{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:47:36Z","timestamp":1780588056268,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T00:00:00Z","timestamp":1553385600000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Penn State University of Medicine Department of Anesthesiology & Perioperative Medicine RIF (DMJ; ANH-R)"},{"name":"NIH","award":["DA037355"],"award-info":[{"award-number":["DA037355"]}]},{"name":"Pennsylvania Department of Health using CURE Tobacco Settlement Funds (DJM)"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.brainresbull.2017.07.017","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T14:31:47Z","timestamp":1501684307000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Increased ethanol drinking in \u201chumanized\u201d mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms"],"prefix":"10.1016","volume":"138","author":[{"given":"Angela N","family":"Henderson-Redmond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy E","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi B","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2017.07.017_bib0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00426964","article-title":"Brain and liver aldehyde dehydrogenase activity and voluntary ethanol consumption by rats: relations to strain, sex, and age","volume":"57","author":"Amir","year":"1978","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1001\/archpsyc.65.2.135","article-title":"An evaluation of the mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence","volume":"65","author":"Anton","year":"2008","journal-title":"Arch. Gen. Psychiary."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0015","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.drugalcdep.2005.11.024","article-title":"Association of an Asn40Asp (A118G) polymorphism in the \u03bc-opioid receptor gene with substance dependence: a meta-analysis","volume":"83","author":"Arias","year":"2006","journal-title":"Drug Alcohol Depen."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0020","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archpsyc.64.3.369","article-title":"Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques","volume":"64","author":"Barr","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biopsych.2009.07.026","article-title":"Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the mu-opioid receptor gene locus","volume":"67","author":"Barr","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0030","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.npp.1300598","article-title":"Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden","volume":"30","author":"Bart","year":"2005","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0035","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/sj.mp.4000331","article-title":"Mu opioid receptor gene variants: lack of association with alcohol dependence","volume":"2","author":"Bergen","year":"1997","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0040","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.biopsych.2014.08.021","article-title":"A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice","volume":"77","author":"Bilbao","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0045","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1073\/pnas.95.16.9608","article-title":"Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction","volume":"95","author":"Bond","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0050","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.amepre.2011.06.045","article-title":"Economic costs of excessive alcohol consumption in the US, 2006","volume":"41","author":"Bouchery","year":"2011","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0055","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1369-1600.2012.00442.x","article-title":"Association of \u03bc-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systemic review and meta-analysis","volume":"17","author":"Chamorro","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-2999(79)90142-0","article-title":"Opiate receptor binding affected differentially by opiates and opioid peptides","volume":"55","author":"Childers","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0065","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/j.1530-0277.2000.tb01973.x","article-title":"Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats","volume":"24","author":"Crews","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0070","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely mocing rats","volume":"85","author":"Di Chiara","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0075","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/S0022-3565(25)24051-4","article-title":"Binding affinity and selectivity of opioids at mu, delta, and kappa receptors in monkey brains","volume":"271","author":"Emmerson","year":"1994","journal-title":"J Pharm Exp Ther"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0080","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/pr.59.1.3","article-title":"The endomorphin system and its evolving neurophysiological role","volume":"59","author":"Fichna","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0085","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.physbeh.2014.11.040","article-title":"Cocaine-induced suppression of saccharin intake and morphine modulation of Ca(2)(+) channel currents in sensory neurons of OPRM1 A118G mice","volume":"139","author":"Freet","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0090","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/sj.mp.4000556","article-title":"Genetics of two mu opioid gene (OPRM1) exon 1 polymorphisms: population studies and allele frequencies in alcohol and drug-dependent subjects","volume":"4","author":"Gelernter","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0095","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1530-0277.2007.00339.x","article-title":"VA Cooperative Study #425 Study Group Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA cooperative study","volume":"31","author":"Gelernter","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/oxfordjournals.alcalc.a008216","article-title":"Implications of endogenous opioids and dopamine in alcoholism: human and basic science studies","volume":"31","author":"Gianoulakis","year":"1996","journal-title":"Alcohol"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0105","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1523\/JNEUROSCI.18-24-10663.1998","article-title":"Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens","volume":"18","author":"Gonzales","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0110","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/03610737508257960","article-title":"Behavioral differences in young and aged mice: strain differences for activity measures, operant learning, sensory discrimination, and alcohol preference","volume":"1","author":"Goodrick","year":"1975","journal-title":"Exp. Aging Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.drugalcdep.2004.02.004","article-title":"The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: united States, 1991\u20131992 and 2001\u20132002","volume":"74","author":"Grant","year":"2004","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/adb.12165","article-title":"Association of OPRM1 A118G and alcohol sensitivity with intravenous alcohol administration in young adults","volume":"21","author":"Hendershot","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002130050169","article-title":"Endogenous opioid system and alcohol addiction","volume":"129","author":"Herz","year":"1997","journal-title":"Psychopharmacol"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0130","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/BJ20111050","article-title":"A common single nucleotide polymorphism A118G of the mu opioid receptor alters its N-glycosylation and protein stability","volume":"441","author":"Huang","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0135","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992","article-title":"Opioids excite dopamine neurons by hyperpolarization of local interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0140","first-page":"71","article-title":"Pharmacotherapy of alcohol dependence: targeting a complex disorder","volume":"2","author":"Kenna","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0145","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-6147(92)90060-J","article-title":"Drugs of abuse: anatomy, pharmacology, and function of reward pathways","volume":"13","author":"Koob","year":"1992","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0150","first-page":"1335","article-title":"Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis","volume":"25","author":"Kranzler","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0155","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/JCP.0b013e3181ac5213","article-title":"Targeted naltrexone for problem drinkers","volume":"29","author":"Kranzler","year":"2009","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0160","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1073\/pnas.0901800106","article-title":"Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior","volume":"106","author":"Mague","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0165","doi-asserted-by":"crossref","first-page":"9981","DOI":"10.1523\/JNEUROSCI.23-31-09981.2003","article-title":"K-opioid agonists directly inhibit midbrain dopaminergic neurons","volume":"23","author":"Margolis","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0170","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pbb.2007.07.011","article-title":"GABAergic modulation of binge-like ethanol intake in C57BL\/6J mice","volume":"88","author":"Moore","year":"2007","journal-title":"Pharmaco. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0175","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0180","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/archpsyc.1992.01820110045007","article-title":"Naltrexone and coping skills therapy for alcohol dependence: a controlled study","volume":"49","author":"O\u2019Malley","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0185","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1369-1600.2009.00159.x","article-title":"Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators","volume":"14","author":"Ooteman","year":"2009","journal-title":"Addict. Biol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0190","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/sj.npp.1300219","article-title":"A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients","volume":"28","author":"Oslin","year":"2003","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0195","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1001\/jamapsychiatry.2014.3053","article-title":"Naltrexone vs placebo for the treatment of alcohol dependence: a randomized clinical trial","volume":"72","author":"Oslin","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0200","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.physbeh.2004.02.008","article-title":"Opioids and alcoholism","volume":"81","author":"Oswald","year":"2004","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/10799898409042545","article-title":"Radioligands for probing opioid receptors","volume":"4","author":"Paterson","year":"1984","journal-title":"J. Recept. Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0210","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/01.jcp.0000245566.52401.20","article-title":"The status of naltrexone in the treatment of alcohol dependence. Specific effects on heavy drinking","volume":"26","author":"Pettinati","year":"2006","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0215","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/mp.2010.56","article-title":"A genetic determinant of the striatal dopamine response to alcohol in men","volume":"16","author":"Ramchandani","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0220","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1097\/01.ALC.0000148114.34000.B9","article-title":"A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans","volume":"28","author":"Ray","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0225","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/archpsyc.64.9.1069","article-title":"Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response","volume":"64","author":"Ray","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0230","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1530-0277.2011.01633.x","article-title":"The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review","volume":"36","author":"Ray","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0235","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.physbeh.2004.10.007","article-title":"Evaluation of a simple model of ethanol drinking to intoxication in C57BL\/6J mice","volume":"84","author":"Rhodes","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0240","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0022-3565(24)39326-7","article-title":"Mu-opioid receptor knockout mice do not self-administer alcohol","volume":"293","author":"Roberts","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0245","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/alcalc\/agt050","article-title":"Mu-opioid receptor gene (OPRM1) polymorphism A118G: Lack of association in finnish populations with alcohol dependence or alcohol consumption","volume":"48","author":"Rouvinen-Lagerstr\u00f6m","year":"2013","journal-title":"Alcohol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0250","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1073\/pnas.70.7.1947","article-title":"Stereospecific binding of the potent narcotic analgesic [3H]etorphine to rat brain homogenate (opiate\/receptor\/morphine\/antagonist)","volume":"70","author":"Simon","year":"1976","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0255","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","article-title":"Alcoholism: a systems approach for molecular physiology to addictive behavior","volume":"89","author":"Spanagel","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0260","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S1461145704004997","article-title":"Naltrexone for the treatment of alcoholism: a meta-analysis of randomized controlled trials","volume":"8","author":"Srisurapanont","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0265","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1176\/ajp.151.10.1463","article-title":"Naltrexone-induced alterations in human ethanol intoxication","volume":"151","author":"Swift","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0270","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(84)90374-1","article-title":"Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonist","volume":"104","author":"Takemori","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0275","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00001756-200303240-00008","article-title":"Mu opioid receptor gene polymorphism and heroin dependence in Asian populations","volume":"14","author":"Tan","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0280","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.alcohol.2013.08.005","article-title":"Drinking in the dark (DID) procedures: a model of binge-like ethanol drinking in non-dependent mice","volume":"48","author":"Thiele","year":"2014","journal-title":"Alcohol"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0285","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1530-0277.2007.00545.x","article-title":"Moderators of naltrexone\u2019s effects on drinking, urge, and alcohol effects in non-treatment seeking heavy drinkers in the natural environment","volume":"32","author":"Tidey","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-201X.1971.tb10998.x","article-title":"Stereotaxic mapping of the monoamine pathway in the rat brain","volume":"367","author":"Ungerstedt","year":"1971","journal-title":"Acta Physio. Scand."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0295","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.biopsych.2010.06.005","article-title":"Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [11C]raclopride","volume":"68","author":"Urban","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0300","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.drugalcdep.2010.01.005","article-title":"A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in monkeys","volume":"109","author":"Vallender","year":"2010","journal-title":"Drug Alcohol Depen."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0305","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/archpsyc.1992.01820110040006","article-title":"Naltrexone in the treatment of alcohol dependence","volume":"49","author":"Volpicelli","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0310","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1176\/ajp.152.4.613","article-title":"Effect of naltrexone on alcohol high in alcoholics","volume":"152","author":"Volpicelli","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0315","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1046\/j.1471-4159.2001.00362.x","article-title":"Inverse agonist and neutral antagnoists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence","volume":"77","author":"Wang","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0320","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1124\/jpet.106.118810","article-title":"Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment","volume":"321","author":"Wang","year":"2007","journal-title":"J Pharm. Exp. Ther."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0325","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2011.12.033","article-title":"Reduced expression of the mu opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G","volume":"205","author":"Wang","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0330","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S146114571200017X","article-title":"Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects","volume":"16","author":"Weerts","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0335","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.ne.19.030196.001535","article-title":"Addictive drugs and brain stimulation reward","volume":"19","author":"Wise","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0340","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0006-8993(98)00406-5","article-title":"Nucleus accumbens dopamine release modulation by mesolimbic GABAA receptors \u2212an in vivo electrochemical study","volume":"798","author":"Xi","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0345","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/hmg\/ddl024","article-title":"Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence","volume":"15","author":"Zhang","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0350","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1038\/npp.2016.60","article-title":"Opioid antagonists and the A118G polymorphism in the mu-opioid receptor gene: effects of GSK1521498 and naltrexone in healthy drinkers stratified by OPRM1 genotype","volume":"41","author":"Ziauddeen","year":"2016","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.brainresbull.2017.07.017_bib0355","doi-asserted-by":"crossref","first-page":"32618","DOI":"10.1074\/jbc.M504942200","article-title":"Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G","volume":"280","author":"Zhang","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923017300928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923017300928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:27:41Z","timestamp":1759782461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923017300928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":71,"alternative-id":["S0361923017300928"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2017.07.017","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased ethanol drinking in \u201chumanized\u201d mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2017.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}