{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:40:09Z","timestamp":1777790409135,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201392"],"award-info":[{"award-number":["81201392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.brainresbull.2016.09.010","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T16:15:15Z","timestamp":1474128915000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats"],"prefix":"10.1016","volume":"127","author":[{"given":"Jing","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2016.09.010_bib0005","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s11011-015-9651-7","article-title":"Blood-brain barrier dysfunction following traumatic brain injury","volume":"30","author":"Alluri","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1097-4644(20000701)78:1<85::AID-JCB8>3.0.CO;2-F","article-title":"Multiple domains of occludin are involved in the regulation of paracellular permeability","volume":"78","author":"Balda","year":"2000","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2015.04.025","article-title":"Pravastatin acute neuroprotective effects depend on blood brain barrier integrity in experimental cerebral ischemia","volume":"1615","author":"Carone","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fnsys.2016.00047","article-title":"Traumatic brain injury and neuronal functionality changes in sensory cortex","volume":"10","author":"Carron","year":"2016","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/neu.1996.13.557","article-title":"An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits","volume":"13","author":"Chen","year":"1996","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0030","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/brain\/awn004","article-title":"Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis","volume":"131","author":"Chen","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0035","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s00221-015-4352-3","article-title":"Protective effect of ginsenoside Rb1 on integrity of blood-brain barrier following cerebral ischemia","volume":"233","author":"Chen","year":"2015","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2040-7378-5-12","article-title":"Anti-inflammatory IL-10 is upregulated in both hemispheres after experimental ischemic stroke: hypertension blunts the response","volume":"5","author":"Fouda","year":"2013","journal-title":"Exp. Transl. Stroke Med."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/scdb.2000.0178","article-title":"MAGUK proteins: structure and role in the tight junction","volume":"11","author":"Gonzalez-Mariscal","year":"2000","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0050","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/jcbfm.1988.96","article-title":"Ischemic brain edema and the osmotic gradient between blood and brain","volume":"8","author":"Hatashita","year":"1988","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0055","doi-asserted-by":"crossref","first-page":"10423","DOI":"10.1074\/jbc.M007136200","article-title":"Regulation of tight junction permeability and occludin phosphorylation by RhoA-p160ROCK-dependent and -independent mechanisms","volume":"276","author":"Hirase","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0060","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","article-title":"Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia","volume":"43","author":"Hu","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0065","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1161\/STROKEAHA.112.670299","article-title":"CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice","volume":"44","author":"Huang","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0070","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuro.2014.01.005","article-title":"The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells","volume":"41","author":"Jin","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0075","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s002329900518","article-title":"Small synthetic peptides homologous to segments of the first external loop of occludin impair tight junction resealing","volume":"168","author":"Lacaz-Vieira","year":"1999","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0080","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/j.1471-4159.2008.05664.x","article-title":"Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke","volume":"107","author":"Liu","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainres.2014.05.022","article-title":"Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1\/2 pathway","volume":"1573","author":"Liu","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0090","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.nutres.2015.04.011","article-title":"Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice","volume":"35","author":"Ma","year":"2015","journal-title":"Nutr. Res."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12012-013-9232-0","article-title":"Cordycepin, 3\u2032-deoxyadenosine, prevents rat hearts from ischemia\/reperfusion injury via activation of Akt\/GSK-3beta\/p70S6K signaling pathway and HO-1 expression","volume":"14","author":"Park","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/jpi.12292","article-title":"The neuroprotective and anti-apoptotic effects of melatonin on hemolytic hyperbilirubinemia-induced oxidative brain damage","volume":"60","author":"Pazar","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0105","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.exger.2012.09.003","article-title":"Cordycepin (3\u2032-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats","volume":"47","author":"Ramesh","year":"2012","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0110","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/cns.12194","article-title":"Resveratrol attenuates early brain injury after subarachnoid hemorrhage through inhibition of NF-kappaB-dependent inflammatory\/MMP-9 pathway","volume":"20","author":"Shao","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0115","first-page":"232","article-title":"Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves","volume":"8","author":"Shetty","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0120","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.lfs.2013.09.030","article-title":"Cordycepin: a bioactive metabolite with therapeutic potential","volume":"93","author":"Tuli","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0125","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jnc.12695","article-title":"Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia","volume":"129","author":"Wang","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2015.02.016","article-title":"Neuroprotective effects of crocin against traumatic brain injury in mice: involvement of notch signaling pathway","volume":"591","author":"Wang","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1537-1891(02)00200-8","article-title":"Tight junctions of the blood-brain barrier: development, composition and regulation","volume":"38","author":"Wolburg","year":"2002","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.brainresbull.2016.09.010_bib0140","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1159\/000430317","article-title":"ROS-dependent neuroprotective effects of NaHS in ischemia brain injury involves the PARP\/AIF pathway","volume":"36","author":"Yu","year":"2015","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923016302167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923016302167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:24:02Z","timestamp":1759782242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923016302167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":28,"alternative-id":["S0361923016302167"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.09.010","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2016.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}