{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:09:45Z","timestamp":1777468185973,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.brainresbull.2016.03.022","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T00:40:34Z","timestamp":1459557634000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Platelet-activating factor receptor (PAFR) plays a crucial role in experimental global cerebral ischemia and reperfusion"],"prefix":"10.1016","volume":"124","author":[{"given":"Eliana Cristina de Brito","family":"Toscano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Costa","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna Constaza G\u00f3mez","family":"Victoria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Clara de Souza","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Silva de","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Adriane","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirl\u00e2ndia Pires","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Andrade de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Miranda","family":"Kangussu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Gon\u00e7alves da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Guimar\u00e3es","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00edola da Silva","family":"Barcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anilton C\u00e9sar","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio Almeida","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio L\u00facio","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milene Alvarenga","family":"Rachid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2016.03.022_bib0005","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2353\/ajpath.2006.051066","article-title":"Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy","volume":"169","author":"Adhami","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/brain\/120.3.435","article-title":"Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats","volume":"120","author":"Anthony","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0015","first-page":"237","article-title":"Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia-an initial screening study","volume":"12","author":"Aspey","year":"1997","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0020","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.expneurol.2008.08.009","article-title":"LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia","volume":"214","author":"Belayev","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0025","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12975-011-0116-y","article-title":"Superior neuroprotective efficacy of LAU-0901, a novel platelet-activating factor antagonist, in experimental stroke","volume":"3","author":"Belayev","year":"2012","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0030","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/01.STR.23.1.98","article-title":"Infarct reduction by the platelet activating factor antagonist apafant in rats","volume":"23","author":"Bielenberg","year":"1992","journal-title":"Stroke J. Cereb. Circ."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0035","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neulet.2007.08.050","article-title":"Synergism in the repression of COX-2-and TNF\u03b1-induction in platelet activating factor-stressed human neural cells","volume":"426","author":"Boetkjaer","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0040","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2007.01.094","article-title":"Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury","volume":"1143","author":"Bozlu","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0045","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2174\/1567202612666150812150606","article-title":"The 5-lipoxygenase (5-LOX)\/Inhibitor zileuton reduces inflammation and infarct size with improvement in neurological outcome following cerebral ischemia","volume":"12","author":"Costa Silva","year":"2015","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0050","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1159\/000332205","article-title":"Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target","volume":"32","author":"Denes","year":"2011","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0055","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.intimp.2013.06.015","article-title":"Neutrophils and stroke\u2014can neutrophils mitigate disease in the central nervous system?","volume":"17","author":"Easton","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0060","doi-asserted-by":"crossref","DOI":"10.1038\/nrneurol.2015.144","article-title":"Immune interventions in stroke","author":"Fu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0065","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.surneu.2005.12.028","article-title":"Inflammation in stroke and focal cerebral ischemia","volume":"66","author":"Huang","year":"2006","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0070","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0169-328X(00)00043-7","article-title":"Differential activation of MAPK\/ERK and p38\/SAPK in neurones and glia following focal cerebral ischaemia in the rat","volume":"77","author":"Irving","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0075","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory mechanisms in ischemic stroke: role of inflammatory cells","volume":"87","author":"Jin","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0080","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/WCO.0b013e32832b4db3","article-title":"Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options","volume":"22","author":"Kleinig","year":"2009","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0085","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ajpath.2011.09.038","article-title":"Platelet-activating factor receptor is essential for the development of experimental cerebral malaria","volume":"180","author":"Lacerda-Queiroz","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0090","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0301-0082(96)00047-0","article-title":"Platelet-activating factor in the CNS","volume":"50","author":"Maclennan","year":"1996","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0095","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1161\/01.STR.25.7.1469","article-title":"Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat","volume":"25","author":"Matsuo","year":"1994","journal-title":"Effects Neutrophil Deplet. Stroke J. Cereb. Circ."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1053-0770(21)00593-0","article-title":"Etiology and incidence of brain dysfunction after cardiac surgery","volume":"13","author":"Murkin","year":"1999","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biopha.2012.08.006","article-title":"Evaluation of the effects of thalidomide-loaded biodegradable devices in solid Ehrlich tumor","volume":"67","author":"Pereira","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0110","first-page":"957","volume":"26","author":"Phipps","year":"1991"},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0115","doi-asserted-by":"crossref","first-page":"391","DOI":"10.6061\/clinics\/2013(03)OA17","article-title":"Blockade of CXCR1\/2 chemokine receptors protects against brain damage in ischemic stroke in mice: ischemia and Reparixin","volume":"68","author":"Sousa","year":"2013","journal-title":"Clinics"},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1474-4422(07)70031-5","article-title":"Preventing stroke: saving lives around the world","volume":"6","author":"Strong","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0125","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1161\/01.STR.0000257981.09329.d2","article-title":"Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia","volume":"38","author":"Umemura","year":"2007","journal-title":"Stroke J. Cereb. Circ."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1326-6-11","article-title":"Pathophysiology, treatment, and animal and cellular models of human ischemic stroke","volume":"6","author":"Woodruff","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0135","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.4103\/1673-5374.143419","article-title":"Inflammatory response and neuronal necrosis in rats with cerebral ischemia","volume":"9","author":"Wu","year":"2014","journal-title":"Neural Regener. Res."},{"key":"10.1016\/j.brainresbull.2016.03.022_bib0140","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11064-006-9248-y","article-title":"Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats","volume":"32","author":"Zhang","year":"2007","journal-title":"Neurochem. Res."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923016300739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923016300739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:22:53Z","timestamp":1759782173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923016300739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":28,"alternative-id":["S0361923016300739"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.03.022","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-activating factor receptor (PAFR) plays a crucial role in experimental global cerebral ischemia and reperfusion","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}