{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:17:13Z","timestamp":1789057033277,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Science Foundation of China","award":["81330016"],"award-info":[{"award-number":["81330016"]}]},{"name":"National Science Foundation of China","award":["81630038"],"award-info":[{"award-number":["81630038"]}]},{"name":"National Science Foundation of China","award":["81300524"],"award-info":[{"award-number":["81300524"]}]},{"name":"National Science Foundation of China","award":["81771634"],"award-info":[{"award-number":["81771634"]}]},{"name":"National Science Foundation of China","award":["81200462"],"award-info":[{"award-number":["81200462"]}]},{"name":"National Key R\uff06D Program of China","award":["2017YFA0104200"],"award-info":[{"award-number":["2017YFA0104200"]}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of China","doi-asserted-by":"publisher","award":["IRT0935"],"award-info":[{"award-number":["IRT0935"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Bureau of Sichuan Province","award":["2016TD0002"],"award-info":[{"award-number":["2016TD0002"]}]},{"DOI":"10.13039\/501100004572","name":"Ministry of Health of China","doi-asserted-by":"publisher","award":["1311200003303"],"award-info":[{"award-number":["1311200003303"]}],"id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.brainresbull.2019.03.015","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T11:25:56Z","timestamp":1553945156000},"page":"79-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Role of toll-like receptor 4 in the regulation of the cell death pathway and neuroinflammation"],"prefix":"10.1016","volume":"148","author":[{"given":"Yafei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-069X","authenticated-orcid":false,"given":"Dezhi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2019.03.015_bib0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"Andersson","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/14728222.2018.1439924","article-title":"Extracellular HMGB1 as a therapeutic target in inflammatory diseases","volume":"22","author":"Andersson","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2018.12.016","article-title":"Toll-like receptor 2 and Toll-like receptor 4 exhibit distinct regulation of cancer cell stemness mediated by cell death-induced high-mobility group box 1","author":"Chen","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0020","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fnbeh.2018.00138","article-title":"Inhibiting RIPK1 limits neuroinflammation and alleviates postoperative cognitive impairments in D-Galactose-Induced aged mice","volume":"12","author":"Duan","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0025","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12035-012-8264-y","article-title":"HMGB1 in development and diseases of the central nervous system","volume":"45","author":"Fang","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0030","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/ijc.28766","article-title":"High hydrostatic pressure induces immunogenic cell death in human tumor cells","volume":"135","author":"Fucikova","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0035","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1523\/JNEUROSCI.3732-10.2011","article-title":"HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration","volume":"31","author":"Gao","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0040","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","article-title":"Sepsis-associated encephalopathy","volume":"8","author":"Gofton","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0045","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/CS20110164","article-title":"Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential","volume":"121","author":"Hanke","year":"2011","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0050","doi-asserted-by":"crossref","first-page":"13391","DOI":"10.1038\/ncomms13391","article-title":"Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse","volume":"7","author":"Imagawa","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0055","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuint.2011.01.004","article-title":"Septic encephalopathy: inflammation in man and mouse","volume":"58","author":"Jacob","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0065","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.4161\/auto.6.8.13651","article-title":"HMGB1: a novel Beclin 1-binding protein active in autophagy","volume":"6","author":"Kang","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2014.05.001","article-title":"HMGB1 in health and disease","volume":"40","author":"Kang","year":"2014","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0075","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1523\/JNEUROSCI.3815-05.2006","article-title":"HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain","volume":"26","author":"Kim","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0080","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0085","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2119\/2008-00034.Klune","article-title":"HMGB1: endogenous danger signaling","volume":"14","author":"Klune","year":"2008","journal-title":"Mol Med."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0090","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1440-1681.2008.05121.x","article-title":"The novel selective toll-like receptor 4 signal transduction inhibitor tak-242 prevents endotoxaemia in conscious Guinea-pigs","volume":"36","author":"Kuno","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.imlet.2009.05.006","article-title":"Partial role of TLR4 as a receptor responding to damage-associated molecular pattern","volume":"125","author":"Lee","year":"2009","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0100","article-title":"TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia","author":"Lee","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0110","first-page":"2735","article-title":"Alpha-Synuclein filaments bind the transcriptional regulator HMGB-1","volume":"15","author":"Lindersson","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0115","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1172\/JCI26322","article-title":"IKK\/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy","volume":"115","author":"Luo","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.freeradbiomed.2018.01.017","article-title":"Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H2O2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: implication for smokers-related osteoporosis","volume":"117","author":"Marinucci","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0125","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s12031-018-1057-7","article-title":"The potential role of toll-like receptor 4 in mediating dopaminergic cell loss and alpha-synuclein expression in the acute MPTP mouse model of parkinson\u2019s disease","volume":"64","author":"Mariucci","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.expneurol.2011.08.012","article-title":"High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products","volume":"232","author":"Mazarati","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0135","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1074\/jbc.M306793200","article-title":"Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein","volume":"279","author":"Park","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0140","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00401.2005","article-title":"High mobility group box 1 protein interacts with multiple Toll-like receptors","volume":"290","author":"Park","year":"2006","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0145","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.1021\/nn402330b","article-title":"Graphene oxide induces toll-like receptor 4 (TLR4)-dependent necrosis in macrophages","volume":"7","author":"Qu","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.expneurol.2016.03.011","article-title":"MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain","volume":"279","author":"Qu","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0155","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1365-2567.2010.03403.x","article-title":"Lipopolysaccharide induces H1 receptor expression and enhances histamine responsiveness in human coronary artery endothelial cells","volume":"132","author":"Raveendran","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0165","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1432-1033.1982.tb06890.x","article-title":"The binding sites for large and small high-mobility-group (HMG) proteins. Studies on HMG-nucleosome interactions in vitro","volume":"127","author":"Schroter","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0170","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejphar.2007.06.027","article-title":"Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model","volume":"571","author":"Sha","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0175","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","article-title":"Autophagy in health and disease: a double-edged sword","volume":"306","author":"Shintani","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0180","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4161\/auto.26751","article-title":"HMGB1 is involved in autophagy inhibition caused by SNCA\/alpha-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B","volume":"10","author":"Song","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0185","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1742-2094-11-106","article-title":"Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro","volume":"11","author":"Sun","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0190","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.200911078","article-title":"Endogenous HMGB1 regulates autophagy","volume":"190","author":"Tang","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0195","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(09)61158-2","article-title":"Systemic infection and delirium: when cytokines and acetylcholine collide","volume":"375","author":"van Gool","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0200","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0205","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12031-011-9575-6","article-title":"Role of autophagy in early brain injury after experimental subarachnoid hemorrhage","volume":"46","author":"Wang","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0210","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1172\/JCI31008","article-title":"TLR4 activation mediates kidney ischemia\/reperfusion injury","volume":"117","author":"Wu","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0215","doi-asserted-by":"crossref","first-page":"20699","DOI":"10.1073\/pnas.1320808110","article-title":"Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection","volume":"110","author":"Yanai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0220","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jneuroim.2017.06.006","article-title":"TLR4 signal ablation attenuated neurological deficits by regulating microglial M1\/M2 phenotype after traumatic brain injury in mice","volume":"310","author":"Yao","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0225","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/01.shk.0000225404.51320.82","article-title":"HMGB1 signals through toll-like receptor (TLR) 4 and TLR2","volume":"26","author":"Yu","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.brainresbull.2019.03.015_bib0230","first-page":"828","article-title":"Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011","volume":"125","author":"Zhang","year":"2012","journal-title":"Chin. Med. J. (Engl.)"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018308220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018308220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:33:58Z","timestamp":1759782838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923018308220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":46,"alternative-id":["S0361923018308220"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.03.015","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of toll-like receptor 4 in the regulation of the cell death pathway and neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}