{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:11:29Z","timestamp":1759785089015,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"am","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["ZIE-HD-008737-12-14"],"award-info":[{"award-number":["ZIE-HD-008737-12-14"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.brainresbull.2018.04.005","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T12:06:41Z","timestamp":1523362001000},"page":"72-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Mice deficient in AKAP13 (BRX) develop compulsive-like behavior and increased body weight"],"prefix":"10.1016","volume":"140","author":[{"given":"K.","family":"Maravet Baig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Chi","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunni L.","family":"Mumford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinnie Sin Man","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-2218","authenticated-orcid":false,"given":"Margaret F.","family":"Keil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamaria Cayton","family":"Vaught","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyse","family":"Pettiford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Burd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-376X","authenticated-orcid":false,"given":"James H.","family":"Segars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2018.04.005_bib0005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/BJ20140606","article-title":"The crystal structure of the RhoA-AKAP-Lbc DH-pH domain complex","volume":"464","author":"Abdul-Azeez","year":"2014","journal-title":"Biochem. J"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tins.2016.12.003","article-title":"Current understanding of the hypothalamic ghrelin pathways inducing appetite and adiposity","volume":"40","author":"Al Massadi","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroscience.2011.08.070","article-title":"Current animal models of obsessive compulsive disorder: an update","volume":"211","author":"Albelda","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0020","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4088\/JCP.v60n0704","article-title":"Open trial of flutamide for treatment of obsessive-compulsive disorder","volume":"60","author":"Altemus","year":"1999","journal-title":"J. Clin. Psychiatry"},{"year":"2013","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","key":"10.1016\/j.brainresbull.2018.04.005_bib0025"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0030","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1440-1819.2009.01981.x","article-title":"Smaller pituitary volume in adult patients with obsessive-compulsive disorder","volume":"63","author":"Atmaca","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2164-11-25","article-title":"High-content siRNA screening of the kinome identifies kinases involved in Alzheimer\u2019s disease-related tau hyperphosphorylation","volume":"11","author":"Azorsa","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.regpep.2007.08.024","article-title":"The vagus nerve, food intake and obesity","volume":"149","author":"Berthoud","year":"2008","journal-title":"Regul. Pept."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0045","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.steroids.2011.02.031","article-title":"Aromatase and its inhibition in behaviour, obsessive compulsive disorder and Parkinsonism","volume":"76","author":"Boon","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0050","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.cpr.2005.04.012","article-title":"Personality and eating disorders: a decade in review","volume":"25","author":"Cassin","year":"2005","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0055","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.gene.2014.02.001","article-title":"Landscape of the relationship between type 2 diabetes and coronary heart disease through an integrated gene network analysis","volume":"539","author":"Dong","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0060","doi-asserted-by":"crossref","first-page":"46792","DOI":"10.1074\/jbc.M106927200","article-title":"The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway","volume":"276","author":"Driggers","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0065","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.brainresbull.2006.02.021","article-title":"Estrogen effects on the expression of Brx in the brain and pituitary of the mouse","volume":"69","author":"Eddington","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0070","first-page":"57","article-title":"Anti-androgenic treatment of obsessive-compulsive disorder: an open-label clinical trial of the long-acting gonadotropin-releasing hormone analogue triptorelin","volume":"22","author":"Eriksson","year":"2007","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0075","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.yhbeh.2008.10.002","article-title":"Ovarian hormones modulate compulsive lever-pressing in female rats","volume":"55","author":"Flaisher-Grinberg","year":"2009","journal-title":"Horm. Behav."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0080","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.4088\/JCP.14r09035","article-title":"Anxiety disorders during pregnancy: a systematic review","volume":"75","author":"Goodman","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0085","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biopsych.2006.01.012","article-title":"Estrogen deficient male mice develop compulsive behavior","volume":"61","author":"Hill","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0090","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1517\/17460441.2011.577772","article-title":"Animal models of obsessive compulsive disorder: recent findings and future directions","volume":"6","author":"Hoffman","year":"2011","journal-title":"Exp. Opin. Drug Discov."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0095","doi-asserted-by":"crossref","first-page":"e0132474","DOI":"10.1371\/journal.pone.0132474","article-title":"Genome-wide gene expression analysis shows AKAP13-mediated PKD1 signaling regulates the transcriptional response to cardiac hypertrophy","volume":"10","author":"Johnson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0100","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneumeth.2004.10.001","article-title":"The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research","volume":"143","author":"Kalueff","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0105","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.psyneuen.2011.09.016","article-title":"Anxiety phenotype in mice that overexpress protein kinase A","volume":"37","author":"Keil","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0110","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R)","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0115","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2337\/db14-1240","article-title":"Salt inducible kinase 1 terminates cAMP signaling by an evolutionarily conserved negative feedback loop in beta cells","volume":"64","author":"Kim","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0120","doi-asserted-by":"crossref","first-page":"9118","DOI":"10.1074\/jbc.M509339200","article-title":"Rho family guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system","volume":"281","author":"Kino","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0125","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/jbmr.2534","article-title":"Mice Deficient in AKAP13 (BRX) are osteoporotic and have impaired osteogenesis","volume":"30","author":"Koide","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0130","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neuroscience.2011.07.077","article-title":"Citalopram-mediated anxiolysis and differing neurobiological responses in both sexes of a genetic model of depression","volume":"194","author":"Kokras","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0135","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4088\/JCP.v66n0404","article-title":"Female reproductive cycle and obsessive-compulsive disorder","volume":"66","author":"Labad","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0140","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.lfs.2005.08.002","article-title":"Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying","volume":"78","author":"Li","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0145","doi-asserted-by":"crossref","first-page":"757461","DOI":"10.1155\/2014\/757461","article-title":"Estrogen deficiency and the origin of obesity during menopause","volume":"2014","author":"Lizcano","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0150","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopsych.2005.06.028","article-title":"Pituitary volume in pediatric obsessive-compulsive disorder","volume":"59","author":"MacMaster","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0376-6357(87)90021-0","article-title":"Measuring Behaviour, an introductory guide","volume":"15","author":"Martin","year":"1987","journal-title":"Behav. Process."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0160","doi-asserted-by":"crossref","first-page":"12344","DOI":"10.1074\/jbc.M110.106856","article-title":"The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice","volume":"285","author":"Mayers","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0165","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0002-9378(00)70213-4","article-title":"Expression of Brx proto-oncogene in normal ovary and in epithelial ovarian neoplasms","volume":"182","author":"Miller","year":"2000","journal-title":"Am. J. Obst. Gynecol."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0170","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fnbeh.2016.00215","article-title":"Ovarian sex hormones modulate compulsive, affective and cognitive functions in a non-induced mouse model of obsessive-compulsive disorder","volume":"10","author":"Mitra","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0175","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.physbeh.2016.11.002","article-title":"Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice","volume":"169","author":"Mitra","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0180","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0185","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1476-5381.1991.tb12392.x","article-title":"Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents","volume":"104","author":"Njung'e","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0190","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pnpbp.2013.01.021","article-title":"Sex- and endocrine-stage-differences in middle-aged rats in an animal model of OCD","volume":"44","author":"Olvera-Hern\u00e1ndez","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0195","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0200","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1192\/bjp.bp.108.055046","article-title":"Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder","volume":"195","author":"Radua","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0205","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/sj.onc.1201783","article-title":"Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action","volume":"16","author":"Rubino","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0210","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fendo.2015.00103","article-title":"The sexual dimorphism of lipid kinetics in humans","volume":"6","author":"Santosa","year":"2015","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0215","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.neubiorev.2013.07.015","article-title":"Is obesity a brain disease?","volume":"37","author":"Shefer","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0220","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00213-009-1466-y","article-title":"Marble burying reflects a repetitive and perseverative behavior more than novely-induced anxiety","volume":"204","author":"Thomas","year":"2009","journal-title":"Psychopharmacology"},{"year":"2015","series-title":"Consideration of Sex as a Biological Variable in NIH-funded Research (NOT-OD-15-102)","author":"U.S. National Institutes of Health","key":"10.1016\/j.brainresbull.2018.04.005_bib0225"},{"key":"10.1016\/j.brainresbull.2018.04.005_bib0230","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923017302253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923017302253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:29:26Z","timestamp":1759782566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923017302253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":46,"alternative-id":["S0361923017302253"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2018.04.005","relation":{},"ISSN":["0361-9230"],"issn-type":[{"type":"print","value":"0361-9230"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mice deficient in AKAP13 (BRX) develop compulsive-like behavior and increased body weight","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2018.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}