doi-asserted-by":"crossref","first-page":"18549","DOI":"10.1074\/jbc.M114.555334","article-title":"Brain-derived neurotrophic factor (BDNF) induces sustained intracellular Ca2+ elevation through the up-regulation of surface transient receptor potential 3 (TRPC3) channels in rodent microglia","volume":"289","author":"Mizoguchi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0225","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fnbeh.2015.00141","article-title":"Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice","volume":"9","author":"Nakao","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0230","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.biopsych.2012.05.004","article-title":"Levels of soluble platelet endothelial cell adhesion molecule-1 and P-selectin are decreased in children with autism spectrum disorder","volume":"72","author":"Onore","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0235","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.neuroscience.2007.03.018","article-title":"Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats","volume":"146","author":"Piet\u00e1 Dias","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0240","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.11.035","article-title":"Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats","volume":"117","author":"Rai","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"February (2)","key":"10.1016\/j.brainresbull.2016.03.013_bib0245","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5014\/ajot.48.2.113","article-title":"Play and preschool children with autism","volume":"48","author":"Restall","year":"1994","journal-title":"Am. J. Occup. Ther."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0250","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1073\/pnas.0704391104","article-title":"Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid","volume":"104","author":"Rinaldi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0255","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/cercor\/bhm117","article-title":"Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid","volume":"4","author":"Rinaldi","year":"2008","journal-title":"Cereb. Cortex"},{"issue":"May (5)","key":"10.1016\/j.brainresbull.2016.03.013_bib0260","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s11064-012-0717-1","article-title":"Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats","volume":"37","author":"Sandhya","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0265","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0270","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.npp.1300767","article-title":"Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism","volume":"31","author":"Schneider","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0275","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12964-014-0075-5","article-title":"NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR\/CD40-activated B cells","volume":"12","author":"Simma","year":"2014","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0280","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.physbeh.2015.02.009","article-title":"Melatonin receptor and KATP channel modulation in experimental vascular dementia","volume":"142","author":"Singh","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0285","first-page":"166","article-title":"Ultrastructural study of cerebellar dentate nucleus astrocytes in chronic experimental model with valproate","volume":"43","author":"Sobaniec-\u0141otowska","year":"2005","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0290","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0940-2993(96)80094-7","article-title":"Morphological features of encephalopathy after chronic administration of the antiepileptic drug valproate to rats. A transmission electron microscopic study of capillaries in the cerebellar cortex","volume":"48","author":"Sobaniec-Lotowska","year":"1999","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0295","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1542\/peds.2012-3774","article-title":"Psychotropic medication use and polypharmacy in children with autism spectrum disorders","volume":"132","author":"Spencer","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0300","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1111\/j.1460-9568.2005.04483.x","article-title":"Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat","volume":"22","author":"Stolp","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0305","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","article-title":"Microglial activation in young adults with autism spectrum disorder","volume":"70","author":"Suzuki","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0310","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13229-015-0004-5","article-title":"Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins","volume":"6","author":"Werling","year":"2015","journal-title":"Mol. Autism"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0315","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nlm.2012.10.003","article-title":"Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice","volume":"99","author":"Wincott","year":"2013","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0320","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1038\/npp.2009.64","article-title":"Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation","volume":"34","author":"Wu","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0325","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/hipo.20984","article-title":"Requirement of phospholipase C and protein kinase C in cholecystokinin-mediated facilitation of NMDA channel function and anxiety-like behavior","volume":"22","author":"Xiao","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0330","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1038\/npp.2013.176","article-title":"Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys","volume":"38","author":"Yamamoto","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0335","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1001\/archneur.63.8.1161","article-title":"Altered vascular phenotype in autism: correlation with oxidative stress","volume":"63","author":"Yao","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0340","doi-asserted-by":"crossref","first-page":"e0121911","DOI":"10.1371\/journal.pone.0121911","article-title":"Repositioning of memantine as a potential novel therapeutic agent against meningitic E. coli-induced pathogenicities through disease-associated alpha7 cholinergic pathway and RNA sequencing-based transcriptome analysis of host inflammatory responses","volume":"10","author":"Yu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2016.03.013_bib0345","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2011.12.012","article-title":"Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia\/reperfusion injury","volume":"1437","author":"Zeng","year":"2012","journal-title":"Brain Res."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923016300569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923016300569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:22:31Z","timestamp":1759782151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923016300569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":69,"alternative-id":["S0361923016300569"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.03.013","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}