{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:51:33Z","timestamp":1786985493655,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102273"],"award-info":[{"award-number":["81102273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201052"],"award-info":[{"award-number":["81201052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["1208085QH149"],"award-info":[{"award-number":["1208085QH149"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for the Outstanding Youth Teachers of Anhui Medical University","award":["2013025"],"award-info":[{"award-number":["2013025"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.brainresbull.2019.01.022","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T20:27:42Z","timestamp":1548966462000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Ro41-5253, a selective antagonist of retinoic acid receptor \u03b1, ameliorates chronic unpredictable mild stress-induced depressive-like behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits"],"prefix":"10.1016","volume":"146","author":[{"given":"Qi","family":"Ke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2019.01.022_bib0005","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.psyneuen.2010.03.007","article-title":"The glucocorticoid receptor: pivot of depression and of antidepressant treatment?","volume":"36","author":"Anacker","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0010","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1365-2826.2008.01759.x","article-title":"Direct inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures","volume":"20","author":"Bali","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0015","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.brainresrev.2007.04.005","article-title":"The stress system in depression and neurodegeneration: focus on the human hypothalamus","volume":"57","author":"Bao","year":"2008","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4088\/JCP.10r05993","article-title":"Retinoic acid and affective disorders: the evidence for an association","volume":"73","author":"Bremner","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0025","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.euroneuro.2010.06.019","article-title":"Chronic all-trans retinoic acid administration induced hyperactivity of HPA axis and behavioral changes in young rats","volume":"20","author":"Cai","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0030","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.euroneuro.2015.04.009","article-title":"Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis","volume":"25","author":"Cai","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0035","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.biopsych.2009.05.031","article-title":"The involvement of retinoic acid receptor-alpha in corticotropin-releasing hormone gene expression and affective disorders","volume":"66","author":"Chen","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0040","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","article-title":"Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0050","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/gb-2004-6-1-204","article-title":"The MAP2\/Tau family of microtubule-associated proteins","volume":"6","author":"Dehmelt","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tins.2011.11.005","article-title":"The neurobiology of anhedonia and other reward-related deficits","volume":"35","author":"Der-Avakian","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1222939","article-title":"Synaptic dysfunction in depression: potential therapeutic targets","volume":"338","author":"Duman","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tins.2011.11.004","article-title":"Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents","volume":"35","author":"Duman","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0075","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.neuroscience.2005.12.058","article-title":"Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone","volume":"139","author":"Dwivedi","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0080","first-page":"429","article-title":"Prenatal stress, anxiety and depression: a mechanism involving CRH peptide family","volume":"35","author":"Fan","year":"2014","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069637","article-title":"The epidemiological modelling of major depressive disorder: application for the Global Burden of Disease Study 2010","volume":"8","author":"Ferrari","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0090","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10915810600961531","article-title":"Nonclinical vehicle use in studies by multiple routes in multiple species","volume":"25","author":"Gad","year":"2006","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0095","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.pnpbp.2012.04.019","article-title":"Effects of a putative antidepressant with a rapid onset of action in defeated mice with different coping strategies","volume":"38","author":"Gomez-Lazaro","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0100","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1002\/hipo.22037","article-title":"Patterning of retinoic acid signaling and cell proliferation in the hippocampus","volume":"22","author":"Goodman","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0105","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.neubiorev.2005.03.019","article-title":"Stress models of depression: forming genetically vulnerable strains","volume":"29","author":"Henn","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0110","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.1038\/tp.2013.98","article-title":"All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation","volume":"3","author":"Hu","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0115","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/hipo.22574","article-title":"Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior","volume":"26","author":"Hu","year":"2016","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0120","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1111\/j.1460-9568.2008.06191.x","article-title":"13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat","volume":"27","author":"Ishikawa","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0125","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.neuint.2013.08.005","article-title":"Etazolate rescues behavioral deficits in chronic unpredictable mild stress model: modulation of hypothalamic-pituitary-adrenal axis activity and brain-derived neurotrophic factor level","volume":"63","author":"Jindal","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.theriogenology.2012.09.001","article-title":"Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro41-5253) in canine testis: an in vitro organ culture study","volume":"79","author":"Kasimanickam","year":"2013","journal-title":"Theriogenology."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psc.2011.11.005","article-title":"The costs of depression","volume":"35","author":"Kessler","year":"2012","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnmol.2015.00041","article-title":"Gene-environment interaction in programming hippocampal plasticity: focus on adult neurogenesis","volume":"8","author":"Koehl","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/bs2020135","article-title":"Behavioral studies and genetic alterations in corticotropin-releasing hormone (CRH) neurocircuitry: insights into human psychiatric disorders","volume":"2","author":"Laryea","year":"2012","journal-title":"Behav. Sci. (Basel)"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0150","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","article-title":"Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure","volume":"69","author":"Li","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0155","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s11064-018-2545-4","article-title":"All-trans retinoic acid ameliorates the early experimental cerebral ischemia-reperfusion injury in rats by inhibiting the loss of the blood-brain barrier via the JNK\/P38MAPK signaling pathway","volume":"43","author":"Li","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2007.05.049","article-title":"Developing early formulations: practice and perspective","volume":"341","author":"Li","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0165","first-page":"97","article-title":"From the womb to adulthood: programming glucocorticoid and mineralocorticoid receptor expression in the brain","volume":"25","author":"Owen","year":"2002","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0170","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0175","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0180","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.psyneuen.2012.09.014","article-title":"Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients","volume":"38","author":"Qi","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0185","first-page":"18","article-title":"Antidepressant effects of abscisic acid mediated by the downregulation of corticotrophin-releasing hormone gene expression in rats","author":"Qi","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/cercor\/bht203","article-title":"Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorders","volume":"25","author":"Qi","year":"2015","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0149-7634(97)00001-8","article-title":"Stress and emotionality: a multidimensional and genetic approach","volume":"22","author":"Ramos","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0200","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.neuroscience.2007.03.027","article-title":"Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats","volume":"146","author":"Raone","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0205","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/jnr.23960","article-title":"Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: implications for cortical development","volume":"95","author":"Shapiro","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.arr.2005.03.003","article-title":"The stress system in the human brain in depression and neurodegeneration","volume":"4","author":"Swaab","year":"2005","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0215","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/(SICI)1097-0215(19980925)78:1<86::AID-IJC14>3.0.CO;2-3","article-title":"RARalpha antagonist Ro41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines","volume":"78","author":"Toma","year":"1998","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0220","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1074\/jbc.M114.602540","article-title":"Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression","volume":"290","author":"Tsukuda","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0225","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12264-010-0329-1","article-title":"Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress","volume":"26","author":"Wang","year":"2010","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0230","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1124\/pr.112.005660","article-title":"Strategies to address low drug solubility in discovery and development","volume":"65","author":"Williams","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0235","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0240","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainresbull.2019.01.022_bib0245","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainresbull.2017.09.015","article-title":"Crassifoside H improve the depressive-like behavior of rats under chronic unpredictable mild stress: possible involved mechanisms","volume":"135","author":"Zhang","year":"2017","journal-title":"Brain Res. Bull."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018308190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018308190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:36:15Z","timestamp":1759782975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923018308190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":49,"alternative-id":["S0361923018308190"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.01.022","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ro41-5253, a selective antagonist of retinoic acid receptor \u03b1, ameliorates chronic unpredictable mild stress-induced depressive-like behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}