{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:00:29Z","timestamp":1778583629842,"version":"3.51.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["039-4654"],"award-info":[{"award-number":["039-4654"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["039-4964"],"award-info":[{"award-number":["039-4964"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.brainresbull.2018.01.016","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T14:33:09Z","timestamp":1517409189000},"page":"356-362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine"],"prefix":"10.1016","volume":"137","author":[{"given":"Anastasia","family":"Hodes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzuri","family":"Lifschytz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haim","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Cohen Ben-Ami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lichtstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 3","key":"10.1016\/j.brainresbull.2018.01.016_bib0005","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1113\/jphysiol.2006.111252","article-title":"The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function","volume":"575","author":"Altamirano","year":"2006","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/pr.108.000711","article-title":"Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets","volume":"61","author":"Bagrov","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0015","doi-asserted-by":"crossref","first-page":"3975101","DOI":"10.1155\/2016\/3975101","article-title":"Oxidative stress implications in the affective disorders: main biomarkers, animal models relevance, genetic perspectives, and antioxidant approaches","volume":"2016","author":"Balmus","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0020","series-title":"The Clinical Neurobiology of the Hippocampus: an Integrative View","author":"Bartsch","year":"2012"},{"issue":"3","key":"10.1016\/j.brainresbull.2018.01.016_bib0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.mp.4001758","article-title":"The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia","volume":"11","author":"Benes","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0447.2007.01058.x","article-title":"Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder","volume":"434","author":"Berk","year":"2007","journal-title":"Acta Psychiatr. Scand. Suppl."},{"issue":"21","key":"10.1016\/j.brainresbull.2018.01.016_bib0035","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1113\/JP272419","article-title":"Pivotal role of alpha2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease","volume":"594","author":"Blaustein","year":"2016","journal-title":"J. Physiol."},{"issue":"11","key":"10.1016\/j.brainresbull.2018.01.016_bib0040","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.2042-7158.1998.tb03348.x","article-title":"Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole","volume":"50","author":"Boireau","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0045","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.brainresbull.2018.01.016_bib0050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pnpbp.2012.03.005","article-title":"Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain","volume":"38","author":"Bruning","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fendo.2015.00049","article-title":"Endogenous digitalis-like factors: an overview of the history","volume":"6","author":"Buckalew","year":"2015","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"3","key":"10.1016\/j.brainresbull.2018.01.016_bib0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/13556210120056544","article-title":"Adaptative response of antioxidant enzymes in different areas of rat brain after repeated d-amphetamine administration","volume":"6","author":"Carvalho","year":"2001","journal-title":"Addict. Biol."},{"issue":"9","key":"10.1016\/j.brainresbull.2018.01.016_bib0065","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jamapsychiatry.2013.1394","article-title":"Comorbidities and mortality in bipolar disorder: a Swedish national cohort study","volume":"70","author":"Crump","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.brainresbull.2018.01.016_bib0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22060990","article-title":"Protein interaction and Na\/K-ATPase-mediated signal transduction","volume":"22","author":"Cui","year":"2017","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.brainresbull.2018.01.016_bib0075","doi-asserted-by":"crossref","first-page":"C442","DOI":"10.1152\/ajpcell.00336.2011","article-title":"Endogenous ouabain regulates cell viability","volume":"302","author":"Dvela","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.brainresbull.2018.01.016_bib0080","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1034\/j.1399-5618.2003.00053.x","article-title":"Intracerebroventricular administration of ouabain as a model of mania in rats","volume":"5","author":"El-Mallakh","year":"2003","journal-title":"Bipolar Disord."},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0085","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.psychres.2009.03.032","article-title":"Aberrant regulation of endogenous ouabain-like factor in bipolar subjects","volume":"178","author":"El-Mallakh","year":"2010","journal-title":"Psychiatry Res."},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0090","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.brainresbull.2018.01.016_bib0095","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/j.1471-4159.1990.tb04880.x","article-title":"In vivo mechanisms underlying dopamine release from rat nigrostriatal terminals: I. studies using veratrine and ouabain","volume":"54","author":"Fairbrother","year":"1990","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.brainresbull.2018.01.016_bib0100","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1139\/jpn.0637","article-title":"Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania","volume":"31","author":"Frey","year":"2006","journal-title":"J. Psychiatry Neurosci."},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1017\/S1461145710000805","article-title":"Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders","volume":"14","author":"Gawryluk","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"5","key":"10.1016\/j.brainresbull.2018.01.016_bib0110","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.biopsych.2005.12.021","article-title":"Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders","volume":"60","author":"Goldstein","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.brainresbull.2018.01.016_bib0115","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.biopsych.2008.10.033","article-title":"Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders","volume":"65","author":"Goldstein","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.euroneuro.2011.05.007","article-title":"Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior","volume":"22","author":"Goldstein","year":"2012","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(00)00318-1","article-title":"Differential sensitivity to lithium's reversal of amphetamine-induced open-field activity in two inbred strains of mice","volume":"118","author":"Gould","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.brainresbull.2018.01.016_bib0130","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.npp.1301254","article-title":"Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium","volume":"32","author":"Gould","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.brainresbull.2018.01.016_bib0135","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0022-510X(89)90103-2","article-title":"Digitalis-like properties of an inhibitor of the Na+\/K+ pump in human cerebrospinal fluid","volume":"90","author":"Halperin","year":"1989","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fendo.2014.00201","article-title":"Natriuretic hormones in brain function","volume":"5","author":"Hodes","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.brainresbull.2018.01.016_bib0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/bdi.12413","article-title":"Endogenous cardiac steroids in animal models of mania","volume":"18","author":"Hodes","year":"2016","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0150","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3389\/fphys.2016.00209","article-title":"Insights into the pathology of the alpha3 Na(+)\/K(+)-ATPase ion pump in neurological disorders; lessons from animal models","volume":"7","author":"Holm","year":"2016","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.brainresbull.2018.01.016_bib0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jpsychires.2010.05.011","article-title":"Lithium and valproate modulate antioxidant enzymes and prevent ouabain-induced oxidative damage in an animal model of mania","volume":"45","author":"Jornada","year":"2011","journal-title":"J. Psychiatr. Res."},{"issue":"44","key":"10.1016\/j.brainresbull.2018.01.016_bib0160","doi-asserted-by":"crossref","first-page":"18144","DOI":"10.1073\/pnas.1108416108","article-title":"Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+, K+-ATPase alpha3 sodium pump","volume":"108","author":"Kirshenbaum","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.brainresbull.2018.01.016_bib0165","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1530\/EC-17-0161","article-title":"Update on angiotensin II: new endocrine connections between the brain, adrenal glands and the cardiovascular system","volume":"6","author":"Leenen","year":"2017","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0170","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","article-title":"Carbonyl assays for determination of oxidatively modified proteins","volume":"233","author":"Levine","year":"1994","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.brainresbull.2018.01.016_bib0175","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00424-008-0470-0","article-title":"The Na\/K-ATPase\/Src complex and cardiotonic steroid-activated protein kinase cascades","volume":"457","author":"Li","year":"2009","journal-title":"Pflugers Arch."},{"issue":"8\u20139","key":"10.1016\/j.brainresbull.2018.01.016_bib0180","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1023\/A:1012340702763","article-title":"Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function","volume":"26","author":"Lichtstein","year":"2001","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.brainresbull.2018.01.016_bib0185","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/0006-291X(80)91346-7","article-title":"Endogenous \u2018ouabain like' activity in rat brain","volume":"96","author":"Lichtstein","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"23","key":"10.1016\/j.brainresbull.2018.01.016_bib0190","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/S0024-3205(98)00186-6","article-title":"Biosynthesis of digitalis-like compounds in rat adrenal cells: hydroxycholesterol as possible precursor","volume":"62","author":"Lichtstein","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neuroscience.2015.08.041","article-title":"Animal models of bipolar mania: the past, present and future","volume":"321","author":"Logan","year":"2016","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.brainresbull.2018.01.016_bib0200","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1520-6394(1997)5:2<53::AID-DA1>3.0.CO;2-6","article-title":"Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness","volume":"5","author":"Looney","year":"1997","journal-title":"Depress. Anxiety"},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2007.05.016","article-title":"Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects","volume":"421","author":"Machado-Vieira","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0210","first-page":"2016","article-title":"Src-independent ERK signaling through the alpha3 isoform of Na\/K-ATPase","author":"Madan","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol.: ajpcell"},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0215","series-title":"Pharmacotherapy of Congestive Heart Failure. Goodman & Gilman's: The Pharmacological Basis of Therapeutics","first-page":"12e","author":"Maron","year":"2011"},{"issue":"1","key":"10.1016\/j.brainresbull.2018.01.016_bib0220","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/0004867412449303","article-title":"Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development","volume":"47","author":"Nierenberg","year":"2013","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.brainresbull.2018.01.016_bib0225","first-page":"685","article-title":"Presynaptic modulation by endogenous ouabain-like substances of noradrenaline release from blood vessels","volume":"40","author":"Oberfrank","year":"1988","journal-title":"Pol. J. Pharmacol. Pharm."},{"issue":"2","key":"10.1016\/j.brainresbull.2018.01.016_bib0230","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0235","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pnpbp.2012.10.017","article-title":"Antioxidants as potential therapeutics for neuropsychiatric disorders","volume":"46","author":"Pandya","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry."},{"issue":"9","key":"10.1016\/j.brainresbull.2018.01.016_bib0240","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.tips.2016.06.007","article-title":"Targeting oxidative stress in central nervous system disorders","volume":"37","author":"Patel","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0245","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neubiorev.2017.05.002","article-title":"The relationship between genetic risk variants with brain structure and function in bipolar disorder: a systematic review of genetic-neuroimaging studies","volume":"79","author":"Pereira","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0250","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pnpbp.2015.11.001","article-title":"Modeling mania in preclinical settings: a comprehensive review","volume":"66","author":"Sharma","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.brainresbull.2018.01.016_bib0255","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000444491","article-title":"Thiobarbituric acid-reactive substances: markers of an acute episode and a late stage of bipolar disorder","volume":"73","author":"Siwek","year":"2016","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0260","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bbr.2014.06.030","article-title":"The protective effect of melatonin against brain oxidative stress and hyperlocomotion in a rat model of mania induced by ouabain","volume":"271","author":"Souza","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.brainresbull.2018.01.016_bib0265","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21091172","article-title":"The role of Na\/K-ATPase signaling in oxidative stress related to obesity and cardiovascular disease","volume":"21","author":"Srikanthan","year":"2016","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.brainresbull.2018.01.016_bib0270","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00702-013-0973-5","article-title":"Intracerebroventricular administration of ouabain alters synaptic plasticity and dopamine release in rat medial prefrontal cortex","volume":"120","author":"Sui","year":"2013","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"Suppl. 2","key":"10.1016\/j.brainresbull.2018.01.016_bib0275","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1590\/1516-4446-2013-1168","article-title":"Contributions of animal models to the study of mood disorders","volume":"35","author":"Valvassori","year":"2013","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0280","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.psychres.2015.11.017","article-title":"Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain","volume":"235","author":"Valvassori","year":"2016","journal-title":"Psychiatry Res."},{"issue":"6","key":"10.1016\/j.brainresbull.2018.01.016_bib0285","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0306-4522(77)90118-X","article-title":"Presynaptic inhibition leading to disinhibition of acetylcholine release from interneurons of the caudate nucleus: effects of dopamine, \u03b2-endorphin and d-Ala2-Pro5-enkephalinamide","volume":"2","author":"Vizi","year":"1977","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.brainresbull.2018.01.016_bib0290","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/0028-3908(87)90177-8","article-title":"Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery","volume":"26","author":"Vizi","year":"1987","journal-title":"Neuropharmacology"},{"issue":"4\u20135","key":"10.1016\/j.brainresbull.2018.01.016_bib0295","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0306-4522(78)90040-4","article-title":"Na+-K+-activated adenosinetriphosphatase as a trigger in transmitter release","volume":"3","author":"Vizi","year":"1978","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.brainresbull.2018.01.016_bib0300","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1399-5618.2009.00717.x","article-title":"Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia","volume":"11","author":"Wang","year":"2009","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.brainresbull.2018.01.016_bib0305","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","article-title":"Glutathione peroxidase","volume":"77","author":"Wendel","year":"1981","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.brainresbull.2018.01.016_bib0310","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mi.3.3.157","article-title":"Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function","volume":"3","author":"Xie","year":"2003","journal-title":"Mol. Interv."},{"issue":"4","key":"10.1016\/j.brainresbull.2018.01.016_bib0315","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/j.1476-5381.2011.01318.x","article-title":"Predictive animal models of mania: hits, misses and future directions","volume":"164","author":"Young","year":"2011","journal-title":"Br. J. Pharmacol."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923017307116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923017307116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:32:03Z","timestamp":1759782723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923017307116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":63,"alternative-id":["S0361923017307116"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2018.01.016","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2018.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}